DE3476399D1 - 4-substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds - Google Patents

4-substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds

Info

Publication number
DE3476399D1
DE3476399D1 DE8484302016T DE3476399T DE3476399D1 DE 3476399 D1 DE3476399 D1 DE 3476399D1 DE 8484302016 T DE8484302016 T DE 8484302016T DE 3476399 T DE3476399 T DE 3476399T DE 3476399 D1 DE3476399 D1 DE 3476399D1
Authority
DE
Germany
Prior art keywords
compounds
substituted
producing
medicaments containing
azetidinone compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484302016T
Other languages
English (en)
Inventor
Hidenori Iwamoto
Makoto Yoshida
Minoru Yamamoto
Toshinari Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58048989A external-priority patent/JPS59225182A/ja
Priority claimed from JP58221470A external-priority patent/JPS60115578A/ja
Priority claimed from JP58221469A external-priority patent/JPS60115577A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3476399D1 publication Critical patent/DE3476399D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
DE8484302016T 1983-03-25 1984-03-26 4-substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds Expired DE3476399D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58048989A JPS59225182A (ja) 1983-03-25 1983-03-25 ２−アゼチジノン−４−カルボン酸の誘導体
JP58221470A JPS60115578A (ja) 1983-11-25 1983-11-25 ２−アゼチジノン−４−置換化合物
JP58221469A JPS60115577A (ja) 1983-11-25 1983-11-25 ２−アゼチジノン−４−置換体

Publications (1)

Publication Number Publication Date
DE3476399D1 true DE3476399D1 (en) 1989-03-02

Family

ID=27293483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484302016T Expired DE3476399D1 (en) 1983-03-25 1984-03-26 4-substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds

Country Status (8)

Country Link
US (3) US4564609A (de)
EP (1) EP0123444B1 (de)
KR (3) KR870000357B1 (de)
CA (1) CA1256650A (de)
DE (1) DE3476399D1 (de)
DK (1) DK164684A (de)
ES (4) ES530960A0 (de)
NO (1) NO158740C (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719207A (en) * 1984-06-25 1988-01-12 Yamanouchi Pharmaceutical Co., Ltd. CNS active substituted azetidinone compounds
JPS6253994A (ja) 1985-05-09 1987-03-09 Yamanouchi Pharmaceut Co Ltd １−置換シリル−４−オキソ−２−アゼチジンカルボン酸低級アルキルエステル
ZA868957B (en) * 1985-12-06 1987-07-29 Yamanouchi Pharma Co Ltd Crystals of nalpha-(((s)-4-oxo-2-azetidinyl)carbonyl)-l-histidyl-l-prolinamide and process for producing the crystals
US5686420A (en) * 1987-06-05 1997-11-11 Georgetown University Thyrotropin-releasing hormone analogs and method of use
US5151497A (en) * 1989-02-21 1992-09-29 Japan Tobacco Inc. Histidyl peptide derivatives
DK437289D0 (da) * 1989-09-04 1989-09-04 Hans Bundgaard Prodrug derivatives of thyrotropin-releasing hormone (trh)
IT1249728B (it) * 1991-11-06 1995-03-09 Sigma Tau Ind Farmaceuti Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
WO1998050032A1 (en) * 1997-05-09 1998-11-12 Smithkline Beecham Corporation BETA-LACTAM INHIBITORS OF CoA-IT
US20020151502A1 (en) * 1997-10-09 2002-10-17 Albert Sattin Tri-peptides for neurological and neurobehavior applications
US7202279B1 (en) * 1998-02-11 2007-04-10 Georgetown University Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
EP1300155A1 (de) * 2000-07-11 2003-04-09 Shionogi & Co., Ltd. Enterische präparation mit physiologisch aktiven peptiden
WO2002017954A1 (fr) 2000-08-31 2002-03-07 Shionogi & Co., Ltd. Medicaments contre la maladie de parkinson
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US20030053981A1 (en) * 2001-01-26 2003-03-20 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
CA2434430A1 (en) * 2001-01-26 2002-08-01 Harry R. Davis The use of substituted azetidinone compounds for the treatment of sitosterolemia
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
RS51449B (sr) * 2001-01-26 2011-04-30 Schering Corporation Kombinacija aktivatora peroksizom proliferator-aktiviranog receptora (ppar) i inhibitora apsorpcije sterola i lečenje vaskularnih indikacija
NZ542090A (en) * 2001-01-26 2006-09-29 Schering Corp Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
TW200840563A (en) * 2001-01-26 2008-10-16 Schering Corp Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications
CZ20032031A3 (cs) * 2001-01-26 2003-12-17 Schering Corporation Farmaceutický prostředek
US20030013699A1 (en) * 2001-05-25 2003-01-16 Davis Harry R. Methods for treating alzheimer's disease and/or regulating levels of amyloid beta peptides in a subject
CN1556700A (zh) * 2001-09-21 2004-12-22 ���鹫˾ 使用甾醇吸收抑制剂治疗或预防脉管炎的方法
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
DE60216300T2 (de) * 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
AU2003291719A1 (en) * 2002-11-06 2004-06-03 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
CN1756755A (zh) * 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
DE602004018617D1 (de) * 2003-03-07 2009-02-05 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
JP5137228B2 (ja) * 2003-03-07 2013-02-06 メルク・シャープ・アンド・ドーム・コーポレーション 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
WO2005046797A2 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US7462595B2 (en) * 2004-09-17 2008-12-09 Prange Jr Arthur Jergen Methods for treating cancer-related fatigue
KR101137503B1 (ko) * 2009-07-14 2012-04-20 웰이앤씨 주식회사 고분자 고체 지지체를 이용한 히스티딜-프롤린아미드 유도체의 제조 방법
RU2652187C2 (ru) * 2013-08-16 2018-04-25 ЛОС АЛАМОС НЭШНЛ СЕКЬЮРИТИ, ЭлЭлСи Композиции и способы для улучшения продуктивности растений

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959248A (en) * 1974-04-03 1976-05-25 Merck & Co., Inc. Analogs of thyrotropin-releasing hormone
GB1523598A (en) * 1975-03-08 1978-09-06 Reckitt & Colmann Prod Ltd Tripeptides
US4271164A (en) * 1979-04-16 1981-06-02 Warner-Lambert Company 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
HU180926B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem
US4328134A (en) * 1980-05-06 1982-05-04 Schally Andrew Victor Anorexigenic peptides
US4426378A (en) * 1981-04-09 1984-01-17 The United States Of America As Represented By The Secretary Of The Army Thyrotropin releasing hormone in therapy of shock and as a central nervous system stimulant

Also Published As

Publication number Publication date
NO158740B (no) 1988-07-18
KR880009550A (ko) 1988-09-15
KR870000357B1 (ko) 1987-03-05
US4564609A (en) 1986-01-14
DK164684A (da) 1984-09-26
ES544235A0 (es) 1986-01-16
KR840008021A (ko) 1984-12-12
EP0123444B1 (de) 1989-01-25
US4610821A (en) 1986-09-09
ES8604136A1 (es) 1986-01-16
ES8600279A1 (es) 1985-10-01
NO841158L (no) 1984-09-26
US4636567A (en) 1987-01-13
KR890002104B1 (ko) 1989-06-19
ES530960A0 (es) 1985-10-01
ES8604209A1 (es) 1986-01-16
ES8604208A1 (es) 1986-01-16
EP0123444A1 (de) 1984-10-31
DK164684D0 (da) 1984-03-23
KR880009549A (ko) 1988-09-15
NO158740C (no) 1988-10-26
CA1256650A (en) 1989-06-27
ES544236A0 (es) 1986-01-16
ES544234A0 (es) 1986-01-16
KR890002105B1 (ko) 1989-06-19

Similar Documents

Publication Publication Date Title
DE3476399D1 (en) 4-substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds
ZA847165B (en) Carbonylmethylene-heterocyclic compounds containing trihalogeno-methyl groups,process for their preparation,and light-sensitive mixture containing the compounds
CS410891A3 (en) 1-benzylaminoalkylpyrrolidinones, process of their preparation andpharmaceuticals containing them
GB2144743B (en) Process for the preparation of penems
AU572163B2 (en) Process for the production of ammonia
HUT36119A (en) Process for production of pirido-4,3-g-indole derivatives and medical preparatives consisting of such compounds
EP0110397A3 (en) Polyprenyl compound, process for the production thereof and drug containing the same
AR241902A1 (es) Procedimiento para la preparacion de compuestos de 4-clorofenilsulfonilo.
DE3462025D1 (en) Process for the production of 2,3,5-trimethylbenzoquinone
DE3461176D1 (en) Catalytic process for the preparation of hexafluoracetone
DE3460828D1 (en) Process for the preparation of pure 3-acetylamino-aniline
IL71446A (en) Process for the preparation of 1,8-dihydroxy-10-alkanoyl-9-anthrones
GR80474B (en) Chinazolinderivatives, method for the preparation thereof, and medicaments containing said compounds
GB8332434D0 (en) Production of chemical compounds
ZA841979B (en) 4-substituted-2-azetidinone compounds,process of producing the compounds,and medicaments containing the compounds
DE3474663D1 (en) Novel method of producing 1,2,3-trithiane compounds
PH22479A (en) B-lactams and process for the manufacture of the same
PH21570A (en) Process for the preparation of b-lactan compounds
DE3465083D1 (en) Process of preparation of 2-substituted-5-nitroso-4,6-diamino-pyrimidines
HUT36080A (en) Herbicide containing new 2-methyl-4-isopropyl-2-pentenoil-anilide compounds as agent and process for the production of the agent
GB2138836B (en) Process for the preparation of 4-azaphthalide compounds
HUT36339A (en) Fungicides containing substituted azolile-tetrahydro-furane-2-ilidene-methane-derivatives as agent and process for the production of substituted azolile-tetrahydro-furano-2-ilidene-methane-derivatives
DE3461078D1 (en) Process for the preparation of diacyloxybutenes
DE3461470D1 (en) Process for the preparation of polycumylene
EP0119546A3 (en) Process for the preparation of compounds of the 4-oxo-damascon series, and perfumes of this compound class

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee