DE3482408D1 - Antithrombogen-polyurethan-polymer sowie verfahren zur verleihung von antithrombogener aktivitaet an ein polyurethan-substrat. - Google Patents

Antithrombogen-polyurethan-polymer sowie verfahren zur verleihung von antithrombogener aktivitaet an ein polyurethan-substrat.

Info

Publication number
DE3482408D1
DE3482408D1 DE8484308999T DE3482408T DE3482408D1 DE 3482408 D1 DE3482408 D1 DE 3482408D1 DE 8484308999 T DE8484308999 T DE 8484308999T DE 3482408 T DE3482408 T DE 3482408T DE 3482408 D1 DE3482408 D1 DE 3482408D1
Authority
DE
Germany
Prior art keywords
polyurethane
antithromogenic
antithromogen
giving
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484308999T
Other languages
English (en)
Inventor
Donald D Solomon
Charles W Mcgary
Vincent J Pascarella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deseret Medical Inc
Original Assignee
Deseret Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deseret Medical Inc filed Critical Deseret Medical Inc
Application granted granted Critical
Publication of DE3482408D1 publication Critical patent/DE3482408D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0011Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0047Enzymes, e.g. urokinase, streptokinase
DE8484308999T 1984-02-10 1984-12-21 Antithrombogen-polyurethan-polymer sowie verfahren zur verleihung von antithrombogener aktivitaet an ein polyurethan-substrat. Expired - Lifetime DE3482408D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/578,909 US4521564A (en) 1984-02-10 1984-02-10 Covalent bonded antithrombogenic polyurethane material

Publications (1)

Publication Number Publication Date
DE3482408D1 true DE3482408D1 (de) 1990-07-12

Family

ID=24314825

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484308999T Expired - Lifetime DE3482408D1 (de) 1984-02-10 1984-12-21 Antithrombogen-polyurethan-polymer sowie verfahren zur verleihung von antithrombogener aktivitaet an ein polyurethan-substrat.

Country Status (6)

Country Link
US (1) US4521564A (de)
EP (1) EP0152699B1 (de)
JP (1) JPH06836B2 (de)
AU (1) AU581831B2 (de)
CA (1) CA1221631A (de)
DE (1) DE3482408D1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600652A (en) * 1985-04-01 1986-07-15 Warner-Lambert Company Permanently bonded antithrombogenic polyurethane surface
US4642242A (en) * 1985-04-01 1987-02-10 Becton, Dickinson And Company Permanently bonded antithrombogenic polyurethane surface
CH665954A5 (fr) * 1985-07-08 1988-06-30 Battelle Memorial Institute Substrat dont la surface presente une activite antithrombogenique.
DE3541478A1 (de) * 1985-11-23 1987-05-27 Beiersdorf Ag Herzklappenprothese und verfahren zu deren herstellung
IT1213023B (it) * 1986-01-16 1989-12-07 Rolando Barbucci Materiale capace di adsorbire stabilmente elevate quantita' di eparina, e suo procedimento di preparazione.
US4720512A (en) * 1986-03-24 1988-01-19 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
US4786556A (en) * 1986-03-24 1988-11-22 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
US4722867A (en) * 1986-04-16 1988-02-02 Gregory Halpern Albumin-enhanced polysaccharide solution
JPH01500730A (ja) * 1986-08-20 1989-03-16 ザ・チャイルドレンズ・メディカル・センター・コーポレーション 生物学的材料移植片
NL8701337A (nl) * 1987-06-09 1989-01-02 Sentron V O F Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.
US4939007A (en) * 1988-03-07 1990-07-03 Becton, Dickinson And Company Article having a hemocompatible surface
US5059269A (en) * 1988-03-07 1991-10-22 Becton, Dickinson And Company Method of making an article having a hemocompatible surface
US5262451A (en) * 1988-06-08 1993-11-16 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5338770A (en) * 1988-06-08 1994-08-16 Cardiopulmonics, Inc. Gas permeable thrombo-resistant coatings and methods of manufacture
US5342693A (en) * 1988-06-08 1994-08-30 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coating and methods of manufacture
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US4865870A (en) * 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
DE68920925T2 (de) * 1988-07-11 1995-06-22 Terumo Corp Medizinisches Material und Gerät.
US5126140A (en) * 1988-08-03 1992-06-30 New England Deaconess Hospital Corporation Thrombomodulin-coated bicompatible substance
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5019393A (en) * 1988-08-03 1991-05-28 New England Deaconess Hospital Corporation Biocompatible substance with thromboresistance
US5281662A (en) * 1988-08-03 1994-01-25 New England Deaconess Hospital Corporation Anthraquinone dye treated materials
US5053048A (en) * 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US5053453A (en) * 1988-11-01 1991-10-01 Baxter International Inc. Thromboresistant materials and methods for making same
CA2000887A1 (en) * 1988-11-01 1990-05-01 Cecilia S.L. Ku Thromboresistant materials and methods for making same
US4888109A (en) * 1988-11-17 1989-12-19 Manohar Namala L Hemofilter for use in a continuous arterio-venous hemofiltration
US5165952A (en) * 1989-01-18 1992-11-24 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US6261271B1 (en) 1989-01-18 2001-07-17 Becton Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
JP2620378B2 (ja) * 1989-05-11 1997-06-11 鐘淵化学工業株式会社 生体適合性に優れた表面を有する医療用具の製造方法
US5216087A (en) * 1989-06-14 1993-06-01 Korea Institute Of Science And Technology Process for the preparation of sulfonated polyethyleneoxide-substituted polymers with improved blood compatibility
US5089205A (en) * 1989-09-25 1992-02-18 Becton, Dickinson And Company Process for producing medical devices having antimicrobial properties
DE69002295T2 (de) 1989-09-25 1993-11-04 Schneider Usa Inc Mehrschichtextrusion als verfahren zur herstellung von ballons zur gefaessplastik.
NL194941C (nl) * 1990-02-15 2003-08-04 Cordis Corp Werkwijze voor het aanbrengen van een fysiologisch actieve verbinding op een substraatoppervlak.
CA2080241A1 (en) * 1990-04-10 1991-10-11 M. Abdul Mazid Nonthrombogenic glycosaminoglycan copolymers
GB9009570D0 (en) * 1990-04-27 1990-06-20 Biocompatibles Ltd Antithrombogenic polymers
US5328698A (en) * 1990-08-06 1994-07-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic and/or anti-infective
US5322659A (en) * 1990-09-21 1994-06-21 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic and/or anti-infective
US5195969A (en) 1991-04-26 1993-03-23 Boston Scientific Corporation Co-extruded medical balloons and catheter using such balloons
US5159050A (en) * 1991-05-09 1992-10-27 Becton, Dickinson And Company Polyurethane and medical article therefrom
US5159051A (en) * 1991-05-09 1992-10-27 Becton, Dickinson And Company Biostable polyurethane
US5219662A (en) * 1991-05-23 1993-06-15 E. I. Du Pont De Nemours And Company Biocompatible polyurethanes by treatment with polyoxazoline block copolymers
US5356433A (en) * 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
EP0572624A4 (en) * 1991-12-18 1994-07-06 Scimed Life Systems Inc Lubricous polymer network
US5336518A (en) * 1992-12-11 1994-08-09 Cordis Corporation Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents
US5308641A (en) * 1993-01-19 1994-05-03 Medtronic, Inc. Biocompatibility of solid surfaces
US5350800A (en) * 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
US5738901A (en) * 1993-09-20 1998-04-14 Scimed Life Systems, Inc. Catheter balloon with retraction coating
WO1996014895A1 (en) * 1994-11-14 1996-05-23 Scimed Life Systems, Inc. Catheter balloon with retraction coating
US6896842B1 (en) 1993-10-01 2005-05-24 Boston Scientific Corporation Medical device balloons containing thermoplastic elastomers
WO1995009667A1 (en) 1993-10-01 1995-04-13 Boston Scientific Corporation Medical device balloons containing thermoplastic elastomers
CA2132783C (en) * 1993-10-18 2001-12-25 Leonard Pinchuk Lubricious silicone surface modification
DE4480681C2 (de) 1994-02-17 2001-09-27 Scimed Life Systems Inc Verfahren zur Herstellung von Katheter-Ballonen und danach hergestellte orientierte Ballone
US5532311A (en) * 1995-02-01 1996-07-02 Minnesota Mining And Manufacturing Company Process for modifying surfaces
US5583213A (en) * 1995-05-12 1996-12-10 Minnesota Mining And Manufacturing Company Process to activate sulfated polysaccharides
US5679659A (en) * 1995-08-22 1997-10-21 Medtronic, Inc. Method for making heparinized biomaterials
US5767108A (en) * 1995-08-22 1998-06-16 Medtronic, Inc. Method for making improved heparinized biomaterials
US5607475A (en) * 1995-08-22 1997-03-04 Medtronic, Inc. Biocompatible medical article and method
US5672638A (en) * 1995-08-22 1997-09-30 Medtronic, Inc. Biocompatability for solid surfaces
US5804318A (en) * 1995-10-26 1998-09-08 Corvita Corporation Lubricious hydrogel surface modification
US5925552A (en) 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
US5821343A (en) * 1996-04-25 1998-10-13 Medtronic Inc Oxidative method for attachment of biomolecules to surfaces of medical devices
US5945319A (en) * 1996-04-25 1999-08-31 Medtronic, Inc. Periodate oxidative method for attachment of biomolecules to medical device surfaces
US6033719A (en) * 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US5928916A (en) * 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
US5728420A (en) * 1996-08-09 1998-03-17 Medtronic, Inc. Oxidative method for attachment of glycoproteins to surfaces of medical devices
US5891506A (en) * 1996-08-09 1999-04-06 Medtronic, Inc. Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices
GB9608882D0 (en) 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers
US5855618A (en) 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US6306165B1 (en) 1996-09-13 2001-10-23 Meadox Medicals ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin
US5877263A (en) 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US5728751A (en) * 1996-11-25 1998-03-17 Meadox Medicals, Inc. Bonding bio-active materials to substrate surfaces
US5741881A (en) * 1996-11-25 1998-04-21 Meadox Medicals, Inc. Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions
US6197289B1 (en) 1997-07-01 2001-03-06 Terumo Cardiovascular Systems Corporation Removal of biologically active agents
US6146771A (en) * 1997-07-01 2000-11-14 Terumo Cardiovascular Systems Corporation Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6500481B1 (en) 1998-06-11 2002-12-31 Johnson & Johnson Vision Care, Inc. Biomedical devices with amid-containing coatings
US6087415A (en) 1998-06-11 2000-07-11 Johnson & Johnson Vision Care, Inc. Biomedical devices with hydrophilic coatings
WO2000041739A1 (en) * 1999-01-15 2000-07-20 University Of Utah Research Foundation Attachment of acid moiety-containing biomolecules to activated polymeric surfaces
US6528107B2 (en) 1999-01-19 2003-03-04 Sulzer Carbomedics Inc. Method for producing antimicrobial antithrombogenic medical devices
US6416549B1 (en) 1999-07-19 2002-07-09 Sulzer Carbomedics Inc. Antithrombogenic annuloplasty ring having a biodegradable insert
US6416548B2 (en) 1999-07-20 2002-07-09 Sulzer Carbomedics Inc. Antimicrobial annuloplasty ring having a biodegradable insert
DE60013323T2 (de) * 1999-10-19 2005-09-08 Commonwealth Scientific And Industrial Research Organisation Herstellung einer funktionalen polymeroberfläche
DE10036907B4 (de) * 2000-07-28 2012-03-22 Xantec Bioanalytics Gmbh Verfahren zur Herstellung einer Beschichtung auf einem mit Gold bedampften Glassubstrat, Beschichtung hergestellt nach diesem Verfahren und deren Verwendung
AU2003278987A1 (en) * 2002-09-26 2004-04-19 The Children's Hospital Of Philadelphia Method of determining surface binding capacity
AU2003276990A1 (en) * 2002-09-26 2004-04-19 The Children's Hospital Of Philadelphia Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
US6890998B2 (en) * 2002-09-26 2005-05-10 The Children's Hospital Of Philadelphia Thiol activation of polyurethanes and methods of making the same
US7408014B2 (en) * 2003-07-08 2008-08-05 The Children's Hospital Of Philadelphia Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
AU2005299672A1 (en) * 2004-10-22 2006-05-04 Benitec, Inc. Therapeutic RNAi agents for treating psoriasis
SG158174A1 (en) * 2005-01-06 2010-01-29 Benitec Inc Rnai agents for maintenance of stem cells
PT103560B (pt) 2006-09-04 2007-06-25 Inst Superior Tecnico Processo de fabrico e membranas hemocompatíveis de poliuretanas
WO2009009493A2 (en) 2007-07-09 2009-01-15 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES Aegyptin and uses thereof
TWI707926B (zh) 2010-07-30 2020-10-21 瑞士商愛爾康公司 可易於使用之聚矽氧水凝膠隱形鏡片
US9861814B2 (en) 2010-12-23 2018-01-09 Medtronic, Inc. Medical electrical lead having biological surface and methods of making and using same
US8702174B2 (en) 2011-09-27 2014-04-22 Bae Industries, Inc. Armrest exhibiting multiple stacked and fixed sectors in alignment with retractable pawls and exhibiting offset engaging teeth for ensuring incremental pivotal adjustability
JP6017572B2 (ja) 2011-10-12 2016-11-02 ノバルティス アーゲー コーティングによるuv吸収性眼用レンズの製造方法
EP2692365A1 (de) * 2012-08-03 2014-02-05 MaRVis Medical GmbH Implantierbare oder einsetzbare, mittels MRT erkennbare medizinische Vorrichtung mit einer Beschichtung, die paramagnetische Ionen umfasst, und Verfahren zu deren Herstellung
CN104684592B (zh) 2012-08-29 2017-07-14 心脏起搏器股份公司 用于医用导线的增强的低摩擦涂层和制造方法
JP6189447B2 (ja) 2012-11-21 2017-08-30 カーディアック ペースメイカーズ, インコーポレイテッド 医療装置、医療装置の電極およびその製造方法
WO2014095690A1 (en) 2012-12-17 2014-06-26 Novartis Ag Method for making improved uv-absorbing ophthalmic lenses
WO2014112956A1 (en) 2013-01-17 2014-07-24 Center Odličnosti Polimerni Marteriali In Tehnologije Method for treatment of a vascular graft
US9867912B2 (en) 2013-11-14 2018-01-16 Pfm Medical Titanium Gmbh Polyurethane having an antithrombogenic coating
JP6435863B2 (ja) * 2013-11-28 2018-12-12 東レ株式会社 抗血栓性材料
US9708087B2 (en) 2013-12-17 2017-07-18 Novartis Ag Silicone hydrogel lens with a crosslinked hydrophilic coating
US10995298B2 (en) * 2014-07-23 2021-05-04 Becton, Dickinson And Company Self-lubricating polymer composition
EP3186070B1 (de) 2014-08-26 2019-09-25 Novartis AG Verfahren zum auftragen einer stabilen beschichtung auf silikonhydrogelkontaktlinsen
WO2016080974A1 (en) 2014-11-19 2016-05-26 Halliburton Energy Services, Inc. Crosslinking resin for sand consolidation operations
EP3391101B1 (de) 2015-12-15 2020-07-08 Alcon Inc. Verfahren zum auftragen einer stabilen beschichtung auf silikonhydrogelkontaktlinsen
US11029446B2 (en) 2017-12-13 2021-06-08 Alcon Inc. Method for producing MPS-compatible water gradient contact lenses
US11613719B2 (en) 2018-09-24 2023-03-28 Becton, Dickinson And Company Self-lubricating medical articles

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3617344A (en) * 1966-08-05 1971-11-02 Us Health Education & Welfare Nonthrombogenic plastic surfaces and preparation thereof
US3616935A (en) * 1970-02-05 1971-11-02 Dow Chemical Co Preparation of antithrombogenic surfaces
US3846353A (en) * 1970-06-08 1974-11-05 Department Of Health Education Nonthrombogenic plastic material and method for making the same
US3853804A (en) * 1970-08-14 1974-12-10 California Inst Of Techn Ionic block elastomeric polymers
US3826678A (en) * 1972-06-06 1974-07-30 Atomic Energy Commission Method for preparation of biocompatible and biofunctional materials and product thereof
US4195127A (en) * 1975-06-10 1980-03-25 W. R. Grace & Co. Process for immobilizing proteins
FR2324664A1 (fr) * 1975-09-22 1977-04-15 Rhone Poulenc Ind Polyurethanes pour objets a usage medical
US4098645A (en) * 1976-02-24 1978-07-04 W. R. Grace & Co. Immobilization of proteins with polyurethane polymers
IT1081627B (it) * 1977-07-27 1985-05-21 Snam Progetti Procedimento per la preparazione di materiali biocompatibili e manufatti cosi' ottenuti
US4273873A (en) * 1977-10-25 1981-06-16 Unitika Ltd. Preparation of antithrombogenic polymeric materials
JPS54157816A (en) * 1978-05-27 1979-12-13 Unitika Ltd Fixing of bioactive substance to solid surface
JPS6037735B2 (ja) * 1978-10-18 1985-08-28 住友電気工業株式会社 人工血管
US4415490A (en) * 1979-07-24 1983-11-15 Nippon Zeon Co., Ltd. Non-thrombogenic material
US4326532A (en) * 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
DE3109141A1 (de) * 1981-03-11 1982-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Antithrombogene ausruestung von matrix-oberflaechen
NL188622C (nl) * 1981-12-15 1992-08-17 Cordis Europ Werkwijze ter verbetering van de bloedcompatibiliteit van een materiaaloppervlak door bekleding daarvan met een heparine of heparine-analoga en een eiwit houdende film, alsmede voorwerp, omvattende een oppervlak met verbeterde bloedcompatibiliteit verkregen onder toepassing van een op het oppervlak aangebrachte heparine of heparine-analoga en een eiwit houdende film.
SE8200751L (sv) * 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
SE456347B (sv) * 1982-02-09 1988-09-26 Ird Biomaterial Ab Ytmodifierat fast substrat samt forfarande for framstellning derav

Also Published As

Publication number Publication date
AU581831B2 (en) 1989-03-02
AU3682584A (en) 1985-08-15
EP0152699A2 (de) 1985-08-28
EP0152699B1 (de) 1990-06-06
CA1221631A (en) 1987-05-12
US4521564A (en) 1985-06-04
EP0152699A3 (en) 1987-01-28
JPS60170617A (ja) 1985-09-04
JPH06836B2 (ja) 1994-01-05

Similar Documents

Publication Publication Date Title
DE3482408D1 (de) Antithrombogen-polyurethan-polymer sowie verfahren zur verleihung von antithrombogener aktivitaet an ein polyurethan-substrat.
DE191613T1 (de) Verfahren zur isolierung von kleinen inseln.
AU4111485A (en) Verfahren zur ruckgewinnung von rohol oder raffinerieprodukt en aus zu schlammigem verdicktem bis kompaktem, sedimentier- tem rohol oder raffinerieprodukten, sowie vorrichtung zur
DE3587442D1 (de) Verfahren zur herstellung von polysilsesquioxanen.
DE58901757D1 (de) Verfahren zur herstellung von modifizierten polyisocyanaten.
DE3575423D1 (de) Verfahren zur herstellung von heteroaryloxyacetamiden.
DE3586638D1 (de) Verfahren zur herstellung von vanadylphthalocyanin.
DE3578062D1 (de) Verfahren zur herstellung von iodbenzol.
DE3584981D1 (de) Verfahren zur leistungsproduktion.
DE3582479D1 (de) Verfahren zur herstellung von polyester.
DE3481609D1 (de) Verfahren zur reinigung von polyisocyanaten.
DE3582015D1 (de) Verfahren zur herstellung von polyester.
DE3578648D1 (de) Loesliche vorstufe fuer polyimid-siloxan sowie verfahren zu dessen herstellung.
DE3580626D1 (de) Verfahren zur herstellung von schleifmitteln.
DE3581186D1 (de) Verfahren zur copolymerisation von aethylen.
DE3774004D1 (de) Verfahren zur haertung von polyurethanlacken.
DE3768605D1 (de) Verfahren zur haertung von polyisocyanat-beschichtungen.
DE3585219D1 (de) Verfahren zur herstellung von n-formyl-alpha-aspartyl-phenylalaninen.
DE3576817D1 (de) Verfahren zur herstellung von aminen.
DE3575133D1 (de) Verfahren zur herstellung von 1-alkyl- oder 1-cycloalkylpiperazinen.
DE3579858D1 (de) Verfahren zur herstellung von p-isobutylstyrol.
ATA58686A (de) Verfahren zur herstellung von polyurethanen, insbesondere von polyurethanelastomeren, sowie verfahren zur radikalischen polymerisation
DE3584754D1 (de) Verfahren zur herstellung von arylalkylketonen.
DE3579782D1 (de) Verfahren zur herstellung von harnstoffgruppen enthaltenden polyisocyanaten.
DE3577205D1 (de) Verfahren zur herstellung von modifizierten polyisocyanaten und ihre verwendung in polyurethananlacken.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee