DE3520008C2 - - Google Patents
Info
- Publication number
- DE3520008C2 DE3520008C2 DE3520008A DE3520008A DE3520008C2 DE 3520008 C2 DE3520008 C2 DE 3520008C2 DE 3520008 A DE3520008 A DE 3520008A DE 3520008 A DE3520008 A DE 3520008A DE 3520008 C2 DE3520008 C2 DE 3520008C2
- Authority
- DE
- Germany
- Prior art keywords
- gel
- substance
- concentration
- dvs
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Description
NaCl-Konzentration, M | |
Quellverhältnis | |
Wasser | |
990 | |
0,05 | 413 |
0,15 | 384 |
0,50 | 219 |
1,00 | 176 |
Gew.-% | |
A. Carbopol® 940 | |
0,4 | |
Gemisch Nr. 3 (Beispiel 23) | 10,0 |
Wasser | 83,3 |
B. Volpo® -3 | 1,0 |
Volpo® -5 | 0,5 |
Solulan® C-24 | 1,8 |
Roban® | 1,0 |
Crodamol® PMP | 0,5 |
Glucam® E-10 | 0,7 |
Konservierungsmittel | 0,3 |
C. Triäthanolamin | 0,4 |
Duftstoff | 0,1 |
Gewicht.-% | |
A. Carbopol® | |
0,25 | |
Karboxymethylcellulose 9H4F, 1% Wasserlösung | 2,00 |
Produkt des Beispiels 18 | 60,00 |
Wasser | 36,70 |
B. Robane® | 0,20 |
Cochin® | 0,10 |
Konservierungsmittel | 0,30 |
C. Triäthanolamin | 0,25 |
Duftstoffe | 0,20 |
Oleth-5 (Polyäthylenglycoläther von Oleylalkohol);
Volpo-3®:
Oleth-3 (Polyäthylenglycoläther von Oleylalkohol);
Solulan®:
Choleth-24 (Polyäthylenglycoläther von Cholesterol);
Crodamol® PMP:
(propoxyliertes Myristyl-Propionat) PPG-3 Myristyl-Äther- Propionat;
Glucam® E-10:
Methylgluceth-10 (Polyäthylenglycoläther von Methylglucose).
Claims (9)
- a) einer in dem gemischten Gel verteilten inerten wasserunlöslichen Substanz, oder
- b) einer kovalent an das makromolare Netz des Mischgels gebundenen niedermolekularen Substanz,
- a) Natriumhyaluronat mit einem Molekulargewicht von 50 000 bis 8×10⁶, und
- b) mindestens eines der hydrophilen Polymere nach Anspruch 1, und gegebenenfalls wahlweise
- c) eine inerte wasserunlösliche Substanz, oder
- d) eine niedermolekulare Substanz, die eine gegenüber Divinylsulfon reaktive funktionelle Guppe aufweist
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/678,895 US4582865A (en) | 1984-12-06 | 1984-12-06 | Cross-linked gels of hyaluronic acid and products containing such gels |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3520008A1 DE3520008A1 (de) | 1986-06-19 |
DE3520008C2 true DE3520008C2 (de) | 1991-10-10 |
Family
ID=24724742
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3546811A Expired - Lifetime DE3546811C2 (de) | 1984-12-06 | 1985-06-04 | |
DE19853520008 Granted DE3520008A1 (de) | 1984-12-06 | 1985-06-04 | Hyaluronsaeure-gele und -mischgele sowie verfahren zu deren herstellung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3546811A Expired - Lifetime DE3546811C2 (de) | 1984-12-06 | 1985-06-04 |
Country Status (9)
Country | Link |
---|---|
US (1) | US4582865A (de) |
JP (2) | JPS61138601A (de) |
AU (2) | AU569157B2 (de) |
CA (1) | CA1230186A (de) |
DE (2) | DE3546811C2 (de) |
FR (1) | FR2574414B1 (de) |
GB (4) | GB2168067B (de) |
IT (1) | IT1187737B (de) |
SE (2) | SE460792B (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252816A1 (de) * | 2002-11-13 | 2004-06-03 | Schwan-Stabilo Cosmetics Gmbh & Co. Kg | Kosmetische Zubereitung |
Families Citing this family (283)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
US4713448A (en) * | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
US5099013A (en) * | 1985-03-12 | 1992-03-24 | Biomatrix, Inc, | Hylan preparation and method of recovery thereof from animal tissues |
US5202431A (en) * | 1985-07-08 | 1993-04-13 | Fidia, S.P.A. | Partial esters of hyaluronic acid |
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
DE3684887D1 (de) * | 1985-11-29 | 1992-05-21 | Biomatrix Inc | Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung. |
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-
1984
- 1984-12-06 US US06/678,895 patent/US4582865A/en not_active Expired - Lifetime
-
1985
- 1985-05-08 CA CA000481055A patent/CA1230186A/en not_active Expired
- 1985-05-13 GB GB8512072A patent/GB2168067B/en not_active Expired
- 1985-05-28 AU AU43045/85A patent/AU569157B2/en not_active Expired
- 1985-05-28 FR FR8507941A patent/FR2574414B1/fr not_active Expired
- 1985-06-04 DE DE3546811A patent/DE3546811C2/de not_active Expired - Lifetime
- 1985-06-04 DE DE19853520008 patent/DE3520008A1/de active Granted
- 1985-07-04 JP JP60147612A patent/JPS61138601A/ja active Granted
- 1985-07-15 SE SE8503486A patent/SE460792B/sv not_active IP Right Cessation
- 1985-09-09 IT IT22089/85A patent/IT1187737B/it active
-
1986
- 1986-07-31 GB GB8618719A patent/GB2181147B/en not_active Expired
- 1986-07-31 GB GB8618720A patent/GB2181148B/en not_active Expired
-
1987
- 1987-04-28 AU AU72173/87A patent/AU572419B2/en not_active Expired
-
1988
- 1988-07-26 GB GB8817772A patent/GB2205848B/en not_active Expired
-
1989
- 1989-05-10 SE SE8901672A patent/SE501828C2/sv not_active IP Right Cessation
- 1989-09-06 JP JP1232667A patent/JPH0637575B2/ja not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252816A1 (de) * | 2002-11-13 | 2004-06-03 | Schwan-Stabilo Cosmetics Gmbh & Co. Kg | Kosmetische Zubereitung |
DE10252816B4 (de) * | 2002-11-13 | 2008-02-14 | Schwan-Stabilo Cosmetics Gmbh & Co. Kg | Kosmetische Zubereitung, sowie ein Verfahren zu ihrer Herstellung und ihre Verwendung |
Also Published As
Publication number | Publication date |
---|---|
DE3546811C2 (de) | 1993-09-02 |
GB8618719D0 (en) | 1986-09-10 |
SE8901672D0 (sv) | 1989-05-10 |
SE8503486L (sv) | 1986-06-07 |
GB2181147A (en) | 1987-04-15 |
IT1187737B (it) | 1987-12-23 |
US4582865A (en) | 1986-04-15 |
GB2168067B (en) | 1989-06-07 |
GB2168067A (en) | 1986-06-11 |
JPS61138601A (ja) | 1986-06-26 |
GB8512072D0 (en) | 1985-06-19 |
JPH0430961B2 (de) | 1992-05-25 |
GB2205848A (en) | 1988-12-21 |
SE460792B (sv) | 1989-11-20 |
AU572419B2 (en) | 1988-05-05 |
CA1230186A (en) | 1987-12-08 |
GB8817772D0 (en) | 1988-09-01 |
GB2181148B (en) | 1989-06-07 |
GB2181148A (en) | 1987-04-15 |
GB8618720D0 (en) | 1986-09-10 |
SE501828C2 (sv) | 1995-05-22 |
SE8901672L (sv) | 1989-05-10 |
AU7217387A (en) | 1987-08-27 |
SE8503486D0 (sv) | 1985-07-15 |
GB2181147B (en) | 1989-06-07 |
FR2574414B1 (fr) | 1987-07-03 |
FR2574414A1 (fr) | 1986-06-13 |
JPH0637575B2 (ja) | 1994-05-18 |
DE3520008A1 (de) | 1986-06-19 |
AU569157B2 (en) | 1988-01-21 |
AU4304585A (en) | 1986-06-12 |
IT8522089A0 (it) | 1985-09-09 |
JPH02138346A (ja) | 1990-05-28 |
GB2205848B (en) | 1989-05-24 |
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