DE3526339A1 - Transdermales abgabesystem zur verabreichung von fentanyl - Google Patents
Transdermales abgabesystem zur verabreichung von fentanylInfo
- Publication number
- DE3526339A1 DE3526339A1 DE19853526339 DE3526339A DE3526339A1 DE 3526339 A1 DE3526339 A1 DE 3526339A1 DE 19853526339 DE19853526339 DE 19853526339 DE 3526339 A DE3526339 A DE 3526339A DE 3526339 A1 DE3526339 A1 DE 3526339A1
- Authority
- DE
- Germany
- Prior art keywords
- active ingredient
- delivery system
- skin
- fentanyl
- reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
Fig. 3 ein Querschnitt durch eine weitere Ausführungsform nach der Erfindung;
Fig. 4 eine Kurve, die den Durchfluß durch die Haut in vitro gegen die Zeit für eine spezielle erfindungsgemäße
Fig. 5 eine Kurve, die den Durchfluß durch die Haut in vitro gegen die Zeit für eine andere spezielle Ausführungsform nach der Erfindung zeigt; Fig. 6 eine Kurve, die den Durchfluß durch die Haut in vitro gegen die Zeit für eine weitere erfindungsgemäße Ausführungsform zeigt;
Fig. 8 ebenfalls eine Kurve, die den Durchfluß durch die Haut in vitro gegen die Zeit für eine erfindungsgemäße Ausführungsform zeigt.
Ethanol 95 % | Mittel | 0-47 | 20-35 | |
gelbildendes | Basenform | 1-10 | 1-5 | |
Wirkstoff in | 0,1-10 | 0,1-2 % | ||
30 | H O | Rest | Rest | |
Silicon 0,025-0,076 mm
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3546830A DE3546830C2 (de) | 1984-07-23 | 1985-07-23 | Transdermales Abgabesystem zur Verabreichung von Fentanyl |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06633762 US4588580B2 (en) | 1984-07-23 | 1984-07-23 | Transdermal administration of fentanyl and device therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3526339A1 true DE3526339A1 (de) | 1986-01-30 |
DE3526339C2 DE3526339C2 (de) | 1992-01-09 |
Family
ID=24541036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19853526339 Granted DE3526339A1 (de) | 1984-07-23 | 1985-07-23 | Transdermales abgabesystem zur verabreichung von fentanyl |
Country Status (13)
Country | Link |
---|---|
US (1) | US4588580B2 (de) |
JP (1) | JP2547726B2 (de) |
BE (2) | BE902884A (de) |
CA (1) | CA1245983A (de) |
CH (1) | CH665351A5 (de) |
CY (1) | CY1560A (de) |
DE (1) | DE3526339A1 (de) |
ES (2) | ES8802276A1 (de) |
FR (1) | FR2567761B1 (de) |
GB (1) | GB2165148B (de) |
HK (1) | HK8191A (de) |
IT (1) | IT1183912B (de) |
NL (1) | NL8501979A (de) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3839410A1 (de) * | 1987-11-23 | 1989-06-01 | Alza Corp | Mittel zur transdermalen verabreichung von wirkstoffen |
US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
US8778382B2 (en) | 2003-04-30 | 2014-07-15 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
US8790689B2 (en) | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
US10568845B2 (en) | 2001-08-24 | 2020-02-25 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with fentanyl or related substances |
Families Citing this family (270)
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US5855908A (en) * | 1984-05-01 | 1999-01-05 | University Of Utah Research Foundation | Non-dissolvable drug-containing dosage-forms for use in the transmucosal delivery of a drug to a patient |
US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
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US5122127A (en) * | 1985-05-01 | 1992-06-16 | University Of Utah | Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues |
US5288497A (en) * | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
US4671953A (en) * | 1985-05-01 | 1987-06-09 | University Of Utah Research Foundation | Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics |
US4885173A (en) * | 1985-05-01 | 1989-12-05 | University Of Utah | Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities |
US5132114A (en) * | 1985-05-01 | 1992-07-21 | University Of Utah Research Foundation | Compositions and methods of manufacture of compressed powder medicaments |
US4645502A (en) * | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
DE3682165D1 (de) * | 1985-11-08 | 1991-11-28 | Nitto Denko Corp | Verwendung von heftpflastern fuer die haut und perkutanen praeparaten. |
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DE3775830D1 (de) * | 1986-06-13 | 1992-02-20 | Alza Corp | Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit. |
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- 1985-07-22 IT IT67666/85A patent/IT1183912B/it active
- 1985-07-22 FR FR8511157A patent/FR2567761B1/fr not_active Expired
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- 1985-07-23 JP JP60162780A patent/JP2547726B2/ja not_active Expired - Lifetime
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3839410A1 (de) * | 1987-11-23 | 1989-06-01 | Alza Corp | Mittel zur transdermalen verabreichung von wirkstoffen |
USRE41571E1 (en) | 1997-02-24 | 2010-08-24 | Purdue Pharma L.P. | Method of providing sustained analgesia with buprenorphine |
US6231886B1 (en) | 1997-02-24 | 2001-05-15 | Robert F. Reder | Methods of providing sustained treatment with opioids |
US6344212B2 (en) | 1997-02-24 | 2002-02-05 | Euro-Celtique S.A. | Method of providing sustained analgesia with buprenorphine |
USRE41408E1 (en) | 1997-02-24 | 2010-06-29 | Purdue Pharma L.P. | Method of providing sustained analgesia with buprenorpine |
USRE41489E1 (en) | 1997-02-24 | 2010-08-10 | Purdue Pharma L.P. | Method of providing sustained analgesia with buprenorphine |
US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
US9642850B2 (en) | 1997-02-24 | 2017-05-09 | Purdue Pharma L.P. | Method of providing sustained analgesia with buprenorphine |
US10568845B2 (en) | 2001-08-24 | 2020-02-25 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with fentanyl or related substances |
US10583093B2 (en) | 2001-08-24 | 2020-03-10 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with fentanyl or related substances |
US10940122B2 (en) | 2001-08-24 | 2021-03-09 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with fentanyl or related substances |
US8778382B2 (en) | 2003-04-30 | 2014-07-15 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
US8790689B2 (en) | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
Also Published As
Publication number | Publication date |
---|---|
ES8802276A1 (es) | 1988-05-01 |
CA1245983A (en) | 1988-12-06 |
GB2165148A (en) | 1986-04-09 |
US4588580A (en) | 1986-05-13 |
DE3526339C2 (de) | 1992-01-09 |
JP2547726B2 (ja) | 1996-10-23 |
ES545366A0 (es) | 1988-05-01 |
ES557179A0 (es) | 1987-08-16 |
CY1560A (en) | 1991-03-22 |
GB2165148B (en) | 1989-05-17 |
HK8191A (en) | 1991-02-01 |
BE902884A (fr) | 1985-11-04 |
ES8707667A1 (es) | 1987-08-16 |
US4588580B1 (de) | 1989-01-03 |
IT1183912B (it) | 1987-10-22 |
JPS6137725A (ja) | 1986-02-22 |
AU4452785A (en) | 1986-01-30 |
FR2567761A1 (fr) | 1986-01-24 |
IT8567666A0 (it) | 1985-07-22 |
BE905568R (fr) | 1987-02-02 |
CH665351A5 (de) | 1988-05-13 |
US4588580B2 (en) | 1999-02-16 |
GB8514445D0 (en) | 1985-07-10 |
FR2567761B1 (fr) | 1988-12-02 |
AU565177B2 (en) | 1987-09-10 |
NL8501979A (nl) | 1986-02-17 |
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