DE3571648C5 - Monoklonale Antikörper gegen menschlichen Brustkrebs, ihre Produktion und Verwendung, Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen. - Google Patents
Monoklonale Antikörper gegen menschlichen Brustkrebs, ihre Produktion und Verwendung, Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen. Download PDFInfo
- Publication number
- DE3571648C5 DE3571648C5 DE3571648T DE3571648T DE3571648C5 DE 3571648 C5 DE3571648 C5 DE 3571648C5 DE 3571648 T DE3571648 T DE 3571648T DE 3571648 T DE3571648 T DE 3571648T DE 3571648 C5 DE3571648 C5 DE 3571648C5
- Authority
- DE
- Germany
- Prior art keywords
- breast cancer
- antibody
- cells
- human breast
- mouse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/804—Drug, bio-affecting and body treating compositions involving IgG3, IgG4, IgA, or IgY
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/861—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
- Y10S530/864—Monoclonal
Abstract
Monoklonaler
Maus-Antikörper,
der
(a) ein menschliches Brustkrebs-Antigen bindet, das von einem Vergleichsantikörper ebenfalls gebunden wird, der von einem der unter ATCC HB8484 und HB8696 erhältlichen Hybridome gebildet wird;
(b) einen G- oder M-Isotyp aufweist; und
(c) nach Konjugation mit der Ricin-A-Kette zumindest gegen eine der Zellen MCF-7, CAmA-1, SKBR-3 oder BT-20 einen TCID 50%-Wert von weniger als etwa 10 nM aufweist;
(d) der an ein im Brustkrebs-Gewebe gefundenes Protein von annähernd 210 000 Dalton bindet; und
(e) menschliche Brustkrebszellen selektiv bindet.
(a) ein menschliches Brustkrebs-Antigen bindet, das von einem Vergleichsantikörper ebenfalls gebunden wird, der von einem der unter ATCC HB8484 und HB8696 erhältlichen Hybridome gebildet wird;
(b) einen G- oder M-Isotyp aufweist; und
(c) nach Konjugation mit der Ricin-A-Kette zumindest gegen eine der Zellen MCF-7, CAmA-1, SKBR-3 oder BT-20 einen TCID 50%-Wert von weniger als etwa 10 nM aufweist;
(d) der an ein im Brustkrebs-Gewebe gefundenes Protein von annähernd 210 000 Dalton bindet; und
(e) menschliche Brustkrebszellen selektiv bindet.
Description
- Das europäische Patent 0 153 114 wird mit Wirkung für das Hoheitsgebiet der Bundesrepublik Deutschland dadurch teilweise für nichtig erklärt, dass die Patentansprüche folgende Fassung erhalten.
Claims (10)
- Monoklonaler Maus-Antikörper, der (a) ein menschliches Brustkrebs-Antigen bindet, das von einem Vergleichsantikörper ebenfalls gebunden wird, der von einem der unter ATCC HB8484 und HB8696 erhältlichen Hybridome gebildet wird; (b) einen G- oder M-Isotyp aufweist; und (c) nach Konjugation mit der Ricin-A-Kette zumindest gegen eine der Zellen MCF-7, CAmA-1, SKBR-3 oder BT-20 einen TCID 50%-Wert von weniger als etwa 10 nM aufweist; (d) der an ein im Brustkrebs-Gewebe gefundenes Protein von annähernd 210 000 Dalton bindet; und (e) menschliche Brustkrebszellen selektiv bindet.
- Monoklonaler Maus-Antikörper, der (a) ein menschliches Brustkrebs-Antigen bindet, das von dem unter ATCC HB8484 erhältlichen Hybridom gebildeten Antikörper gebunden wird; (b) einen G-Isotyp aufweist; und (c) nach Konjugation mit der Ricin-A-Kette gegen MCF-7 Zellen einen TCID 50%-Wert von weniger als etwa 10 nM aufweist; (d) menschliche Brustkrebszellen selektiv bindet; und (e) der durch das Hybridom ATCC HB8484 gebildet wird.
- Monoklonaler Antikörper nach Anspruch 1, der durch das Hybridom HB8696 gebildet wird, oder ein monoklonaler Antikörper, der mit dem vorstehend genannten Antikörper oder mit dem Antikörper gemäß Anspruch 2 funktionell äquivalent ist.
- Maus × Maus-Hybridom, das einen monoklonalen Antikörper nach Anspruch 1 oder 2 bildet, und seine zur Herstellung des gegen menschlichen Brustkrebs gerichteten monoklonalen Antikörpers der Eltern-Zellen fähigen Nachkommen.
- Hybridom, nämlich HB8484 und HB8696; oder seine zur Herstellung des gegen menschlichen Brustkrebs gerichteten monoklonalen Antikörpers der Eltern-Zellen fähiger Nachkommen.
- Immuntoxin, das ein Konjugat aus einem monoklonalen Antikörper nach einem der Ansprüche 1 bis 3 und einer cytotoxischen Gruppe darstellt.
- Verfahren zur in vitro-Abtötung von menschlichen Brustkrebs-Zellen, umfassend, dass man die Zellen mit einer cytotoxisch-wirksamen Menge eines Immuntoxins nach Anspruch 6 in Kontakt bringt.
- Monoklonaler Antikörper nach einem der Ansprüche 1 bis 3, der mit einem nachweisbaren Marker markiert ist.
- Verfahren zur in vitro-Diagnose, ob eine menschliche Zelle eine Brustkrebszelle ist, bei dem man (a) eine menschliche Zelle mit einem Antikörper nach Anspruch 8 inkubiert; und (b) das Vorliegen von markierten binären Immun-Komplexen auf der menschlichen Zelle bestimmt.
- Verfahren zur Herstellung eines Hybridoms nach Anspruch 4, umfassend, dass man Maus-Tumorzellen mit Maus-Milzzellen aus einer mit menschlichen Brustkrebs-Antigen immunisierten Maus fusioniert und auf Hybridome selektiert, die Antikörper nach Anspruch 1 bilden.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57797684A | 1984-02-08 | 1984-02-08 | |
US577976 | 1984-02-08 | ||
US690750 | 1985-01-11 | ||
US06/690,750 US4753894A (en) | 1984-02-08 | 1985-01-11 | Monoclonal anti-human breast cancer antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3571648D1 DE3571648D1 (en) | 1989-08-24 |
DE3571648C5 true DE3571648C5 (de) | 2006-05-11 |
Family
ID=27077394
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3571648T Expired - Lifetime DE3571648C5 (de) | 1984-02-08 | 1985-02-08 | Monoklonale Antikörper gegen menschlichen Brustkrebs, ihre Produktion und Verwendung, Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen. |
DE2001199017 Pending DE10199017I1 (de) | 1984-02-08 | 1985-02-08 | Monoklonale Antikoerper gegen menschlichen Brustkrebs ihre Produktion und Verwendung Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2001199017 Pending DE10199017I1 (de) | 1984-02-08 | 1985-02-08 | Monoklonale Antikoerper gegen menschlichen Brustkrebs ihre Produktion und Verwendung Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen |
Country Status (14)
Country | Link |
---|---|
US (1) | US4753894A (de) |
EP (1) | EP0153114B1 (de) |
JP (4) | JPH0646958B2 (de) |
AT (1) | ATE44769T1 (de) |
DE (2) | DE3571648C5 (de) |
DK (1) | DK167194B1 (de) |
FI (1) | FI853884A0 (de) |
IE (1) | IE58974B1 (de) |
IL (1) | IL74271A (de) |
LU (1) | LU90734I2 (de) |
NL (1) | NL300040I2 (de) |
NO (2) | NO164306C (de) |
NZ (1) | NZ211070A (de) |
WO (1) | WO1985003523A1 (de) |
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US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
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AU601379B2 (en) * | 1985-11-07 | 1990-09-13 | Trustees Of Columbia University In The City Of New York, The | Antigen indicative of human breast cancer and assays based thereon |
-
1985
- 1985-01-11 US US06/690,750 patent/US4753894A/en not_active Expired - Lifetime
- 1985-01-24 WO PCT/US1985/000114 patent/WO1985003523A1/en active Application Filing
- 1985-01-24 JP JP60501030A patent/JPH0646958B2/ja not_active Expired - Lifetime
- 1985-02-07 NZ NZ211070A patent/NZ211070A/xx unknown
- 1985-02-07 IL IL74271A patent/IL74271A/xx not_active IP Right Cessation
- 1985-02-08 EP EP85300877A patent/EP0153114B1/de not_active Expired
- 1985-02-08 DE DE3571648T patent/DE3571648C5/de not_active Expired - Lifetime
- 1985-02-08 DE DE2001199017 patent/DE10199017I1/de active Pending
- 1985-02-08 AT AT85300877T patent/ATE44769T1/de active
- 1985-05-07 IE IE30085A patent/IE58974B1/en active Protection Beyond IP Right Term
- 1985-10-07 NO NO85853961A patent/NO164306C/no not_active IP Right Cessation
- 1985-10-07 FI FI853884A patent/FI853884A0/fi not_active Application Discontinuation
- 1985-10-08 DK DK460385A patent/DK167194B1/da active Protection Beyond IP Right Term
-
1992
- 1992-04-15 JP JP4095610A patent/JP2546570B2/ja not_active Expired - Lifetime
- 1992-04-15 JP JP4095607A patent/JP2502000B2/ja not_active Expired - Lifetime
-
1996
- 1996-04-03 JP JP8081684A patent/JP2769311B2/ja not_active Expired - Lifetime
-
2001
- 2001-02-28 LU LU90734C patent/LU90734I2/en unknown
- 2001-02-28 NO NO2001004C patent/NO2001004I1/no unknown
- 2001-02-28 NL NL300040C patent/NL300040I2/nl unknown
Also Published As
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---|---|
IE850300L (en) | 1985-08-08 |
ATE44769T1 (de) | 1989-08-15 |
EP0153114A3 (en) | 1985-10-09 |
NL300040I2 (nl) | 2004-01-05 |
FI853884L (fi) | 1985-10-07 |
WO1985003523A1 (en) | 1985-08-15 |
DE10199017I1 (de) | 2001-05-23 |
JPH05279400A (ja) | 1993-10-26 |
JPH05184360A (ja) | 1993-07-27 |
JP2502000B2 (ja) | 1996-05-29 |
NZ211070A (en) | 1989-02-24 |
LU90734I2 (en) | 2001-04-30 |
NO164306B (no) | 1990-06-11 |
NO164306C (no) | 1990-09-19 |
IE58974B1 (en) | 1993-12-15 |
NL300040I1 (nl) | 2001-05-01 |
JPH08295700A (ja) | 1996-11-12 |
DK460385D0 (da) | 1985-10-08 |
NO2001004I1 (no) | 2001-04-09 |
FI853884A0 (fi) | 1985-10-07 |
JPH0646958B2 (ja) | 1994-06-22 |
US4753894A (en) | 1988-06-28 |
JP2546570B2 (ja) | 1996-10-23 |
IL74271A0 (en) | 1985-05-31 |
EP0153114A2 (de) | 1985-08-28 |
DK460385A (da) | 1985-10-08 |
JPS61500789A (ja) | 1986-04-24 |
JP2769311B2 (ja) | 1998-06-25 |
DK167194B1 (da) | 1993-09-13 |
IL74271A (en) | 1988-11-30 |
DE3571648D1 (en) | 1989-08-24 |
NO853961L (no) | 1985-10-07 |
EP0153114B1 (de) | 1989-07-19 |
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