DE3585069D1 - Biologisch degradierbare form und verfahren zu deren herstellung. - Google Patents

Biologisch degradierbare form und verfahren zu deren herstellung.

Info

Publication number
DE3585069D1
DE3585069D1 DE8585901827T DE3585069T DE3585069D1 DE 3585069 D1 DE3585069 D1 DE 3585069D1 DE 8585901827 T DE8585901827 T DE 8585901827T DE 3585069 T DE3585069 T DE 3585069T DE 3585069 D1 DE3585069 D1 DE 3585069D1
Authority
DE
Germany
Prior art keywords
production
biodegradable form
biodegradable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585901827T
Other languages
English (en)
Inventor
Frederick H Silver
Richard A Berg
David E Birk
Kevin Weadock
Conrad Whyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Application granted granted Critical
Publication of DE3585069D1 publication Critical patent/DE3585069D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/08—Collagen
DE8585901827T 1984-03-27 1985-03-27 Biologisch degradierbare form und verfahren zu deren herstellung. Expired - Fee Related DE3585069D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59373384A 1984-03-27 1984-03-27
PCT/US1985/000504 WO1985004413A1 (en) 1984-03-27 1985-03-27 Biodegradable matrix and methods for producing same

Publications (1)

Publication Number Publication Date
DE3585069D1 true DE3585069D1 (de) 1992-02-13

Family

ID=24375922

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585901827T Expired - Fee Related DE3585069D1 (de) 1984-03-27 1985-03-27 Biologisch degradierbare form und verfahren zu deren herstellung.

Country Status (17)

Country Link
US (2) US4703108A (de)
EP (1) EP0177573B1 (de)
JP (1) JPH0811121B2 (de)
CN (1) CN85101396A (de)
AR (1) AR240608A1 (de)
AU (1) AU4210585A (de)
BR (1) BR8506206A (de)
CA (1) CA1295796C (de)
DE (1) DE3585069D1 (de)
DK (1) DK547485A (de)
ES (1) ES8605988A1 (de)
FI (1) FI854692A (de)
IL (1) IL74715A0 (de)
IT (1) IT1182725B (de)
MX (1) MX163953B (de)
NO (1) NO854723L (de)
WO (1) WO1985004413A1 (de)

Families Citing this family (458)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US4925924A (en) * 1984-03-27 1990-05-15 University Of Medicine And Dentistry Of New Jersey Biocompatible synthetic and collagen compositions having a dual-type porosity for treatment of wounds and pressure ulcers and therapeutic methods thereof
EP0487116B1 (de) * 1984-10-12 1999-12-29 ZymoGenetics, Inc. Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5498600A (en) * 1984-10-12 1996-03-12 Zymogenetics, Inc. Biologically active mosaic proteins
US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US5629191A (en) * 1985-01-03 1997-05-13 Integra Lifesciences Corporation Method of making a porous matrix particle
US5045633A (en) * 1985-02-25 1991-09-03 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5516896A (en) * 1985-02-25 1996-05-14 Zymogenetics, Inc. Biologically active B-chain homodimers
US4863856A (en) * 1985-04-04 1989-09-05 Verax Corporation Weighted collagen microsponge for immobilizing bioactive materials
US4861714A (en) * 1985-04-04 1989-08-29 Verax Corporation Weighted collagen microsponge for immobilizing bioactive material
US4997753A (en) * 1985-04-04 1991-03-05 Verax Corporation Weighted collagen microsponge for immobilizing bioactive material
US5628781A (en) * 1985-06-06 1997-05-13 Thomas Jefferson University Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
US4713446A (en) * 1985-09-06 1987-12-15 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for ophthalmic use and method of preparation
US4883864A (en) * 1985-09-06 1989-11-28 Minnesota Mining And Manufacturing Company Modified collagen compound and method of preparation
CA1284250C (en) * 1985-09-06 1991-05-14 Dale P. Devore Viscoelastic collagen solution for ophthalmic use and method of preparation
US4851513A (en) * 1985-09-06 1989-07-25 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for opthalmic use and method of preparation
IT1181737B (it) * 1985-11-26 1987-09-30 Pierfrancesco Morganti Supproto di collagene biologicamente attivo per uso cosmetico e farmaceutico e metodo per prepararlo
US5904718A (en) * 1986-03-27 1999-05-18 Biocoll Laboratories, Inc. Delayed drug delivery system
US6311690B1 (en) * 1986-03-27 2001-11-06 Gensci Orthobiologics, Inc. Bone repair material and delayed drug delivery system
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
HU202578B (en) * 1986-04-18 1991-03-28 Marrow Tech Inc Process for repricating bone marrow celles in three-dimension celle-cultivating systhem, three-dimension vehicle for the systhem and process for testing citotoxicity of the systhem
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5510254A (en) * 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
EP0318488A4 (de) * 1986-08-18 1990-02-26 Biota Scient Management Stimulierung der angiogenese und promotion der endothelialisierung.
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US5976878A (en) * 1987-04-28 1999-11-02 The Regents Of The University Of California Method and apparatus for preparing composite skin replacement
US5273900A (en) * 1987-04-28 1993-12-28 The Regents Of The University Of California Method and apparatus for preparing composite skin replacement
US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
JPS642643A (en) * 1987-06-26 1989-01-06 Bio Material Yunibaasu:Kk Artificial skin
US4983393A (en) * 1987-07-21 1991-01-08 Maximed Corporation Intra-vaginal device and method for sustained drug release
US5078744A (en) * 1987-09-04 1992-01-07 Bio-Products, Inc. Method of using tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5527893A (en) * 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
EP0352330A4 (de) * 1987-11-02 1990-03-27 Terumo Corp Fibroin-giessformen, verfahren zur herstellung, heparin-immobilisierungsträger und verfahren zur herstellung.
US5053388A (en) * 1987-11-09 1991-10-01 Chiron Ophthalmics, Inc. Wound healing composition and method
WO1989004172A1 (en) * 1987-11-09 1989-05-18 Chiron Ophthalmics Inc. Wound healing composition and method
US5759815A (en) * 1988-02-11 1998-06-02 Creative Biomolecules, Inc. Production of platelet derived growth factor (PDGF) an muteins thereof
US5660692A (en) * 1988-02-24 1997-08-26 Cedars-Sinai Medical Center Method of crosslinking amino acid-containing polymers using photoactivatable chemical crosslinkers
EP0403650B1 (de) * 1988-03-09 1994-05-25 Terumo Kabushiki Kaisha Für zellen eindringbares medizinisches material und kunsthaut
US5350583A (en) * 1988-03-09 1994-09-27 Terumo Kabushiki Kaisha Cell-penetrable medical material and artificial skin
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US4948540A (en) * 1988-08-01 1990-08-14 Semex Medical, Inc. Method of preparing collagen dressing sheet material
FR2635459B1 (fr) * 1988-08-17 1992-06-19 Cird Procede de fabrication de microspheres par reticulation de proteines, microspheres ainsi obtenues et leurs utilisations
US5298243A (en) * 1988-10-20 1994-03-29 Denki Kagaku Kogyo Kabushiki Kaisha Colony stimulating factor-gelatin conjugate
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5819748A (en) * 1988-11-30 1998-10-13 Ed Geistlich Sohne Ag Fur Chemische Industrie Implant for use in bone surgery
DE68926051T2 (de) * 1988-12-20 1996-08-29 Jolla Cancer Res Found Polypeptid-polymer-konjugate mit wundheilender wirkung
US5654267A (en) * 1988-12-20 1997-08-05 La Jolla Cancer Research Center Cooperative combinations of ligands contained within a matrix
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
CS277464B6 (en) * 1989-09-26 1993-03-17 Ustav Makromolekularni Chemie Contact lens made of hydrophilic gels
CA2042577A1 (en) * 1989-10-17 1991-04-18 Hermann Oppermann Osteogenic devices
DE3936568C2 (de) * 1989-11-03 1997-06-19 Karlheinz Prof Dr Dr Schmidt Wirkstoffkomplex für die Herstellung von biologischen Teilen in Form von Organen für Lebewesen; Verfahren zum Herstellen desselben und seine Verwendung
BR9106354A (pt) * 1990-04-24 1993-04-27 Mark Eisenberg Equivalente de pele viva composta,seu processo de preparacao; kit de teste,seu processo de preparacao,e processo de testar efeito de substancia sobre a pele
US5197882A (en) * 1990-05-14 1993-03-30 Gary R. Jernberg Periodontal barrier and method for aiding periodontal tissue regeneration agents
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
US5833665A (en) 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5603872A (en) * 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
US5785983A (en) * 1991-05-23 1998-07-28 Euroresearch Srl Non-porous collagen sheet for therapeutic use, and the method and apparatus for preparing it
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
JPH06500802A (ja) * 1991-06-14 1994-01-27 アムジエン・インコーポレーテツド コラーゲンフィルムによるタンパクのドラッグ・デリバリー
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
WO1994007505A1 (en) * 1991-07-03 1994-04-14 Norpharmco Inc. Use of hyaluronic acid and forms to prevent arterial restenosis
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
CA2071137A1 (en) * 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
IT1251151B (it) * 1991-08-05 1995-05-04 Fidia Spa Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati
WO1993003757A1 (en) * 1991-08-16 1993-03-04 Chiron Corporation Muteins of epidermal growth factor exhibiting enhanced binding at low ph
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US6147059A (en) * 1992-02-20 2000-11-14 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
GB9206509D0 (en) * 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
EP0567886A3 (de) * 1992-04-21 1994-11-02 Kurashiki Boseki Kk Beschichtungszusammensetzung zur Züchtung von haftenden Tierzellen und Verfahren zur Züchtung der Zellen in serumfreien Verhältnissen.
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
US6350274B1 (en) 1992-05-11 2002-02-26 Regen Biologics, Inc. Soft tissue closure systems
US5326350A (en) * 1992-05-11 1994-07-05 Li Shu Tung Soft tissue closure systems
US5928635A (en) * 1994-12-07 1999-07-27 Schmidt; Karlheinz Process for producing active agent complexes
US7214654B1 (en) 1994-12-07 2007-05-08 Karlheinz Schmidt Agent for the manufacture of biological parts including an active ingredient complex and carrying materials suitable for the active ingredient complex
US5916553A (en) * 1992-09-17 1999-06-29 Schmidt; Karlheinz Complex for inducing bone growth in the mastoid cavity
WO1994006460A1 (en) * 1992-09-21 1994-03-31 Vitaphore Corporation Embolization plugs for blood vessels
US5331092A (en) * 1992-11-06 1994-07-19 Coletica Process of preparation of collagen containing in major proportion insoluble collagen and collagen having high mechanical resistance and thermal stability obtained thereby
WO1994017097A1 (en) * 1993-01-19 1994-08-04 Regents Of The University Of Minnesota Synthetic fibronectin fragments as inhibitors of retroviral infections
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
US5565210A (en) * 1993-03-22 1996-10-15 Johnson & Johnson Medical, Inc. Bioabsorbable wound implant materials
WO1994027630A1 (fr) * 1993-05-31 1994-12-08 Kaken Pharmaceutical Co., Ltd. Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base
US5316942A (en) * 1993-06-16 1994-05-31 Battelle Memorial Institute Process for the production of low-cost soluble high-molecular weight collagen
US5700354A (en) * 1993-06-16 1997-12-23 Ranpak Corp. Paper strengthened with solubilized collagen and method
US5711853A (en) * 1993-06-16 1998-01-27 Ranpak Corp. Paper strengthened with solubilized collagen and method
US5810970A (en) * 1993-06-16 1998-09-22 Ranpak Corporation Paper strengthened with solubilized collagen and method
WO1995003036A1 (en) 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5487895A (en) * 1993-08-13 1996-01-30 Vitaphore Corporation Method for forming controlled release polymeric substrate
EP0664699A1 (de) * 1993-08-13 1995-08-02 Vitaphore Corporation Arzneimittelabgabesystem auf der Basis von Hydrogelmikrokugeln
GB2281861B (en) * 1993-09-21 1997-08-20 Johnson & Johnson Medical Bioabsorbable wound implant materials containing microspheres
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
SE9400036D0 (sv) * 1994-01-10 1994-01-10 Pharmacia Ab Low modecular weight hyaluronic acid
CA2140053C (en) * 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US6074840A (en) * 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6334872B1 (en) 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
DE4414755C2 (de) 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
US5558875A (en) * 1994-06-06 1996-09-24 Wang; Su Method of preparing collagenous tissue
JPH10508504A (ja) 1994-09-16 1998-08-25 バイオプシス メディカル インコーポレイテッド 組織を特定しおよびマーキングする方法および装置
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5709934A (en) * 1994-11-22 1998-01-20 Tissue Engineering, Inc. Bipolymer foams having extracellular matrix particulates
US5660854A (en) * 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6485723B1 (en) * 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US6962979B1 (en) * 1995-03-14 2005-11-08 Cohesion Technologies, Inc. Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
US6337389B1 (en) * 1995-03-17 2002-01-08 Bioscience Consultants, L.L.C. Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof
US5714582A (en) * 1995-03-17 1998-02-03 Bioscience Consultants Invertebrate type V telopeptide collagen, methods of making, and use thereof
US5723010A (en) * 1995-03-31 1998-03-03 Toyo Boseki Kabushiki Kaisha Medical device and method for producing the same
US20020095218A1 (en) * 1996-03-12 2002-07-18 Carr Robert M. Tissue repair fabric
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
JP3799626B2 (ja) * 1995-04-25 2006-07-19 有限会社ナイセム 心臓血管修復材及びその製造方法
US20040002772A1 (en) * 1995-04-28 2004-01-01 Organogenesis, Inc. Tissue equivalents with perforations for improved integration to host tissues and methods for producing perforated tissue equivalents
US6705323B1 (en) 1995-06-07 2004-03-16 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and methods
BR9609393A (pt) * 1995-06-07 1999-12-21 Organogenesis Inc Composição injetável de colágeno; segmentos de fibra de colágeno reconstituìdos.
US6176240B1 (en) 1995-06-07 2001-01-23 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and their delivery
US6528483B2 (en) 1995-06-07 2003-03-04 André Beaulieu Method of producing concentrated non-buffered solutions of fibronectin
US5674292A (en) * 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US7112320B1 (en) 1995-06-07 2006-09-26 Andre Beaulieu Solid wound healing formulations containing fibronectin
US5792090A (en) * 1995-06-15 1998-08-11 Ladin; Daniel Oxygen generating wound dressing
JP2731833B2 (ja) * 1995-06-26 1998-03-25 大同ほくさん株式会社 海洋生物を原料とした代用皮膚
US6010694A (en) * 1995-07-27 2000-01-04 Thomas Jefferson University Fibrillin 1 gene comprising duplication mutation and compositions and kits using the same
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
US6423095B1 (en) * 1995-10-16 2002-07-23 Sdgi Holdings, Inc. Intervertebral spacers
US5733884A (en) * 1995-11-07 1998-03-31 Nestec Ltd. Enteral formulation designed for optimized wound healing
US5863984A (en) * 1995-12-01 1999-01-26 Universite Laval, Cite Universitaire Biostable porous material comprising composite biopolymers
PT1704878E (pt) * 1995-12-18 2013-07-17 Angiodevice Internat Gmbh Composições de polímeros reticulados e métodos para a sua utilização
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US7883693B2 (en) 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
GB2311027B (en) * 1996-03-15 1999-10-27 Johnson & Johnson Medical Coated bioabsorbable beads for wound treatment
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US5834232A (en) * 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
US5792478A (en) * 1996-07-08 1998-08-11 Advanced Uro Science Tissue injectable composition and method of use
US6666892B2 (en) * 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US8716227B2 (en) * 1996-08-23 2014-05-06 Cook Biotech Incorporated Graft prosthesis, materials and methods
DE69725592T2 (de) 1996-08-23 2004-08-05 Cook Biotech, Inc., West Lafayette Verfahren zur gewinnung einer gereignigten matrix auf kollagenbasis aus submukosa gewebe
US6165487A (en) * 1996-09-30 2000-12-26 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
FR2754268B1 (fr) * 1996-10-07 1998-12-24 Dev Des Utilisations Du Collag Composition adhesive a base de polyaldehyde macromoleculaire et procede de reticulation de collagene ou de gelatine
US5814328A (en) 1997-01-13 1998-09-29 Gunasekaran; Subramanian Preparation of collagen using papain and a reducing agent
US6221997B1 (en) 1997-04-28 2001-04-24 Kimberly Ann Woodhouse Biodegradable polyurethanes
US6123957A (en) * 1997-07-16 2000-09-26 Jernberg; Gary R. Delivery of agents and method for regeneration of periodontal tissues
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
EP1007673B1 (de) 1997-07-30 2008-12-17 Emory University Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
DE19739031A1 (de) * 1997-09-05 1999-03-11 Suwelack Nachf Dr Otto Mittel zur peroralen Verabreichung, seine Herstellung und Verwendung
AU1075699A (en) 1997-10-10 1999-05-03 Allegheny Health, Education And Research Foundation Hybrid nanofibril matrices for use as tissue engineering devices
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US7637948B2 (en) * 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US6270464B1 (en) 1998-06-22 2001-08-07 Artemis Medical, Inc. Biopsy localization method and device
US20040081704A1 (en) * 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US6194378B1 (en) 1998-02-18 2001-02-27 The Research Foundation Of State University Of New York Fibronectin peptides-based extracellular matrix for wound healing
US5958874A (en) * 1998-02-18 1999-09-28 The Research Foundation Of State University Of New York Recombinant fibronectin-based extracellular matrix for wound healing
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
ATE423577T1 (de) * 1998-06-05 2009-03-15 Organogenesis Inc Biologisch modellierte implantierbare prothesen
MXPA00012062A (es) * 1998-06-05 2003-04-22 Organogenesis Inc Protesis biodisenadas de injerto de hoja plana.
EP1083843A4 (de) * 1998-06-05 2005-06-08 Organogenesis Inc Biotechnisch hergestelltes gefässimplantat
ATE424147T1 (de) * 1998-06-05 2009-03-15 Organogenesis Inc Biotechnisch erzeugte gefässprothese für die implantation
US6630001B2 (en) 1998-06-24 2003-10-07 International Heart Institute Of Montana Foundation Compliant dehyrated tissue for implantation and process of making the same
US6458109B1 (en) 1998-08-07 2002-10-01 Hill-Rom Services, Inc. Wound treatment apparatus
US20020015724A1 (en) * 1998-08-10 2002-02-07 Chunlin Yang Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US6586406B2 (en) 1998-10-14 2003-07-01 Depuy Acromed, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
ATE410119T1 (de) 1998-12-01 2008-10-15 Univ Washington Vorrichtung zur intravaskulären embolisierung
US8882850B2 (en) 1998-12-01 2014-11-11 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
DE19856668A1 (de) * 1998-12-09 2000-06-15 Aesculap Ag & Co Kg Wirkstoffmatrix in Form eines biologisch resorbierbaren porösen Vlieses, Verfahren zu ihrer Herstellung und Verwendung
US9669113B1 (en) 1998-12-24 2017-06-06 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US6356782B1 (en) 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6371904B1 (en) 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6977231B1 (en) * 1999-01-21 2005-12-20 Nipro Corporation Suturable adhesion-preventing membrane
US8498693B2 (en) * 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US20090216118A1 (en) 2007-07-26 2009-08-27 Senorx, Inc. Polysaccharide markers
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US6375672B1 (en) * 1999-03-22 2002-04-23 Board Of Trustees Of Michigan State University Method for controlling the chemical and heat induced responses of collagenous materials
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
US6592794B1 (en) * 1999-09-28 2003-07-15 Organogenesis Inc. Process of making bioengineered collagen fibrils
US6352708B1 (en) 1999-10-14 2002-03-05 The International Heart Institute Of Montana Foundation Solution and method for treating autologous tissue for implant operation
US6764462B2 (en) 2000-11-29 2004-07-20 Hill-Rom Services Inc. Wound treatment apparatus
US6824533B2 (en) 2000-11-29 2004-11-30 Hill-Rom Services, Inc. Wound treatment apparatus
US20090028953A1 (en) * 1999-12-10 2009-01-29 Yamamoto Ronald K Method of treatment using microparticulate biomaterial composition
US20030211166A1 (en) * 2001-07-31 2003-11-13 Yamamoto Ronald K Microparticulate biomaterial composition for medical use
WO2001054735A2 (en) * 2000-01-28 2001-08-02 Orthogene, Inc. Gel-infused sponges for tissue repair and augmentation
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
WO2001057121A1 (fr) * 2000-02-03 2001-08-09 Menicon Co., Ltd. Moulage spongieux comprenant un polymere hydrosoluble et procede pour en controler les pores
US7039453B2 (en) * 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
ES2299423T3 (es) * 2000-03-09 2008-06-01 Syntacoll Ag Nuevo material basado en colageno natural con propiedades mejoradas para uso en medicina humana y veterinaria, y metodo de fabricacion del mismo.
DE60018480T2 (de) * 2000-03-09 2006-02-16 Syntacoll Ag Mehrschicht-kollagenmatrix zur geweberekonstruktion
US20010046968A1 (en) * 2000-03-23 2001-11-29 Zagon Ian S. Opioid growth factor modulates angiogenesis
US20010043943A1 (en) 2000-05-22 2001-11-22 Coffey Arthur C. Combination SIS and vacuum bandage and method
US20050048614A1 (en) * 2000-06-13 2005-03-03 Children's Medical Center Corporation Biosynthetic oncolytic molecules and uses therefor
US8366787B2 (en) * 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US6638312B2 (en) * 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US6599526B2 (en) * 2000-08-18 2003-07-29 The University Of North Texas Health Science Center At Fort Worth Pericardial anti-adhesion patch
EP1320390A2 (de) * 2000-09-18 2003-06-25 Organogenesis Inc. Bioartifizielle flache schichtförmige prothesen und ihre verwendung
US20040028738A1 (en) * 2000-10-05 2004-02-12 Lynn L.H. Huang Process for the preparation of porous collagen matrix
WO2002039948A2 (en) * 2000-11-14 2002-05-23 N.V.R. Labs Inc. Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
WO2002041786A2 (en) * 2000-11-20 2002-05-30 Senorx, Inc. Tissue site markers for in vivo imaging
FR2816847B1 (fr) * 2000-11-22 2006-07-14 Assist Publ Hopitaux De Paris Biomateriaux polymeriques poreux, procede de preparation et utilisations
US6855135B2 (en) 2000-11-29 2005-02-15 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US6685681B2 (en) 2000-11-29 2004-02-03 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US7157614B1 (en) * 2000-12-21 2007-01-02 Fountainhead, Llc Treatment devices providing targeted antimicrobial action
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7041868B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
EP1368309B2 (de) * 2001-02-22 2014-10-01 Anika Therapeutics Inc. Thiol-modifizierte hyaluronan-derivate
US7119062B1 (en) 2001-02-23 2006-10-10 Neucoll, Inc. Methods and compositions for improved articular surgery using collagen
US6656488B2 (en) 2001-04-11 2003-12-02 Ethicon Endo-Surgery, Inc. Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
CA2388723C (en) * 2001-06-06 2012-10-23 Becton, Dickinson & Company Method of providing a substrate with a ready-to-use, uniformly distributed extracellular matrix
AU2002320182B2 (en) * 2001-06-29 2008-02-21 Cook Biotech Incorporated Porous sponge matrix medical devices and methods
US7163563B2 (en) 2001-07-16 2007-01-16 Depuy Products, Inc. Unitary surgical device and method
US8025896B2 (en) * 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
AU2002354915B8 (en) * 2001-07-16 2008-04-17 Depuy Products, Inc. Porous extracellular matrix scaffold and method
EP1416886A4 (de) * 2001-07-16 2007-04-18 Depuy Products Inc Gerüst und verfahren für die knorpelreparatur und regeneration
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US7201917B2 (en) 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
EP1416888A4 (de) 2001-07-16 2007-04-25 Depuy Products Inc Vorrichtung und verfahren zur regeneration des meniskus
EP1416866A4 (de) 2001-07-16 2007-04-18 Depuy Products Inc Vorrichtungen aus natürlich vorkommenden mitteln biologischer herkunft
WO2003007790A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
TW574302B (en) * 2001-08-10 2004-02-01 Ind Tech Res Inst A method for producing cross-linked hyaluronic acid-protein bio-composites
TWI284665B (en) * 2001-08-17 2007-08-01 Univ Nat Cheng Kung Fabrication method of the porous collagen matrix
CA2462877A1 (en) 2001-10-11 2003-04-17 Hill-Rom Services, Inc. Waste container for negative pressure therapy
US20030114061A1 (en) * 2001-12-13 2003-06-19 Kazuhisa Matsuda Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same
WO2003057070A2 (en) 2001-12-26 2003-07-17 Hill-Rom Services Inc. Vented vacuum bandage and method
CA2468307A1 (en) 2001-12-26 2003-07-17 Hill-Rom Services, Inc. Vacuum bandage packing
CA2468309A1 (en) 2001-12-26 2003-07-17 Robert Petrosenko Wound vacuum therapy dressing kit
US20030143388A1 (en) * 2001-12-31 2003-07-31 Reeves William G. Regenerated carbohydrate foam composition
US20030125683A1 (en) * 2001-12-31 2003-07-03 Reeves William G. Durably hydrophilic, non-leaching coating for hydrophobic substances
US20030155679A1 (en) * 2001-12-31 2003-08-21 Reeves William G. Method of making regenerated carbohydrate foam compositions
US20060189516A1 (en) * 2002-02-19 2006-08-24 Industrial Technology Research Institute Method for producing cross-linked hyaluronic acid-protein bio-composites
WO2003086232A2 (en) 2002-04-10 2003-10-23 Hill-Rom Services, Inc. Access openings in vacuum bandage
AUPS242702A0 (en) * 2002-05-21 2002-06-13 Colltech Australia Limited Improved method for the extraction and purification of collagen
US20060159731A1 (en) * 2002-06-03 2006-07-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-layer collagenic article useful for wounds healing and a method for its production thereof
ES2424348T3 (es) * 2002-06-24 2013-10-01 Incept, Llc Cargas y métodos para desplazar tejidos para mejorar los resultados radiológicos
US7160326B2 (en) * 2002-06-27 2007-01-09 Depuy Products, Inc. Method and apparatus for implantation of soft tissue implant
JP2005536275A (ja) 2002-08-21 2005-12-02 ヒル−ロム サービシズ，インコーポレイテッド 創傷閉鎖を防止するための創傷用パッキング
US7744651B2 (en) 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) * 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
CN100394989C (zh) 2002-11-15 2008-06-18 华沙整形外科股份有限公司 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节
US20060036158A1 (en) * 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US20040122349A1 (en) * 2002-12-20 2004-06-24 Lafontaine Daniel M. Closure device with textured surface
US8709038B2 (en) * 2002-12-20 2014-04-29 Boston Scientific Scimed, Inc. Puncture hole sealing device
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
EP1605862A4 (de) * 2003-02-28 2008-09-03 Fibrogen Inc Kollagen-zusammensetzungen und biomaterialien
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
ATE510605T1 (de) 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
EP1644011A1 (de) 2003-06-25 2006-04-12 Stephen F. Badylak Konditionierte matrix-zusammensetzungen zur gewebe-wiederherstellung
US7942897B2 (en) * 2003-07-10 2011-05-17 Boston Scientific Scimed, Inc. System for closing an opening in a body cavity
JP4719676B2 (ja) * 2003-08-22 2011-07-06 シンセス ゲーエムベーハー 硬膜代用品及びその作製方法
WO2005021580A2 (en) * 2003-08-28 2005-03-10 Arizona Board Of Regents Hydrogels for modulating cell migration and matrix deposition
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
DE602004021022D1 (de) 2003-10-28 2009-06-18 Medtronic Inc Verfahren zur herstellung von vernetzten materialien und bioprothetischen vorrichtungen
US20050273002A1 (en) * 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US7842667B2 (en) * 2003-12-22 2010-11-30 Regentis Biomaterials Ltd. Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
EP1722834B1 (de) 2003-12-22 2012-06-27 Regentis Biomaterials Ltd. Matrix mit natürlich vorkommendem vernetztem proteingerüst
US20050148922A1 (en) * 2003-12-31 2005-07-07 Reeves William G. Thermoplastic composition and products made therefrom
US20050175659A1 (en) * 2004-02-09 2005-08-11 Macomber Laurel R. Collagen device and method of preparing the same
US20050283256A1 (en) * 2004-02-09 2005-12-22 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
JP4840136B2 (ja) * 2004-03-31 2011-12-21 ニプロ株式会社 癒着防止用キット、癒着防止用キットの製造方法および癒着防止方法
KR101148445B1 (ko) 2004-04-28 2012-07-05 안지오디바이스 인터내셔널 게엠베하 가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및 이와 관련된 제조 및 사용 방법
US7569233B2 (en) 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
FR2873927B1 (fr) * 2004-08-05 2007-05-11 Symatese Soc Par Actions Simpl Procede de preparation de collagene reticule et substitut osseux comprenant ledit collagene ainsi reticule
EP1791499A4 (de) * 2004-08-13 2011-08-17 Ottawa Health Research Inst Die sehkraft verbessernde ophthalmische vorrichtungen und relevante verfahren und zusammensetzungen
WO2006028415A1 (en) * 2004-09-09 2006-03-16 Agency For Science, Technology And Research Process for isolating biomaterial from tissue and an isolated biomaterial extract prepared therefrom
CA2581093C (en) 2004-09-17 2014-11-18 Angiotech Biomaterials Corporation Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
JP5047797B2 (ja) * 2004-09-30 2012-10-10 コヴァロン・テクノロジーズ・インコーポレーテッド 非接着性の弾性ゼラチンマトリックス
US7513866B2 (en) 2004-10-29 2009-04-07 Depuy Products, Inc. Intestine processing device and associated method
US20060111778A1 (en) * 2004-10-29 2006-05-25 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US20060100138A1 (en) * 2004-11-10 2006-05-11 Olsen David R Implantable collagen compositions
US9044462B2 (en) 2004-12-08 2015-06-02 Avent, Inc. Method for oxygen treatment of intact skin
US20060121101A1 (en) * 2004-12-08 2006-06-08 Ladizinsky Daniel A Method for oxygen treatment of intact skin
US7354627B2 (en) 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
US8283312B2 (en) * 2005-02-04 2012-10-09 The Research Foundation Of State University Of New York Compositions and methods for modulating body weight and treating obesity-related disorders
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
WO2006107207A2 (en) 2005-04-06 2006-10-12 Fujifilm Manufacturing Europe B.V. A non-porous film for culturing cells
WO2006107188A1 (en) 2005-04-06 2006-10-12 Fujifilm Manufacturing Europe B.V. A non-porous film for culturing cells
US10357328B2 (en) * 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US8741832B2 (en) * 2005-06-10 2014-06-03 Albert Einstein College Of Medicine Of Yeshiva University Pegylated albumin and uses thereof
US20060293760A1 (en) * 2005-06-24 2006-12-28 Dedeyne Patrick G Soft tissue implants with improved interfaces
EP1741453A3 (de) * 2005-07-07 2007-01-17 Nipro Corporation Collagensubstrat, dessen Herstellung und Verwendung
WO2007126411A2 (en) * 2005-07-28 2007-11-08 Carnegie Mellon University Biocompatible polymers and methods of use
US7595062B2 (en) 2005-07-28 2009-09-29 Depuy Products, Inc. Joint resurfacing orthopaedic implant and associated method
CA2518298A1 (fr) * 2005-09-06 2007-03-06 Chaimed Technologies Inc. Polymeres biodegradables, leur preparation et leur usage pour la fabrication de pansements
US7429241B2 (en) * 2005-09-29 2008-09-30 Codman & Shurtleff, Inc. Dural graft and method of preparing the same
CA2562580C (en) 2005-10-07 2014-04-29 Inrad, Inc. Drug-eluting tissue marker
US20070112360A1 (en) * 2005-11-15 2007-05-17 Patrick De Deyne Bioprosthetic device
JP2006181389A (ja) * 2006-03-10 2006-07-13 Angiotech Biomaterials Corp 架橋生体物質組成物を調製するための疎水性架橋剤の使用
MX2008014732A (es) 2006-05-22 2009-04-07 Univ Columbia Sistemas y metodos de intercambio sin membrana microfluidica usando filtracion de corrientes de salida de fluidos de extraccion.
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
EP2034955B1 (de) 2006-06-22 2015-05-13 University of South Florida Collagengerüste, medizinische implantate damit und verwendungsverfahren dafür
US20080003244A1 (en) * 2006-06-28 2008-01-03 Gary Viole Inflammation and Oxidative Stress Reducing Compostion for Topical or Oral Administration
US8118779B2 (en) 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US8399619B2 (en) 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US7945307B2 (en) * 2006-08-04 2011-05-17 Senorx, Inc. Marker delivery system with obturator
US20080294039A1 (en) * 2006-08-04 2008-11-27 Senorx, Inc. Assembly with hemostatic and radiographically detectable pellets
US20090171198A1 (en) * 2006-08-04 2009-07-02 Jones Michael L Powdered marker
KR100845515B1 (ko) * 2006-08-31 2008-07-10 포항공과대학교 산학협력단 골 충진 복합체 및 그 제조 방법
CN101522164B (zh) * 2006-09-13 2014-03-26 提升肤质产品公司 用于治疗皮肤的化妆品组合物及其方法
US8093027B2 (en) 2006-09-13 2012-01-10 University Of South Florida Method for producing biocomposite comprising collagen and polymer
ES2443526T3 (es) 2006-10-23 2014-02-19 C.R. Bard, Inc. Marcador mamario
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US9579077B2 (en) * 2006-12-12 2017-02-28 C.R. Bard, Inc. Multiple imaging mode tissue marker
EP2101670B1 (de) 2006-12-18 2013-07-31 C.R.Bard, Inc. Biopsiemarker mit in situ erzeugten bildgebungseigenschaften
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
JP5295121B2 (ja) 2006-12-22 2013-09-18 ラボラトワール・メディドム・エス・アー 関節内軟骨および骨組織修復のためのｉｎｓｉｔｕシステム
JPWO2008081590A1 (ja) * 2006-12-27 2010-04-30 富士フイルム株式会社 医療用組成物
WO2008109407A2 (en) * 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods
WO2008130068A1 (en) * 2007-04-23 2008-10-30 Modern Cell & Tissue Technologies Inc. Method for preparing a porous polymer scaffold using dry ice
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
US8834578B2 (en) * 2007-07-30 2014-09-16 Sofradim Production Bioresorbable implant
US8198087B2 (en) * 2007-07-30 2012-06-12 Sofradim Production Sas Tissue engineering support
WO2009043052A1 (en) * 2007-09-27 2009-04-02 Columbia University Methods and systems for forming biocompatible materials
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
US8613776B2 (en) * 2007-12-27 2013-12-24 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
US8530415B2 (en) * 2008-01-30 2013-09-10 Histogen, Inc. Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
US8535913B2 (en) * 2008-01-30 2013-09-17 Histogen, Inc. Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
SG10201906494PA (en) * 2008-01-30 2019-09-27 Histogen Inc Extracellular matrix compositions
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
WO2009099767A2 (en) * 2008-01-31 2009-08-13 C.R. Bard, Inc. Biopsy tissue marker
CA2714594A1 (en) 2008-02-04 2009-08-13 Edward F. Leonard Fluid separation devices, systems and methods
WO2009102967A2 (en) 2008-02-13 2009-08-20 The Cleveland Clinic Foundation Molecular enhancement of extracellular matrix and methods of use
AU2009201541B2 (en) * 2008-04-23 2014-12-04 Integra Lifesciences Corporation Flowable collagen material for dural closure
EP2300042A4 (de) 2008-04-30 2012-05-02 Cleveland Clinic Foundation Zusammensetzungen und verfahren zur behandlung von harninkontinenz
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
CA2731082C (en) * 2008-08-14 2016-08-09 Kci Licensing, Inc. Tissue scaffold comprising an acellular tissue matrix and sodium acetate
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
WO2010077244A1 (en) * 2008-12-30 2010-07-08 C.R. Bard Inc. Marker delivery device for tissue marker placement
US20100204570A1 (en) * 2009-02-06 2010-08-12 Paul Lubock Anchor markers
MX2012000455A (es) * 2009-07-10 2012-04-11 Histogen Inc Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas.
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
WO2011084465A2 (en) 2009-12-15 2011-07-14 Incept, Llc Implants and biodegradable fiducial markers
WO2012024390A2 (en) 2010-08-17 2012-02-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid composite scaffold
JP2013536246A (ja) 2010-08-24 2013-09-19 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 心臓治療のための組成物及び方法
CN103313733A (zh) 2010-11-15 2013-09-18 捷迈整形外科生物材料有限公司 骨空隙填充剂
US8722854B2 (en) 2010-12-23 2014-05-13 Medskin Solutions Dr. Suwelack Ag Degradation-stabilised, biocompatible collagen matrices
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
US9694106B2 (en) 2011-07-11 2017-07-04 Mimedx Group, Inc. Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
WO2013046058A2 (en) 2011-09-30 2013-04-04 Sofradim Production Reversible stiffening of light weight mesh
JP5973873B2 (ja) * 2011-11-08 2016-08-23 Hoya株式会社 人工軟骨及びその製造方法
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
US9592278B2 (en) 2012-03-08 2017-03-14 Lifecell Corporation Enzyme-activated collagen and tissue matrices
CN102580139A (zh) * 2012-03-27 2012-07-18 黑龙江省华信药业有限公司 一种胶原透明质酸敷料
US11090338B2 (en) 2012-07-13 2021-08-17 Lifecell Corporation Methods for improved treatment of adipose tissue
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
EP2884944B1 (de) 2012-08-15 2020-10-07 MiMedx Group, Inc. Verstärkte plazentagewebetransplantate sowie verfahren zu ihrer herstellung und verwendung
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
WO2014052376A1 (en) 2012-09-26 2014-04-03 Lifecell Corporation Processed adipose tissue
FR2995904B1 (fr) 2012-09-27 2015-09-18 Sofradim Production Procede de preparation d'une couche poreuse
US10159555B2 (en) 2012-09-28 2018-12-25 Sofradim Production Packaging for a hernia repair device
US9180145B2 (en) 2012-10-12 2015-11-10 Mimedx Group, Inc. Compositions and methods for recruiting and localizing stem cells
US9155799B2 (en) 2012-11-19 2015-10-13 Mimedx Group, Inc. Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent
US8940684B2 (en) 2012-11-19 2015-01-27 Mimedx Group, Inc. Cross-linked collagen comprising an antifungal agent
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
US10206977B1 (en) 2013-01-18 2019-02-19 Mimedx Group, Inc. Isolated placental stem cell recruiting factors
EP2945639B1 (de) 2013-01-18 2020-09-30 MIMEDX Group Inc. Verfahren zur behandlung von herzkrankheiten
JP5909610B2 (ja) * 2013-02-15 2016-04-27 国立大学法人大阪大学 コラーゲンスポンジ
US10029030B2 (en) 2013-03-15 2018-07-24 Mimedx Group, Inc. Molded placental tissue compositions and methods of making and using the same
US10335433B2 (en) 2013-04-10 2019-07-02 Mimedx Group, Inc. NDGA polymers and metal complexes thereof
US9446142B2 (en) 2013-05-28 2016-09-20 Mimedx Group, Inc. Polymer chelator conjugates
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
WO2015031681A1 (en) 2013-08-30 2015-03-05 Mimedx Group, Inc. Micronized placental compositions comprising a chelator
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
EP3094336A4 (de) 2014-01-17 2018-02-14 MIMEDX Group Inc. Verfahren zur induzierung von angiogenese
JP6681872B2 (ja) 2014-03-21 2020-04-15 ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 細胞外マトリクス由来最終滅菌ヒドロゲルの調製方法
WO2015181395A1 (en) 2014-05-30 2015-12-03 Sofradim Production Method for preparing neutralized matrix of non-antigenic collagenous material
JP7099822B2 (ja) 2014-08-28 2022-07-12 ミメディクス グループ インコーポレイテッド コラーゲンで強化した組織移植片
US11028140B2 (en) * 2014-09-22 2021-06-08 Northeast Ohio Medical University Osteogenic biomaterial
EP3000488A1 (de) 2014-09-26 2016-03-30 Sofradim Production Verfahren zur Herstellung von Chitosan-Matrizen mit verbesserten mechanischen Eigenschaften
EP3000433B1 (de) 2014-09-29 2022-09-21 Sofradim Production Vorrichtung zur Einführung einer Prothese zur Hernie-Behandlung in einen Einschnitt und flexible textile Prothese
EP3000432B1 (de) 2014-09-29 2022-05-04 Sofradim Production Textilbasierte Prothese für die Behandlung von Leistenbruch
KR20190008432A (ko) * 2014-11-27 2019-01-23 도요보 가부시키가이샤 다공질 복합체, 골 재생 재료, 및 다공질 복합체의 제조 방법
EP3029189B1 (de) 2014-12-05 2021-08-11 Sofradim Production Prothetisches poröses Netz, sein Herstellungsverfahren und Hernienprothese
EP3059255B1 (de) 2015-02-17 2020-05-13 Sofradim Production Verfahren zur Herstellung einer Matrix auf Chitosanbasis mit faseroptischem Verstärkungselement
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
EP3085337B1 (de) 2015-04-24 2022-09-14 Sofradim Production Prothese zur unterstützung einer bruststruktur
EP3088010B1 (de) 2015-04-28 2022-12-21 DiCosmo, Frank Bioaktive kollagenbiomaterialien und verfahren zur herstellung
ES2676072T3 (es) 2015-06-19 2018-07-16 Sofradim Production Prótesis sintética que comprende un tejido de punto y una película no porosa y método para formarla
EP3195830B1 (de) 2016-01-25 2020-11-18 Sofradim Production Prothese zur hernienreparatur
EP3777907A1 (de) 2016-07-05 2021-02-17 LifeCell Corporation Gewebematrizen mit mehreren gewebetypen
EP3312325B1 (de) 2016-10-21 2021-09-22 Sofradim Production Verfahren zur herstellung eines netzes mit einem daran befestigten nahtmaterial mit widerhaken und dadurch erhaltenes netz
CN110352064B (zh) 2017-03-02 2023-11-10 联邦高等教育系统匹兹堡大学 用于癌症治疗的胞外基质(ecm)水凝胶及其可溶级分
US11739291B2 (en) 2017-04-25 2023-08-29 Purdue Research Foundation 3-dimensional (3D) tissue-engineered muscle for tissue restoration
EP3398554A1 (de) 2017-05-02 2018-11-07 Sofradim Production Prothese zur leistenbruch-reparatur
WO2018209101A1 (en) * 2017-05-10 2018-11-15 Marquette University Medical and dental integrated multiphasic biomaterials for single or multi-tissue reconstruction/regeneration
CN107320786B (zh) * 2017-06-16 2020-06-23 卓阮医疗科技（苏州）有限公司 一种缓释抗感染的复合软组织修复材料及其制备方法
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
AU2018351051A1 (en) 2017-10-18 2020-03-19 Lifecell Corporation Adipose tissue products and methods of production
CA3075106A1 (en) 2017-10-19 2019-04-25 Lifecell Corporation Flowable acellular tissue matrix products and methods of production
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
CN108478869A (zh) * 2018-04-17 2018-09-04 上海市第六人民医院 一种再生修复用脱细胞青鱼皮仿生基质及其制备方法和应用
WO2020087181A1 (en) * 2018-11-02 2020-05-07 Covalon Technologies Inc. Foam compositions, foam matrices and methods
EP3653171A1 (de) 2018-11-16 2020-05-20 Sofradim Production Implantate zur weichgewebereparatur
RU2704623C1 (ru) * 2018-12-07 2019-10-30 Общество с ограниченной ответственностью "Научно-производственное объединение "Ликом" Перевязочное средство на биополимерной основе
MX2021014654A (es) 2019-05-30 2022-03-11 Lifecell Corp Implante de mama biologico.
CN115029402A (zh) * 2021-03-05 2022-09-09 湖州蔻婷生物科技有限公司 一种寡聚透明质酸及其水解胶原蛋白和纤连蛋白复配化妆品组合物
CN114010839B (zh) * 2021-11-09 2022-11-29 深圳齐康医疗器械有限公司 一种梯度降解人工真皮及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3098693A (en) * 1960-05-27 1963-07-23 Little Inc A Treatment of protein and peptide materials to form amide linkages
US3300470A (en) * 1963-10-04 1967-01-24 Swift & Co Reaction products of protein with cyanamide under acidic conditions
US3955012A (en) * 1970-08-06 1976-05-04 Zaidan Hojin, Seisan Kaihatsu Kagaku Kenkyusho Method for manufacturing medical articles composed of silicone rubber coated with collagen
US3800792A (en) * 1972-04-17 1974-04-02 Johnson & Johnson Laminated collagen film dressing
US3903882A (en) * 1974-04-19 1975-09-09 American Cyanamid Co Composite dressing
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4280954A (en) * 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4193813A (en) * 1976-09-07 1980-03-18 Medi-Coll, Inc. Method for making collagen sponge
DE2734503C2 (de) * 1977-07-30 1984-04-05 Fa. Carl Freudenberg, 6940 Weinheim Verfahren zur Herstellung von Kollagenschwamm
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4412947A (en) * 1979-09-12 1983-11-01 Seton Company Collagen sponge
US4374121A (en) * 1979-09-12 1983-02-15 Seton Company Macromolecular biologically active collagen articles
US4399123A (en) * 1980-04-01 1983-08-16 Oliver Roy F Fibrous tissue dressing or implant
US4522753A (en) * 1980-07-17 1985-06-11 Massachusetts Institute Of Technology Method for preserving porosity in porous materials
US4440680A (en) * 1980-09-24 1984-04-03 Seton Company Macromolecular biologically active collagen articles
JPS57106625A (en) * 1980-12-22 1982-07-02 Teijin Ltd Cytotoxic protein complex and its preparation
US4350629A (en) * 1981-07-29 1982-09-21 Massachusetts Institute Of Technology Procedures for preparing composite materials from collagen and glycosaminoglycan
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4418691A (en) * 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4409332A (en) * 1982-01-12 1983-10-11 Jefferies Steven R Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same

Also Published As

Publication number Publication date
IT8547869A0 (it) 1985-03-26
JPS61502129A (ja) 1986-09-25
ES541629A0 (es) 1986-04-01
US4703108A (en) 1987-10-27
CN85101396A (zh) 1987-01-31
FI854692A0 (fi) 1985-11-27
CA1295796C (en) 1992-02-18
AU4210585A (en) 1985-11-01
EP0177573B1 (de) 1992-01-02
DK547485D0 (da) 1985-11-27
US4970298A (en) 1990-11-13
JPH0811121B2 (ja) 1996-02-07
WO1985004413A1 (en) 1985-10-10
FI854692A (fi) 1985-11-27
IT8547869A1 (it) 1986-09-26
AR240608A1 (es) 1990-06-30
ES8605988A1 (es) 1986-04-01
NO854723L (no) 1985-11-26
IT1182725B (it) 1987-10-05
BR8506206A (pt) 1986-04-15
IL74715A0 (en) 1985-06-30
EP0177573A1 (de) 1986-04-16
MX163953B (es) 1992-07-03
DK547485A (da) 1986-01-24

Similar Documents

Publication Publication Date Title
DE3585069D1 (de) Biologisch degradierbare form und verfahren zu deren herstellung.
DE3586822D1 (de) Halbleiteranordnung und verfahren zu deren herstellung.
DE3684085D1 (de) Reinigungsmittelzusammensetzung und verfahren zu deren herstellung.
DE68907057T2 (de) Nährstoffzusammensetzung und verfahren zu deren herstellung.
DE3585171D1 (de) Mehrschichtstoff und verfahren zu dessen herstellung.
DE3581563D1 (de) Polysiloxanpfropfcopolymer und verfahren zu dessen herstellung.
DE3577552D1 (de) Vitamin d-derivate und verfahren zu deren herstellung.
DE3577590D1 (de) Keramisch-metallische verbindung und verfahren zu deren herstellung.
DE3580487D1 (de) Aromatische aminosulfonverbindungen und verfahren zu deren herstellung.
DE3576931D1 (de) Mehrschichtstoffe und verfahren zu deren herstellung.
DE3688799D1 (de) Biologisch abbaubare mikrokugeln und verfahren zu deren herstellung.
DE3782952D1 (de) Supraleitende dipolmagnete und verfahren zu deren herstellung.
DE3686597T2 (de) Uricase und verfahren zu deren herstellung.
DE3579765D1 (de) Strukturelles betonteil und verfahren zu seiner herstellung.
DE3578270D1 (de) Feldeffekt-transistor-anordnung und verfahren zu deren herstellung.
DE3877709D1 (de) Indan-derivate und verfahren zu deren herstellung.
DE68906949D1 (de) Waschmittelpulver und verfahren zu deren herstellung.
DE3686561D1 (de) Klebstrukturen und verfahren zu deren herstellung.
DE3580783D1 (de) Polyester und verfahren zu dessen herstellung.
DE3576342D1 (de) Penam-derivate und verfahren zu deren herstellung.
DE3685209D1 (de) Urease und verfahren zu deren herstellung.
DE3679739D1 (de) Dekorative fassung und verfahren zu deren herstellung.
DE3578045D1 (de) Stranggiessvorrichtung und verfahren zu deren herstellung.
DE3583449D1 (de) Lieferschein und verfahren zu seiner herstellung.
DE3587204D1 (de) Metall-boride und verfahren zu deren herstellung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee