DE3586616T2 - Verfahren zur verhuetung und induktion menschlicher plaettchen-aggregation. - Google Patents

Verfahren zur verhuetung und induktion menschlicher plaettchen-aggregation.

Info

Publication number
DE3586616T2
DE3586616T2 DE8585901891T DE3586616T DE3586616T2 DE 3586616 T2 DE3586616 T2 DE 3586616T2 DE 8585901891 T DE8585901891 T DE 8585901891T DE 3586616 T DE3586616 T DE 3586616T DE 3586616 T2 DE3586616 T2 DE 3586616T2
Authority
DE
Germany
Prior art keywords
fibrinogen
adp
platelet
thrombin
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585901891T
Other languages
English (en)
Other versions
DE3586616D1 (de
Inventor
J Hawiger
Sheila Timmons
J Lukas
Marek Kloczewiak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Original Assignee
New England Deaconess Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Deaconess Hospital filed Critical New England Deaconess Hospital
Publication of DE3586616D1 publication Critical patent/DE3586616D1/de
Application granted granted Critical
Publication of DE3586616T2 publication Critical patent/DE3586616T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE8585901891T 1984-04-10 1985-04-08 Verfahren zur verhuetung und induktion menschlicher plaettchen-aggregation. Expired - Fee Related DE3586616T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/599,477 US4661471A (en) 1984-04-10 1984-04-10 Method of inhibiting and inducing human platelet aggregation
PCT/US1985/000589 WO1985004584A1 (en) 1984-04-10 1985-04-08 Method of inhibiting and inducing human platelet aggregation

Publications (2)

Publication Number Publication Date
DE3586616D1 DE3586616D1 (de) 1992-10-15
DE3586616T2 true DE3586616T2 (de) 1993-04-08

Family

ID=24399770

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585901891T Expired - Fee Related DE3586616T2 (de) 1984-04-10 1985-04-08 Verfahren zur verhuetung und induktion menschlicher plaettchen-aggregation.

Country Status (6)

Country Link
US (1) US4661471A (de)
EP (1) EP0180595B1 (de)
AT (1) ATE80305T1 (de)
AU (1) AU4159685A (de)
DE (1) DE3586616T2 (de)
WO (1) WO1985004584A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor
US5340727A (en) * 1987-11-17 1994-08-23 The Scripps Research Institute GPIbα fragments and recombinant DNA expression vectors
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
EP0731110A1 (de) * 1987-12-10 1996-09-11 La Jolla Cancer Research Foundation Verfahren zur Herstellung von konformationell stabilisierten Zelladhäsionspeptiden
AU3149289A (en) * 1988-03-18 1989-09-21 Rockefeller University, The Method and agent for inhibiting the binding of human polymorphonuclear leukocytes to endothelium and compositions therefor
US5686569A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5780595A (en) * 1989-06-16 1998-07-14 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
CA2021951A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
CA2021950A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
US5061693A (en) * 1989-07-28 1991-10-29 Merck & Co., Inc. Fibrinogen receptor antagonists
US5591431A (en) * 1990-03-09 1997-01-07 G.D. Searle & Co. Enhancement of clot lysis
US5428020A (en) * 1990-03-23 1995-06-27 Rei Matsueda Cysteine (NPYS)-containing peptides and use thereof for inhibiting platelet aggregation
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
CA2136330C (en) * 1992-05-21 2002-03-19 Richard T. Dean Technetium-99m labeled peptides for thrombus imaging
US5516889A (en) * 1993-06-21 1996-05-14 University Technologies International, Inc. Synthetic thrombin receptor peptides
CA2269335C (en) * 1996-10-21 2010-05-25 Quadrant Healthcare (Uk) Limited Platelet substitutes and conjugation methods suitable for their preparation
US7148190B2 (en) * 2000-01-20 2006-12-12 Hadasit Medical Research Services & Development Company Ltd. Haptotactic peprides
US20030003515A1 (en) * 2000-12-05 2003-01-02 Farrell David H. Monocloral antibody-based diagnostic assay for gamma fibrinogen
IL152609A0 (en) * 2002-11-03 2003-06-24 Hapto Biotech Inc Liposomal compositions comprising haptotactic peptides and uses thereof
CN100360554C (zh) * 2003-02-06 2008-01-09 学校法人庆应义塾 肽缀合物
US20070059376A1 (en) * 2003-02-06 2007-03-15 Shinji Takeoka Peptide conjugate
GB2462022B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US4303592A (en) * 1980-01-09 1981-12-01 Center For Blood Research, Inc. Amidinophenylmethylsulfonylfluoride
US4455290A (en) * 1981-04-02 1984-06-19 Research Corporation Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption

Also Published As

Publication number Publication date
EP0180595A1 (de) 1986-05-14
DE3586616D1 (de) 1992-10-15
AU4159685A (en) 1985-11-01
US4661471A (en) 1987-04-28
WO1985004584A1 (en) 1985-10-24
EP0180595A4 (de) 1988-03-22
EP0180595B1 (de) 1992-09-09
ATE80305T1 (de) 1992-09-15

Similar Documents

Publication Publication Date Title
DE3586616D1 (de) Verfahren zur verhuetung und induktion menschlicher plaettchen-aggregation.
PT93910A (pt) Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula
EP1484339A3 (de) Kallikreinhemmende "Kunitz-Domäne"Proteine dafür kodierende Nukleinsäure
DE68919229T2 (de) Hybride prokoagulierende proteine.
PT90861B (pt) Processo para a extraccao e purificacao de um principio anticoagulante a partir da sanguessuga sul-americana "haementeria ghilianii"
ATE529444T1 (de) Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
DE68906975T2 (de) Verfahren zur Herstellung von Sulfonaten von internen Olefinen.
DE68916932D1 (de) Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus.
DE69001972T2 (de) Mittel zum nachweis von gehirnkrankheiten in zusammenhang mit nervenscheidenmarkzerstoerung, insbesondere sklerosis multiplex.
DE3751218D1 (de) Verfahren und therapeutische Zubereitungen für die Behandlung von Gerinnungsstörungen.
DK270489A (da) Protein med thrombininhiberende virkning, fremgangsmaade til dets isolering, samt dets anvendelse som laegemiddel
DE69010750T2 (de) Antikörper gegen Fibrin, immunogene Peptide für die Herstellung dieser Antikörper, Verfahren zur Bestimmung von Fibrin und pharmazeutische Zubereitungen auf der Basis dieser Antikörper.
ATE115188T1 (de) Antikörper gegen fibrin, immunogen zur herstellung desselben, verfahren zur bestimmung von fibrin und pharmazeutisches präparat auf basis der antikörper.
ES2033295T3 (es) Un metodo para preparar un activador de plasminogeno.
DK0609242T3 (da) Nyt thrombininhibitorisk protein fra blodmider
TH6967EX (th) สารผสมเหนี่ยวนำการยึดเกาะ
DE3677436D1 (de) Reinigung des blutgerinnungsfaktors-viii durch faellung.
LV5829B4 (lv) Mazmolekularie cikliskie trombocitu agregacijas inhibitori

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee