DE3587806D1 - Tricyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung. - Google Patents
Tricyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung.Info
- Publication number
- DE3587806D1 DE3587806D1 DE3587806T DE3587806T DE3587806D1 DE 3587806 D1 DE3587806 D1 DE 3587806D1 DE 3587806 T DE3587806 T DE 3587806T DE 3587806 T DE3587806 T DE 3587806T DE 3587806 D1 DE3587806 D1 DE 3587806D1
- Authority
- DE
- Germany
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- tricyclic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/55—Streptomyces hygroscopicus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/898—Streptomyces hygroscopicus
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848430455A GB8430455D0 (en) | 1984-12-03 | 1984-12-03 | Fr-900506 substance |
GB858502869A GB8502869D0 (en) | 1985-02-05 | 1985-02-05 | Ws 7238 substances |
GB858508420A GB8508420D0 (en) | 1985-04-01 | 1985-04-01 | Fr-900506 & fr-900525 substances |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3587806D1 true DE3587806D1 (de) | 1994-06-01 |
DE3587806T2 DE3587806T2 (de) | 1994-08-25 |
Family
ID=27262535
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1995175026 Active DE19575026I2 (de) | 1984-12-03 | 1985-11-30 | Tricyclische Verbindungen Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung |
DE3587806T Expired - Lifetime DE3587806T2 (de) | 1984-12-03 | 1985-11-30 | Tricyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1995175026 Active DE19575026I2 (de) | 1984-12-03 | 1985-11-30 | Tricyclische Verbindungen Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung |
Country Status (24)
Country | Link |
---|---|
US (15) | US4894366A (de) |
EP (1) | EP0184162B1 (de) |
JP (6) | JPH0720970B2 (de) |
KR (5) | KR930010704B1 (de) |
CN (1) | CN1013687B (de) |
AT (1) | ATE104984T1 (de) |
AU (1) | AU592067B2 (de) |
CA (1) | CA1338491C (de) |
CY (1) | CY1912A (de) |
DE (2) | DE19575026I2 (de) |
DK (1) | DK169550B1 (de) |
ES (1) | ES8705038A1 (de) |
FI (2) | FI87803C (de) |
GR (1) | GR852904B (de) |
HK (1) | HK18596A (de) |
HU (1) | HU195250B (de) |
IE (1) | IE62865B1 (de) |
IL (2) | IL92345A (de) |
LU (1) | LU90317I2 (de) |
MX (1) | MX9202943A (de) |
NL (1) | NL960023I2 (de) |
NO (1) | NO168372C (de) |
NZ (1) | NZ214407A (de) |
PT (1) | PT81589B (de) |
Families Citing this family (311)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5266692A (en) * | 1984-12-03 | 1993-11-30 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5254562A (en) * | 1984-12-03 | 1993-10-19 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
GB8608080D0 (en) * | 1986-04-02 | 1986-05-08 | Fujisawa Pharmaceutical Co | Solid dispersion composition |
ES2060621T3 (es) * | 1987-06-05 | 1994-12-01 | Fujisawa Pharmaceutical Co | Anticuerpos anti-sustancia fr-900506 y metodo de inmunoensayo enzimatico altamente sensible. |
DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
GB2212061B (en) * | 1987-11-09 | 1991-08-28 | Sandoz Ltd | Topical compositions comprising 11,28-dioxa-4-azatricyclo [22.3.1.0(4,9)] octacos-18-ene derivatives |
US5366971A (en) * | 1987-11-09 | 1994-11-22 | Sandoz Ltd. | Use of 11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them |
DE3844904C2 (de) * | 1987-11-09 | 1997-01-30 | Sandoz Ag | Neue Verwendung von 11,28-Dioxa-4-azatricyclo-[22.3.1.0·4·,·9·]octacos-18-en-Derivaten |
AT400808B (de) * | 1987-11-09 | 1996-03-25 | Sandoz Ag | Verwendung von tricyclischen verbindungen zur herstellung von topischen arzneimitteln |
DE3838035C2 (de) * | 1987-11-09 | 1994-03-24 | Sandoz Ag | Neue Verwendung von 11,28-dioxa-4-azatricyclo[22.3.1.O·4··,··9·]octacos-18-en-Derivaten |
DE3853477T2 (de) | 1987-12-09 | 1995-11-09 | Fisons Plc | Makrozyklische verbindungen. |
GB8728820D0 (en) * | 1987-12-09 | 1988-01-27 | Fisons Plc | Compounds |
AT407957B (de) * | 1987-12-17 | 2001-07-25 | Novartis Erfind Verwalt Gmbh | Neue verwendung von 11,28-dioxa-4-azatricyclo- (22.3.1.04,9)octacos-18-en-derivaten und sie enthaltende pharmazeutische zubereitungen |
EP0323865A1 (de) * | 1988-01-07 | 1989-07-12 | Merck & Co. Inc. | Immunopressantes Mittel |
US5290772A (en) * | 1988-06-29 | 1994-03-01 | Merck & Co., Inc. | Immunosuppressant agent |
EP0349061B1 (de) * | 1988-06-29 | 1995-03-29 | Merck & Co. Inc. | Immunsuppressives Agens |
US4981792A (en) * | 1988-06-29 | 1991-01-01 | Merck & Co., Inc. | Immunosuppressant compound |
DE68925080T2 (de) * | 1988-08-01 | 1996-05-15 | Fujisawa Pharmaceutical Co | FR-901154- und FR-901155-Derivate, Verfahren zu ihrer Herstellung |
US5202258A (en) * | 1988-08-05 | 1993-04-13 | Merck & Co., Inc. | Immunosuppressant-producing culture |
EP0356399A3 (de) * | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen |
EP0358508A3 (de) * | 1988-09-08 | 1991-03-20 | Merck & Co. Inc. | Verbindung zur Unterdrückung der Immunabwehr |
US4980466A (en) * | 1988-10-12 | 1990-12-25 | Merck & Co., Inc. | Hydroxide mediated FK-506 rearrangement product |
CA1316916C (en) * | 1988-10-12 | 1993-04-27 | David Askin | Hydroxide mediated fk-506 rearrangement product |
DE68904037T2 (de) * | 1988-10-12 | 1993-06-03 | Merck & Co Inc | Verfahren zur umlagerung von fk-506 unter beteiligung von hydroxid. |
CH678855A5 (de) * | 1988-11-29 | 1991-11-15 | Sandoz Ag | |
US4975372A (en) * | 1989-01-13 | 1990-12-04 | Merck & Co., Inc. | Microbial transformation product of L-683,590 |
EP0378320A3 (de) * | 1989-01-13 | 1990-11-28 | Merck & Co. Inc. | Mikrobielles Umwandlungsprodukt |
EP0378317A3 (de) * | 1989-01-13 | 1990-11-28 | Merck & Co. Inc. | Mikrobisches Umbildungsprodukt von L-679,934 |
US5268370A (en) * | 1989-01-13 | 1993-12-07 | Merck & Co., Inc. | Microbial transformation product of L-679,934 |
US5272068A (en) * | 1989-03-15 | 1993-12-21 | Merck & Co., Inc. | Process for producing immunosuppressant agent L-683942 by fermentation |
EP0388153B1 (de) * | 1989-03-15 | 1994-12-28 | Merck & Co. Inc. | Immunosuppressives Mittel |
DE69013189T2 (de) * | 1989-03-15 | 1995-05-11 | Merck & Co Inc | Verfahren zur Herstellung einer immunosuppressiven Substanz (demethimmunomycin) durch Verwendung eines Stamm-Mutanten eines Mikroorganismus. |
US5155228A (en) * | 1989-03-23 | 1992-10-13 | Merck & Co., Inc. | FK-506 C10-C18 process intermediates |
US4940797A (en) * | 1989-03-23 | 1990-07-10 | Merck & Co., Inc. | Process for synthesis of FK-506 C10-C18 intermediates |
US5068323A (en) * | 1989-04-21 | 1991-11-26 | Merck & Co., Inc. | Thermally re-arranged FK-506 derivatives having immunosuppressant activity |
CA2014841A1 (en) * | 1989-04-21 | 1990-10-21 | Byron H. Arison | Macrolides having immunosuppressive activity |
US5057608A (en) * | 1989-04-21 | 1991-10-15 | Merck & Co., Inc. | Immunoregulants, immunosuppressants, process to make ring expanded macrolide related to FK-506/FK-520 |
US5270187A (en) * | 1989-05-05 | 1993-12-14 | Merck & Co., Inc. | Microbial transformation product |
EP0396400A1 (de) * | 1989-05-05 | 1990-11-07 | Merck & Co. Inc. | Mikrobielles Transformationsprodukt |
US4987139A (en) * | 1989-05-05 | 1991-01-22 | Merck & Co., Inc. | FK-520 microbial transformation product |
IE64214B1 (en) * | 1989-06-06 | 1995-07-26 | Fujisawa Pharmaceutical Co | Macrolides for the treatment of reversible obstructive airways diseases |
CA2018710A1 (en) * | 1989-06-13 | 1990-12-13 | Shieh-Shung T. Chen | L-683,590 microbial transformation product |
US5138052A (en) * | 1989-06-13 | 1992-08-11 | Merck & Co., Inc. | L-683,590 microbial transformation product |
CA2032159A1 (en) * | 1989-06-14 | 1990-12-15 | Andrew J. F. Edmunds | Heteroatoms-containing tricyclic compounds |
US5164525A (en) * | 1989-06-30 | 1992-11-17 | Merck & Co., Inc. | Synthetic process for fk-506 type macrolide intermediates |
US5235066A (en) * | 1989-06-30 | 1993-08-10 | Merck & Co., Inc. | FK-506 type macrolide intermediate |
WO1991002736A1 (en) * | 1989-08-18 | 1991-03-07 | Fisons Plc | Macrocyclic compounds |
EP0413532A3 (en) * | 1989-08-18 | 1991-05-15 | Fisons Plc | Macrocyclic compounds |
US5011943A (en) * | 1989-08-28 | 1991-04-30 | Merck Frosst Canada, Inc. | FK-506 C10 -C24 process intermediates |
GR1001225B (el) * | 1989-09-14 | 1993-06-30 | Fisons Plc | Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους. |
US5215995A (en) * | 1989-10-16 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Hair revitalizing agent |
DK0427680T3 (da) * | 1989-11-09 | 1995-12-18 | Sandoz Ltd | Heteroatom-holdige cykliske forbindelser |
US5208228A (en) * | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
IE904050A1 (en) * | 1989-11-13 | 1991-05-22 | Merck & Co Inc | Aminomacrolides and derivatives having immunosuppressive¹activity |
GB8925797D0 (en) * | 1989-11-15 | 1990-01-04 | Fisons Plc | Compositions |
EP0444829A3 (en) * | 1990-02-27 | 1992-06-03 | Fisons Plc | Immunosuppressive compounds |
US5064835A (en) * | 1990-03-01 | 1991-11-12 | Merck & Co., Inc. | Hydroxymacrolide derivatives having immunosuppressive activity |
US5260301A (en) * | 1990-03-01 | 1993-11-09 | Fujisawa Pharmaceutical Co., Ltd. | Pharmaceutical solution containing FK-506 |
JPH05504956A (ja) * | 1990-03-12 | 1993-07-29 | 藤沢薬品工業株式会社 | トリシクロ化合物 |
EP0594600A1 (de) * | 1990-03-13 | 1994-05-04 | FISONS plc | Immunosuppressive makrozyklische verbindungen |
US5296489A (en) * | 1990-03-13 | 1994-03-22 | Fisons | Immunosuppressive macrocyclic compounds |
EP0455427A1 (de) * | 1990-04-30 | 1991-11-06 | Merck & Co. Inc. | Deoxyaycrolid-Derivate mit immunsuppressiver Wirkung |
WO1991017754A1 (en) * | 1990-05-11 | 1991-11-28 | Fujisawa Pharmaceutical Co., Ltd. | Methods for treating and preventing inflammation of mucosa and blood vessels using fk 506 and related compounds |
US5643901A (en) * | 1990-06-11 | 1997-07-01 | Fujisawa Pharmaceutical Co., Ltd. | Medicament for treating idiopathic thrombocytopenic purpura |
WO1991019495A1 (en) * | 1990-06-11 | 1991-12-26 | Fujisawa Pharmaceutical Co., Ltd. | Use of a macrolide compound such as fk 506 for manufacturing a medicament for treating idiopathic thrombocytopenic purpura and basedow's disease |
US5342935A (en) * | 1990-06-25 | 1994-08-30 | Merck & Co., Inc. | Antagonists of immunosuppressive macrolides |
GB9014136D0 (en) * | 1990-06-25 | 1990-08-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same |
US5190950A (en) * | 1990-06-25 | 1993-03-02 | Merck & Co., Inc. | Antagonists of immunosuppressive macrolides |
CA2044846A1 (en) * | 1990-06-25 | 1991-12-26 | Thomas R. Beattie | Antagonists of immunosuppressive macrolides |
US5210030A (en) * | 1990-06-25 | 1993-05-11 | Merck & Co., Inc. | Process for selectively acylating immunomycin |
GB9014681D0 (en) * | 1990-07-02 | 1990-08-22 | Fujisawa Pharmaceutical Co | Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same |
MY110418A (en) * | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
EP0466365A3 (en) * | 1990-07-03 | 1992-04-15 | Merck & Co. Inc. | Novel immunosuppressant fermentation products of a microorganism |
GB2245891A (en) * | 1990-07-09 | 1992-01-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
GB2246350A (en) * | 1990-07-23 | 1992-01-29 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
US5089517A (en) * | 1990-08-03 | 1992-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Neuroprotection by indolactam v and derivatives thereof |
US5384316A (en) * | 1990-08-18 | 1995-01-24 | Fisons Plc | 4,16-diazatetracyclo[23.3.1.1.Hu 14,17=b . 0 Hu 4,9 triaconta-16,19-diene-2,3,10-trione derivatives |
GB2247620A (en) * | 1990-09-07 | 1992-03-11 | Fujisawa Pharmaceutical Co | The use of macrolide compounds for cytomegalovirus infection |
CA2051872A1 (en) * | 1990-09-24 | 1992-03-25 | Kevin M. Byrne | Directed biosynthesis process for prolyl-immunomycin |
GB2248184A (en) * | 1990-09-28 | 1992-04-01 | Fujisawa Pharmaceutical Co | New use of macrolide compounds for active oxygen-mediated diseases |
US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
US5233036A (en) * | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
US5348966A (en) * | 1990-10-24 | 1994-09-20 | Fujisawa Pharmaceutical Co., Ltd. | Method for treating pyoderma and Sezary's syndrome using FK 506 and related compounds |
CA2054128A1 (en) * | 1990-10-29 | 1992-04-30 | Kevin M. Byrne | Process for the production of analogues of immunomycin |
PH31204A (en) * | 1990-11-02 | 1998-05-05 | Fujisawa Pharmaceutical Co | Pharmaceutical composition. |
IE65341B1 (en) * | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
GB2249787A (en) * | 1990-11-19 | 1992-05-20 | Fujisawa Pharmaceutical Co | Lactone compounds |
GB9027471D0 (en) * | 1990-12-19 | 1991-02-06 | Fujisawa Pharmaceutical Co | Novel compound |
US5194378A (en) * | 1991-01-28 | 1993-03-16 | Merck & Co., Inc. | Process for producing fk-506 |
US5116756A (en) * | 1991-01-28 | 1992-05-26 | Merck & Co., Inc. | Process for producing FK-506 |
WO1992013862A1 (en) * | 1991-02-05 | 1992-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Lactone compounds |
US5147877A (en) * | 1991-04-18 | 1992-09-15 | Merck & Co. Inc. | Semi-synthetic immunosuppressive macrolides |
JP3158437B2 (ja) * | 1991-04-26 | 2001-04-23 | 藤沢薬品工業株式会社 | 眼疾患に対するマクロライド化合物の使用 |
US5162334A (en) * | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
US5250678A (en) * | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
US5262533A (en) * | 1991-05-13 | 1993-11-16 | Merck & Co., Inc. | Amino O-aryl macrolides having immunosuppressive activity |
US5565560A (en) * | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
CA2071066A1 (en) * | 1991-06-19 | 1992-12-20 | Ali Shafiee | Fk-900520 enzymatic and/or microbial methylation products |
US5225403A (en) * | 1991-06-25 | 1993-07-06 | Merck & Co., Inc. | C-21 hydroxylated FK-506 antagonist |
US5149701A (en) * | 1991-08-01 | 1992-09-22 | Merck & Co., Inc. | C-31 methylated FR-900520 cyclic hemiketal immunosuppressant agents |
US5273979A (en) * | 1991-08-01 | 1993-12-28 | Merck & Co., Inc. | C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent |
US5198358A (en) * | 1991-08-28 | 1993-03-30 | Merck & Co., Inc. | Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent |
US5189042A (en) * | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
US5708002A (en) * | 1991-09-05 | 1998-01-13 | Abbott Laboratories | Macrocyclic immunomodulators |
US5561228A (en) * | 1991-09-05 | 1996-10-01 | Abbott Laboratories | Macrocyclic immunomodulators |
US5252732A (en) * | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
US5208241A (en) * | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
ZA926812B (en) | 1991-09-09 | 1993-04-28 | Merck & Co Inc | O-heteroaryl,o-alkylheteroaryl,o-alkenylheteroaryl and o-alkynylheteroaryl macrolides having immunosupressive activity |
US5164495A (en) * | 1991-09-18 | 1992-11-17 | Abbott Laboratories | Method for preparing a dicarboxylic acid half-acid ester of FK506 |
US5221625A (en) * | 1992-01-10 | 1993-06-22 | Merck & Co., Inc. | Cyclcic FR-900520 microbial biotransformation agent |
CA2128790A1 (en) * | 1992-01-28 | 1993-08-05 | Abraham Karpas | Use of a compound for the manufacture of a medicament for the treatment of hiv infection |
JP3140228B2 (ja) * | 1992-02-17 | 2001-03-05 | ファイザー製薬株式会社 | 新規な大環状ラクトンおよびその生産菌 |
US5612316A (en) * | 1992-03-02 | 1997-03-18 | Pfizer Inc. | Fluorosugar derivatives of macrolides |
JP2563080B2 (ja) * | 1992-03-02 | 1996-12-11 | フアイザー・インコーポレイテツド | マクロライドの糖誘導体 |
DK0636136T3 (da) * | 1992-03-02 | 1997-12-22 | Pfizer | 2-aminosukkerderivater af makrolider |
ATE205496T1 (de) * | 1992-03-02 | 2001-09-15 | Pfizer | Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel |
ES2089723T3 (es) | 1992-03-27 | 1996-10-01 | American Home Prod | 29-demetoxirapamicina para inducir la inmunodepresion. |
CA2091194A1 (en) * | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
HUT66531A (en) * | 1992-05-07 | 1994-12-28 | Sandoz Ag | Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them |
WO1993025533A1 (en) * | 1992-06-05 | 1993-12-23 | Abbott Laboratories | Methods and reagents for the determination of immunosuppressive agents |
US5284877A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkyl and alkenyl macrolides having immunosuppressive activity |
US5284840A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
US5264355A (en) * | 1992-07-02 | 1993-11-23 | Merck & Co., Inc. | Methlating enzyme from streptomyces MA6858 |
ZA935112B (en) * | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
US5324644A (en) * | 1992-07-28 | 1994-06-28 | Merck & Co., Inc. | Process for producing immunosuppressant agent |
JP3185221B2 (ja) * | 1992-08-12 | 2001-07-09 | 藤沢薬品工業株式会社 | Fk506結合蛋白質を認識するモノクローナル抗体,fk506結合蛋白質の濃度測定法,および測定用キット |
US5365948A (en) * | 1992-08-21 | 1994-11-22 | J & W Mcmichael Software Inc. | Method for use in treating a patient with FK 506 to prevent an adverse immune response |
US5290689A (en) * | 1992-09-28 | 1994-03-01 | Merck & Co., Inc. | New cyclic FR-900520 microbial biotransformation agent |
US5268282A (en) * | 1992-09-28 | 1993-12-07 | Merck & Co., Inc. | Cyclic FR-900520 microbial biotransformation agent |
US5268281A (en) * | 1992-09-28 | 1993-12-07 | Merck & Co., Inc. | Cyclic FR-900520 microbial biotransformation agent |
US5283183A (en) * | 1992-09-28 | 1994-02-01 | Merck & Co., Inc. | Cyclic FR-900520 microbial biotransformation agent |
US5318895A (en) * | 1992-10-05 | 1994-06-07 | Merck & Co., Inc. | Aspergillus niger mutants |
GB9227055D0 (en) * | 1992-12-29 | 1993-02-24 | Fujisawa Pharmaceutical Co | New use |
DE4300478C2 (de) * | 1993-01-11 | 1998-05-20 | Eos Electro Optical Syst | Verfahren und Vorrichtung zum Herstellen eines dreidimensionalen Objekts |
WO1994021254A1 (en) * | 1993-03-17 | 1994-09-29 | Abbott Laboratories | Substituted alicyclic amine-containing macrocyclic immunomodulators |
AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
MY110603A (en) * | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
GB2279006A (en) * | 1993-06-03 | 1994-12-21 | Fujisawa Pharmaceutical Co | Treatment of amyotrophic lateral sclerosis |
JPH06345646A (ja) * | 1993-06-08 | 1994-12-20 | Fujisawa Pharmaceut Co Ltd | ローション剤 |
US5352783A (en) * | 1993-06-09 | 1994-10-04 | Merck & Co., Inc. | Microbial transformation product having immunosuppressive activity |
US5359060A (en) * | 1993-07-06 | 1994-10-25 | Pfizer, Inc. | Phosponated derivatives of macrolides |
JPH09501162A (ja) * | 1993-07-30 | 1997-02-04 | アボツト・ラボラトリーズ | 免疫調節活性を有する活性化マクロラクタム |
GB2281294A (en) * | 1993-08-23 | 1995-03-01 | Fujisawa Pharmaceutical Co | Process for producing half esters of the macrolide FK506 |
US5616588A (en) | 1993-09-30 | 1997-04-01 | American Home Products Corporation | Rapamycin formulation for IV injection |
UA41884C2 (uk) * | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
US5898029A (en) * | 1994-04-12 | 1999-04-27 | The John Hopkins University | Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors |
US5880280A (en) * | 1994-06-15 | 1999-03-09 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
US5693648A (en) * | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
ATE299017T1 (de) | 1994-10-26 | 2005-07-15 | Novartis Pharma Gmbh | Arzneimittel |
AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
US5616595A (en) * | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
JP3266005B2 (ja) | 1995-09-19 | 2002-03-18 | 藤沢薬品工業株式会社 | エアゾール製剤およびその製造方法 |
SI1208847T1 (sl) | 1996-07-30 | 2007-06-30 | Novartis Ag | Farmacevtski sestavki za zdravljenje stanj zavračanja transplantatov in avtoimunskih ali vnetnih stanj |
KR100244164B1 (ko) * | 1997-07-15 | 2000-03-02 | 김용옥 | 수용성 고분자-타크로리무스 접합체 화합물 및 그의 제조 방법 |
US6562620B2 (en) * | 1997-09-19 | 2003-05-13 | Mcgill University | Medium to promote islet cell survival |
US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
US20030129215A1 (en) | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
US7399480B2 (en) | 1997-09-26 | 2008-07-15 | Abbott Laboratories | Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices |
US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
US7357942B2 (en) | 1997-09-26 | 2008-04-15 | Abbott Laboratories | Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens |
US8257726B2 (en) | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices |
US8057816B2 (en) | 1997-09-26 | 2011-11-15 | Abbott Laboratories | Compositions and methods of administering paclitaxel with other drugs using medical devices |
US8257725B2 (en) | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
US8394398B2 (en) | 1997-09-26 | 2013-03-12 | Abbott Laboratories | Methods of administering rapamycin analogs with anti-inflammatories using medical devices |
DE69907418T2 (de) * | 1998-02-23 | 2003-11-13 | Fujisawa Pharmaceutical Co | Verwendung von makroliden zur behandlung von glaukom |
AUPP223198A0 (en) * | 1998-03-06 | 1998-04-02 | Fujisawa Pharmaceutical Co., Ltd. | New use |
EP1421939B9 (de) | 1998-03-26 | 2011-03-02 | Astellas Pharma Inc. | Retardpräparat mit Makroliden wie Tacrolimus |
EA200100149A1 (ru) | 1998-07-17 | 2001-08-27 | Агурон Фармасьютикалз, Инк. | Соединения, композиции и способы стимуляции роста и удлинения нейронов |
US7960405B2 (en) | 1998-09-24 | 2011-06-14 | Abbott Laboratories | Compounds and methods for treatment and prevention of diseases |
US8257724B2 (en) | 1998-09-24 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
US7455853B2 (en) | 1998-09-24 | 2008-11-25 | Abbott Cardiovascular Systems Inc. | Medical devices containing rapamycin analogs |
WO2000020601A2 (en) | 1998-10-02 | 2000-04-13 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant dna constructs therefor |
DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
EP1165575A1 (de) * | 1999-03-31 | 2002-01-02 | Abbott Laboratories | Phosphat-enthaltende makrozyclische immunomodulatoren |
US6121257A (en) * | 1999-03-31 | 2000-09-19 | Abbott Laboratories | Sulfamate containing macrocyclic immunomodulators |
US20030119029A1 (en) * | 1999-04-30 | 2003-06-26 | Regents Of The University Of Michigan | Compositions and methods relating to novel benzodiazepine compounds and targets thereof |
US20050113460A1 (en) * | 1999-04-30 | 2005-05-26 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
US20060025388A1 (en) | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
US7572788B2 (en) * | 1999-04-30 | 2009-08-11 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
CA2372150C (en) * | 1999-04-30 | 2011-08-30 | The Regents Of The University Of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
US20040176358A1 (en) * | 1999-04-30 | 2004-09-09 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
GB9917158D0 (en) * | 1999-07-21 | 1999-09-22 | Fujisawa Pharmaceutical Co | New use |
US20030018044A1 (en) * | 2000-02-18 | 2003-01-23 | Peyman Gholam A. | Treatment of ocular disease |
US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
US7018405B2 (en) | 2000-12-22 | 2006-03-28 | Avantec Vascular Corporation | Intravascular delivery of methylprednisolone |
AR033151A1 (es) * | 2001-04-12 | 2003-12-03 | Sucampo Pharmaceuticals Inc | Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares |
US6656460B2 (en) | 2001-11-01 | 2003-12-02 | Yissum Research Development | Method and composition for dry eye treatment |
CN100338043C (zh) | 2002-02-13 | 2007-09-19 | 特瓦药厂私人有限公司 | 从生物物质中提取大环内酯的方法 |
US7452692B2 (en) * | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
EP1478327B1 (de) * | 2002-02-22 | 2015-04-29 | Meda AB | Verfahren zur reduzierung und behandlung von uvb-induzierter immunsuppression |
AU2002321821A1 (en) * | 2002-06-28 | 2004-01-19 | Biocon Limited | Solid state fermentation and fed batch for the production of an immunosuppressant |
CA2497640C (en) | 2002-09-06 | 2012-02-07 | Abbott Laboratories | Medical device having hydration inhibitor |
JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
WO2004069845A1 (en) * | 2003-02-10 | 2004-08-19 | Biocon Limited | Solid state fermentation and fed batch for the production of an immunosuppressant |
ES2229975T1 (es) | 2003-03-31 | 2005-05-01 | Teva Gyogyszergyar Reszvenytarsasag | Cristalizacion y purificacion de macrolidos. |
US20060169199A1 (en) * | 2003-03-31 | 2006-08-03 | Vilmos Keri | Crystallization and purification of macrolides |
US20060177500A1 (en) * | 2003-07-09 | 2006-08-10 | Hee-Jong Shin | Solid dispersion of tacrolimus |
CA2533548C (en) * | 2003-07-24 | 2010-02-16 | Teva Gyogyszergyar Reszvenytarsasag | Method of purifying macrolides |
WO2005011796A1 (ja) * | 2003-08-05 | 2005-02-10 | Kaneka Corporation | 生体留置用ステント |
JP4996249B2 (ja) | 2003-08-29 | 2012-08-08 | ベロクシス ファーマシューティカルズ エー/エス | タクロリムスを含む改質放出組成物 |
CN1859909B (zh) | 2003-08-29 | 2011-04-06 | 生命周期药物公司 | 含有他克莫司的固态分散体 |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
CN1867664A (zh) * | 2003-10-17 | 2006-11-22 | 兰贝克赛实验室有限公司 | 使用新的链霉菌菌种生产他克莫司(fk-506) |
WO2005051293A2 (en) | 2003-11-21 | 2005-06-09 | Combinatorx, Incorporated | Methods and reagents for the treatment of inflammatory disorders |
AU2003286417A1 (en) * | 2003-12-05 | 2005-06-24 | Biocon Limited | Process for the purification of macrolides |
KR100485877B1 (ko) * | 2003-12-30 | 2005-04-28 | 종근당바이오 주식회사 | 타크롤리무스를 생산하는 미생물 및 이를 이용한타크롤리무스의 대량 생산방법 |
US20050176080A1 (en) * | 2004-02-10 | 2005-08-11 | Vani Bodepudi | Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays |
US8431145B2 (en) | 2004-03-19 | 2013-04-30 | Abbott Laboratories | Multiple drug delivery from a balloon and a prosthesis |
JP4949227B2 (ja) | 2004-03-19 | 2012-06-06 | アボット・ラボラトリーズ | バルーンおよびプロテーゼからの多剤送達 |
EP1756290B1 (de) | 2004-04-12 | 2016-05-04 | Biocon Limited | Streptomyces sp. bicc 7522 und seine verwendung zur herstellung von makroliden |
US20090275099A1 (en) * | 2004-04-27 | 2009-11-05 | Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
US20050272723A1 (en) * | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
JP2006014722A (ja) * | 2004-06-02 | 2006-01-19 | Keio Gijuku | 遺伝子マーカー及びその利用 |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
JP2008512350A (ja) * | 2004-07-01 | 2008-04-24 | イェール ユニバーシティ | 標的化され、そして高密度で薬物が負荷されるポリマー性物質 |
US20060014677A1 (en) * | 2004-07-19 | 2006-01-19 | Isotechnika International Inc. | Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds |
US20060052369A1 (en) * | 2004-09-07 | 2006-03-09 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
US20080269479A1 (en) * | 2004-09-10 | 2008-10-30 | Ivax Pharmaceuticals S.R.O. | Process for Isolation of Macrolide Compounds |
JP2008512126A (ja) * | 2004-09-10 | 2008-04-24 | アイバックス ファーマシューティカルズ スポレツノスト エス ルチェニム オメゼニム | 結晶質タクロリムスの単離法 |
GT200500282A (es) * | 2004-10-12 | 2006-05-04 | Heteroatomos conteniendo compuestos triciclicos. | |
ITMI20042098A1 (it) * | 2004-11-03 | 2005-02-03 | Antibioticos Spa | Processo per la purificazione di tacrolimus |
CA2584365A1 (en) | 2004-12-01 | 2006-06-08 | Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag | Ascomycin crystalline forms and preparation thereof |
AU2005316473B2 (en) * | 2004-12-15 | 2011-07-14 | Elan Pharma International Ltd. | Nanoparticulate tacrolimus formulations |
CA2586700A1 (en) * | 2004-12-22 | 2006-06-29 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Method of purifying tacrolimus |
AU2006203946B2 (en) * | 2005-01-03 | 2009-07-23 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
JP2007527434A (ja) * | 2005-01-05 | 2007-09-27 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | 非晶質タクロリマス及びその調製 |
ATE532064T1 (de) * | 2005-01-13 | 2011-11-15 | Univ Keio | Genmarker und dessen verwendung |
ATE533520T1 (de) | 2005-03-23 | 2011-12-15 | Abbott Lab | Abgabe von stark lipophilen mitteln durch medizinprodukte |
JP5242374B2 (ja) | 2005-03-23 | 2013-07-24 | アボット・ラボラトリーズ | 組成物ならびに長期効力を得るための医療機器を用いたラパマイシン類縁体の投与方法 |
JP2008545757A (ja) | 2005-06-01 | 2008-12-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 溶媒和されていないベンゾジアゼピン組成物および方法 |
CN1876822B (zh) * | 2005-06-06 | 2010-05-12 | 上海市农药研究所 | 他克莫司的产生菌株及生产方法 |
WO2007013017A1 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | A process for purification of macrolides |
ITMI20051549A1 (it) * | 2005-08-05 | 2007-02-06 | Antibioticos Spa | Purificazione del tacrolimus su supporti dimorigine vegetale |
WO2007029082A2 (en) * | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | An improved fermentation process for preparing ascomycin |
US20080318289A1 (en) * | 2005-10-05 | 2008-12-25 | Parveen Kumar | Fermentation Processes for the Preparation of Tacrolimus |
US20070105844A1 (en) * | 2005-10-26 | 2007-05-10 | Regents Of The University Of Michigan | Therapeutic compositions and methods |
EP1948191B1 (de) | 2005-11-01 | 2013-01-16 | The Regents of the University of Michigan | Neuartige 1,4-benzodiazepin-2,5-dione mit therapeutischen eigenschaften |
NZ568694A (en) | 2005-11-09 | 2011-09-30 | Zalicus Inc | Method, compositions, and kits for the treatment of medical conditions |
US7678901B2 (en) | 2006-02-28 | 2010-03-16 | Wyeth | Rapamycin analogs containing an antioxidant moiety |
US7622477B2 (en) | 2006-02-28 | 2009-11-24 | Cordis Corporation | Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same |
DE602007006601D1 (de) * | 2006-03-15 | 2010-07-01 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur reinigung von tacrolimus |
US8022188B2 (en) * | 2006-04-24 | 2011-09-20 | Abbott Laboratories | Immunosuppressant binding antibodies and methods of obtaining and using same |
US7759338B2 (en) * | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
US8097612B2 (en) | 2006-06-09 | 2012-01-17 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
JPWO2008026781A1 (ja) | 2006-08-31 | 2010-01-21 | 直人 奥 | 逆標的化脂質小胞体 |
WO2008033466A2 (en) * | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
TW200837067A (en) * | 2006-11-06 | 2008-09-16 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
US9044391B2 (en) * | 2007-01-10 | 2015-06-02 | Board Of Regents, The University Of Texas System | Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery |
US10265407B2 (en) | 2007-02-15 | 2019-04-23 | Yale University | Modular nanodevices for smart adaptable vaccines |
US20100151436A1 (en) * | 2007-03-02 | 2010-06-17 | Fong Peter M | Methods for Ex Vivo Administration of Drugs to Grafts Using Polymeric Nanoparticles |
CA2783589A1 (en) | 2007-03-09 | 2008-09-18 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
DK2167033T3 (en) | 2007-05-30 | 2017-08-14 | Veloxis Pharmaceuticals As | Once daily oral dosage form comprising tacrolism |
KR100891313B1 (ko) * | 2007-08-17 | 2009-03-31 | (주) 제노텍 | 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법 |
CN101855203B (zh) | 2007-09-14 | 2014-03-19 | 密执安州立大学董事会 | F1f0-atp合成酶抑制剂以及相关的方法 |
NZ584842A (en) | 2007-11-06 | 2012-06-29 | Univ Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions, in particular, psoriasis |
EP2245165A4 (de) * | 2008-01-11 | 2011-06-01 | Massachusetts Eye & Ear Infirm | Transgene konditionalstopp-dimerisierbare-caspase-tiere |
KR101003042B1 (ko) | 2008-03-17 | 2010-12-21 | 종근당바이오 주식회사 | 고순도 타크로리무스의 정제 방법 |
CA2719923A1 (en) * | 2008-04-08 | 2009-10-15 | Amyris Biotechnologies, Inc. | Expression of heterologous sequences |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
US8497307B2 (en) | 2008-09-11 | 2013-07-30 | The Regents Of The University Of Michigan | Aryl guanidine F1F0-ATPase inhibitors and related methods |
KR100910165B1 (ko) * | 2008-09-18 | 2009-07-30 | (주) 제노텍 | 은 이온 용액 추출을 이용한 불포화 알킬기를 가진 락톤 화합물 정제방법 |
US8575189B2 (en) * | 2008-10-08 | 2013-11-05 | Takata Seiyaku Co., Ltd. | Tacrolimus preparation for external applications |
CN102753563A (zh) | 2008-12-23 | 2012-10-24 | 吉利德制药有限责任公司 | 核苷类似物 |
AR074977A1 (es) | 2008-12-23 | 2011-03-02 | Pharmasset Inc | Sintesis de nucleosidos de purina |
PT2376088T (pt) | 2008-12-23 | 2017-05-02 | Gilead Pharmasset Llc | Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída |
WO2010121164A2 (en) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
CN101712686B (zh) * | 2009-06-22 | 2012-08-29 | 鲁南制药集团股份有限公司 | 一种发酵液中他克莫司的分离纯化方法 |
EP2272963A1 (de) * | 2009-07-09 | 2011-01-12 | LEK Pharmaceuticals d.d. | Verfahren zur Herstellung von Tacrolimus |
JP2013505258A (ja) | 2009-09-18 | 2013-02-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ベンゾジアゼピノン化合物およびそれを使用する治療方法 |
ES2703752T3 (es) | 2009-11-17 | 2019-03-12 | Univ Michigan Regents | 1,4-Benzodiazepina-2,5-dionas y compuestos relacionados que presentan propiedades terapéuticas |
CA2780333C (en) | 2009-11-17 | 2016-05-24 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
US20110130711A1 (en) * | 2009-11-19 | 2011-06-02 | Follica, Inc. | Hair growth treatment |
US8480620B2 (en) | 2009-12-11 | 2013-07-09 | Abbott Cardiovascular Systems Inc. | Coatings with tunable solubility profile for drug-coated balloon |
US8951595B2 (en) | 2009-12-11 | 2015-02-10 | Abbott Cardiovascular Systems Inc. | Coatings with tunable molecular architecture for drug-coated balloon |
EP2575769B1 (de) | 2010-02-17 | 2016-06-15 | Veloxis Pharmaceuticals A/S | Stabilisierte tacrolimus formulierungen |
CN102858790A (zh) | 2010-03-31 | 2013-01-02 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
US20110318277A1 (en) | 2010-06-25 | 2011-12-29 | APT Pharmaceuticals, Inc. University of Maryland, Baltimore | Tacrolimus compositions for aerosol administration |
KR101261131B1 (ko) | 2010-08-24 | 2013-05-06 | 이화여자대학교 산학협력단 | 신규 타크롤리무스 유도체, 상기 유도체를 포함하는 신경 보호용 조성물, 상기 유도체를 포함하는 면역 억제용 조성물, 상기 유도체의 생산 방법 및 상기 유도체의 생산 균주 |
MA34586B1 (fr) | 2010-08-25 | 2013-10-02 | Medis Lab | Particules cristallines de tacrolimus micronise a surface modifiee et compositions pharmaceutiques associees |
US10117411B2 (en) | 2010-10-06 | 2018-11-06 | Dow Agrosciences Llc | Maize cytoplasmic male sterility (CMS) C-type restorer RF4 gene, molecular markers and their use |
US9987356B2 (en) | 2011-03-11 | 2018-06-05 | Beth Israel Deaconess Medical Center, Inc. | Anti-CD40 antibodies and methods of administering thereof |
US9597385B2 (en) | 2012-04-23 | 2017-03-21 | Allertein Therapeutics, Llc | Nanoparticles for treatment of allergy |
US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
UA116648C2 (uk) | 2013-03-14 | 2018-04-25 | Алкермес Фарма Айерленд Лімітед | Фумарати як проліки та їх застосування при лікуванні різних захворювань |
EP2981285B1 (de) | 2013-04-03 | 2020-06-03 | N-Fold Llc | Neuartige nanopartikelzusammensetzungen |
US9814703B2 (en) | 2013-11-14 | 2017-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of BMP signaling |
CN104650112B (zh) * | 2013-11-18 | 2018-07-31 | 山东新时代药业有限公司 | 他克莫司8-丙基类似物的制备方法 |
UY35927A (es) | 2013-12-31 | 2015-07-31 | Dow Agrosciences Llc | ?gen restaurador rf3 de tipo s de la esterilidad masculina citoplasmática del maíz (cms), marcadores moleculares y sus usos?. |
CA2935801A1 (en) | 2014-01-13 | 2015-07-16 | Amplyx Pharmaceuticals, Inc. | Antifungal compounds |
US10428331B2 (en) | 2014-01-16 | 2019-10-01 | Musc Foundation For Research Development | Targeted nanocarriers for the administration of immunosuppressive agents |
ES2753361T3 (es) | 2014-02-24 | 2020-04-08 | Alkermes Pharma Ireland Ltd | Sulfonamida y profármacos de fumaratos de sulfinamida y su uso en el tratamiento de diversas enfermedades |
KR101694879B1 (ko) * | 2014-08-01 | 2017-01-12 | 주식회사 인트론바이오테크놀로지 | 면역억제활성 없이 신경재생활성이 유지되는 fk506 유도체 및 그의 용도 |
US10143682B2 (en) | 2014-10-28 | 2018-12-04 | Koushi Yamaguchi | Medicine for improving state of pregnancy, and use thereof |
EP4066822A1 (de) | 2015-08-19 | 2022-10-05 | Vivus, Inc. | Pharmazeutische formulierungen |
EP3307322B1 (de) | 2015-09-04 | 2021-02-17 | Primatope Therapeutics Inc. | Humanisierte anti-cd40-antikörper und verwendungen dafür |
CN106074367A (zh) * | 2016-07-20 | 2016-11-09 | 中山大学中山眼科中心 | 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法 |
CN108384819B (zh) * | 2017-02-03 | 2021-06-25 | 上海医药工业研究院 | 一种用于发酵他克莫司的培养基以及发酵方法 |
RU2686779C1 (ru) * | 2018-07-26 | 2019-04-30 | Общество с ограниченной ответственностью "Изварино Фарма" | Штамм streptomyces tsukubensis - продуцент такролимуса и способ получения такролимуса |
CA3108863A1 (en) | 2018-08-10 | 2020-02-13 | Koushi Yamaguchi | Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship |
WO2020076738A2 (en) * | 2018-10-12 | 2020-04-16 | Bellicum Pharmaceuticals, Inc | Protein-binding compounds |
WO2020117134A1 (en) | 2018-12-04 | 2020-06-11 | İlko İlaç Sanayi̇ Ve Ti̇caret A.Ş. | Stable tacrolimus ointment formulation for topical treatment of skin conditions |
KR102135527B1 (ko) * | 2018-12-18 | 2020-07-20 | 이문수 | 발가락 습기 제거 양말 |
WO2020129348A1 (ja) | 2018-12-18 | 2020-06-25 | 晃史 山口 | 不妊・不育症または妊娠状態を改善するための薬剤 |
GR1009790B (el) | 2019-03-20 | 2020-08-03 | Φαρματεν Α.Β.Ε.Ε. | Σκευασμα παρατεταμενης αποδεσμευσης που περιλαμβανει τακρολιμους |
CA3212370A1 (en) | 2021-03-03 | 2022-09-09 | Sana Biotechnology, Inc. | Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3244592A (en) * | 1962-06-09 | 1966-04-05 | Arai Tadashi | Ascomycin and process for its production |
JPS54110000A (en) * | 1978-02-17 | 1979-08-29 | Kaken Pharmaceut Co Ltd | Novel streptovaricin c derivative |
US4309504A (en) * | 1980-01-28 | 1982-01-05 | Eli Lilly And Company | Process for preparing narasin |
US4654334A (en) * | 1980-10-08 | 1987-03-31 | International Minerals & Chemical Corp. | Manganese-containing antibiotic agents |
US4415669A (en) * | 1981-12-07 | 1983-11-15 | Merck & Co., Inc. | Substance and process for its production |
US4390546A (en) * | 1981-12-07 | 1983-06-28 | Merck & Co., Inc. | Antiparasitic macrolide from a strain of Streptomyces hygroscopicus |
US4510317A (en) * | 1983-07-28 | 1985-04-09 | Hoffmann-La Roche Inc. | Antibiotic X-14934A |
GB8430455D0 (en) * | 1984-12-03 | 1985-01-09 | Fujisawa Pharmaceutical Co | Fr-900506 substance |
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5266692A (en) * | 1984-12-03 | 1993-11-30 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5254562A (en) * | 1984-12-03 | 1993-10-19 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
GB2212061B (en) * | 1987-11-09 | 1991-08-28 | Sandoz Ltd | Topical compositions comprising 11,28-dioxa-4-azatricyclo [22.3.1.0(4,9)] octacos-18-ene derivatives |
US5956352A (en) * | 1992-04-24 | 1999-09-21 | Digital Equipment Corporation | Adjustable filter for error detecting and correcting system |
-
1985
- 1985-11-20 US US06/799,855 patent/US4894366A/en not_active Expired - Lifetime
- 1985-11-26 IE IE297185A patent/IE62865B1/en not_active IP Right Cessation
- 1985-11-28 CA CA000496479A patent/CA1338491C/en not_active Expired - Lifetime
- 1985-11-29 AU AU50596/85A patent/AU592067B2/en not_active Expired
- 1985-11-29 FI FI854731A patent/FI87803C/fi not_active IP Right Cessation
- 1985-11-29 DK DK556285A patent/DK169550B1/da not_active IP Right Cessation
- 1985-11-30 DE DE1995175026 patent/DE19575026I2/de active Active
- 1985-11-30 AT AT8585115202T patent/ATE104984T1/de active
- 1985-11-30 DE DE3587806T patent/DE3587806T2/de not_active Expired - Lifetime
- 1985-11-30 CY CY191285A patent/CY1912A/xx unknown
- 1985-11-30 EP EP85115202A patent/EP0184162B1/de not_active Expired - Lifetime
- 1985-12-02 HU HU854600A patent/HU195250B/hu unknown
- 1985-12-02 GR GR852904A patent/GR852904B/el unknown
- 1985-12-02 NO NO85854833A patent/NO168372C/no not_active IP Right Cessation
- 1985-12-02 NZ NZ214407A patent/NZ214407A/xx unknown
- 1985-12-02 PT PT81589A patent/PT81589B/pt unknown
- 1985-12-02 KR KR1019850009022A patent/KR930010704B1/ko not_active IP Right Cessation
- 1985-12-02 ES ES549478A patent/ES8705038A1/es not_active Expired
- 1985-12-03 IL IL92345A patent/IL92345A/xx not_active IP Right Cessation
- 1985-12-03 CN CN85109492A patent/CN1013687B/zh not_active Expired
- 1985-12-03 IL IL77222A patent/IL77222A/xx not_active IP Right Cessation
-
1986
- 1986-05-30 US US06/868,749 patent/US4929611A/en not_active Expired - Lifetime
- 1986-11-07 FI FI864527A patent/FI85977C/fi not_active IP Right Cessation
-
1989
- 1989-08-17 US US07/395,798 patent/US4956352A/en not_active Expired - Lifetime
-
1990
- 1990-03-09 US US07/491,205 patent/US5110811A/en not_active Expired - Lifetime
- 1990-07-31 JP JP2204519A patent/JPH0720970B2/ja not_active Expired - Lifetime
- 1990-07-31 JP JP2204518A patent/JPH0372483A/ja active Granted
-
1992
- 1992-06-17 MX MX9202943A patent/MX9202943A/es unknown
-
1993
- 1993-09-01 KR KR1019930017417A patent/KR930010706B1/ko not_active IP Right Cessation
- 1993-09-01 KR KR1019930017419A patent/KR930010708B1/ko not_active IP Right Cessation
- 1993-09-01 KR KR1019930017416A patent/KR930010705B1/ko not_active IP Right Cessation
- 1993-09-01 KR KR1019930017418A patent/KR930010707B1/ko not_active IP Right Cessation
-
1994
- 1994-09-01 JP JP6208445A patent/JP2746134B2/ja not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/450,412 patent/US5624842A/en not_active Expired - Lifetime
- 1995-05-25 US US08/450,639 patent/US5496727A/en not_active Expired - Lifetime
- 1995-10-19 US US08/545,172 patent/US5565559A/en not_active Expired - Fee Related
-
1996
- 1996-02-01 HK HK18596A patent/HK18596A/xx not_active IP Right Cessation
- 1996-10-07 NL NL960023C patent/NL960023I2/nl unknown
- 1996-12-03 US US08/753,950 patent/US5830717A/en not_active Expired - Lifetime
-
1997
- 1997-04-18 JP JP9101673A patent/JP2828091B2/ja not_active Expired - Fee Related
-
1998
- 1998-05-26 US US09/084,099 patent/US6028097A/en not_active Expired - Fee Related
- 1998-05-28 JP JP10146822A patent/JP2976966B2/ja not_active Expired - Fee Related
- 1998-11-11 LU LU90317C patent/LU90317I2/xx unknown
-
1999
- 1999-04-14 JP JP10603999A patent/JP3211891B2/ja not_active Expired - Fee Related
- 1999-10-01 US US09/411,630 patent/US6201005B1/en not_active Expired - Fee Related
-
2000
- 2000-11-27 US US09/721,650 patent/US6482845B1/en not_active Expired - Fee Related
-
2002
- 2002-09-20 US US10/247,305 patent/US20030170831A1/en not_active Abandoned
-
2003
- 2003-04-25 US US10/422,901 patent/US20030229115A1/en not_active Abandoned
- 2003-05-01 US US10/426,659 patent/US20040029908A1/en not_active Abandoned
-
2004
- 2004-11-09 US US10/983,710 patent/US20050124646A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3587806D1 (de) | Tricyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung. | |
DE59208559D1 (de) | Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung | |
ATE58534T1 (de) | 2-pyrimidinyl-l-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. | |
ATE45153T1 (de) | Benzisoselenazolthione, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische produkte. | |
ATE324T1 (de) | Hydroxypropyl-triazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. | |
JPS5665869A (en) | Novel 22hydroxyalkyll3*4*55trihydroxyypiperidine compound* its manufacture and drug | |
ATE19773T1 (de) | Nitroaliphatische verbindungen, verfahren zu deren herstellung und deren verwendung. | |
ATE18226T1 (de) | Pyrrolo(2,3-d)carbazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. | |
ATE200492T1 (de) | 7-acyl-3-(substituierte carbamoyloxy) cephem verbindungen, verfahren zu ihrer herstellung und anwendung | |
ATE291T1 (de) | Fluorenyl-azolylmethyl-carbinole, verfahren zu ihrer herstellung, arzneimittel, die diese verbindungen enthalten und verfahren zur herstellung dieser arzneimittel. | |
ES8308471A1 (es) | "un procedimiento para la preparacion de composiciones efectivas contra acaros". | |
ATE275576T1 (de) | Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen | |
ATE25517T1 (de) | Delta-1-pyrrolin-thiolactimaether und verfahren zu ihrer herstellung. | |
IL110865A (en) | Difluoro statone analogs process for their preparation and pharmaceutical compositions containing them | |
ATE38837T1 (de) | Gesaettigten stickstoff enthaltende tricyclische dione, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. | |
ATE49003T1 (de) | Pregnane derivate, verfahren zu ihrer herstellung und pharmazeutische zusammenstellungen, die sie enthalten. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
V448 | Application of spc |
Free format text: PRODUCT NAME: TACROLIMUS (INN); REGISTRATION NO/DATE: 30793.00.00, 30793.00.01, 30793.01.00; 19950321 Spc suppl protection certif: 195 75 026 Filing date: 19950727 |
|
V457 | Spc granted |
Free format text: PRODUCT NAME: TACROLIMUS (INN); REGISTRATION NO/DATE: 30793.00.00, 30793.00.01, 30793.01.00; 19950321 Spc suppl protection certif: 195 75 026 Filing date: 19950727 |
|
V464 | Spc expired |
Free format text: PRODUCT NAME: TACROLIMUS (INN); REGISTRATION NO/DATE: 30793.00.00, 30793.00.01, 30793.01.00; 19950321 Spc suppl protection certif: 195 75 026 Filing date: 19950727 |