DE3650501D1 - Hyaluronsäureester und ihre Salze. - Google Patents

Hyaluronsäureester und ihre Salze.

Info

Publication number
DE3650501D1
DE3650501D1 DE3650501T DE3650501T DE3650501D1 DE 3650501 D1 DE3650501 D1 DE 3650501D1 DE 3650501 T DE3650501 T DE 3650501T DE 3650501 T DE3650501 T DE 3650501T DE 3650501 D1 DE3650501 D1 DE 3650501D1
Authority
DE
Germany
Prior art keywords
salts
acid esters
hyaluronic acid
hyaluronic
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3650501T
Other languages
English (en)
Other versions
DE3650501T2 (de
Inventor
Valle Francesco Della
Aurelio Romeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT8548322A external-priority patent/IT1214658B/it
Priority claimed from IT48202/86A external-priority patent/IT1203815B/it
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of DE3650501D1 publication Critical patent/DE3650501D1/de
Publication of DE3650501T2 publication Critical patent/DE3650501T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
DE3650501T 1985-07-08 1986-07-07 Hyaluronsäureester und ihre Salze. Expired - Lifetime DE3650501T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8548322A IT1214658B (it) 1985-07-08 1985-07-08 Esteri polisaccaridici e loro sali
IT48202/86A IT1203815B (it) 1986-06-30 1986-06-30 Esteri polisaccaridici e loro sali

Publications (2)

Publication Number Publication Date
DE3650501D1 true DE3650501D1 (de) 1996-04-25
DE3650501T2 DE3650501T2 (de) 1996-11-21

Family

ID=26329289

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3650501T Expired - Lifetime DE3650501T2 (de) 1985-07-08 1986-07-07 Hyaluronsäureester und ihre Salze.
DE3650776T Expired - Lifetime DE3650776T2 (de) 1985-07-08 1986-07-07 Polysaccharideester und ihre Salze

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3650776T Expired - Lifetime DE3650776T2 (de) 1985-07-08 1986-07-07 Polysaccharideester und ihre Salze

Country Status (21)

Country Link
US (3) US4851521A (de)
EP (2) EP0696598B1 (de)
JP (1) JP2569012B2 (de)
KR (1) KR870001901B1 (de)
AR (1) AR242593A1 (de)
AT (2) ATE135713T1 (de)
AU (1) AU591501B2 (de)
CA (2) CA1341276C (de)
DE (2) DE3650501T2 (de)
DK (1) DK175661B1 (de)
ES (1) ES2001512A6 (de)
FI (6) FI94766C (de)
HU (1) HU201966B (de)
IE (1) IE81120B1 (de)
IL (1) IL79362A (de)
IN (1) IN165582B (de)
NO (2) NO175716C (de)
NZ (2) NZ233045A (de)
PH (1) PH25189A (de)
PT (1) PT82941B (de)
SG (1) SG90006A1 (de)

Families Citing this family (348)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
AU600257B2 (en) * 1986-03-21 1990-08-09 International Pharmaceutical Products, Inc. Non-inflammatory hyaluronic acid fraction and process for preparing it
US5264422A (en) * 1986-06-30 1993-11-23 Fidia S.P.A. Esters of alginic acid with steroidal alcohols
IT1203814B (it) * 1986-06-30 1989-02-23 Fidia Farmaceutici Esteri dell'acido alginico
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
LU87350A1 (fr) * 1988-09-28 1990-04-06 Oreal Application cosmetique de polysiloxanes a fonction diester et compositions mises en oeuvre
US4965071A (en) * 1988-10-19 1990-10-23 The Gillette Company Wrinkle masking composition of sodium polystyrene sulfonate and process for use
US5700479A (en) * 1988-12-23 1997-12-23 Guidor Ab Surgical element and method for selective tissue regeneration
ES2070335T3 (es) * 1989-09-12 1995-06-01 Shiseido Co Ltd Procedimiento para la produccion de acido hialuronico de bajo peso molecular.
CA1340994C (en) 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
JP2945993B2 (ja) * 1989-12-05 1999-09-06 武田薬品工業株式会社 外用剤
JP2788340B2 (ja) * 1989-12-21 1998-08-20 株式会社ニッショー 炎症治療剤
EP0589871B1 (de) * 1990-02-13 2000-04-26 Ethicon, Inc. Peritoneal wirksame medikamente
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
CA2082398C (en) * 1990-05-14 2004-06-29 Gary R. Jernberg Surgical implant and method incorporating chemotherapeutic agents
IT1248934B (it) * 1990-06-01 1995-02-11 Fidia Spa Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
DE69125595T2 (de) * 1990-10-18 1997-11-13 Shiseido Co Ltd Kombination von hyaluronsäure mit einem medizinischen bestandteil, und seine herstellung
US5733891A (en) * 1990-10-18 1998-03-31 Shiseido Co., Ltd. Compound for medicinal ingredient and hyaluronic acid and process for producing the same
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
IT1247157B (it) * 1991-02-11 1994-12-12 Fidia Spa Canali di guida biodegradabili e bioassorbibili da impiegare per la rigenerazione nervosa.
ATE138389T1 (de) * 1991-02-11 1996-06-15 Fidia Spa Gellanester
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
WO1994007505A1 (en) * 1991-07-03 1994-04-14 Norpharmco Inc. Use of hyaluronic acid and forms to prevent arterial restenosis
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
IT1251151B (it) * 1991-08-05 1995-05-04 Fidia Spa Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati
IT1254119B (it) * 1991-09-13 1995-09-08 Fidia Esteri di derivati carbossilici di polisaccaridi
IT1263755B (it) * 1991-09-16 1996-08-29 Fidia Spa Uso di esteri della colina con polisaccaridi acidi come agenti antiulcera e gastroprotettivi
AU3124793A (en) * 1991-10-29 1993-06-07 Clover Consolidated, Limited Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
IT1254704B (it) * 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico
US5824335A (en) * 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
IT1254170B (it) * 1991-12-18 1995-09-11 Mini Ricerca Scient Tecnolog Membrane composite per la rigenerazione guidata di tessuti
IT1254706B (it) 1991-12-23 1995-10-09 Fidia Spa Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US6147059A (en) * 1992-02-20 2000-11-14 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5879359A (en) * 1992-08-03 1999-03-09 Fidia S.P.A. Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids
IT1259141B (it) * 1992-08-03 1996-03-11 Fidia Spa Canali di guida biodegradabili e bioriassorbibili da impiegare per la riparazione tissutale come adiuvante in interventi chirurgici
DE4328329C2 (de) * 1992-08-26 1998-02-12 Suwelack Nachf Dr Otto Gefriergetrocknete Biomatrix
US5550112A (en) * 1992-12-30 1996-08-27 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions and uses
IT1263144B (it) * 1993-02-04 1996-08-01 Lanfranco Callegaro Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive
IT1263316B (it) * 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
IT1263394B (it) 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Composizioni farmaceutiche per uso topico a base di acido ialuronico e suoi derivati
US5430142A (en) * 1993-08-06 1995-07-04 The Center For Innovative Technology Thermoplastic pentosan-rich polysaccharides from biomass
WO1995007085A1 (en) * 1993-09-07 1995-03-16 Escalon Ophthalmics, Inc. Surface active viscoelastic solutions for ocular use
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
ES2255059T3 (es) 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
US5498527A (en) * 1994-02-18 1996-03-12 Ube Industries, Ltd. Phosphorylcholine-containing glyceroglycolipid
JPH0881501A (ja) * 1994-03-22 1996-03-26 Agawamura 酸性多糖
US5633003A (en) * 1994-03-31 1997-05-27 Cantor; Jerome O. Use of intratracheally administered hyaluronic acid to ameliorate emphysema
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
CZ293637B6 (cs) * 1995-02-07 2004-06-16 Fidia Advanced Biopolymers, S.R.L. Způsob potahování povrchu předmětu kyselinou hyaluronovou nebo jejím derivátem
IT1281870B1 (it) * 1995-04-27 1998-03-03 Fidia Advanced Biopolymers Srl Pelle artificiale umana costituita da materiali biocompatibili a base di derivati dell'acido ialuronico
US6017901A (en) * 1995-05-10 2000-01-25 Fidia Advanced Bioplymers S.R.L. Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions
IT1281877B1 (it) * 1995-05-10 1998-03-03 Fidia Advanced Biopolymers Srl Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici
US5531910A (en) * 1995-07-07 1996-07-02 The Procter & Gamble Company Biodegradable fabric softener compositions with improved perfume longevity
US5559088A (en) * 1995-07-07 1996-09-24 The Proctor & Gamble Company Dryer-activated fabric conditioning and antistatic compositions with improved perfume longevity
HU226962B1 (en) 1995-08-29 2010-03-29 Fidia Advanced Biopolymers Srl Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
KR100236771B1 (ko) * 1997-04-01 2000-02-01 성재갑 히아루론산을 이용한 약물의 서방성 미세입자 제형
US5939047A (en) * 1996-04-16 1999-08-17 Jernberg; Gary R. Local delivery of chemotherapeutic agents for treatment of periodontal disease
CA2256400A1 (en) * 1996-05-28 1997-12-04 Brown University Research Foundation Hyaluronan based biodegradable scaffolds for tissue repair
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US6632802B2 (en) * 1996-08-29 2003-10-14 Fidia Advanced Biopolymers S.R.L. Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
IT1287698B1 (it) * 1996-08-29 1998-08-18 Fidia Advanced Biopolymers Srl Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico
IT1287967B1 (it) 1996-10-17 1998-09-10 Fidia Spa In Amministrazione S Preparazioni farmaceutiche per uso anestetico locale
ES2615357T3 (es) 1996-12-06 2017-06-06 Amgen Inc. Terapia de combinación usando un inhibidor de IL-1 para tratar enfermedades mediadas por IL-1
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US6596703B1 (en) 1997-07-11 2003-07-22 Jagotec Ag Promotion of wound healing utilizing steroids having reduced deteriorous systemic side effects typical of glucocorticoids, mineralocorticoids and sex steroids
US6123957A (en) * 1997-07-16 2000-09-26 Jernberg; Gary R. Delivery of agents and method for regeneration of periodontal tissues
IT1294797B1 (it) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
IT1296689B1 (it) * 1997-11-06 1999-07-14 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
US6503527B1 (en) * 1997-11-17 2003-01-07 Haemacure Corporation Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
US6099952A (en) * 1998-02-18 2000-08-08 Xomed Surgical Products, Inc. Medical sponge having mucopolysaccharide coating
ITPD980037A1 (it) * 1998-02-25 1999-08-25 Fidia Advanced Biopolymers Srl Acido ialuronico solfatato e i suoi derivati legati covalentemente a polimeri sintetici pe la preparazione di biomateriali e per il rivesti
US7115417B1 (en) 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
US6866842B1 (en) * 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
US20020086852A1 (en) * 1998-05-14 2002-07-04 Cantor Jerome O. Method for treating respiratory disorders associated with pulmonary elastic fiber injury
KR20010025040A (ko) * 1998-05-20 2001-03-26 나가야마 오사무 관절질환 치료제 및 히알루론산의 결합체
US6872819B1 (en) 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
US6824793B1 (en) * 1998-06-01 2004-11-30 Chiron Corporation Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1303735B1 (it) * 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
IT1302534B1 (it) * 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
DE60036915T2 (de) 1999-01-13 2008-08-07 Alchemia Oncology Pty Ltd., Hawthorn Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2000044367A2 (en) * 1999-02-01 2000-08-03 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
US6884427B1 (en) * 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
US6589760B1 (en) 1999-02-10 2003-07-08 Eastman Chemical Company Methods of separating a corn fiber lipid fraction from corn fiber
IT1309588B1 (it) * 1999-03-05 2002-01-24 Altergon Sa Cerotto con spessore sottile contenente betametasone ed acidoialuronico per il trattamento di psoriasi, dermatite, dermatosi.
IT1306644B1 (it) * 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
FR2794763B1 (fr) * 1999-06-08 2001-08-24 Centre Nat Rech Scient Nouveaux derives de l'acide hyaluronique, leur preparation et leur utilisation
IT1306679B1 (it) * 1999-06-29 2001-10-02 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico per la preparazione dicomposizoni farmaceutiche e biomateriali per la prevenzione della
EP1223990B1 (de) * 1999-10-15 2004-07-28 Genetics Institute, LLC Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
EP1481695A1 (de) * 1999-10-15 2004-12-01 Genetics Institute, LLC Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
EP1110971B1 (de) * 1999-12-14 2004-08-11 Kibun Food Chemifa Co., Ltd. Propylenglykolhyaluronat und äusserlich anzuwendendes Hautpflegemittel, dass dieses enthält
DE60012866T2 (de) * 1999-12-14 2005-09-08 Kibun Food Chemifa Co., Ltd. Propylenglykolhyaluronat und äusserlich anzuwendendes Hautpflegemittel, das dieses enthält
US6710038B1 (en) 1999-12-14 2004-03-23 Kibun Food Chemifa Co., Ltd. Emulsification method using propylene glycol hyaluronate
IT1318403B1 (it) * 2000-03-17 2003-08-25 Cooperativa Ct Ricerche Poly T Esteri polisaccaridici di n-derivati di acido glutammico.
AU2001251599B2 (en) * 2000-04-14 2006-03-02 University Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
JP4017977B2 (ja) * 2000-08-08 2007-12-05 アデランス リサーチ インスティテュート インコーポレイテッド 組織工学で処置した毛髪用の台
IT1317359B1 (it) * 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
US20030013643A1 (en) * 2000-09-21 2003-01-16 Wessels Michael R. Prevention and treatment of streptococcal and staphylococcal infection
AU2002239697A1 (en) * 2000-10-24 2002-06-03 Clear Solutions Biotech, Inc. Sodium hyaluronate microspheres
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6576226B1 (en) 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
PL361732A1 (en) * 2000-12-28 2004-10-04 Fidia Advanced Biopolymers S.R.L. Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy
CA2438904C (en) * 2001-02-23 2012-09-04 The University Of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
EP1249247B1 (de) * 2001-03-30 2007-02-28 Chisso Corporation Pharmazeutische Zusammensetzung zur Behandlung gynäkologischer Erkrankungen
ATE393573T1 (de) * 2001-06-01 2008-05-15 Wyeth Corp Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US20050042303A1 (en) * 2001-08-27 2005-02-24 Brown Tracey Jean Therapeutic protocols
KR100514582B1 (ko) * 2001-09-05 2005-09-13 한스바이오메드 주식회사 생체복원물질의 제조방법
WO2003029418A2 (en) * 2001-10-02 2003-04-10 Becton, Dickinson And Company Proliferation and differentiation of stem cells using extracellular matrix and other molecules
US7662954B2 (en) * 2001-10-30 2010-02-16 Colorado State University Research Foundation Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest
US8524884B2 (en) 2001-10-30 2013-09-03 Colorado State University Research Foundation Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest
DE10161110A1 (de) * 2001-12-12 2003-06-26 Ursapharm Arzneimittel Gmbh Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
AU2002367394A1 (en) * 2001-12-28 2003-07-24 Genzyme Corporation Bioresorbable foam packing device and use thereof
ITPD20020003A1 (it) * 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
US20040068284A1 (en) * 2002-01-29 2004-04-08 Barrows Thomas H. Method for stimulating hair growth and kit for carrying out said method
ITPD20020064A1 (it) * 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
JP2005530768A (ja) * 2002-05-09 2005-10-13 メディジーンズ 血漿または血清を含有した創傷治療用医薬組成物
MXPA04011337A (es) * 2002-05-17 2005-07-01 Wyeth Corp Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas.
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20060094643A1 (en) * 2002-07-03 2006-05-04 Yuri Svirkin Compositions of hyaluronic acid and methods of use
FR2842737B1 (fr) * 2002-07-25 2006-01-27 Centre Nat Rech Scient Particules revetues en surface de hyaluronane ou d'un de ses derives et leur utilisation a titre de vecteurs biologiques pour des matieres actives
CN100393322C (zh) 2002-08-16 2008-06-11 电气化学工业株式会社 分离型医疗材料
US20040062882A1 (en) * 2002-09-30 2004-04-01 Andrea Liebmann-Vinson Cell adhesion resisting surfaces
ITPD20020271A1 (it) * 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
WO2004046200A1 (ja) 2002-11-21 2004-06-03 Chugai Seiyaku Kabushiki Kaisha 薬物徐放担体
PL377477A1 (pl) * 2002-12-11 2006-02-06 Ferrosan A/S Materiały na bazie żelatyny jako waciki
WO2004060404A1 (ja) * 2002-12-27 2004-07-22 Chugai Seiyaku Kabushiki Kaisha 薬物担体
US20040185022A1 (en) * 2003-02-19 2004-09-23 Steven Rubin Regimen for acne treatment
US7238677B2 (en) * 2003-03-28 2007-07-03 Kimberly-Clark Worldwide, Inc. Prevention of urogenital infections
BR0318237A (pt) * 2003-04-04 2006-04-04 Bayco Tech Ltd sonda vascular
US6821331B2 (en) * 2003-04-09 2004-11-23 Wisconsin Alumni Research Foundation Protein-polysaccharide hybrid hydrogels
CN1812800B (zh) * 2003-04-25 2013-01-16 匹兹堡大学 用于促进和增强神经修复和再生的肌肉来源的细胞(mdc)
JP2007500027A (ja) * 2003-07-30 2007-01-11 アンタイス エス.エイ. 生物医学的な使用のための複合マトリックス
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
GB2404920A (en) * 2003-08-12 2005-02-16 Johnson & Johnson Medical Ltd Antimicrobial polymer
US7074615B2 (en) * 2003-08-15 2006-07-11 Becton, Dickinson And Company Peptides for enhanced cell attachment and cell growth
US7157275B2 (en) * 2003-08-15 2007-01-02 Becton, Dickinson And Company Peptides for enhanced cell attachment and growth
US7198855B2 (en) * 2003-09-12 2007-04-03 Becton, Dickinson And Company Methods of surface modification of a flexible substrate to enhance cell adhesion
CN1878565B (zh) * 2003-09-12 2011-01-12 惠氏公司 用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂
CA2538793C (en) * 2003-09-19 2011-01-11 Colorado State University Research Foundation (Csurf) Hyaluronan (ha) esterification via acylation technique for moldable devices
US20050095219A1 (en) * 2003-10-29 2005-05-05 Shu-Ping Yang Compositions for promoting vaginal cell proliferation and maturation
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US8313765B2 (en) * 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
US7625581B2 (en) * 2003-12-19 2009-12-01 Ethicon, Inc. Tissue scaffolds for use in muscoloskeletal repairs
US7091191B2 (en) * 2003-12-19 2006-08-15 Ethicon, Inc. Modified hyaluronic acid for use in musculoskeletal tissue repair
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
EP2497785B1 (de) * 2004-01-07 2018-09-12 Seikagaku Corporation Hyaluronsäurederivat und dieses enthaltendes Arzneimittel
WO2005072700A2 (en) * 2004-01-30 2005-08-11 Ferrosan A/S Haemostatic sprays and compositions
WO2005077304A1 (en) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Load bearing biocompatible device
WO2005077013A2 (en) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Surface directed cellular attachment
US7354980B1 (en) 2004-03-12 2008-04-08 Key Medical Technologies, Inc. High refractive index polymers for ophthalmic applications
US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
GB0411166D0 (en) * 2004-05-19 2004-06-23 Bionovate Ltd Treatment for asthma and arthritis
GB0411165D0 (en) * 2004-05-19 2004-06-23 Bionovate Ltd Hyaluronic acid containing pharmaceutical or veterinary compounds
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
EP1896053B1 (de) 2004-07-06 2018-10-31 ZymoGenetics, Inc. Pharmazeutische zusammensetzung enthaltend fgf-18 und einen il-1 antagonisten sowie verfahren zur verwendung derselben
AU2005262070B2 (en) * 2004-07-09 2011-01-27 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
AR050212A1 (es) * 2004-08-13 2006-10-04 Aderans Res Inst Inc Organogenesis a partir de celulas disociadas
US7858107B2 (en) * 2004-09-10 2010-12-28 Medtronic Xomed, Inc. Flexible bioresorbable hemostatic packing and stent having a preselectable in-vivo residence time
US7446157B2 (en) 2004-12-07 2008-11-04 Key Medical Technologies, Inc. Nanohybrid polymers for ophthalmic applications
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
ITMI20050262A1 (it) * 2005-02-21 2006-08-22 Carlo Ghisalberti Sostanze composizioni e metodi di trattamento dell'alopecia
ITPD20050056A1 (it) 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
GB0513552D0 (en) 2005-07-01 2005-08-10 Bristol Myers Squibb Co Bandage
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
ITPD20050207A1 (it) 2005-07-07 2007-01-08 Fidia Farmaceutici Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere
JP5465431B2 (ja) 2005-07-27 2014-04-09 アルケミア オンコロジー ピーティーワイ リミテッド ヒアルロナンを用いる治療プロトコル
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
US7323184B2 (en) * 2005-08-22 2008-01-29 Healagenics, Inc. Compositions and methods for the treatment of wounds and the reduction of scar formation
US8623354B2 (en) 2005-09-07 2014-01-07 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
WO2007038252A2 (en) * 2005-09-22 2007-04-05 Key Douglas J Methods and compositions for treating skin lines and wrinkles and improving skin quality
CN103120701B (zh) * 2005-10-12 2014-11-05 生化学工业株式会社 包含疏水基团结合型糖胺聚糖在制备预防或治疗角膜上皮层病症的药物中的用途
KR101430760B1 (ko) 2005-10-18 2014-08-19 알러간, 인코포레이티드 후안부 조직으로 선택적으로 침투하는 글루코코르티코이드유도체를 사용한 안과 요법
US20090082321A1 (en) * 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US20070148138A1 (en) * 2005-11-22 2007-06-28 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
TW200803877A (en) * 2005-11-22 2008-01-16 Aderans Res Inst Inc Hair grafts derived from plucked hair
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7993675B2 (en) * 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US20090075935A1 (en) * 2006-07-03 2009-03-19 L'oreal Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
AU2007295894B2 (en) * 2006-09-13 2013-10-17 Enhance Skin Products, Inc. Cosmetic composition for the treatment of skin and methods thereof
AU2007325698B2 (en) * 2006-11-28 2014-03-20 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
WO2008070118A1 (en) * 2006-12-05 2008-06-12 Landec Corporation Drug delivery
US20100158875A1 (en) 2006-12-18 2010-06-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
AU2007334331B2 (en) * 2006-12-18 2014-05-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
JP5425641B2 (ja) 2007-01-11 2014-02-26 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 尿路病状の処置のための筋由来細胞ならびにその作製および使用の方法
TW200838552A (en) * 2007-01-25 2008-10-01 Novozymes Biopolymer As Methyl esters of hyaluronic acid
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
JP5241708B2 (ja) * 2007-04-24 2013-07-17 キユーピー株式会社 カチオン化ヒアルロン酸および/またはその塩、およびその製造方法、ならびにこれを用いた毛髪改質剤、キューティクル修復剤、皮膚改質剤および化粧料
US9579341B2 (en) 2007-05-16 2017-02-28 Johnson & Johnson Consumer Inc. Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
US8609634B2 (en) 2007-05-16 2013-12-17 Mcneil-Ppc, Inc. Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
CA2722758C (en) * 2007-05-29 2017-04-25 Thomas Payne Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof
US7985537B2 (en) * 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
WO2009019840A1 (ja) * 2007-08-09 2009-02-12 Kibun Food Chemifa Co., Ltd. ヒアルロン酸プロピレングリコールエステルおよびそれを用いた皮膚外用剤
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
KR20100094982A (ko) * 2007-11-13 2010-08-27 바이오-테크널러지 제너럴 (이스라엘) 리미티드 점탄성 바이오폴리머의 희석식 여과 멸균 방법
AU2009207796B2 (en) 2008-01-25 2014-03-27 Grunenthal Gmbh Pharmaceutical dosage form
JP5569398B2 (ja) 2008-02-29 2014-08-13 フェッローサン メディカル ディバイス エー/エス 止血および/または創傷治癒を促進するための装置
KR101594552B1 (ko) 2008-04-04 2016-02-17 유니버시티 오브 유타 리서치 파운데이션 알킬화된 반합성 글리코사미노글리코산 에테르 및 이의 제조 및 사용 방법
ES2599031T3 (es) 2008-05-09 2017-01-31 Grünenthal GmbH Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización
CA2727432C (en) 2008-06-12 2016-10-11 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
WO2010022083A2 (en) * 2008-08-18 2010-02-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof
AU2009288118B2 (en) 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
EP2346324A4 (de) 2008-10-06 2012-10-10 Microbial Defense Systems Llc Antimikrobielle zusammensetzung sowie verfahren zu ihrer herstellung und verwendung
JP5542687B2 (ja) 2008-11-05 2014-07-09 国立大学法人 東京医科歯科大学 ヒアルロン酸誘導体、およびその医薬組成物
US20100233138A1 (en) * 2008-11-07 2010-09-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof
JP2010163485A (ja) * 2009-01-13 2010-07-29 Teijin Ltd カルボキシ多糖類の溶液
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
IT1394570B1 (it) 2009-07-02 2012-07-05 Fidia Farmaceutici Materiale biologico adatto per la terapia dell osteoartrosi del danno dei legamenti e per il trattamento delle patologie delle articolazioni.
NZ596667A (en) 2009-07-22 2013-09-27 Gruenenthal Chemie Hot-melt extruded controlled release dosage form
PT2456424E (pt) 2009-07-22 2013-09-30 Gruenenthal Gmbh Forma de dosagem resistente à adulteração e estabilizada contra a oxidação
US8273725B2 (en) * 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
CZ2009835A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
WO2011102462A1 (ja) * 2010-02-19 2011-08-25 キユーピー株式会社 修飾ヒアルロン酸および/またはその塩、ならびにその製造方法およびこれを含む化粧料
ES2809999T3 (es) * 2010-03-25 2021-03-08 Lifecell Corp Preparación de supercóntigos de tejido regenerativo
WO2011148116A2 (fr) 2010-05-27 2011-12-01 Laboratoire Idenov Acide hyaluronique modifie, procede de fabrication et utilisations
EP2598536A1 (de) * 2010-07-29 2013-06-05 Université de Genève Verfahren zur veresterung von hyaluronsäure mit wasserabweisenden organischen verbindungen
MX2013002377A (es) 2010-09-02 2013-04-29 Gruenenthal Gmbh Forma de dosificacion resistente a manipulacion que comprende una sal inorganica.
CA2808541C (en) 2010-09-02 2019-01-08 Gruenenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
CZ20101001A3 (cs) 2010-12-31 2012-02-08 Cpn S.R.O. Hyaluronová vlákna, zpusob jejich prípravy a použití
CZ303548B6 (cs) 2011-01-05 2012-11-28 Contipro Pharma A.S. Zdravotní prípravek tvorící jód, zpusob jeho prípravy a bandáž, která jej obsahuje
EP2688402B1 (de) 2011-03-23 2018-10-24 University of Utah Research Foundation Mittel zur behandlung bzw. prävention von harnwegsentzündungen
EP3456200B1 (de) 2011-05-10 2023-05-03 Next Science IP Holdings Pty Ltd Artikel mit einem antimikrobiellen feststoff und dessen verwendung
CA3048443C (en) 2011-05-26 2021-01-05 Cartiva, Inc. Tapered joint implant and related tools
MX348054B (es) 2011-07-29 2017-05-25 Gruenenthal Gmbh Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco.
AR087360A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
CN103298838B (zh) * 2011-12-29 2015-08-19 财团法人工业技术研究院 pH敏感的透明质酸衍生物和其应用
AU2013225106B2 (en) 2012-02-28 2017-11-02 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
CZ303879B6 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
EP2822474B1 (de) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Druckbehälter mit einer blutstillenden paste
RS57913B1 (sr) 2012-04-18 2019-01-31 Gruenenthal Gmbh Farmaceutske dozne forme otporne na neovlašćenu upotrebu i naglo oslobađanje celokupne doze
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
ITPD20120173A1 (it) 2012-05-31 2013-12-01 Fidia Farmaceutici "nuovo sistema di rilascio di proteine idrofobiche"
AU2013275758B2 (en) 2012-06-12 2015-03-12 Ferrosan Medical Devices A/S Dry haemostatic composition
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CN104703583A (zh) 2012-10-09 2015-06-10 希格马托制药工业公司 经修饰的透明质酸衍生物及其用途
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZ2012841A3 (cs) 2012-11-27 2014-02-19 Contipro Biotech S.R.O. Vlákna založená na hydrofobizovaném hyaluronanu, způsob jejich přípravy a použití, textilie na jejich bázi a použití
ITPD20120360A1 (it) 2012-11-30 2014-05-31 Fidia Farmaceutici "nuovi geli viscoelastici in chirurgia oftalmica"
TWI484983B (zh) * 2012-12-06 2015-05-21 Univ Nat Taiwan 應用於呼吸上皮細胞之敷料
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 1個または複数の粒子を含有する改変防止(tamper−resistant)剤形
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US20160158369A1 (en) * 2013-07-10 2016-06-09 Seikagaku Corporation Pharmaceutical composition for respiratory administration
JP6449871B2 (ja) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エチレン−酢酸ビニルポリマーを含有する改変防止剤形
US20160220685A1 (en) 2013-10-02 2016-08-04 Ao Technology Ag Thermosensitive hyaluronic acid conjugates and methods for the preparation thereof
BR112016010482B1 (pt) 2013-11-26 2022-11-16 Grünenthal GmbH Preparação de uma composição farmacêutica em pó por meio de criomoagem
ITMI20131971A1 (it) 2013-11-26 2015-05-27 Fidia Farmaceutici Composizioni farmaceutiche ad attività idratante e lubrificante
JP6489485B2 (ja) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ/エス 押し出し増強因子を含んでいる乾燥組成物
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
JP2017516789A (ja) 2014-05-26 2017-06-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エタノール過量放出に対して防護されている多粒子
ES2897733T3 (es) 2014-06-15 2022-03-02 Yeda Res & Dev Tratamiento de superficies de lentes de contacto y tratamiento de molestias oculares mediante polímeros solubles en agua y lípidos/liposomas
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CA2959414C (en) 2014-09-05 2023-03-14 Symbiomix Therapeutics, Llc Secnidazole for use in the treatment of bacterial vaginosis
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CA2981064C (en) 2015-03-31 2024-01-02 Cartiva, Inc. Carpometacarpal (cmc) implants and methods
EP3753531A1 (de) 2015-03-31 2020-12-23 Cartiva, Inc. Hydrogelimplantate mit porösen materialien
MA41912A (fr) * 2015-04-07 2018-02-13 Hyalblue S R L Esters de glycosaminoglycane, procédés pour leur préparation et leur utilisation dans des formulations à usage ophtalmique
WO2016168363A1 (en) 2015-04-14 2016-10-20 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
EA035434B1 (ru) 2015-04-24 2020-06-15 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
WO2017010518A1 (ja) * 2015-07-13 2017-01-19 コスメディ製薬株式会社 薬物徐放性担体及びその製造方法
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
AU2016355653B2 (en) 2015-11-18 2021-04-01 Lifecell Corporation Hydrogel coated mesh
NZ747413A (en) 2016-04-27 2020-09-25 Anika Therapeutics Inc Compositions for use in treating tendon degeneration
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
AU2017311636B2 (en) 2016-08-19 2023-08-10 Orasis Pharmaceuticals Ltd. Ophthalmic pharmaceutical compositions and uses relating thereto
US11337994B2 (en) 2016-09-15 2022-05-24 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
CZ2016826A3 (cs) 2016-12-22 2018-07-04 Contipro A.S. Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití
CZ2016827A3 (cs) * 2016-12-23 2018-02-07 Contipro A.S. Oftalmologický prostředek
US11129862B2 (en) 2017-08-30 2021-09-28 Johnson & Johnson Consumer Inc. Ophthalmic compositions
JP6279801B1 (ja) * 2017-09-19 2018-02-14 株式会社らいむ 組成物およびその製造方法
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
IT201700122135A1 (it) * 2017-10-26 2019-04-26 Jointherapeutics S R L Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori
WO2020144372A1 (en) 2019-01-10 2020-07-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
CN112055564A (zh) 2018-01-10 2020-12-08 都柏林圣三一学院教务长研究员学者及董事会其他成员 用于封闭组织中的通道的系统和方法
PL3681500T3 (pl) 2018-04-24 2022-08-01 Allergan, Inc. Zastosowanie chlorowodorku pilokarpiny w leczeniu starczowzroczności
IT201900006250A1 (it) 2019-04-23 2020-10-23 Fidia Farm Spa Medicazione per il trattamento della cute lesa
AU2019266529A1 (en) 2018-05-09 2020-12-03 Ethicon Inc. Method for preparing a haemostatic composition
WO2020016820A1 (en) 2018-07-18 2020-01-23 Bio-Technology General (Israel) Ltd. Process of, and arrangement for, sterile filtering a non-newtonian liquid and formulation of a liquid obtainable thereby
EP3976123A1 (de) 2019-05-31 2022-04-06 University College Dublin Hyaluronsäurebasiertes hybridhydrogel
US20230133656A1 (en) * 2019-07-03 2023-05-04 Molly Sandra Shoichet Hydrogel compositions and uses thereof
IT201900019762A1 (it) 2019-10-24 2021-04-24 Fidia Farm Spa Composizione farmaceutica per uso nel trattamento della cistite di varia eziologia
CZ308980B6 (cs) * 2020-01-24 2021-11-03 Contipro A.S. Dentální přípravek z vláken na bázi kyseliny hyaluronové s regulovatelnou biodegradabilitou
EP4255517A1 (de) 2020-12-02 2023-10-11 Anika Therapeutics, Inc. Bioabsorbierbare textilien und verfahren zur wiederherstellung der gelenkfunktion
IT202000032243A1 (it) 2020-12-23 2022-06-23 Fidia Farm Spa Nuovi agenti antivirali
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo
WO2023169949A1 (en) 2022-03-10 2023-09-14 Cmed Aesthetics S.R.L. Process for the preparation of sterile products

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3402236A (en) * 1964-01-29 1968-09-17 Chemstrand Ltd Manufacture and treatment of synthetic fibres and fabrics containing the same
US3474163A (en) * 1967-11-22 1969-10-21 Celanese Corp Process of spinning filaments of vinylidene cyanide
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
JPS53105583A (en) * 1977-02-25 1978-09-13 Grelan Pharmaceut Co Ltd Polysaccharide sulfate derivative
DE2736065A1 (de) * 1977-08-10 1979-02-22 Bayer Ag Verfahren zur herstellung von hydrophilen faeden und fasern nach dem trocken-duesen-nasspinnverfahren
JPS5436388A (en) * 1977-08-26 1979-03-17 Sumitomo Electric Ind Ltd Porous polysaccharide and its preparation
JPS5629597A (en) * 1979-08-21 1981-03-24 Seikagaku Kogyo Co Ltd Alkyl glycoside of constituent unit disaccharide of acid mucopolysaccharide and oligosaccharide consisting of said disaccharide, and preparation thereof
US4352770A (en) * 1980-04-30 1982-10-05 International Telephone And Telegraph Corporation Process for forming shaped cellulosic product
FR2482603A1 (fr) * 1980-05-14 1981-11-20 Pharmindustrie Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation
US4328803B1 (en) * 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
FR2519987A1 (fr) * 1982-01-15 1983-07-22 Choay Sa Trisaccharides a structures d-glucosamine, acide d-glucuronique, d-glucosamine et leur preparation
US4593091A (en) * 1981-08-04 1986-06-03 Fidia, S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
JPS5837001A (ja) * 1981-08-27 1983-03-04 Green Cross Corp:The ヒアルロン酸の製造法
SE8200751L (sv) * 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
JPS58135551U (ja) * 1982-03-09 1983-09-12 株式会社クボタ トラクタの駆動構造
US4551296A (en) * 1982-03-19 1985-11-05 Allied Corporation Producing high tenacity, high modulus crystalline article such as fiber or film
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4440711A (en) * 1982-09-30 1984-04-03 Allied Corporation Method of preparing high strength and modulus polyvinyl alcohol fibers
JPS59110612A (ja) * 1982-12-15 1984-06-26 Pola Chem Ind Inc 毛髪処理剤
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
JPS59219209A (ja) * 1983-05-28 1984-12-10 Kanebo Ltd 皮膚化粧料
JPS6028401A (ja) * 1983-07-27 1985-02-13 Advance Res & Dev Co Ltd トリグリセリド低下活性多糖類
IE57931B1 (en) * 1983-10-11 1993-05-19 Fidia Spa Hyaluronic acid fractions having pharmaceutical activity,methods for preparation thereof,and pharmaceutical compositions containing the same
JPS60116618A (ja) * 1983-11-30 1985-06-24 Shiseido Co Ltd 化粧料
JPS60130601A (ja) * 1983-12-15 1985-07-12 バイオマトリツクス,インコ−ポレイテツド ヒアルロン酸水不溶性組成物の製法
CA1238043A (en) * 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
US4716224A (en) * 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4636524A (en) * 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
EP0221167A4 (de) * 1985-05-09 1988-08-24 David Cullis-Hill Herstellung von hyaluronsäure.
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8519416D0 (en) * 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
DE3684887D1 (de) * 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
US4696677A (en) * 1986-04-11 1987-09-29 Merck & Co., Inc. Quaternary ammonium salts of anionic gums
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico

Also Published As

Publication number Publication date
DK323686D0 (da) 1986-07-07
EP0216453A2 (de) 1987-04-01
EP0216453B1 (de) 1996-03-20
FI892710A0 (fi) 1989-06-02
NO910295D0 (no) 1991-01-25
DE3650776T2 (de) 2004-03-11
NO910295L (no) 1987-01-09
CA1341603C (en) 2010-04-20
AU5983686A (en) 1987-02-26
EP0216453A3 (en) 1988-10-26
IN165582B (de) 1989-11-25
NO305369B1 (no) 1999-05-18
CA1341276C (en) 2001-07-31
US4851521A (en) 1989-07-25
FI862878A (fi) 1987-01-09
IE861813L (en) 1987-01-08
FI94767B (fi) 1995-07-14
FI94766B (fi) 1995-07-14
HU201966B (en) 1991-01-28
AU591501B2 (en) 1989-12-07
PT82941A (en) 1986-08-01
NO862734D0 (no) 1986-07-07
FI94766C (fi) 1995-10-25
IL79362A (en) 1995-07-31
KR870001901B1 (ko) 1987-10-21
DE3650501T2 (de) 1996-11-21
NO175716C (no) 1994-11-23
EP0696598B1 (de) 2002-11-13
FI892711A0 (fi) 1989-06-02
FI912619A0 (fi) 1991-05-31
NO175716B (no) 1994-08-15
ATE227741T1 (de) 2002-11-15
FI901341A0 (fi) 1990-03-16
US4965353A (en) 1990-10-23
NZ233045A (en) 1992-05-26
IE81120B1 (en) 2000-03-22
FI912618A0 (fi) 1991-05-31
FI892711A (fi) 1989-06-02
FI862878A0 (fi) 1986-07-08
US5336767A (en) 1994-08-09
SG90006A1 (en) 2002-07-23
ATE135713T1 (de) 1996-04-15
NZ216786A (en) 1992-05-26
PH25189A (en) 1991-03-27
IL79362A0 (en) 1986-10-31
DK323686A (da) 1987-01-09
FI94778B (fi) 1995-07-14
EP0696598A1 (de) 1996-02-14
FI94767C (fi) 1995-10-25
AR242593A1 (es) 1993-04-30
FI94778C (fi) 1995-10-25
KR870001230A (ko) 1987-03-12
JP2569012B2 (ja) 1997-01-08
HUT42512A (en) 1987-07-28
ES2001512A6 (es) 1988-06-01
PT82941B (pt) 1988-05-27
NO862734L (no) 1987-01-09
JPS6264802A (ja) 1987-03-23
DE3650776D1 (de) 2002-12-19
DK175661B1 (da) 2005-01-10
FI892710A (fi) 1989-06-02

Similar Documents

Publication Publication Date Title
ATE135713T1 (de) Hyaluronsäureester und ihre salze.
DK536087A (da) Tvaerbundne hyaluronsyreestere
DE3669882D1 (de) 2-zyanakrylsaeureester enthaltende zusammensetzung.
DE3684410D1 (de) Heterocyclische oxophthalazinylessigsaeure.
FI862722A (fi) Anordning foer sammanfogning ena aendan av en matningskanyl foer sammanfogning av en injektionsspruta i en medikament innehaollande ampull.
NO893385D0 (no) Karbaminsyre-ester.
FI863077A (fi) Farmaceutisk dosenhet.
DE3778132D1 (de) 2-beta-substituierte methylpenicillansaeure-derivate und deren salze und ester.
DE3581547D1 (de) Piperazine-derivate und ihre saeure-additionsalze.
NO860870L (no) Kinolonkarboksylsyrederivater.
DE3576341D1 (de) Deuteroporphyrinderivate und ihre salze.
NO883960L (no) Arylcyklobutenylamidoalkensyrer og salter derav.
NL8601011A (nl) 7-amino-3-propenylcefalosporanzuur en esters daarvan.
DK138486D0 (da) Androstan-17beta-karboxylsyreestere
DE3873167T2 (de) Thiazolidin-4-on-derivate und deren saeure-additionssalze.
OA08349A (fr) Acides propenylaminothiazolylcephalosporaniques 3-substitués et leurs esters.
DE3689702D1 (de) Dihydrolysergsäureester.
TR24983A (tr) Venilsiklopropan karboksilik asit esterleri
IT8619594A1 (it) Acid 8-osso-2-ossa-l-azabiciclo 4.2.0 ottano-3-carbossilici
DE3768557D1 (de) Trans-hexahydroterephthalsaeureesterderivate.
DE3676594D1 (de) Cyclohexanalkansaeuren.
DE191912T1 (de) 2-adamantanonoxim-karbaminsaeureesterderivate.
DK694987D0 (da) 1-cyclyl- eller polycyclylsubstituerede 1h-imidazol-5-carboxylsyrer
DE58905261T2 (de) Thermochromsäure-ester.
ATE102622T1 (de) Dihydrolysergsaeureester.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: HARTMANN, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 81679 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: FIDIA FARMACEUTICI S.P.A., ABANO TERME, PADUA/PADO