DE3650662D1 - Verfahren zur Isolierung von kleinen Inseln - Google Patents

Verfahren zur Isolierung von kleinen Inseln

Info

Publication number
DE3650662D1
DE3650662D1 DE3650662T DE3650662T DE3650662D1 DE 3650662 D1 DE3650662 D1 DE 3650662D1 DE 3650662 T DE3650662 T DE 3650662T DE 3650662 T DE3650662 T DE 3650662T DE 3650662 D1 DE3650662 D1 DE 3650662D1
Authority
DE
Germany
Prior art keywords
isolation process
small island
island isolation
small
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3650662T
Other languages
English (en)
Inventor
David W Scharp
Paul E Lacy
Edward H Finke
Thomas J Poteat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
McDonnell Douglas Corp
Washington University in St Louis WUSTL
Original Assignee
University of Washington
McDonnell Douglas Corp
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, McDonnell Douglas Corp, Washington University in St Louis WUSTL filed Critical University of Washington
Application granted granted Critical
Publication of DE3650662D1 publication Critical patent/DE3650662D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
DE3650662T 1985-02-07 1986-02-07 Verfahren zur Isolierung von kleinen Inseln Expired - Lifetime DE3650662D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69934385A 1985-02-07 1985-02-07
US06/773,459 US4868121A (en) 1985-02-07 1985-09-09 Islet isolation process

Publications (1)

Publication Number Publication Date
DE3650662D1 true DE3650662D1 (de) 1998-02-05

Family

ID=27106396

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198686300858T Pending DE191613T1 (de) 1985-02-07 1986-02-07 Verfahren zur isolierung von kleinen inseln.
DE3650662T Expired - Lifetime DE3650662D1 (de) 1985-02-07 1986-02-07 Verfahren zur Isolierung von kleinen Inseln

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198686300858T Pending DE191613T1 (de) 1985-02-07 1986-02-07 Verfahren zur isolierung von kleinen inseln.

Country Status (3)

Country Link
US (2) US4868121A (de)
EP (1) EP0191613B1 (de)
DE (2) DE191613T1 (de)

Families Citing this family (69)

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US4868121A (en) * 1985-02-07 1989-09-19 Mcdonnell Douglas Corporation Islet isolation process
GB8604497D0 (en) * 1986-02-24 1986-04-03 Connaught Lab Separation of islets of langerhans
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US5759830A (en) * 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
EP0287896A1 (de) * 1987-04-21 1988-10-26 Walter Huber Verfahren und Einrichtung zur Gewinnung endokriner Inseln aus einem Spenderorgan sowie Verwendung der Inseln zur Behandlung von Stoffwechselkrankheiten
US5079160A (en) * 1987-06-08 1992-01-07 Lacy Paul E Method to isolate clusters of cell subtypes from organs
US5739033A (en) * 1989-09-20 1998-04-14 Vivorx, Inc. Physiological cell separation and method of separating cells using same
AU666118B2 (en) * 1991-04-25 1996-02-01 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
AU2900792A (en) * 1991-10-24 1993-05-21 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5334315A (en) * 1992-01-17 1994-08-02 Pall Corporation Priming system
US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5830492A (en) * 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5824331A (en) * 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5273904A (en) * 1992-03-18 1993-12-28 Cobe Laboratories, Inc. Apparatus for purifying islets of Langerhans
AU4788993A (en) * 1992-07-29 1994-03-03 Washington University Use of pouch for implantation of living cells
DE4227066A1 (de) * 1992-08-16 1994-02-17 Bernhard Josef Dr Med Hering Langerhans'sche Inseln in reiner Form
FR2696754B1 (fr) * 1992-10-14 1994-11-18 Hospal Ind Méthode d'isolement de cellules à partir d'un organe et dispositif pour sa mise en Óoeuvre.
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5908623A (en) * 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
DE69430824T2 (de) * 1993-08-12 2003-01-23 Neurotech Sa Biokompatible immunoisolatorische Kapseln, die genetisch veränderte Zellen enthalten
US5550050A (en) 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
EP0766733A4 (de) * 1994-06-24 1998-06-10 Boehringer Mannheim Corp Gereinigte mischung aus kollagenase und zwei witeren proteasen aus clostridium histolyticum erhaltend
US5629194A (en) * 1994-10-21 1997-05-13 Diacrin, Inc. Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5679565A (en) * 1995-04-10 1997-10-21 The Regents Of The University Of California Method of preserving pancreatic islets
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5879939A (en) 1995-05-17 1999-03-09 Neocrin Company Isolation of cells from organ tissue using sonication
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5702444A (en) * 1995-09-11 1997-12-30 Struthers, Mehta And Maxwell Implantable artificial endocrine pancreas
US5670358A (en) * 1995-10-19 1997-09-23 Baxter International Inc. Method for inhibiting chymopapain and papain enzyme activity with polysaccharides of animal origin
WO1997014788A1 (en) * 1995-10-19 1997-04-24 Baxter International Inc. Method for inhibiting chymopapain and papain enzyme activity with zinc ions
US5989888A (en) * 1996-01-24 1999-11-23 Roche Diagnostics Corporation Purified mixture of collagenase I, collagenase II and two other proteases
US5837444A (en) * 1996-07-16 1998-11-17 Shah; Kumarpal A. Islet cell transplantation machine for diabetes cure
US5830741A (en) * 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
US5922339A (en) * 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
JP2000007593A (ja) * 1998-06-24 2000-01-11 Asahi Glass Co Ltd ペルフルオロ（ｎ−ペンタン）の製造方法
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
AU6378900A (en) * 1999-07-26 2001-02-13 Uab Research Foundation Protecting pancreatic beta-cells during islet isolation; assessing islet viability and candidate diabetes drugs after islet isolation
EP1289537B1 (de) 2000-05-31 2005-11-30 Encelle, Inc. Verfahren zur behandlung von chronischen geschwüren
US20020086431A1 (en) * 2000-08-21 2002-07-04 Markham Walter Bruce Sample preparation and slide plating apparatus and method
US7045349B2 (en) * 2001-01-23 2006-05-16 Benedict Daniel J Method of islet isolation using process control
US20040248077A1 (en) * 2002-11-27 2004-12-09 Horacio L. Rodriguez Rilo Cell separation apparatus
US20040161845A1 (en) * 2003-02-14 2004-08-19 Poo Ramon E. Heating apparatus
US20050164522A1 (en) * 2003-03-24 2005-07-28 Kunz Roderick R. Optical fluids, and systems and methods of making and using the same
WO2005035742A2 (en) 2003-10-08 2005-04-21 Vet-Stem Inc. Methods of preparing and using stem cell compositions and kits comprising the same
DE102004011400A1 (de) * 2004-03-05 2005-09-22 Cavis Microcaps Gmbh Technischer Prozess sowie Anlage zur Gewinnung und/oder Verkapselung von lebenden Zellen aus Organen
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
WO2006118564A2 (en) * 2004-04-29 2006-11-09 Washington State University Research Foundation MODIFIED CELLS EXPRESSING A PROTEIN THAT MODULATES ACTIVITY OF bHLH PROTEINS, AND USES THEREOF
DE102006026179A1 (de) * 2006-05-29 2007-12-06 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zur in vitro Präparation von lebenden Zellen und/oder Zellansammlungen aus einem Gewebe
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
WO2012112982A2 (en) 2011-02-18 2012-08-23 Massachusetts Institute Of Technology Hydrogel encapsulated cells and anti-inflammatory drugs
EP3636286A1 (de) 2011-05-18 2020-04-15 The Regents of The University of California Zusammensetzungen und verfahren zur behandlung von netzhauterkrankungen
CA2884852A1 (en) * 2011-09-28 2013-04-04 Islet Sciences, Inc. Ex vivo maturation of islet cells
US10172791B2 (en) 2013-03-14 2019-01-08 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
US9555007B2 (en) 2013-03-14 2017-01-31 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
CN112999429B (zh) 2014-08-01 2022-07-22 麻省理工学院 用于抗纤维化材料的修饰的藻酸盐以及应用
WO2016187225A1 (en) 2015-05-17 2016-11-24 Massachusetts Institute Of Technology Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
RU2018120104A (ru) 2015-11-01 2019-12-02 Массачусетс Инститьют Оф Текнолоджи Модифицированные альгинаты в качестве противофиброзных материалов и их применения
EP3167911A1 (de) 2015-11-10 2017-05-17 Oniris In si-hpmc-eingekapselte insulinerzeugende zellen zur behandlung von typ-1-diabetes
BR112018075841A2 (pt) 2016-06-13 2019-03-19 Massachusetts Institute Of Technology polímero biocompatível, hidrogel, dispositivo, biomaterial e método de preparação do hidrogel
SG11201906804UA (en) 2017-01-27 2019-08-27 Univ Cornell Zwitterionically modified polymers and hydrogels
TW201920654A (zh) 2017-06-05 2019-06-01 加州大學董事會 用來治療視網膜疾病的組合物及其製造與使用方法
AU2020223379A1 (en) 2019-02-15 2021-09-02 William Marsh Rice University Vascularizing devices and methods for implanted diagnostics and therapeutics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868121A (en) * 1985-02-07 1989-09-19 Mcdonnell Douglas Corporation Islet isolation process

Also Published As

Publication number Publication date
EP0191613A2 (de) 1986-08-20
EP0191613A3 (de) 1989-03-08
US4868121A (en) 1989-09-19
US5322790A (en) 1994-06-21
DE191613T1 (de) 1987-05-21
EP0191613B1 (de) 1997-12-29

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8332 No legal effect for de