DE3685958T2 - Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe. - Google Patents

Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe.

Info

Publication number
DE3685958T2
DE3685958T2 DE8686106725T DE3685958T DE3685958T2 DE 3685958 T2 DE3685958 T2 DE 3685958T2 DE 8686106725 T DE8686106725 T DE 8686106725T DE 3685958 T DE3685958 T DE 3685958T DE 3685958 T2 DE3685958 T2 DE 3685958T2
Authority
DE
Germany
Prior art keywords
active substances
delivering active
controlled polymers
ultrasonically controlled
ultrasonically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686106725T
Other languages
English (en)
Other versions
DE3685958D1 (de
Inventor
Robert S Langer
Joseph Kost
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE3685958D1 publication Critical patent/DE3685958D1/de
Application granted granted Critical
Publication of DE3685958T2 publication Critical patent/DE3685958T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
    • C08G67/04—Polyanhydrides
DE8686106725T 1984-07-23 1986-05-16 Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe. Expired - Lifetime DE3685958T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/633,366 US4657543A (en) 1984-07-23 1984-07-23 Ultrasonically modulated polymeric devices for delivering compositions
CA000507996A CA1291064C (en) 1984-07-23 1986-04-30 Ultrasonically modulated polymeric devices for delivering drug compositions
EP86106725A EP0245535B1 (de) 1984-07-23 1986-05-16 Durch Ultraschall gesteuerte polymere Vorrichtungen zur Wirkstoffabgabe

Publications (2)

Publication Number Publication Date
DE3685958D1 DE3685958D1 (de) 1992-08-13
DE3685958T2 true DE3685958T2 (de) 1993-01-14

Family

ID=39628920

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198686106725T Pending DE245535T1 (de) 1984-07-23 1986-05-16 Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe.
DE8686106725T Expired - Lifetime DE3685958T2 (de) 1984-07-23 1986-05-16 Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198686106725T Pending DE245535T1 (de) 1984-07-23 1986-05-16 Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe.

Country Status (4)

Country Link
US (1) US4657543A (de)
EP (1) EP0245535B1 (de)
CA (1) CA1291064C (de)
DE (2) DE245535T1 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857049A (en) * 1986-08-05 1989-08-15 Kortum, Inc. Method and apparatus for inducing immunological and resistant response in mammary glands
JPS63135179A (ja) * 1986-11-26 1988-06-07 立花　俊郎 薬物の経皮投与具
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US5122367A (en) * 1989-03-31 1992-06-16 Massachusetts Institute Of Technology Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
JPH0366384A (ja) * 1989-08-04 1991-03-22 Senjiyu Seiyaku Kk 生理活性物質放出制御システム
US5147291A (en) * 1990-06-11 1992-09-15 Cukier A David Sound transmission apparatus for uniformly administering chemical composition through the skin
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
CA2063529A1 (en) * 1991-03-22 1992-09-23 Katsuro Tachibana Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same
US5171215A (en) * 1991-08-22 1992-12-15 Flanagan Dennis F Endermic method and apparatus
WO1993015722A1 (en) * 1992-02-07 1993-08-19 Syntex (Usa) Inc. Controlled delivery of pharmaceuticals from preformed porous microparticles
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
DE69322286T2 (de) * 1992-11-30 1999-04-22 Pfizer Verabreichungsvorrichtungen mit gestützten flüssigen membranen
JP3459421B2 (ja) * 1992-12-23 2003-10-20 サイテック ソチエタ レスポンサビリタ リミテ 調節された開放医薬形の調製法及びそのようにして得られた医薬形
IT1274879B (it) * 1994-08-03 1997-07-25 Saitec Srl Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.
US5643246A (en) * 1995-02-24 1997-07-01 Gel Sciences, Inc. Electromagnetically triggered, responsive gel based drug delivery device
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US6017496A (en) * 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US5874214A (en) * 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5833647A (en) * 1995-10-10 1998-11-10 The Penn State Research Foundation Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery
US7789841B2 (en) 1997-02-06 2010-09-07 Exogen, Inc. Method and apparatus for connective tissue treatment
US5904659A (en) * 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
US6582392B1 (en) * 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
JP2002500201A (ja) 1998-01-05 2002-01-08 ユニバーシティ オブ ワシントン 膜破壊剤を使用する増強された輸送
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US8287483B2 (en) * 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US7066884B2 (en) * 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
ATE342102T1 (de) * 1998-05-06 2006-11-15 Exogen Inc Ultraschallbandagen
GB9814507D0 (en) * 1998-07-03 1998-09-02 Univ Southampton A method and apparatus for controlling pests
US7343710B2 (en) * 1998-07-03 2008-03-18 I.D.A Limited Method and apparatus for controlling pests
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6231528B1 (en) * 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6267776B1 (en) 1999-05-03 2001-07-31 O'connell Paul T. Vena cava filter and method for treating pulmonary embolism
AU770327B2 (en) 1999-05-21 2004-02-19 Exogen, Inc. Apparatus and method for ultrasonically and electromagnetically treating tissue
WO2000076406A1 (en) 1999-06-14 2000-12-21 Exogen, Inc. Method and kit for cavitation-induced tissue healing with low intensity ultrasound
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
US6969382B2 (en) 1999-07-26 2005-11-29 Zuli Holdings, Ltd. Method and apparatus for treating bodily tissues with medicinal substance
WO2001051092A2 (en) * 2000-01-07 2001-07-19 University Of Washington Enhanced transport of agents using membrane disruptive agents
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6748944B1 (en) 2000-05-03 2004-06-15 Dellavecchia Michael Anthony Ultrasonic dosage device and method
AU2001288383A1 (en) * 2000-08-24 2002-03-26 Encapsulation Systems, Inc. Ultrasonically enhanced substance delivery system and device
JP4126228B2 (ja) * 2000-10-25 2008-07-30 エクソジェン インコーポレイテッド 変換器取付用組立体
EP1345588A2 (de) * 2000-12-29 2003-09-24 Bausch & Lomb Incorporated Arzneistoffabgabesysteme mit verzögerter freisetzung
EP1347741B1 (de) 2001-01-03 2009-01-21 Bausch & Lomb Incorporated Wirkstoffabgabevorrichtungen mit verzögerter freisetzung mehrere stoffe enthaltend
US7429248B1 (en) 2001-08-09 2008-09-30 Exogen, Inc. Method and apparatus for controlling acoustic modes in tissue healing applications
US20050075599A1 (en) * 2001-08-24 2005-04-07 Redding Bruce K. Ultrasonically enhanced saline treatment for burn damaged skin
US6908448B2 (en) * 2001-08-24 2005-06-21 Dermisonics, Inc. Substance delivery device
ATE520362T1 (de) 2001-12-03 2011-09-15 Ekos Corp Katheter mit mehreren ultraschall-abstrahlenden teilen
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20040064051A1 (en) * 2002-09-30 2004-04-01 Talish Roger J. Ultrasound transducer coupling apparatus
US6921371B2 (en) * 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
NL1023720C2 (nl) * 2003-06-23 2004-12-28 Univ Eindhoven Tech Werkwijze voor het wijzigen van de transporteigenschappen van een materiaal, werkwijze voor het vrijmaken van een werkstof uit een implantaat, evenals implantaat met werkstof.
US7687239B2 (en) 2003-07-12 2010-03-30 Accelrs Technology Corporation Sensitive and rapid determination of antimicrobial susceptibility
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US20050137520A1 (en) * 2003-10-29 2005-06-23 Rule Peter R. Catheter with ultrasound-controllable porous membrane
US20050136095A1 (en) * 2003-12-22 2005-06-23 Brian Levy Drug delivery device with suture ring
US20050158365A1 (en) * 2003-12-22 2005-07-21 David Watson Drug delivery device with mechanical locking mechanism
US7341569B2 (en) * 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US7794490B2 (en) * 2004-06-22 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices with antimicrobial and biodegradable matrices
US7356368B2 (en) * 2004-07-21 2008-04-08 Boston Scientific Scimed, Inc. Light-activated anti-infective coatings and devices made thereof
EP2594259A1 (de) * 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Verfahren zur Herstellung von Abgabevorrichtungen und damit erhaltene Vorrichtungen
AU2005205820B2 (en) * 2004-09-04 2011-04-14 Smith & Nephew Plc Ultrasound device and method of use
US20150165243A1 (en) * 2004-09-24 2015-06-18 Guided Therapy Systems, Llc System and Method for Treating Cartilage and Injuries to Joints and Connective Tissue
US8224414B2 (en) * 2004-10-28 2012-07-17 Echo Therapeutics, Inc. System and method for analyte sampling and analysis with hydrogel
US20060134162A1 (en) * 2004-12-16 2006-06-22 Larson Christopher W Methods for fabricating a drug delivery device
US20060134176A1 (en) * 2004-12-22 2006-06-22 Bausch & Lomb Incorporated Pharmaceutical delivery system and method of use
JP2008534223A (ja) * 2005-04-04 2008-08-28 ビー ブラウン メディカル ソシエテ パル アクシオン サンプリフィエ 着脱可能なフィルタヘッド
US20060264809A1 (en) * 2005-04-12 2006-11-23 Hansmann Douglas R Ultrasound catheter with cavitation promoting surface
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US7718193B2 (en) * 2006-03-16 2010-05-18 University Of Washington Temperature- and pH-responsive polymer compositions
EP2015846A2 (de) 2006-04-24 2009-01-21 Ekos Corporation Ultraschalltherapiesystem
EP1902728A1 (de) * 2006-09-19 2008-03-26 Stichting Katholieke Universiteit, meer in het bijzonder het Universitair Medisch Centrum St Radboud Medizinische Vorrichtung enthaltend einer bioresorbierbaren Zusammensetzung
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US8812071B2 (en) * 2007-03-07 2014-08-19 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
SI2152358T1 (sl) 2007-04-27 2011-08-31 Echo Therapeutics Inc Naprava za prodiranje skozi koĺ˝o za analizno merjenje ali za transdermalni prenos zdravil
EP2494932B1 (de) 2007-06-22 2020-05-20 Ekos Corporation Vorrichtung zur Behandlung von intrakranialen Blutungen
WO2009079415A1 (en) * 2007-12-14 2009-06-25 Ekos Corporation Ultrasound pulse shaping
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
JP2012517430A (ja) * 2009-02-10 2012-08-02 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 外部からの合図によるオンデマンドで可逆的な薬物放出
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
CN102740830A (zh) * 2009-12-23 2012-10-17 普西维达公司 缓释递送装置
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
EP2732832A3 (de) 2012-11-14 2015-07-01 Universitair Medisch Centrum Groningen (UMCG) Arzneimittelabgabevorrichtung mit einem Wirkstoff und einem wärmeempfindlichen Polymermaterial
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474777A (en) * 1966-02-10 1969-10-28 Amp Inc Method of administering therapeutic agents
US3464413A (en) * 1967-05-26 1969-09-02 United Merchants & Mfg Medical bandages
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4182750A (en) * 1977-04-21 1980-01-08 Sullivan Thomas E Bloodcompatible functional polymers
US4249531A (en) * 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4468220A (en) * 1982-04-05 1984-08-28 Milliken Research Corporation Low flow constant rate pump

Also Published As

Publication number Publication date
DE3685958D1 (de) 1992-08-13
EP0245535B1 (de) 1992-07-08
CA1291064C (en) 1991-10-22
US4657543A (en) 1987-04-14
EP0245535A1 (de) 1987-11-19
DE245535T1 (de) 1989-03-30

Similar Documents

Publication Publication Date Title
DE3685958T2 (de) Durch ultraschall gesteuerte polymere vorrichtungen zur wirkstoffabgabe.
DE3586713D1 (de) Vorrichtung zur kontrollierten abgabe von arzneimittelwirkstoffen.
DE3587518T2 (de) Vorrichtung zur transdermalen Applikation von Medikamenten.
DE3580924D1 (de) Vorrichtung zur verzoegerten freigabe von wirksubstanzen.
AU558167B2 (en) Sec. injection of cat. in fccu
DE3685094D1 (de) Pharmazeutisches praeparat zur kontrollierten freisetzung von wirkstoffen.
DE3886980D1 (de) Vorrichtung mit Durchflusszelle.
DE3582242D1 (de) Vorrichtung zum elektronisch geregelten mischen von gasen.
IT8619307A0 (it) Siringa per iniezione.
DE3577039D1 (de) Fingerbetaetigtes infusionssystem zur medikamentoesen versorgung.
DE3851909T2 (de) Flüssigkeitseinspritzsystem.
DE3581089D1 (de) Vorrichtung zur portionierung von produkten.
DE3484416D1 (de) Intraalveolare vorrichtung zur verabreichung von wirkstoffen zum behandeln periodontaler krankheiten.
DE3884287T2 (de) Polymere Flüssigkristallzusammensetzung.
DE3679366D1 (de) Vorrichtung zur abgabe von fluechtigen stoffen.
ATA355084A (de) Verfahren zur herstellung von granulaten bzw. von presstabletten mit regulierter wirkstoffabgabe
DE68904816D1 (de) Spritze zur einmaligen injektion.
DE3676601D1 (de) Mittel zur injektion von aktiviertem vitamin-d3.
DE3481360D1 (de) Polymere materialien.
DE3861977D1 (de) Vorrichtung zur dosierbaren klebstoff-applikation.
DE3152182A1 (de) Polymere diffusionsmatrix zur verabreichung von medikamenten
DE69002034D1 (de) Vorrichtung mit gesteuerter wirkstoffabgabe.
DE3582985D1 (de) Vorrichtung zur spurnachlaufsteuerung.
DE3674623D1 (de) Tripeptide mit pharmazeutischer wirksamkeit und verfahren zu ihrer herstellung.
DE68912536D1 (de) Flüssiges Nahrungsmittel zur Proteinzuführung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition