DE3686221T2 - Emulsionen zur parenteralen und/oder oralen verabreichung schwer wasserloeslicher ionisierbarer hydrophober arzneistoffe. - Google Patents

Emulsionen zur parenteralen und/oder oralen verabreichung schwer wasserloeslicher ionisierbarer hydrophober arzneistoffe.

Info

Publication number
DE3686221T2
DE3686221T2 DE8686111470T DE3686221T DE3686221T2 DE 3686221 T2 DE3686221 T2 DE 3686221T2 DE 8686111470 T DE8686111470 T DE 8686111470T DE 3686221 T DE3686221 T DE 3686221T DE 3686221 T2 DE3686221 T2 DE 3686221T2
Authority
DE
Germany
Prior art keywords
parenteral
emulsions
oral administration
heavy water
medicinal substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686111470T
Other languages
English (en)
Other versions
DE3686221D1 (de
Inventor
Narendra Raghunathji Desai
Eugene Albert Carpentier
Madurai Ganesan
Edward Charles Shinal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE3686221D1 publication Critical patent/DE3686221D1/de
Publication of DE3686221T2 publication Critical patent/DE3686221T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
DE8686111470T 1985-09-16 1986-08-19 Emulsionen zur parenteralen und/oder oralen verabreichung schwer wasserloeslicher ionisierbarer hydrophober arzneistoffe. Expired - Fee Related DE3686221T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/776,306 US4784845A (en) 1985-09-16 1985-09-16 Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs

Publications (2)

Publication Number Publication Date
DE3686221D1 DE3686221D1 (de) 1992-09-03
DE3686221T2 true DE3686221T2 (de) 1993-02-25

Family

ID=25107019

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686111470T Expired - Fee Related DE3686221T2 (de) 1985-09-16 1986-08-19 Emulsionen zur parenteralen und/oder oralen verabreichung schwer wasserloeslicher ionisierbarer hydrophober arzneistoffe.

Country Status (18)

Country Link
US (1) US4784845A (de)
EP (1) EP0215313B1 (de)
JP (1) JPS6267018A (de)
KR (1) KR890004684B1 (de)
AR (1) AR242716A1 (de)
AT (1) ATE78683T1 (de)
AU (1) AU591705B2 (de)
CA (1) CA1272447A (de)
DE (1) DE3686221T2 (de)
DK (1) DK165730C (de)
ES (1) ES2002750A6 (de)
FI (1) FI863728A (de)
GR (1) GR862354B (de)
HU (1) HU199282B (de)
NO (1) NO863670L (de)
NZ (1) NZ217484A (de)
PH (1) PH23736A (de)
ZA (1) ZA867009B (de)

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AU622664B2 (en) * 1988-03-21 1992-04-16 Daratech Pty Ltd Teat dip
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US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
US5004593A (en) * 1989-04-17 1991-04-02 Mayo Foundation For Medical Education And Research Hexamethylmelamine formulation exhibiting reduced neurotoxicity
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GB8919172D0 (en) * 1989-08-23 1989-10-04 Univ Nottingham Useful composition
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EP0556392A4 (de) * 1990-11-06 1994-03-17 Nippon Shinyaku Co Ltd Verfahren zur produktion einer fettemulsion.
DE4124252A1 (de) * 1991-07-22 1993-01-28 Knoll Ag Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung
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YU87892A (sh) * 1991-10-01 1995-12-04 Eli Lilly And Company Lilly Corporate Center Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu
JPH06245700A (ja) * 1993-02-23 1994-09-06 Snow Brand Milk Prod Co Ltd 消化吸収性を低減した油脂組成物
AU6956494A (en) * 1993-06-04 1995-01-03 Warner-Lambert Company Non-alcoholic cold and sinus medication
WO1995020943A1 (en) * 1994-02-04 1995-08-10 Scotia Lipidteknik Ab Oil-in-water emulsions
EP0746318A1 (de) * 1994-02-25 1996-12-11 Takeda Chemical Industries, Ltd. Injizierbare emulsionen enthaltend fungizide triazolderivate
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
CA2185803C (en) * 1994-03-18 2006-07-11 Edward M. Rudnic Emulsified drug delivery systems
US5616330A (en) * 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
US5616342A (en) * 1995-04-11 1997-04-01 Pdt, Inc. Emulsioin suitable for administering a poorly water-soluble photosensitizing compound and use thereof
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
KR100277287B1 (ko) * 1995-09-25 2001-01-15 맨슨 하비 콜린 거대환 락톤 구충제 조성물
DE69725745D1 (de) 1996-06-05 2003-11-27 Ashmont Holdings Ltd Injizierbare zusammensetzungen
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6054421A (en) * 1997-09-23 2000-04-25 Scimed Life Systems, Inc. Medical emulsion lubricant
US6281175B1 (en) 1997-09-23 2001-08-28 Scimed Life Systems, Inc. Medical emulsion for lubrication and delivery of drugs
NZ503641A (en) * 1997-09-30 2002-09-27 Lilly Co Eli Sustained release formulation of olanzapine pamoate suitable for treating psychotic patients
US6036946A (en) * 1997-12-24 2000-03-14 Shaklee Corporation Methods for protecting skin from damaging effects of ultraviolet light
WO1999043301A1 (en) * 1998-02-24 1999-09-02 The Board Of Trustees Of The University Of Illinois Lipid emulsions in the treatment of systemic poisoning
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6146664A (en) * 1998-07-10 2000-11-14 Shaklee Corporation Stable topical ascorbic acid compositions
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
US6777450B1 (en) * 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
EP1461044A4 (de) * 2001-12-03 2007-06-13 Novacea Inc Pharmazeutische zusammensetzungen mit aktiven vitamin-d-verbindungen
WO2003057128A2 (en) * 2001-12-11 2003-07-17 Dor Biopharma, Inc. Lipid particles and suspensions and uses thereof
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040062779A1 (en) * 2002-09-26 2004-04-01 Jerry Whittemore Dermatologic composition using ultra-fine/micronized 1-ascorbic acid and other antioxidant ingredients in a stabilized anhydrous vehicle
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US20050186230A1 (en) * 2004-01-23 2005-08-25 Sd Pharmaceuticals, Inc. Elemene compositions containing liquid oil
PT1838716E (pt) 2005-01-05 2011-07-15 Lilly Co Eli Di-hidrato de pamoato de olanzapina
JP5096138B2 (ja) 2005-03-31 2012-12-12 サントリーホールディングス株式会社 リグナン類化合物含有水中油滴型エマルション及びそれを含有する組成物
CN101547687A (zh) * 2005-11-17 2009-09-30 生物药效率有限公司 生物相容的潜在乳化剂
ES2424167T3 (es) * 2006-10-04 2013-09-27 Suntory Holdings Limited Emulsión de aceite/agua/aceite que contiene un compuesto de lignano, y composición que contiene la anterior
EP2200613B1 (de) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazin-derivate und ihre verwendungen
AU2009271299B2 (en) * 2008-06-24 2014-09-11 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic formulations
CA2928568A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Combinatorial methods to improve the therapeutic benefit of bisantrene
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
EP3661487A4 (de) * 2017-09-12 2021-05-05 Academic Pharmaceuticals, Inc. Formulierung einer metolazonemulsion
US20210401775A1 (en) * 2018-11-02 2021-12-30 Amaterasu Lifesciences Llp A liquid injectable composition

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US3172816A (en) * 1963-01-28 1965-03-09 Smith Kline French Lab Method of increasing the oil solubility of compounds and products thereof
US3647624A (en) * 1969-07-24 1972-03-07 Wisconsin Alumni Res Found Treatment of blood with oleaginous substance
US4124720A (en) * 1970-11-09 1978-11-07 Wenmaekers Georges E J Therapeutic hydrodispersible emulsion
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
FR2313078A1 (fr) * 1975-02-07 1976-12-31 Anvar Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention
DE2526938C2 (de) * 1975-02-14 1982-04-22 F. Hoffmann-La Roche & Co. AG, 4002 Basel Vitaminpräparate
US3991206A (en) * 1976-01-15 1976-11-09 American Cyanamid Company Alleviation of eye inflammation by topical application of p-biphenylacetic acid
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
JPS5822085B2 (ja) * 1977-07-19 1983-05-06 株式会社ミドリ十字 静注用ガンマ・グロブリン製剤
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US4340054A (en) * 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
GB2105589B (en) * 1981-09-11 1985-10-23 Wellcome Found Injectable suspensions containing maleic acid or a salt thereof as a stabilising agent
JPS5859912A (ja) * 1981-10-06 1983-04-09 Green Cross Corp:The 鎮痛消炎物質脂肪乳剤
JPS59134710A (ja) * 1983-01-21 1984-08-02 Suntory Ltd 発酵養毛化粧料
US4563354A (en) * 1983-10-26 1986-01-07 Kabivitrum Ab Oil-in-water emulsion for parenteral administration
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US4816247A (en) * 1985-09-11 1989-03-28 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs

Also Published As

Publication number Publication date
HUT43947A (en) 1988-01-28
KR890004684B1 (ko) 1989-11-25
HU199282B (en) 1990-02-28
DK438286A (da) 1987-03-17
ZA867009B (en) 1987-07-29
GR862354B (en) 1987-01-19
NZ217484A (en) 1990-04-26
ES2002750A6 (es) 1988-10-01
US4784845A (en) 1988-11-15
FI863728A (fi) 1987-03-17
NO863670D0 (no) 1986-09-15
FI863728A0 (fi) 1986-09-15
CA1272447A (en) 1990-08-07
KR870002835A (ko) 1987-04-13
NO863670L (no) 1987-03-17
AU6269686A (en) 1987-03-19
EP0215313B1 (de) 1992-07-29
AR242716A1 (es) 1993-05-31
EP0215313A2 (de) 1987-03-25
PH23736A (en) 1989-11-03
DK165730C (da) 1993-06-07
ATE78683T1 (de) 1992-08-15
DE3686221D1 (de) 1992-09-03
EP0215313A3 (en) 1987-09-09
JPS6267018A (ja) 1987-03-26
DK438286D0 (da) 1986-09-12
DK165730B (da) 1993-01-11
AU591705B2 (en) 1989-12-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee