DE3687868D1 - Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt. - Google Patents

Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt.

Info

Publication number
DE3687868D1
DE3687868D1 DE8686306347T DE3687868T DE3687868D1 DE 3687868 D1 DE3687868 D1 DE 3687868D1 DE 8686306347 T DE8686306347 T DE 8686306347T DE 3687868 T DE3687868 T DE 3687868T DE 3687868 D1 DE3687868 D1 DE 3687868D1
Authority
DE
Germany
Prior art keywords
rigalkyl
solvent
amino acid
acid polymer
formula containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686306347T
Other languages
English (en)
Other versions
DE3687868T2 (de
Inventor
Rajan Bawa
William G Deichert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Lomb Inc
Original Assignee
Bausch and Lomb Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch and Lomb Inc filed Critical Bausch and Lomb Inc
Application granted granted Critical
Publication of DE3687868D1 publication Critical patent/DE3687868D1/de
Publication of DE3687868T2 publication Critical patent/DE3687868T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
DE8686306347T 1985-08-16 1986-08-15 Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt. Expired - Fee Related DE3687868T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/766,734 US4713244A (en) 1985-08-16 1985-08-16 Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent

Publications (2)

Publication Number Publication Date
DE3687868D1 true DE3687868D1 (de) 1993-04-08
DE3687868T2 DE3687868T2 (de) 1993-08-19

Family

ID=25077355

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686306347T Expired - Fee Related DE3687868T2 (de) 1985-08-16 1986-08-15 Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt.

Country Status (5)

Country Link
US (1) US4713244A (de)
EP (1) EP0212959B1 (de)
JP (1) JPS6296417A (de)
CA (1) CA1277235C (de)
DE (1) DE3687868T2 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
CS263203B1 (en) * 1986-07-22 1989-04-14 Sulc Jiri Soft intraocular lenses
US5032109A (en) * 1987-02-10 1991-07-16 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5110600A (en) * 1988-01-25 1992-05-05 The Regents Of The University Of California Method of treating viral infections with amino acid analogs
US5192316A (en) * 1988-02-16 1993-03-09 Allergan, Inc. Ocular device
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5760261A (en) * 1990-02-28 1998-06-02 Guttag; Alvin Higher fatty acid derivatives of salicylic acid and salts thereof
US5173302A (en) * 1990-09-28 1992-12-22 Medtronic, Inc. Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs
ES2149178T3 (es) * 1991-08-16 2000-11-01 Miles A Galin Implante ocular para la camara anterior refractivo, recubierto con un medicamento.
AU3469893A (en) * 1992-01-15 1993-08-03 Allergan, Inc. Hydrogel compositions and structures made from same
US5596007A (en) * 1992-05-18 1997-01-21 Pharmaco Behavioral Associates, Inc. Therapeutic method to alleviate the craving associated with cessation of tobacco with cotinine
US5643928A (en) * 1992-10-21 1997-07-01 Pharmaco Behavioral Associates, Inc. Human body weight management
US5612357A (en) * 1992-05-18 1997-03-18 Pharmaco Behavioral Associates, Inc. Use of cotinine to assist in the cessation of tobacco smoking
US5869505A (en) * 1993-02-02 1999-02-09 Keenan; Robert M. Nicotine metabolites and nicotine dependence
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
CA2144407C (en) * 1992-09-10 2000-05-30 Charles B. Berde Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US6162456A (en) * 1992-09-24 2000-12-19 Ortho-Mcneil Pharmaceutical, Inc. Adhesive transdermal drug delivery matrix of a physical blend of hydrophilic and hydrophobic polymers
US5989586A (en) * 1992-10-05 1999-11-23 Cygnus, Inc. Two-phase matrix for sustained release drug delivery device
US5573774A (en) * 1993-02-02 1996-11-12 Keenan; Robert M. Nicotine metabolites, nicotine dependence and human body weight
DE4313928C2 (de) * 1993-04-28 1996-09-19 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur kontrollierten Abgabe von Pilocarpin an die Haut, Verfahren zu seiner Herstellung und seine Verwendung
US5505952A (en) * 1994-04-19 1996-04-09 United States Surgical Corporation Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom
US5972326A (en) * 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
US5612027A (en) * 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
NZ311474A (en) * 1995-06-09 1997-09-22 Euro Celtique Sa Formulations for providing prolonged local anesthesia
AU6286796A (en) * 1995-07-12 1997-02-10 Corning Incorporated Novel photochromic organic materials
US5723131A (en) 1995-12-28 1998-03-03 Johnson & Johnson Vision Products, Inc. Contact lens containing a leachable absorbed material
JPH11511763A (ja) 1996-06-24 1999-10-12 ユーロ―セルティーク，エス．エイ． 安全な局所麻酔の提供方法
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US6476103B1 (en) * 1996-10-11 2002-11-05 Corning Incorporated Photochromic organic material, its manufacture and the photochromic articles containing it
AUPO379596A0 (en) * 1996-11-22 1996-12-19 Soltec Research Pty Ltd Percutaneous delivery system
EP1009390A4 (de) 1997-07-02 2004-05-06 Euro Celtique Sa Verlängerte narkose in gelenken und körperzwischenräumen
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6410045B1 (en) 1999-02-22 2002-06-25 Clyde Lewis Schultz Drug delivery system for antiglaucomatous medication
US20020197300A1 (en) * 1999-02-22 2002-12-26 Schultz Clyde L. Drug delivery system for anti-glaucomatous medication
TWI279401B (en) * 1999-08-31 2007-04-21 Incyte San Diego Inc Heterocyclic derivatives for the treatment of diabetes and other diseases
US6315987B1 (en) * 2000-05-10 2001-11-13 Isp Investments Inc. Polymeric delivery and release systems for oral care actives
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
US6348475B1 (en) 2000-06-01 2002-02-19 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
US20040151755A1 (en) * 2000-12-21 2004-08-05 Osman Rathore Antimicrobial lenses displaying extended efficacy, processes to prepare them and methods of their use
EA200300982A1 (ru) 2001-03-07 2004-12-30 Инсайт Сан Диего, Инк. Гетероциклические производные для лечения рака и других пролиферативных заболеваний
CA2473156A1 (en) * 2001-03-08 2002-09-19 Incyte San Diego, Inc. Rxr activating molecules
CA2340824A1 (en) * 2001-03-14 2002-09-14 Ibm Canada Limited-Ibm Canada Limitee Method and system for application behavior analysis
US20030083357A1 (en) * 2001-08-17 2003-05-01 Magnus Pfahl Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia
EP1446099B1 (de) * 2001-11-14 2009-07-15 Durect Corporation Injizierbare depotzusammensetzungen
KR20040058101A (ko) 2001-11-14 2004-07-03 알자 코포레이션 카테터 주입가능한 데포 조성물 및 그의 용도
AU2002352706A1 (en) 2001-11-15 2003-06-10 Maxia Pharmaceuticals, Inc. N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
WO2004011054A2 (en) 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
DE60226282T2 (de) 2002-07-31 2009-09-17 Alza Corp., Mountain View Injizierbare depotzusammensetzungen und deren verwendung
US7795203B2 (en) * 2002-09-30 2010-09-14 Babizhayev Mark A Method for topical treatment of eye disease and composition and device for said treatment
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004066952A2 (en) * 2003-01-29 2004-08-12 Incyte Corporation Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
KR20060036896A (ko) * 2003-04-18 2006-05-02 인사이트 산 디에고 인코포레이티드 대사 장애, 암 및 다른 질병의 치료를 위한 치환된이소크로만 화합물
WO2005007714A1 (ja) * 2003-07-18 2005-01-27 Japan Exlan Company Limited アミノ酸誘導体徐放性重合体、該重合体を含有する化粧料及び繊維構造物並びにそれらの製造法及び再生処理法
PT1682537E (pt) 2003-11-05 2012-06-20 Sarcode Bioscience Inc Moduladores de adesão celular
WO2006017275A1 (en) 2004-07-13 2006-02-16 The University Of Tennessee Research Foundation Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts
JP2008519847A (ja) * 2004-11-10 2008-06-12 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク 運動障害の治療方法
NZ554783A (en) * 2004-11-15 2010-12-24 Ceptyr Inc Protein tyrosine phosphatase inhibitors and methods of use thereof
US9804295B2 (en) † 2005-05-05 2017-10-31 Novartis Ag Ophthalmic devices for sustained delivery of active compounds
LT2444079T (lt) 2005-05-17 2017-03-27 Sarcode Bioscience Inc. Kompozicijos ir būdai, skirti akių sutrikimų gydymui
EP3081215B9 (de) 2005-05-23 2020-08-19 Natural Alternatives International, Inc. Zusammensetzungen und verfahren zur anhaltenden freisetzung von beta-alanin
DE102006052342B4 (de) * 2006-11-07 2015-08-20 Wöhlk-Contact-Linsen GmbH Kontaktlinsenmaterial
US8071119B2 (en) * 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US20090148498A1 (en) * 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
WO2008143906A2 (en) * 2007-05-14 2008-11-27 Sustained Nano Systems Llc Hypercompressed particles for controlled release of ophthalmic medications
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2010004281A (es) 2007-10-19 2010-09-10 Sarcode Corp Composiciones y metodos para el tratamiento de la retinopatia diabetica.
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
EP2276508A4 (de) * 2008-04-15 2011-12-28 Sarcode Bioscience Inc Freisetzung von lfa-1-antagonisten gegen das magen-darm-system
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9732324B2 (en) 2008-10-23 2017-08-15 Cornell University Anti-viral method
US10201548B2 (en) * 2009-03-06 2019-02-12 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
US10980818B2 (en) 2009-03-06 2021-04-20 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2719512A1 (en) 2010-11-01 2012-05-01 Stiefel Research Australia Pty Ltd Polymeric topical compositions
MX362218B (es) 2011-05-04 2019-01-09 Balance Therapeutics Inc Derivados de pentilentetrazol.
US20130004651A1 (en) * 2011-07-01 2013-01-03 Patty Fu-Giles Sustained drug release from body implants using nanoparticle-embedded polymeric coating materials
EP3715345B1 (de) 2012-07-25 2024-04-10 Novartis AG Herstellung eines lfa-1-hemmers
EP2912121B1 (de) 2012-10-29 2019-09-25 Ariste Medical, LLC Polymerbeschichtungszusammensetzungen und beschichtete gegenstände
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2926691A1 (en) 2013-10-10 2015-04-16 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
EP3079668A1 (de) 2013-12-09 2016-10-19 Durect Corporation Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit
AU2015249769A1 (en) 2014-04-22 2016-11-10 Ariste Medical, Llc. Methods and processes for application of drug delivery polymeric coatings
EP3291886A1 (de) 2015-05-04 2018-03-14 Ecole Polytechnique Federale de Lausanne (EPFL) Ophthalmische kontaktlinse mit komprimierbarer affinitätsmatrix
CN108884130B (zh) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 用于治疗溃疡性结肠炎的制剂和方法
PT109154B (pt) 2016-02-12 2019-11-05 Univ De Coimbra Tecnologia não-invasiva de inserto ocular para libertação controlada de fármacos
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
AT251910B (de) * 1964-07-02 1967-01-25 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von weichen, biegsamen Kontaktlinsen
DE1617393C2 (de) * 1966-01-06 1982-11-11 Československá akademie věd, Praha Verfahren zur Herstellung von biologisch aktive Stoffe enthaltenden hydrophilen vernetzten Copolymeren
US3557261A (en) * 1967-10-05 1971-01-19 Ceskoslovenska Akademie Ved Method of centrifugally casting layered contact lenses
US3822089A (en) * 1968-09-25 1974-07-02 Akademie Ved Contact lens blank or replica made from anhydrous, sparingly cross-linked hydrophilic copolymers
US3618604A (en) * 1969-06-09 1971-11-09 Alza Corp Ocular insert
CS159361B1 (de) * 1970-09-08 1975-01-31
US3857932A (en) * 1970-09-09 1974-12-31 F Gould Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants
US3641237A (en) * 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
GB1391438A (en) * 1971-04-20 1975-04-23 Contact Lens Mfg Ltd Hydrophilic copolymers and articles formed therefrom
US3826258A (en) * 1972-02-07 1974-07-30 S Abraham Gradual release medicine carrier
US3786812A (en) * 1972-03-10 1974-01-22 C Neefe Contact lens for olar drug delivery
US3811444A (en) * 1972-12-27 1974-05-21 Alza Corp Bioerodible ocular device
DE2364675C2 (de) * 1972-12-29 1983-06-23 Kuraray Co., Ltd., Kurashiki, Okayama Aus einer Polymerenhauptkette und Polymerenseitenketten bestehendes Copolymeres und seine Verwendung zur Herstellung von Gegenständen für biomedizinische Zwecke
US4003991A (en) * 1974-08-27 1977-01-18 National Patent Development Corporation Ophthalmic formulation
US4143949A (en) * 1976-10-28 1979-03-13 Bausch & Lomb Incorporated Process for putting a hydrophilic coating on a hydrophobic contact lens
JPS5374049A (en) * 1976-11-04 1978-07-01 Toray Industries Soft contact lens material
US4153641A (en) * 1977-07-25 1979-05-08 Bausch & Lomb Incorporated Polysiloxane composition and contact lens
US4182802A (en) * 1977-12-27 1980-01-08 Samuel Loshaek Hydrophilic polymers and contact lenses of high water content
US4158089A (en) * 1977-12-27 1979-06-12 Wesley-Jessen Inc. Contact lenses of high water content
US4271143A (en) * 1978-01-25 1981-06-02 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
US4157418A (en) * 1978-02-08 1979-06-05 Minnesota Mining And Manufacturing Company Acrylic functional aminocarboxylic acids and derivatives as components of pressure sensitive adhesives
US4152508A (en) * 1978-02-15 1979-05-01 Polymer Technology Corporation Silicone-containing hard contact lens material
CS216992B1 (en) * 1980-07-21 1982-12-31 Miroslav Stol Composite polymere material for the biological and medicinal utilitation and method of preparation thereof
GB2087408B (en) * 1980-11-04 1984-05-23 Patel Pravin Gordhanbhai Da Co Cross-linked hydrophilic polymers
US4462665A (en) * 1981-01-29 1984-07-31 The Kendall Company Composite hydrogel-forming lens and method of making same
US4436887A (en) * 1981-11-12 1984-03-13 Bausch & Lomb Incorporated N-Vinyl lactam based biomedical devices
US4440919A (en) * 1981-11-12 1984-04-03 Bausch & Lomb Incorporated Low N-vinyl lactam content based biomedical devices
JPS58134019A (ja) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法
US4495361A (en) * 1983-04-29 1985-01-22 Bausch & Lomb Incorporated Polysiloxane composition with improved surface wetting characteristics and biomedical devices made thereof
US4548990A (en) * 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
CS239282B1 (en) * 1983-08-17 1986-01-16 Otto Wichterle Preparation method of objects made from hydrophilic gelsnamely contact lences by polymer casting
US4536554A (en) * 1984-02-22 1985-08-20 Barnes-Hind, Inc. Hydrophilic polymers and contact lenses made therefrom

Also Published As

Publication number Publication date
DE3687868T2 (de) 1993-08-19
JPS6296417A (ja) 1987-05-02
EP0212959B1 (de) 1993-03-03
EP0212959A2 (de) 1987-03-04
CA1277235C (en) 1990-12-04
US4713244A (en) 1987-12-15
EP0212959A3 (en) 1988-06-01

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