DE3687868T2 - Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt. - Google Patents

Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt.

Info

Publication number
DE3687868T2
DE3687868T2 DE8686306347T DE3687868T DE3687868T2 DE 3687868 T2 DE3687868 T2 DE 3687868T2 DE 8686306347 T DE8686306347 T DE 8686306347T DE 3687868 T DE3687868 T DE 3687868T DE 3687868 T2 DE3687868 T2 DE 3687868T2
Authority
DE
Germany
Prior art keywords
rigalkyl
solvent
amino acid
acid polymer
formula containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686306347T
Other languages
English (en)
Other versions
DE3687868D1 (de
Inventor
Rajan Bawa
William G Deichert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Lomb Inc
Original Assignee
Bausch and Lomb Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch and Lomb Inc filed Critical Bausch and Lomb Inc
Publication of DE3687868D1 publication Critical patent/DE3687868D1/de
Application granted granted Critical
Publication of DE3687868T2 publication Critical patent/DE3687868T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE8686306347T 1985-08-16 1986-08-15 Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt. Expired - Fee Related DE3687868T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/766,734 US4713244A (en) 1985-08-16 1985-08-16 Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent

Publications (2)

Publication Number Publication Date
DE3687868D1 DE3687868D1 (de) 1993-04-08
DE3687868T2 true DE3687868T2 (de) 1993-08-19

Family

ID=25077355

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686306347T Expired - Fee Related DE3687868T2 (de) 1985-08-16 1986-08-15 Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt.

Country Status (5)

Country Link
US (1) US4713244A (de)
EP (1) EP0212959B1 (de)
JP (1) JPS6296417A (de)
CA (1) CA1277235C (de)
DE (1) DE3687868T2 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
CS263203B1 (en) * 1986-07-22 1989-04-14 Sulc Jiri Soft intraocular lenses
US5032109A (en) * 1987-02-10 1991-07-16 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5110600A (en) * 1988-01-25 1992-05-05 The Regents Of The University Of California Method of treating viral infections with amino acid analogs
US5192316A (en) * 1988-02-16 1993-03-09 Allergan, Inc. Ocular device
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5760261A (en) * 1990-02-28 1998-06-02 Guttag; Alvin Higher fatty acid derivatives of salicylic acid and salts thereof
US5173302A (en) * 1990-09-28 1992-12-22 Medtronic, Inc. Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs
DK0601055T3 (da) * 1991-08-16 2000-10-02 Joseph C Salamone Medikamentovertrukket brydende okulært forkammerimplantat
AU3469893A (en) * 1992-01-15 1993-08-03 Allergan, Inc. Hydrogel compositions and structures made from same
US5643928A (en) * 1992-10-21 1997-07-01 Pharmaco Behavioral Associates, Inc. Human body weight management
US5596007A (en) * 1992-05-18 1997-01-21 Pharmaco Behavioral Associates, Inc. Therapeutic method to alleviate the craving associated with cessation of tobacco with cotinine
US5612357A (en) * 1992-05-18 1997-03-18 Pharmaco Behavioral Associates, Inc. Use of cotinine to assist in the cessation of tobacco smoking
US5869505A (en) * 1993-02-02 1999-02-09 Keenan; Robert M. Nicotine metabolites and nicotine dependence
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
WO1994005265A1 (en) * 1992-09-10 1994-03-17 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US6162456A (en) * 1992-09-24 2000-12-19 Ortho-Mcneil Pharmaceutical, Inc. Adhesive transdermal drug delivery matrix of a physical blend of hydrophilic and hydrophobic polymers
US5989586A (en) * 1992-10-05 1999-11-23 Cygnus, Inc. Two-phase matrix for sustained release drug delivery device
US5573774A (en) * 1993-02-02 1996-11-12 Keenan; Robert M. Nicotine metabolites, nicotine dependence and human body weight
DE4313928C2 (de) * 1993-04-28 1996-09-19 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur kontrollierten Abgabe von Pilocarpin an die Haut, Verfahren zu seiner Herstellung und seine Verwendung
US5505952A (en) * 1994-04-19 1996-04-09 United States Surgical Corporation Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom
US5972326A (en) * 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
US5612027A (en) * 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
CN1156961A (zh) 1995-06-09 1997-08-13 欧罗赛铁克股份有限公司 产生长效局部麻醉的制剂和方法
JPH11508943A (ja) * 1995-07-12 1999-08-03 コーニング インコーポレイテッド 新規のフォトクロミック有機材料
US5723131A (en) 1995-12-28 1998-03-03 Johnson & Johnson Vision Products, Inc. Contact lens containing a leachable absorbed material
CA2260750C (en) 1996-06-24 2004-11-09 Euro-Celtique, S.A. Methods for providing safe local anesthesia
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
CN1233329A (zh) * 1996-10-11 1999-10-27 康宁股份有限公司 光致变色有机材料,其制造方法和含该材料的光致变色制品
AUPO379596A0 (en) * 1996-11-22 1996-12-19 Soltec Research Pty Ltd Percutaneous delivery system
IL129951A0 (en) 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6410045B1 (en) 1999-02-22 2002-06-25 Clyde Lewis Schultz Drug delivery system for antiglaucomatous medication
US20020197300A1 (en) * 1999-02-22 2002-12-26 Schultz Clyde L. Drug delivery system for anti-glaucomatous medication
MXPA02002257A (es) 1999-08-31 2002-09-30 Maxia Pharmaceuticals Inc Bencilideno-tiazolidinadionas y analogos y su uso en el tratamiento de la diabetes.
US6315987B1 (en) * 2000-05-10 2001-11-13 Isp Investments Inc. Polymeric delivery and release systems for oral care actives
WO2001090077A1 (en) 2000-05-19 2001-11-29 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses
AU2001275085A1 (en) 2000-06-01 2001-12-11 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
US20040151755A1 (en) * 2000-12-21 2004-08-05 Osman Rathore Antimicrobial lenses displaying extended efficacy, processes to prepare them and methods of their use
CA2440184A1 (en) 2001-03-07 2002-09-19 Incyte San Diego, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
EP1377559A4 (de) * 2001-03-08 2005-09-28 Incyte San Diego Inc Rxr-aktivierende moleküle
CA2340824A1 (en) * 2001-03-14 2002-09-14 Ibm Canada Limited-Ibm Canada Limitee Method and system for application behavior analysis
US20030083357A1 (en) * 2001-08-17 2003-05-01 Magnus Pfahl Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia
KR20040058101A (ko) 2001-11-14 2004-07-03 알자 코포레이션 카테터 주입가능한 데포 조성물 및 그의 용도
BR0206469A (pt) * 2001-11-14 2004-01-13 Alza Corp Composição injetável para depósito
JP2005513026A (ja) 2001-11-15 2005-05-12 インサイト サン ディエゴ インコーポレイテッド 高コレステロール血症、異脂肪血症および他の代謝障害;癌、および他の疾患を治療するn−置換複素環
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
MXPA05001242A (es) 2002-07-31 2005-06-08 Alza Corp Composiciones de deposito inyectable y usos de las mismas.
ES2321505T3 (es) 2002-07-31 2009-06-08 Alza Corporation Composiciones de deposito de polimero multimodal inyectables y empleo de las mismas.
JP2006504701A (ja) * 2002-09-30 2006-02-09 マーク・エー・バビザイェフ 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20050014767A1 (en) * 2003-01-29 2005-01-20 Magnus Pfahl Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
US20050038098A1 (en) * 2003-04-18 2005-02-17 Catherine Tachdjian Substituted dihydronaphthalene and isochroman compounds for the treatment of metabolic disorders, cancer and other diseases
EP1657263B1 (de) * 2003-07-18 2008-07-02 Japan Exlan Company Limited Gleichmässig hinhaltend ein aminosäurederivat freisetzendes polymer, kosmetikum und faserkonstrukt mit dem polymer, herstellungsverfahren dafür und regenerationsverfahren dafür
EP1682537B1 (de) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulatoren der zellulären adhäsion
US8236338B2 (en) 2004-07-13 2012-08-07 The University Of Tennessee Research Foundation Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts
AU2005304352A1 (en) * 2004-11-10 2006-05-18 The Trustees Of Columbia University In The City Of New York Method for treatment of movement disorders
CN101094677A (zh) * 2004-11-15 2007-12-26 塞普泰尔公司 蛋白酪氨酸磷酸酶抑制剂及其使用方法
US9804295B2 (en) * 2005-05-05 2017-10-31 Novartis Ag Ophthalmic devices for sustained delivery of active compounds
PL2444079T3 (pl) 2005-05-17 2017-07-31 Sarcode Bioscience Inc. Kompozycje i sposoby leczenia chorób oczu
CN106038473A (zh) 2005-05-23 2016-10-26 自然选择国际公司 持续释放β‑丙氨酸的组合物和方法
DE102006052342B4 (de) * 2006-11-07 2015-08-20 Wöhlk-Contact-Linsen GmbH Kontaktlinsenmaterial
US20090148498A1 (en) * 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US8071119B2 (en) * 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US20080292680A1 (en) * 2007-05-14 2008-11-27 Sustained Nano Systems Llc Hypercompressed polymer particles for controlled release ophthalmic medications
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20090155176A1 (en) 2007-10-19 2009-06-18 Sarcode Corporation Compositions and methods for treatment of diabetic retinopathy
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US20090258069A1 (en) * 2008-04-15 2009-10-15 John Burnier Delivery of LFA-1 antagonists to the gastrointestinal system
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
WO2010048572A1 (en) 2008-10-23 2010-04-29 Cornell University A novel anti-viral method
US10980818B2 (en) 2009-03-06 2021-04-20 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
US10201548B2 (en) * 2009-03-06 2019-02-12 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
US8299079B2 (en) * 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US8481591B2 (en) 2010-11-01 2013-07-09 Stiefel Research Australia Pty. Ltd. Polymeric topical compositions
WO2012151343A1 (en) 2011-05-04 2012-11-08 Balance Therapeutics, Inc. Pentylenetetrazole derivatives
US20130004651A1 (en) * 2011-07-01 2013-01-03 Patty Fu-Giles Sustained drug release from body implants using nanoparticle-embedded polymeric coating materials
EP3715345B1 (de) 2012-07-25 2024-04-10 Novartis AG Herstellung eines lfa-1-hemmers
CA2889981A1 (en) 2012-10-29 2014-05-08 Ariste Medical, Inc. Polymer coating compositions and coated products
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonisten der guanylatcyclase und deren verwendungen
EP3054969B1 (de) 2013-10-10 2021-03-10 Bausch Health Ireland Limited Gunaylatcyclase-cyclase-agonisten zur behandlung von opioidinduzierten störungen
EP3079668A1 (de) 2013-12-09 2016-10-19 Durect Corporation Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit
WO2015164524A1 (en) 2014-04-22 2015-10-29 Ariste Medical, Inc. Methods and processes for application of drug delivery polymeric coatings
EP3291886A1 (de) 2015-05-04 2018-03-14 Ecole Polytechnique Federale de Lausanne (EPFL) Ophthalmische kontaktlinse mit komprimierbarer affinitätsmatrix
CN108884130B (zh) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 用于治疗溃疡性结肠炎的制剂和方法
PT109154B (pt) 2016-02-12 2019-11-05 Univ De Coimbra Tecnologia não-invasiva de inserto ocular para libertação controlada de fármacos
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
DE1570359B2 (de) * 1964-07-02 1970-12-10 Ceskoslovenskä akademie v§d, Prag Verfahren zur Herstellung von Kontaktlinsen
DE1617393C2 (de) * 1966-01-06 1982-11-11 Československá akademie věd, Praha Verfahren zur Herstellung von biologisch aktive Stoffe enthaltenden hydrophilen vernetzten Copolymeren
US3557261A (en) * 1967-10-05 1971-01-19 Ceskoslovenska Akademie Ved Method of centrifugally casting layered contact lenses
US3822089A (en) * 1968-09-25 1974-07-02 Akademie Ved Contact lens blank or replica made from anhydrous, sparingly cross-linked hydrophilic copolymers
US3618604A (en) * 1969-06-09 1971-11-09 Alza Corp Ocular insert
CS159361B1 (de) * 1970-09-08 1975-01-31
US3857932A (en) * 1970-09-09 1974-12-31 F Gould Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants
US3641237A (en) * 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
GB1391438A (en) * 1971-04-20 1975-04-23 Contact Lens Mfg Ltd Hydrophilic copolymers and articles formed therefrom
US3826258A (en) * 1972-02-07 1974-07-30 S Abraham Gradual release medicine carrier
US3786812A (en) * 1972-03-10 1974-01-22 C Neefe Contact lens for olar drug delivery
US3811444A (en) * 1972-12-27 1974-05-21 Alza Corp Bioerodible ocular device
DE2364675C2 (de) * 1972-12-29 1983-06-23 Kuraray Co., Ltd., Kurashiki, Okayama Aus einer Polymerenhauptkette und Polymerenseitenketten bestehendes Copolymeres und seine Verwendung zur Herstellung von Gegenständen für biomedizinische Zwecke
US4003991A (en) * 1974-08-27 1977-01-18 National Patent Development Corporation Ophthalmic formulation
US4143949A (en) * 1976-10-28 1979-03-13 Bausch & Lomb Incorporated Process for putting a hydrophilic coating on a hydrophobic contact lens
JPS5374049A (en) * 1976-11-04 1978-07-01 Toray Industries Soft contact lens material
US4153641A (en) * 1977-07-25 1979-05-08 Bausch & Lomb Incorporated Polysiloxane composition and contact lens
US4182802A (en) * 1977-12-27 1980-01-08 Samuel Loshaek Hydrophilic polymers and contact lenses of high water content
US4158089A (en) * 1977-12-27 1979-06-12 Wesley-Jessen Inc. Contact lenses of high water content
US4271143A (en) * 1978-01-25 1981-06-02 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
US4157418A (en) * 1978-02-08 1979-06-05 Minnesota Mining And Manufacturing Company Acrylic functional aminocarboxylic acids and derivatives as components of pressure sensitive adhesives
US4152508A (en) * 1978-02-15 1979-05-01 Polymer Technology Corporation Silicone-containing hard contact lens material
CS216992B1 (en) * 1980-07-21 1982-12-31 Miroslav Stol Composite polymere material for the biological and medicinal utilitation and method of preparation thereof
GB2087408B (en) * 1980-11-04 1984-05-23 Patel Pravin Gordhanbhai Da Co Cross-linked hydrophilic polymers
US4462665A (en) * 1981-01-29 1984-07-31 The Kendall Company Composite hydrogel-forming lens and method of making same
US4436887A (en) * 1981-11-12 1984-03-13 Bausch & Lomb Incorporated N-Vinyl lactam based biomedical devices
US4440919A (en) * 1981-11-12 1984-04-03 Bausch & Lomb Incorporated Low N-vinyl lactam content based biomedical devices
JPS58134019A (ja) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法
US4495361A (en) * 1983-04-29 1985-01-22 Bausch & Lomb Incorporated Polysiloxane composition with improved surface wetting characteristics and biomedical devices made thereof
US4548990A (en) * 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
CS239282B1 (en) * 1983-08-17 1986-01-16 Otto Wichterle Preparation method of objects made from hydrophilic gelsnamely contact lences by polymer casting
US4536554A (en) * 1984-02-22 1985-08-20 Barnes-Hind, Inc. Hydrophilic polymers and contact lenses made therefrom

Also Published As

Publication number Publication date
EP0212959B1 (de) 1993-03-03
US4713244A (en) 1987-12-15
DE3687868D1 (de) 1993-04-08
JPS6296417A (ja) 1987-05-02
CA1277235C (en) 1990-12-04
EP0212959A3 (en) 1988-06-01
EP0212959A2 (de) 1987-03-04

Similar Documents

Publication Publication Date Title
DE3687868D1 (de) Formulierung mit verzoegerter wirkstoffabgabe, die ein aminosaeurepolymer und ein polares niedrigalkyl(c1-c4)-loesungsmittel enthaelt.
DE3685793T2 (de) Ein aminosaeurepolymer enthaltende zusammensetzung mit verzoegerter abgabe.
DE68915207D1 (de) Aminosäure-Derivate.
NL300181I1 (nl) N-(pyrroloÄ2,3-dÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.
IL78155A0 (en) Pyrimidinylbenzoic acid derivatives,their manufacture and their use as herbicides
DE3669104D1 (de) Pharmazeutische praeparate, die ascorbinsaeurederivate enthalten.
DE3872306D1 (de) Bipolare zylindrische batterie.
AU5894486A (en) Solid, stable dosage forms with an elastic film coating
DE3763424D1 (de) Fluessiges stabiles diperoxysaeure-bleichmittel.
DE3787657T2 (de) Aminosäure-Derivate.
DE3685869T2 (de) Formulierung mit verzoegerter wirkstoffabgabe, die ein hydrophobes polymersystem enthaelt.
DE3582728D1 (de) Tertiaere aminoverbindungen.
DE68913498T2 (de) 1,1-dioxo-cephem-4-carbothiolsäure-derivate.
DK207388A (da) Nitrogenholdige, cycloaliphatiske forbindelser med en aminosyregruppe samt en pyridingruppe
NO884110D0 (no) Nye aminosyreestere, samt fremgangsmaater for fremstilling derav.
DE69018816T2 (de) Aminosäurederivate.
AU5899386A (en) 1,4-dihydro-nicotinic acid derivatives
NO870834D0 (no) Glysero-3(2)-fosfo-l-serinderivater og salter derav, fremgangsmaater for fremstilling derav og farmasoeytiske preparater inneholdende derivatene.
FI865244A0 (fi) Foerfarande foer framstaellning av optiskt aktiva 2-klor-12-(3-dimetylamino-2-metylpropyl)-12h-dibenzo-/d,g//1,3,6/ dioxazociner.
ATE58735T1 (de) 5-chloro-s-triazolo(4,3-a>pyridin-7-carbonsaeure .
NO900331D0 (no) Blyakkumulator.
AU591110B2 (en) Salts of n-(vinyloxiethyl)dithiocarbamic acid, method of obtaining thereof and pesticides based on them
DE3681441D1 (de) Aminosaeureabkoemmlinge.
ATE60766T1 (de) Chromoglycinsaeureabkoemmlinge, herstellung und arzneimittel.
ATE95518T1 (de) Aminosaeure-derivate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee