DE3751846T2 - Hybrid-Rezeptoren, diese kodierende Nukleinsäure, ihre Herstellung und ihre Verwendung zur Bestimmung von Liganden sowie deren Antagonisten oder Agonisten - Google Patents

Hybrid-Rezeptoren, diese kodierende Nukleinsäure, ihre Herstellung und ihre Verwendung zur Bestimmung von Liganden sowie deren Antagonisten oder Agonisten

Info

Publication number
DE3751846T2
DE3751846T2 DE3751846T DE3751846T DE3751846T2 DE 3751846 T2 DE3751846 T2 DE 3751846T2 DE 3751846 T DE3751846 T DE 3751846T DE 3751846 T DE3751846 T DE 3751846T DE 3751846 T2 DE3751846 T2 DE 3751846T2
Authority
DE
Germany
Prior art keywords
agonists
antagonists
hybrid receptors
ligands
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751846T
Other languages
English (en)
Other versions
DE3751846D1 (de
Inventor
Thomas Joseph Dull
Heimo Riedel
Axel Ullrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE3751846D1 publication Critical patent/DE3751846D1/de
Application granted granted Critical
Publication of DE3751846T2 publication Critical patent/DE3751846T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/32Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/90Fusion polypeptide containing a motif for post-translational modification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/968High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806Antigenic peptides or proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
DE3751846T 1986-04-30 1987-04-29 Hybrid-Rezeptoren, diese kodierende Nukleinsäure, ihre Herstellung und ihre Verwendung zur Bestimmung von Liganden sowie deren Antagonisten oder Agonisten Expired - Lifetime DE3751846T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/857,899 US4859609A (en) 1986-04-30 1986-04-30 Novel receptors for efficient determination of ligands and their antagonists or agonists

Publications (2)

Publication Number Publication Date
DE3751846D1 DE3751846D1 (de) 1996-08-01
DE3751846T2 true DE3751846T2 (de) 1997-01-09

Family

ID=25326982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751846T Expired - Lifetime DE3751846T2 (de) 1986-04-30 1987-04-29 Hybrid-Rezeptoren, diese kodierende Nukleinsäure, ihre Herstellung und ihre Verwendung zur Bestimmung von Liganden sowie deren Antagonisten oder Agonisten

Country Status (9)

Country Link
US (1) US4859609A (de)
EP (1) EP0244221B1 (de)
JP (2) JP2592063B2 (de)
AT (1) ATE139784T1 (de)
CA (1) CA1328419C (de)
DE (1) DE3751846T2 (de)
ES (1) ES2090007T3 (de)
GR (1) GR3021017T3 (de)
HK (1) HK1008022A1 (de)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861511B1 (en) 1986-06-04 2005-03-01 Bayer Corporation Detection and quantification of neu related proteins in the biological fluids of humans
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US7214511B1 (en) 1986-10-24 2007-05-08 The Salk Institute For Biological Studies Hormone receptor compositions and methods
US7084251B1 (en) 1987-02-12 2006-08-01 Genentech, Inc. Methods and Deoxyribonucleic acid for the preparation of tissue factor protein
US6994988B1 (en) 1987-02-12 2006-02-07 Genetech, Inc. Methods and deoxyribonucleic acid for the preparation of tissue factor protein
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5571692A (en) * 1987-12-02 1996-11-05 The Salk Institute For Biological Studies Retinoic acid receptor α, vectors and cells comprising the same DNA encoding
US5149781A (en) * 1987-12-16 1992-09-22 Institut Pasteur Steroid/thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma
US5317090A (en) * 1987-12-16 1994-05-31 Institut Pasteur Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor
US5223606A (en) * 1987-12-16 1993-06-29 Institut Pasteur Steroid/thyroid hormone receptor-related protein inappropriately expressed in human hepatocellular carcinoma
EP0321362B1 (de) * 1987-12-16 1996-09-25 Institut Pasteur Retinoesäurerezeptor und Derivate davon, beide Substanzen codierende DNS und die Verwendung der Proteine und der DNS
EP0325224B1 (de) * 1988-01-22 1996-07-31 ZymoGenetics, Inc. Verfahren zur Herstellung von sekretierten Rezeptoranalogen
US5567584A (en) * 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
US6018026A (en) 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
US5750375A (en) * 1988-01-22 1998-05-12 Zymogenetics, Inc. Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
FR2628750B1 (fr) * 1988-03-21 1991-11-08 Pasteur Institut Vecteur modifie par une sequence codant pour une sequence d'acides amines contenue dans une proteine de mammifere ayant une activite biologique de recepteur membranaire
SE8802939D0 (sv) * 1988-08-19 1988-08-19 Kabigen Ab A method for the production and isolation of a fusion protein in eukaryotic cells
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
EP1201757A3 (de) * 1988-12-22 2002-09-11 Genentech, Inc. Verfahren zur Herstellung von wasserlöslichen Polypeptiden
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
SG72657A1 (en) * 1989-07-06 2000-05-23 Univ California Receptors for fibroblast growth factors
FR2650598B1 (fr) * 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
US5284746A (en) * 1990-02-08 1994-02-08 Zymogenetics, Inc. Methods of producing hybrid G protein-coupled receptors
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
CA2075974C (en) * 1990-02-15 2001-02-06 Dana M. Fowlkes Totally synthetic affinity reagents
EP0522054A4 (en) 1990-03-22 1993-02-10 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US5861274A (en) * 1990-03-22 1999-01-19 The Salk Institute For Biological Studies Nucleic acids encoding peroxisome proliferator-activated receptor
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US6440681B1 (en) 1990-04-03 2002-08-27 Merck & Co., Inc. Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
IL97996A0 (en) * 1990-04-30 1992-06-21 Novo Nordisk As Hybrid cellular receptor
DK106490D0 (da) * 1990-04-30 1990-04-30 Novo Nordisk As Celle
WO1993022339A1 (en) * 1992-04-29 1993-11-11 Georgetown University BINDING PEPTIDES WHICH INTERACT WITH LIGAND GROWTH FACTORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR AND erbB-2-RECEPTOR
US5578482A (en) * 1990-05-25 1996-11-26 Georgetown University Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses
US5218090A (en) * 1990-06-12 1993-06-08 Warner-Lambert Company EGF receptor truncates
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5453491A (en) * 1990-09-11 1995-09-26 Kiyoshi Takatsu Murine interleukin-5 receptor
DK0548165T3 (da) 1990-09-13 2001-07-16 Univ Duke Ekspression af G-proteinkoblede receptorer i gær
WO1992006220A1 (en) * 1990-10-05 1992-04-16 President And Fellows Of Harvard College Detection and isolation of ligands
DE4037837A1 (de) * 1990-11-28 1992-06-04 Behringwerke Ag Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
US5385831A (en) * 1990-12-12 1995-01-31 Zymogenetics, Inc. Method for producing a mammalian G protein coupled glutamate receptor
US5869609A (en) * 1990-12-12 1999-02-09 Zymogenetics, Inc. G protein coupled glutamate receptors
NZ240921A (en) * 1990-12-12 1994-06-27 Zymogenetics Inc G protein coupled glutamate receptor (neurotransmitters), recombinant production
DK0517895T3 (da) * 1990-12-14 1997-04-07 Univ California Kimæriske kæder til receptorforbundne signaltransduktionsveje
EP0492179A3 (en) * 1990-12-28 1992-12-09 American Cyanamid Company Avian growth hormone receptor and binding protein
US5264565A (en) * 1991-01-22 1993-11-23 Affymax Technologies, N.V. Nucleic acid encoding the D2 /Ml chimeric receptor
US7119182B1 (en) 1991-02-19 2006-10-10 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
US5256766A (en) * 1991-02-19 1993-10-26 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
US5688768A (en) * 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
GEP19991604B (en) * 1991-03-15 1999-04-29 Applied Res Systems Ars Holding N V Human Follicle Stimulating Hormone Receptor
US5212075A (en) * 1991-04-15 1993-05-18 The Regents Of The University Of California Compositions and methods for introducing effectors to pathogens and cells
US5245011A (en) * 1991-04-16 1993-09-14 Duke University Aqueous solution containing D1B dopamine receptor
US5215915A (en) * 1991-04-16 1993-06-01 Duke University Cloned gene encoding rat d1b dopamine receptor
SE9101433D0 (sv) * 1991-05-13 1991-05-13 Marianne Hansson Recombinant dna sequence and its use
AU2179192A (en) * 1991-06-05 1993-01-08 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Transfected mammalian cell lines expressing the a1 adenosine receptor
ATE173295T1 (de) * 1991-08-08 1998-11-15 Genentech Inc Ecdysteroid-abhängige gen regulierung in säugetier-zellen
IL100219A0 (en) * 1991-12-02 1992-09-06 Yeda Res & Dev Variable region within fibroblast growth factor receptors that confers ligand specificity
US5436155A (en) * 1991-12-31 1995-07-25 Arch Development Corporation Isolated DNA encoding a somatostatin receptor
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
WO1993018141A1 (en) * 1992-03-02 1993-09-16 Biogen, Inc. Thrombin receptor antagonists
JPH08501211A (ja) * 1992-07-02 1996-02-13 ザ ソールク インスチチュート フォア バイオロジカル スタディズ ウルトラスピラクル受容体とのマルチマー型ステロイド/甲状腺スーパーファミリー受容体メンバー
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
ATE253118T1 (de) * 1993-02-10 2003-11-15 Unilever Nv Isolierungsverfahren verwendend immobilisierte proteine mit spezifischen bindungskapazitäten
EP1508614A1 (de) * 1993-03-08 2005-02-23 MERCK & CO. INC. Menschliche neuronale Nikotin-acetylcholin-rezeptor-verbindungen und Methoden ihres Einsatzes
FR2703935B1 (fr) * 1993-04-14 1995-07-21 Usinor Sacilor Dispositif de changement rapide et de maintien d'une paroi laterale d'une machine de coulee continue d'un produit metallique entre cylindres.
CA2164623A1 (en) * 1993-06-07 1994-12-22 Robert Enrico Pacifici Hybrid receptor molecules
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
US5679582A (en) * 1993-06-21 1997-10-21 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5707798A (en) * 1993-07-13 1998-01-13 Novo Nordisk A/S Identification of ligands by selective amplification of cells transfected with receptors
US5989893A (en) * 1993-09-27 1999-11-23 University Of Massachusetts Medical Center Receptor-activated reporter systems
WO1995009240A1 (en) * 1993-09-27 1995-04-06 University Of Massachusetts Medical Center Receptor-activated reporter systems
GB2287941B (en) * 1993-11-08 1998-01-28 Salk Inst Biotech Ind Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same
JP3442784B2 (ja) * 1993-11-23 2003-09-02 ジェネンテク,インコーポレイテッド キナーゼ受容体活性化検定法
US6287784B1 (en) 1993-11-23 2001-09-11 Genentech, Inc. Kinase receptor activation assay
CA2175893C (en) * 1993-11-23 2010-06-22 Paul J. Godowski Protein tyrosine kinases named rse
US5523227A (en) * 1994-06-17 1996-06-04 The Board Of Trustees Of The Leland Stanford Junior Univ. DNA encoding calcium-signal modulating cyclophilin ligand
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
WO1996024063A1 (en) * 1995-01-30 1996-08-08 The General Hospital Corporation Methods for identifying integrin antagonists
US5665873A (en) * 1995-02-09 1997-09-09 Dana Farber Cancer Institute Glucocorticoid response elements
US6485967B1 (en) 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
ATE400653T1 (de) * 1995-07-26 2008-07-15 Astrazeneca Ab Chimäre rezeptoren und verfahren zur identifizieren verbindungen mit einem aktivität als metabotropischen glutamatrezeptoren sowie verwendung solcher verbindungen in der behandlung von neurologischer erkrankungen und neurologischenstörrungen
WO1997009342A1 (en) 1995-09-08 1997-03-13 Scriptgen Pharmaceuticals, Inc. Screen for compounds with affinity for rna
CA2184195C (en) * 1995-10-25 2002-04-16 Andrew Pakula Screening method for identifying ligands for target proteins
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US5981199A (en) 1996-06-14 1999-11-09 Boehringer Mannheim Corporation Method for measuring antigen concentration
JP4440344B2 (ja) 1996-08-16 2010-03-24 シェーリング コーポレイション 哺乳動物細胞表面抗原;関連試薬
US6544523B1 (en) * 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
BR9714401A (pt) 1996-12-13 2000-04-18 Schering Corp Antìgenos de supefìcie de célula de mamìfero; regentes relacionados
CA2282418A1 (en) * 1997-03-05 1998-09-11 Scriptgen Pharmaceuticals, Inc. Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids
ATE443139T1 (de) 1997-05-07 2009-10-15 Schering Corp Menschliche toll-ähliche rezeptorproteine, zugehörige reagenzien und verfahren
HUP0002472A3 (en) 1997-07-09 2003-08-28 Schering Corp Isolated dendritic cell membrane protein genes
US6461610B1 (en) 1997-07-18 2002-10-08 Novo Nordisk A/S Methods for modifying cell motility using factor VIIa or inactivated factor VIIa
AU8101698A (en) 1997-07-18 1999-02-10 Novo Nordisk A/S Use of fviia or fviiai for the treatment of adverse conditions related to the fviia mediated intracellular signalling pathway
CO4810232A1 (es) 1997-07-25 1999-06-30 Schering Corp Citoquinas de mamiferos y sus secuencias codificadoras
EP1798286B1 (de) 1997-08-01 2011-09-07 Schering Corporation Membranproteine aus Säugetierzellen und verwandte Reagentien
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
WO1999024050A1 (en) 1997-11-12 1999-05-20 3-Dimensional Pharmaceuticals, Inc. High throughput method for functionally classifying proteins identified using a genomics approach
AUPP135698A0 (en) * 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US7262280B1 (en) 1998-04-03 2007-08-28 Nps Pharmaceuticals, Inc. G-protein fusion receptors and constructs encoding same
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
AU6246199A (en) 1998-09-21 2000-04-10 Schering Corporation Human interleukin-b50, therapeutic uses
EP0997476A3 (de) 1998-09-25 2000-07-19 Schering-Plough Antikörper gegen ein Antigen auf Langerhans Zellen in Säugetieren und deren Verwendungen
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
ATE444365T1 (de) 1999-01-11 2009-10-15 Schering Corp Interleukin-17 verwandte zytokine aus säugetieren. dafür kodierende polynukleotide. verwendungen
US6972198B2 (en) 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
CA2366706A1 (en) 1999-03-11 2000-09-14 Schering Corporation Mammalian cytokines; related reagents and methods
EP1177295A1 (de) 1999-05-13 2002-02-06 Medical Research Council Ox2 rezeptoren und dessen homologen
AU5305300A (en) 1999-06-01 2000-12-18 Schering Corporation Mammalian receptor proteins; related reagents and methods
DK1200592T3 (da) 1999-07-30 2009-12-07 Schering Corp Mammalske cytokiner og relaterede reagenser
EP1905832A3 (de) 1999-09-09 2009-09-09 Schering Corporation Säuger Interleukin-12 P40 und Interleukin B30, Antikörper, Verwendungen in pharmazeutischen Zusammenstellungen
WO2001020326A2 (en) * 1999-09-13 2001-03-22 Equitech Laboratories, Inc. Materials and methods for the determination of an analyte
US20050148018A1 (en) 1999-10-07 2005-07-07 David Weiner Methods of identifying inverse agonists of the serotonin 2A receptor
US20040033600A1 (en) * 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
ES2529300T3 (es) 2000-04-12 2015-02-18 Novozymes Biopharma Dk A/S Proteínas de fusión de albúmina
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
WO2001085790A2 (en) 2000-05-10 2001-11-15 Schering Corporation Mammalian cytokine receptor subunit proteins, related reagents and methods
US7422743B2 (en) 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
JP2003533996A (ja) 2000-05-25 2003-11-18 シェーリング コーポレイション ヒトレセプタータンパク質、関連試薬および方法
EP1304573A4 (de) * 2000-07-17 2006-06-07 Chugai Pharmaceutical Co Ltd Verfahren zum screenen eines liganden mit biologischer aktivität
AU2001294541A1 (en) 2000-09-08 2002-03-22 Schering Corporation Mammalian genes; related reagents and methods
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
US6890734B2 (en) 2000-11-10 2005-05-10 Schering Corporation Nucleic acids encoding a cytokine receptor complex
WO2002064154A2 (en) * 2001-02-15 2002-08-22 The Government Of The United States Of America, Asrepresented By The Secretary Of The Department Of Health And Human Services Methods and compositions for inhibiting hiv-coreceptor interactions
WO2002066614A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
JP4955904B2 (ja) 2001-02-20 2012-06-20 イントレキソン コーポレーション 新規エクジソン受容体/無脊椎動物レチノイドx受容体−ベースの誘導性遺伝子発現システム
JP4994563B2 (ja) 2001-02-20 2012-08-08 イントレキソン コーポレーション 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用
EP3470520A2 (de) 2001-02-20 2019-04-17 Intrexon Corporation Neuartige substitution mutanter rezeptoren und deren verwendung in einem auf nuklearen rezeptoren beruhenden induzierbaren genexpressionssystem
AU2002315157A1 (en) * 2001-06-14 2003-01-02 Anadys Pharmaceuticals, Inc. Methods of screening for ligands of target molecules
EP1436394A4 (de) 2001-09-26 2004-12-29 Rheo Gene Holdings Inc Zikaden-ecdyson-rezeptor-nukleinsäuren, -polypeptide und ihre verwendungen
JP2005507247A (ja) 2001-09-26 2005-03-17 レオジーン・ホールディングス,インコーポレーテッド コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用
EP2261250B1 (de) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin Fusionsproteine
US20070077642A1 (en) * 2002-12-23 2007-04-05 Joseph Strauss Steroid receptor modulation of gene expression
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20040185548A1 (en) * 2003-03-17 2004-09-23 Qun-Sheng Ji Hybrid receptors for efficient assay of modulators of receptor protein-tyrosine kinases
US20050186658A1 (en) * 2003-10-17 2005-08-25 Nps Pharmaceuticals, Inc. Chimeric metabotropic glutamate receptors and uses thereof
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
AU2005247943A1 (en) 2004-05-23 2005-12-08 Gerard M. Housey Theramutein modulators
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
US20090275070A1 (en) * 2005-11-23 2009-11-05 Housey Gerard M Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
DOP2007000020A (es) 2006-01-31 2007-09-15 Bayer Schering Pharma Ag Modulación de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
KR20150129034A (ko) 2013-03-15 2015-11-18 인트렉손 코포레이션 붕소-함유 디아실하이드라진류
AU2015317862A1 (en) 2014-09-17 2017-04-06 Intrexon Corporation Boron-containing diacylhydrazine compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935074A (en) * 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US4374925A (en) * 1978-11-24 1983-02-22 Syva Company Macromolecular environment control in specific receptor assays
US4446231A (en) * 1979-10-03 1984-05-01 Self Colin H Immunoassay using an amplified cyclic detection system
SE8101665L (sv) * 1980-03-17 1981-09-18 Harvard College Polypeptidframstellning
JPS57106625A (en) * 1980-12-22 1982-07-02 Teijin Ltd Cytotoxic protein complex and its preparation
DE3100061A1 (de) * 1981-01-02 1982-08-05 Hans A. Dipl.-Chem. Dr. 8000 München Thoma Verfahren zur bestimmung von liganden mittels kompetitionsreaktion
DE3209149A1 (de) * 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
US4544629A (en) * 1982-11-19 1985-10-01 Minnesota Mining And Manufacturing Company Receptor-based histamine assay
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8314362D0 (en) * 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
JPS60166699A (ja) * 1984-02-03 1985-08-29 Japan Found Cancer 成人t細胞白血病ウイルス抗原ポリペプチド
EP0173494A3 (de) * 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimäre Rezeptoren durch Verbindung und Expression von DNS

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ES2090007T3 (es) 1996-10-16
JPS62272990A (ja) 1987-11-27
JPH09117285A (ja) 1997-05-06
EP0244221B1 (de) 1996-06-26
ATE139784T1 (de) 1996-07-15
US4859609A (en) 1989-08-22
DE3751846D1 (de) 1996-08-01
JP2592063B2 (ja) 1997-03-19
EP0244221A1 (de) 1987-11-04

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