DE3850055D1 - Mittel und Verfahren zur Erhöhung der Nukleinsäure-Hybridisierung. - Google Patents

Mittel und Verfahren zur Erhöhung der Nukleinsäure-Hybridisierung.

Info

Publication number
DE3850055D1
DE3850055D1 DE3850055T DE3850055T DE3850055D1 DE 3850055 D1 DE3850055 D1 DE 3850055D1 DE 3850055 T DE3850055 T DE 3850055T DE 3850055 T DE3850055 T DE 3850055T DE 3850055 D1 DE3850055 D1 DE 3850055D1
Authority
DE
Germany
Prior art keywords
nucleic acid
probe
target
methods
acid hybridization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3850055T
Other languages
English (en)
Other versions
DE3850055T2 (de
Inventor
James John Hogan
Curt Lawrence Milliman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22417674&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3850055(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of DE3850055D1 publication Critical patent/DE3850055D1/de
Publication of DE3850055T2 publication Critical patent/DE3850055T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/12Nitrate to nitrite reducing bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6832Enhancement of hybridisation reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
DE3850055T 1987-11-24 1988-11-22 Mittel und Verfahren zur Erhöhung der Nukleinsäure-Hybridisierung. Expired - Lifetime DE3850055T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/124,975 US5030557A (en) 1987-11-24 1987-11-24 Means and method for enhancing nucleic acid hybridization

Publications (2)

Publication Number Publication Date
DE3850055D1 true DE3850055D1 (de) 1994-07-14
DE3850055T2 DE3850055T2 (de) 1994-09-29

Family

ID=22417674

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3850055T Expired - Lifetime DE3850055T2 (de) 1987-11-24 1988-11-22 Mittel und Verfahren zur Erhöhung der Nukleinsäure-Hybridisierung.

Country Status (11)

Country Link
US (1) US5030557A (de)
EP (1) EP0318245B1 (de)
JP (1) JP2820749B2 (de)
KR (1) KR960015893B1 (de)
AT (1) ATE106947T1 (de)
CA (1) CA1319336C (de)
DE (1) DE3850055T2 (de)
ES (1) ES2056115T3 (de)
FI (1) FI893526A (de)
PT (1) PT89050B (de)
WO (1) WO1989004876A1 (de)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641630A (en) * 1985-06-13 1997-06-24 Amgen Inc. Method and kit for performing nucleic acid hybridization assays
US5541308A (en) * 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
JPH04500316A (ja) * 1989-05-24 1992-01-23 ジーン―トラック・システムス 淋菌を検出するための核酸プローブ
US5217862A (en) * 1989-05-24 1993-06-08 Amoco Corporation Method for the detection of Neisseria gonorrhoeae
US7009041B1 (en) * 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
CA1337639C (en) * 1989-08-01 1995-11-28 Joseph Eugene Celebuski Dna probe assay using neutrally charged probe strands
US5134066A (en) * 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
US5681698A (en) * 1991-04-25 1997-10-28 Gen-Probe Incorporated 23S rRNA nucleic acid probes to mycobacterium kansasii
US5472843A (en) * 1991-04-25 1995-12-05 Gen-Probe Incorporated Nucleic acid probes to Haemophilus influenzae
US6028187A (en) * 1991-08-01 2000-02-22 Gen-Probe Incorporated Nucleic acid probes to Listeria monocytogenes
US5738987A (en) * 1991-09-04 1998-04-14 Gen-Probe Incorporated 16S ribosomal nucleic acid probes to streptococcus pneumoniae
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5387510A (en) * 1991-10-02 1995-02-07 Eastman Kodak Company Detection of amplified nucleic acid using secondary capture oligonucleotides and test kit
ATE161586T1 (de) 1991-10-11 1998-01-15 Behringwerke Ag Verfahren zur herstellung eines polynukleotids zum gebrauch in ''single-primer'' amplifizierung und phosphorothioat-enthaltende oligonukleotide als primer in nukleinsäureamplifizierung
US5284747A (en) * 1991-12-18 1994-02-08 Gen-Probe Incorporated Nucleic acid probes to Coccidioides immitis
US5763163A (en) * 1991-12-18 1998-06-09 Gen-Probe Incorporated Nucleic acid probes to Cryptococcus neoformans
WO1993013223A1 (en) 1991-12-23 1993-07-08 Chiron Corporation Hiv probes for use in solution phase sandwich hybridization assays
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
AU666200B2 (en) * 1992-04-28 1996-02-01 Gen-Probe Incorporated Nucleic acid process probes to (mycobacterium tuberculosis)
US6093538A (en) * 1992-05-06 2000-07-25 Gen-Probe Incorporated Nucleic acid probes to ureaplasma
CA2135073C (en) * 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
WO1994002500A1 (en) * 1992-07-17 1994-02-03 Aprogenex, Inc. Oligonucleotide probes and primers for detecting chromosomal translocation
ATE152180T1 (de) * 1992-07-31 1997-05-15 Behringwerke Ag Verfahren zur einführung von definierten sequenzen am 3' ende von polynukleotiden
US5374718A (en) * 1992-08-26 1994-12-20 Gen-Probe Incorporated Nucleic acid probes to chlamydia pneumoniae
JP3495752B2 (ja) * 1992-12-11 2004-02-09 キヤノン株式会社 生標的個体の検出方法およびプローブ
FR2701961B1 (fr) * 1993-02-24 1995-04-21 Bio Merieux Procédé de destabilisation d'une structure secondaire intracaténaire d'un polynucléotide simple brin, et de capture dudit nucléotide.
KR100325554B1 (ko) 1993-03-26 2002-11-02 젠-프로브 인코포레이티드 사람의면역결핍 바이러스타입1의검출
KR960704034A (ko) * 1993-07-19 1996-08-31 다니엘 엘. 캐시앙 단백질 생산, 세포 증식 및(또는) 전염병 병원균의 증식에 대한 올리고뉴클레오티드 저해의 향상법(Enhancement of Oligonucleotide Inhibition of Protein Production, Cell Proliferation, and/or Multiplication of Infectious Disease Pathogens)
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
JP3789471B2 (ja) * 1993-07-19 2006-06-21 ジェン−プローブ・インコーポレイテッド オリゴヌクレオチドスクリーニングアッセイ
US6136529A (en) * 1993-09-03 2000-10-24 Gen-Probe Incorporated Nucleic acid probes to Mycobacterium avium complex
US5484909A (en) * 1993-09-10 1996-01-16 Amoco Corporation Nucleic acid probes for the detection of bacteria of the genera Pediococcus and Lactobacillus and methods for the detection of the bacterial agents causing spoilage of beer
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6468742B2 (en) 1993-11-01 2002-10-22 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
US5582978A (en) * 1994-01-21 1996-12-10 Amoco Corporation Nucleic acid probes for the detection of Haemophilus influenzae
CA2180723A1 (en) * 1994-01-26 1995-08-03 Aharon S. Cohen Method of detecting sub-ppb levels of oligonucleotides in biological fluids
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
EP0709466B1 (de) * 1994-10-28 2006-09-27 Gen-Probe Incorporated Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
DK0805876T3 (da) * 1995-01-19 2000-11-06 Gen Probe Inc Nukleinsyreamplifikationsoligonukleotider og prober til Lyme-sygdom-associeret Borrelia
US5622827A (en) * 1995-02-07 1997-04-22 Gen-Probe Incorporated Amplification primers and nucleic acid probes targeted to coccidioides immitis nucleic acid
JPH11501511A (ja) * 1995-03-04 1999-02-09 ベーリンガー マンハイム ゲーエムベーハー 核酸結合パートナーの結合特性の調節
US5925518A (en) * 1995-05-19 1999-07-20 Akzo Nobel N.V. Nucleic acid primers for amplification of a mycobacteria RNA template
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
AU707691B2 (en) * 1995-06-07 1999-07-15 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for neisseria species
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
US5705365A (en) * 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5710029A (en) * 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
CA2237891C (en) 1995-11-15 2013-07-30 Gen-Probe Incorporated Nucleic acid probes complementary to human papillomavirus nucleic acid and related methods and kits
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US6218107B1 (en) 1996-05-22 2001-04-17 Gen-Probe Incorporated Compositions and methods for detecting the presence of Mycobacterium kansassii
US6130038A (en) 1996-07-16 2000-10-10 Gen-Probe Incorporated Method for amplifying target nucleic acids using modified primers
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
GB9620075D0 (en) 1996-09-26 1996-11-13 Dynal As Method
JP4185185B2 (ja) 1997-05-08 2008-11-26 征夫 軽部 部分二重鎖dnaを利用したdnaの検出方法
US20030054378A1 (en) * 1997-05-08 2003-03-20 Isao Karube Method for detecting target nucleotide sequence
US5994076A (en) * 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
WO1999022023A2 (de) * 1997-10-29 1999-05-06 Mira Diagnostica Gmbh Verfahren zum nachweis von mikroorganismen
US20050053962A1 (en) * 1998-01-27 2005-03-10 Gary Blackburn Amplification of nucleic acids with electronic detection
US6066625A (en) * 1998-02-03 2000-05-23 Methylgene, Inc. Optimized antisense oligonucleotides complementary to DNA methyltransferase sequences
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6015676A (en) * 1998-07-31 2000-01-18 Epiclone Inc. Method for knocking out gene transcripts by covalently binding of an anti-sense probe
GB9827912D0 (en) * 1998-12-19 1999-02-10 Univ Manchester Detecting nucleic acids
CA2644688C (en) * 1999-04-20 2012-11-13 Kankyo Engineering Co., Ltd. Method for determining a concentration of target nucleic acid molecules, nucleic acid probes for the method, and method for analysing data obtained by the method
JP4724380B2 (ja) * 1999-04-20 2011-07-13 独立行政法人産業技術総合研究所 核酸の測定方法に用いる核酸プローブおよびデータを解析する方法
WO2000066785A2 (en) 1999-05-03 2000-11-09 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae
ES2265344T3 (es) 1999-05-03 2007-02-16 Gen-Probe Incorporated Sondas de polinucleotido para la deteccion y cuantificacion de actinomicetos.
EP1177317B1 (de) 1999-05-03 2006-08-09 Gen-Probe Incorporated POYNUKLEOTIDSONDEN ZUR exklusiven DETEKTION UND QUANTIFIZIERUNG VON STAPHYLOCOCCUS
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US7824859B2 (en) * 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US6893819B1 (en) * 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7838225B2 (en) * 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US6924108B2 (en) * 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
DE10021947A1 (de) * 2000-05-05 2001-11-08 Max Planck Gesellschaft Helferoligonukleotide für die in situ Hybridisierung
GB0016814D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (3)
AU2002211814A1 (en) 2000-09-12 2002-03-26 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of cryptosporidium organisms in a test sample
JP2002125687A (ja) * 2000-10-30 2002-05-08 Tosoh Corp Hiv−1検出のためのオリゴヌクレオチドおよび検出法
EP1251183A3 (de) * 2001-04-18 2003-12-10 Exiqon A/S Verbesserte Helfersonden zur Detektion einer Zielsequenz mittels Fangoligonukleotid
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
DE10237284A1 (de) * 2002-08-14 2004-03-04 Advalytix Ag Nukleinsäurenachweis
US20040157238A1 (en) * 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
US8394944B2 (en) 2002-09-20 2013-03-12 Siemens Healthcare Diagnostics Inc. Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
JP5656273B2 (ja) * 2003-05-19 2015-01-21 ジェン−プロウブ インコーポレイテッド 試験サンプルにおいてtrichomonasvaginalisの存在を決定するための組成物、方法およびキット
US20050058985A1 (en) * 2003-09-12 2005-03-17 Dodgson Kirsty Jane Method and kit for identifying vancomycin-resistant enterococcus
WO2005028647A1 (ja) * 2003-09-22 2005-03-31 Kyoto University 核酸プローブ、核酸チップ、標的核酸検出方法、薬剤スクリーニング方法、標的核酸検出装置及び遺伝子診断方法
CA2545917C (en) 2003-11-14 2014-07-29 Duke University Methods of detecting charcot-marie tooth disease type 2a
WO2005071117A2 (en) 2004-01-23 2005-08-04 Biomerieux, Inc. Primer and probe design for efficient amplification and detection of hcv 3′ non-translating region
US20050260636A1 (en) * 2004-03-24 2005-11-24 Li X J Methods for the detection of biological organisms using transfer ribonucleic acids as biomarkers
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
EP2071031B1 (de) * 2004-08-27 2013-10-09 Gen-Probe Incorporated Einfach-Primernukleinsäuren-Erweiterungsverfahren
JP5020825B2 (ja) 2004-12-08 2012-09-05 ジェン−プローブ・インコーポレーテッド 複数型のヒトパピローマウイルスに由来する核酸の検出
US7993853B2 (en) 2005-05-06 2011-08-09 Gen-Probe Incorporated Methods of nucleic acid target capture
CA2609206A1 (en) * 2005-06-06 2006-12-14 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of chlamydophila pneumoniae in a test sample
EP1937847A2 (de) 2005-10-17 2008-07-02 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von legionella pneumophila-nukleinsäure
US8030080B2 (en) 2006-01-18 2011-10-04 Argos Therapeutics, Inc. Systems and methods for processing samples in a closed container, and related devices
ATE531818T1 (de) * 2006-05-02 2011-11-15 Univ Paris Curie Methode zur bestimmung und auszählung von mikroorganismen
JP5635772B2 (ja) 2006-08-01 2014-12-03 ジェン−プロウブ インコーポレイテッド 核酸の非特異的標的の捕捉方法
DE602006008150D1 (de) * 2006-10-12 2009-09-10 Bio Rad Pasteur Doppelsträngige Sonden zur Fluoreszenzdetektion von Nukleinsäuren
US20090149342A1 (en) * 2006-10-13 2009-06-11 Welldoc Communications Method for reduction of nonspecific binding in nucleic acid assays, nucleic acid synthesis and multiplex amplification reactions
WO2008046056A1 (en) * 2006-10-13 2008-04-17 Welldoc Communications, Inc. Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
JP5211790B2 (ja) * 2007-03-26 2013-06-12 住友化学株式会社 Dnaメチル化測定方法
EP1978111B1 (de) * 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
US20090253142A1 (en) * 2008-03-15 2009-10-08 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
JP2011521651A (ja) 2008-05-30 2011-07-28 ジェン−プロウブ インコーポレイテッド サルモネラの検出および/またはモニタリングのための組成物、キットおよび関連方法
EP2910647A1 (de) 2008-12-30 2015-08-26 Gen-Probe Incorporated Zusammensetzungen, Kits und damit verbundene Verfahren zum Nachweis und/oder Überwachen von Listerien
CA2896129C (en) * 2010-01-22 2015-12-29 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
EP2536849B1 (de) 2010-02-17 2016-05-11 Gen-Probe Incorporated Zusammensetzungen und verfahren für den nachweis von atopobium vaginae -nukleinsäure
ES2623859T3 (es) 2010-03-04 2017-07-12 Miacom Diagnostics Gmbh FISH múltiple mejorada
WO2011133811A2 (en) 2010-04-21 2011-10-27 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
KR20130080007A (ko) 2010-05-11 2013-07-11 다우 아그로사이언시즈 엘엘씨 Spnk 균주
US9938590B2 (en) 2010-09-16 2018-04-10 Gen-Probe Incorporated Capture probes immobilizable via L-nucleotide tail
EP2625297B1 (de) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
EP2702166B1 (de) 2011-04-25 2018-06-06 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
EP2998399A1 (de) 2011-05-03 2016-03-23 Dow AgroSciences LLC Erhöhung der spinosynherstellung mit sauerstoffbindenden proteinen
EP2753713B1 (de) 2011-09-08 2017-07-19 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
CN104136611B (zh) * 2012-02-27 2018-03-27 东丽株式会社 核酸的检测方法
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
CA2938817A1 (en) 2014-02-05 2015-08-13 Fuso Pharmaceutical Industries, Ltd. Nucleic acid detection or quantification method using mask oligonucleotide, and device for same
WO2018209068A1 (en) 2017-05-11 2018-11-15 Gen-Probe Incorporated Compositions and methods for isolating target nucleic acids
EP4058187A1 (de) 2019-11-14 2022-09-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum einfangen von zielnukleinsäuren

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
DD200432A1 (de) * 1981-09-08 1983-05-04 Werner Fleck Verfahren zur herstellung eines proteolytischen enzym-praeparates
US4717653A (en) * 1981-09-25 1988-01-05 Webster John A Jr Method for identifying and characterizing organisms
EP0756010B1 (de) * 1983-01-10 2001-07-04 Gen-Probe Incorporated Verfahren zum Nachweis, Identifizieren und Quantifizieren von Organismen und Viren
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
PT86204B (pt) * 1986-11-24 1990-11-07 Hogan James John Metodo para a preparacao de sondas de acido nucleico para a deteccao e/ou quantificacao de organismos nao-virais

Also Published As

Publication number Publication date
DE3850055T2 (de) 1994-09-29
EP0318245A2 (de) 1989-05-31
US5030557A (en) 1991-07-09
JPH02502250A (ja) 1990-07-26
FI893526A0 (fi) 1989-07-21
KR960015893B1 (ko) 1996-11-23
JP2820749B2 (ja) 1998-11-05
EP0318245B1 (de) 1994-06-08
EP0318245A3 (en) 1990-09-12
PT89050B (pt) 1993-03-31
FI893526A (fi) 1989-07-21
KR890701768A (ko) 1989-12-21
ATE106947T1 (de) 1994-06-15
CA1319336C (en) 1993-06-22
WO1989004876A1 (en) 1989-06-01
ES2056115T3 (es) 1994-10-01
PT89050A (pt) 1988-12-01

Similar Documents

Publication Publication Date Title
DE3850055T2 (de) Mittel und Verfahren zur Erhöhung der Nukleinsäure-Hybridisierung.
ATE145248T1 (de) Schnellverfahren zum nachweis und/oder zur identifizierung einer einzelbase in einer nukleinsäuresequenz und seine verwendungen
CA2194761A1 (en) Immunomodulatory oligonucleotides
DE69220946D1 (de) Verwendung von nukleinsäureanaloga in diagnostischen und analytischen verfahren
DE69109100D1 (de) Oligonukleotid-analoge.
DE69324678D1 (de) Verfahren zur typisierung von hcv-isolaten
SE8801070D0 (sv) Method for immobilizing a dna sequence on a solid support
DK1017848T3 (da) Nucleinsyresekvensanalyse
DE69732535D1 (de) Oligonucleotidzusammenstellung und verfahren zur regulierung der protein b7 expression
ATE48140T1 (de) Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung.
DE3485811T2 (de) Molekulare genetische sonde und verfahren zu ihrer herstellung, testmethode und satz in denen diese molekulare genetische sonde gebraucht wird.
SE7806087L (sv) Forfarande for rening av nukleotidsekvenser lempliga som syntetiseringsmall i bakterier, mikroorganism innefattande dylik nukleotidsekvens samt rekombinant dna-overforingsvektor innefattande dylik nukleotid
EP0286958A3 (de) Verfahren und Mittel zur Bestimmung von Nucleinsäuren
ES2092568T3 (es) Identificacion de nuevos farmacos y reactivos.
DE68910836T2 (de) In vitro mutagenese.
DE3678702D1 (de) Antitumorprotein-gen von streptococcus pyogenes su, plasmide, die das gen enthalten, transformantenzellen, die die plasmide beherbergen, und verfahren zur herstellung des antitumorproteins.
DE69019770T2 (de) Verfahren zur Reinigung, Vervielfachung und zum Nachweis einer Nukleinsäure.
ATE105871T1 (de) Verfahren zur stabilisierung der hybridisierung von komplementären polynukleotidsequenzen.
DE68916905T2 (de) Spezifische Nukleinsäurefragmente des menschlichen Villingens, ihre Anwendung für diagnostische Zwecke.
AU2782989A (en) Dna and rna molecules stabilized by modifications of the 3'-terminal phosphodiester linkage and their use as nucleic acid probes and as therapeutic agents to block the expression of specifically targeted genes
NO875058D0 (no) Oligonukleotidprober og fremgangsmaate for detektering av nukleinsyrene i bakterier og andre levende organismer ved hybridisering.
ATE98701T1 (de) Verfahren zur durchfuehrung von hybridisierungstests von nukleinsaeuren.
GB8720381D0 (en) Hybridising probe to dna/rna target
ATE55608T1 (de) Mittel und verfahren zur funktionalisierung von nukleinsaeuren.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition