DE3851187D1 - 3'-azido-2',3'-dideoxyuridin anti-retrovirale zusammensetzung. - Google Patents

3'-azido-2',3'-dideoxyuridin anti-retrovirale zusammensetzung.

Info

Publication number
DE3851187D1
DE3851187D1 DE3851187T DE3851187T DE3851187D1 DE 3851187 D1 DE3851187 D1 DE 3851187D1 DE 3851187 T DE3851187 T DE 3851187T DE 3851187 T DE3851187 T DE 3851187T DE 3851187 D1 DE3851187 D1 DE 3851187D1
Authority
DE
Germany
Prior art keywords
dideoxyuridine
azido
retroviral composition
retroviral
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3851187T
Other languages
English (en)
Inventor
Chung K Chu
Raymond F Schinazi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
University of Georgia Research Foundation Inc UGARF
Original Assignee
Emory University
University of Georgia Research Foundation Inc UGARF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University, University of Georgia Research Foundation Inc UGARF filed Critical Emory University
Application granted granted Critical
Publication of DE3851187D1 publication Critical patent/DE3851187D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
DE3851187T 1987-01-28 1988-01-13 3'-azido-2',3'-dideoxyuridin anti-retrovirale zusammensetzung. Expired - Lifetime DE3851187D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US747387A 1987-01-28 1987-01-28
US07/104,438 US4916122A (en) 1987-01-28 1987-10-02 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
PCT/US1988/000073 WO1988005657A1 (en) 1987-01-28 1988-01-13 3'-azido-2',3'-dideoxyuridine anti-retroviral composition

Publications (1)

Publication Number Publication Date
DE3851187D1 true DE3851187D1 (de) 1994-09-29

Family

ID=26677039

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3851187T Expired - Lifetime DE3851187D1 (de) 1987-01-28 1988-01-13 3'-azido-2',3'-dideoxyuridin anti-retrovirale zusammensetzung.

Country Status (14)

Country Link
US (1) US4916122A (de)
EP (1) EP0301064B1 (de)
JP (1) JPH0649652B2 (de)
AR (1) AR240251A1 (de)
AT (1) ATE110271T1 (de)
AU (1) AU606391B2 (de)
BR (1) BR8804823A (de)
CA (1) CA1313498C (de)
DE (1) DE3851187D1 (de)
ES (1) ES2009168A6 (de)
IL (1) IL85078A0 (de)
MX (1) MX167702B (de)
PT (1) PT86648B (de)
WO (1) WO1988005657A1 (de)

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US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5122517A (en) * 1988-06-10 1992-06-16 Regents Of The University Of Minnesota Antiviral combination comprising nucleoside analogs
US6911470B1 (en) 1988-09-22 2005-06-28 Raymond F. Schinazi Polyoxometalate compounds as antiviral agents
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FR2653771B1 (fr) * 1989-10-27 1994-09-23 Univ Paris Curie Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
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US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
US5583000A (en) * 1991-09-03 1996-12-10 The Regents Of The University Of California Protease-binding compounds and methods of use
FI90552C (fi) * 1991-10-09 1994-02-25 Leiras Oy Menetelmä nukleosidijohdannaisten valmistamiseksi
US6008045A (en) * 1991-11-15 1999-12-28 Board Of Trustees Of The Leland Stanford University Nucleic acid encoding human DNA polymerase α
US20050192299A1 (en) * 1992-04-16 2005-09-01 Yung-Chi Cheng Method of treating or preventing hepatitis B virus
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
CA2637774C (en) 1993-09-10 2011-07-19 Emory University Nucleosides with anti-hepatitis b virus activity
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5824706A (en) * 1994-09-26 1998-10-20 Schinazi; Raymond F. Method, compositions, and apparatus for treating and preventing respiratory viral infections
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
PT831852E (pt) 1995-06-07 2007-02-28 Uab Research Foundation Nucleósidos com actividade anti-vírus da hepatite b
WO1997006179A1 (fr) * 1995-08-04 1997-02-20 Kobayashi Perfumery Co., Ltd. Procede permettant de produire des derives d'azidonucleoside
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
AU4716299A (en) 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
US6444652B1 (en) * 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
WO2000009531A2 (en) 1998-08-10 2000-02-24 Novirio Pharmaceuticals Limited β-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HEPATITIS B
MXPA01004504A (es) 1998-11-05 2005-04-19 Centre Nat Rech Scient Nucleosidos con actividad contra virus de la hepatitis b.
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
AU2003278816A1 (en) * 2002-09-13 2004-04-30 Idenix (Cayman) Limited ss-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES
CN102014919B (zh) 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法
PA8852101A1 (es) * 2008-12-08 2010-07-27 Medivir Ab Nucleótidos uracil ciclopropílicos
CN114276359B (zh) * 2022-01-05 2023-05-05 浙江大学 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

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US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
DE2627076A1 (de) * 1976-06-16 1977-12-29 Max Planck Gesellschaft Mittel zur inhibierung des zellwachstums
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AT390000B (de) * 1985-03-16 1990-02-26 Wellcome Found Verwendung von 3'-azido-3'-desoxythymidin oder eines pharmazeutisch annehmbaren derivats hievon zur herstellung von medikamenten
GB8511774D0 (en) 1985-05-09 1985-06-19 Wellcome Found Antiviral compounds
GB8511775D0 (en) 1985-05-09 1985-06-19 Wellcome Found Antibacterial compounds
ZA867013B (en) * 1985-09-17 1988-04-27 Wellcome Found Therapeutic nucleosides
GB8523878D0 (en) 1985-09-27 1985-10-30 Wellcome Found Therapeutic compounds
ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.
GB8603719D0 (en) 1986-02-14 1986-03-19 Wellcome Found Antiviral compounds
GB8603447D0 (en) 1986-02-12 1986-03-19 Wellcome Found Therapeutic compounds
GB8608272D0 (en) 1986-04-04 1986-05-08 Wellcome Found Antiviral combination
GB8615322D0 (en) 1986-06-23 1986-07-30 Wellcome Found Antiviral combinations
US4649161A (en) * 1986-06-16 1987-03-10 Massachusetts Institute Of Technology Method for treating depression with d-fenfluramine
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses

Also Published As

Publication number Publication date
JPH01502027A (ja) 1989-07-13
AR240251A1 (es) 1990-03-30
AU606391B2 (en) 1991-02-07
EP0301064A1 (de) 1989-02-01
MX167702B (es) 1993-04-06
AU1242688A (en) 1988-08-24
US4916122A (en) 1990-04-10
EP0301064B1 (de) 1994-08-24
BR8804823A (pt) 1989-10-17
IL85078A0 (en) 1988-06-30
CA1313498C (en) 1993-02-09
PT86648A (pt) 1988-02-01
PT86648B (pt) 1991-02-08
JPH0649652B2 (ja) 1994-06-29
ATE110271T1 (de) 1994-09-15
WO1988005657A1 (en) 1988-08-11
ES2009168A6 (es) 1989-09-01

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Legal Events

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8332 No legal effect for de