DE3854904T2 - Peptide, die von der Faktor VIII-Bindungsdomäne des von Willebrand-Faktors abgeleitet sind - Google Patents

Peptide, die von der Faktor VIII-Bindungsdomäne des von Willebrand-Faktors abgeleitet sind

Info

Publication number
DE3854904T2
DE3854904T2 DE3854904T DE3854904T DE3854904T2 DE 3854904 T2 DE3854904 T2 DE 3854904T2 DE 3854904 T DE3854904 T DE 3854904T DE 3854904 T DE3854904 T DE 3854904T DE 3854904 T2 DE3854904 T2 DE 3854904T2
Authority
DE
Germany
Prior art keywords
factor
von willebrand
binding domain
factor viii
peptides derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3854904T
Other languages
English (en)
Other versions
DE3854904D1 (de
Inventor
Theodore S Zimmerman
Carol A Fulcher
Paul A Foster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of DE3854904D1 publication Critical patent/DE3854904D1/de
Application granted granted Critical
Publication of DE3854904T2 publication Critical patent/DE3854904T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
DE3854904T 1987-05-01 1988-04-27 Peptide, die von der Faktor VIII-Bindungsdomäne des von Willebrand-Faktors abgeleitet sind Expired - Lifetime DE3854904T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07045032 US5043429B1 (en) 1987-05-01 1987-05-01 Protein fragments containing factor VIII binding domain of von willebrand factor

Publications (2)

Publication Number Publication Date
DE3854904D1 DE3854904D1 (de) 1996-02-29
DE3854904T2 true DE3854904T2 (de) 1996-07-04

Family

ID=21935641

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3854904T Expired - Lifetime DE3854904T2 (de) 1987-05-01 1988-04-27 Peptide, die von der Faktor VIII-Bindungsdomäne des von Willebrand-Faktors abgeleitet sind

Country Status (9)

Country Link
US (3) US5043429B1 (de)
EP (1) EP0294025B1 (de)
JP (1) JP2631127B2 (de)
AT (1) ATE133183T1 (de)
AU (1) AU626255B2 (de)
CA (1) CA1341097C (de)
DE (1) DE3854904T2 (de)
ES (1) ES2081804T3 (de)
GR (1) GR3018870T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
US6008193A (en) * 1990-03-02 1999-12-28 Bio-Technology General Corp. Methods of using human von Willebrand factor GPIb binding domain polypeptides
US5849536A (en) * 1990-03-02 1998-12-15 Bio-Technology General Corp. Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US5530100A (en) * 1990-05-07 1996-06-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Methods for purification of recombinantly produced proteins
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
ATE283864T1 (de) * 1991-06-20 2004-12-15 Aventis Behring L L C Ein verfahren zur herstellung therapeutisch wirksamer bruchstücke von von willebrand-faktor
US5847086A (en) * 1991-06-20 1998-12-08 Centeon L.L.C. Therapeutic fragments of von Willebrand factor
WO1993021226A1 (en) * 1992-04-10 1993-10-28 The General Hospital Corporation Cartilage matrix protein and methods for use
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
DE19740310A1 (de) * 1997-09-13 1999-04-01 Octapharma Ag Peptid mit Affinität zu Gerinnungsfaktor VIII
KR100398058B1 (ko) * 2001-05-18 2003-09-19 주식회사 경동도시가스 수식된 θ-알루미나에 담지되어 이루어진 니켈계 개질촉매및 이를 이용한 천연가스로부터 합성가스의 제조방법
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
EP1789096A4 (de) * 2004-09-07 2009-07-08 Archemix Corp Aptamere für den von-willebrand-faktor und ihre verwendung als therapeutika für thrombotische erkrankungen
WO2006029258A2 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
US20090203766A1 (en) * 2007-06-01 2009-08-13 Archemix Corp. vWF aptamer formulations and methods for use
MX2012005527A (es) 2009-11-13 2012-08-08 Grifols Therapeutics Inc Preparaciones que contienen el factor de von willebrand (fvw) procedimientos, kits y aplicaciones relacionados con las mismas.
EP2652491B1 (de) 2010-12-15 2017-11-29 Baxalta GmbH Eluatsammlung mit leitfähigkeitsgradient
WO2013093760A2 (en) 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
CN109790529A (zh) 2016-06-24 2019-05-21 财团法人牧岩生命科学研究所 包含FVIII和vWF因子的嵌合蛋白及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
ATE87663T1 (de) * 1986-01-03 1993-04-15 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ- proteinen.
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor

Also Published As

Publication number Publication date
AU626255B2 (en) 1992-07-30
US5597711A (en) 1997-01-28
US5260274A (en) 1993-11-09
ES2081804T3 (es) 1996-03-16
US5260274B1 (en) 1998-01-20
EP0294025A3 (en) 1989-11-08
ATE133183T1 (de) 1996-02-15
US5043429A (en) 1991-08-27
DE3854904D1 (de) 1996-02-29
US5043429B1 (en) 1997-10-14
JPS6456697A (en) 1989-03-03
EP0294025B1 (de) 1996-01-17
EP0294025A2 (de) 1988-12-07
CA1341097C (en) 2000-09-12
JP2631127B2 (ja) 1997-07-16
AU1527188A (en) 1988-11-03
GR3018870T3 (en) 1996-05-31

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: THE SCRIPPS RESEARCH INSTITUTE, LA JOLLA, CALIF.,

8364 No opposition during term of opposition