US5258506A
(en)
*
|
1984-10-16 |
1993-11-02 |
Chiron Corporation |
Photolabile reagents for incorporation into oligonucleotide chains
|
US5430136A
(en)
*
|
1984-10-16 |
1995-07-04 |
Chiron Corporation |
Oligonucleotides having selectably cleavable and/or abasic sites
|
US5714380A
(en)
|
1986-10-23 |
1998-02-03 |
Amoco Corporation |
Closed vessel for isolating target molecules and for performing amplification
|
US6147198A
(en)
*
|
1988-09-15 |
2000-11-14 |
New York University |
Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
|
US5720928A
(en)
|
1988-09-15 |
1998-02-24 |
New York University |
Image processing and analysis of individual nucleic acid molecules
|
US5324829A
(en)
*
|
1988-12-16 |
1994-06-28 |
Ortho Diagnostic Systems, Inc. |
High specific activity nucleic acid probes having target recognition and signal generating moieties
|
US6610256B2
(en)
|
1989-04-05 |
2003-08-26 |
Wisconsin Alumni Research Foundation |
Image processing and analysis of individual nucleic acid molecules
|
US5102784A
(en)
*
|
1990-05-04 |
1992-04-07 |
Oncor, Inc. |
Restriction amplification assay
|
US5677440A
(en)
*
|
1990-07-16 |
1997-10-14 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Oligonucleotide-polyamide conjugates
|
WO1992015708A1
(en)
*
|
1991-02-27 |
1992-09-17 |
Amoco Corporation |
Methods for improving the sensitivity of hybridization assays
|
EP0610215A1
(de)
*
|
1991-06-17 |
1994-08-17 |
Chiron Corporation |
Polynukleotid-Bestimmung mit selektierbaren Spaltstellen.
|
US5294534A
(en)
*
|
1991-08-13 |
1994-03-15 |
Miles, Inc. |
Amplification method for polynucleotide assays
|
US5846717A
(en)
|
1996-01-24 |
1998-12-08 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
US5994069A
(en)
*
|
1996-01-24 |
1999-11-30 |
Third Wave Technologies, Inc. |
Detection of nucleic acids by multiple sequential invasive cleavages
|
US6872816B1
(en)
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
EP0648281A4
(de)
*
|
1991-09-10 |
1997-06-04 |
Jack D Love |
Zielgerichte amplifikation von dna und rna und signalamplifikation.
|
US5632957A
(en)
*
|
1993-11-01 |
1997-05-27 |
Nanogen |
Molecular biological diagnostic systems including electrodes
|
US6569382B1
(en)
*
|
1991-11-07 |
2003-05-27 |
Nanogen, Inc. |
Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
|
US6017696A
(en)
|
1993-11-01 |
2000-01-25 |
Nanogen, Inc. |
Methods for electronic stringency control for molecular biological analysis and diagnostics
|
US6652808B1
(en)
*
|
1991-11-07 |
2003-11-25 |
Nanotronics, Inc. |
Methods for the electronic assembly and fabrication of devices
|
GB9207380D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Compounds
|
GB9207381D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Synthesis of oligonucleotides
|
JPH07505297A
(ja)
*
|
1992-04-06 |
1995-06-15 |
アボツト・ラボラトリーズ |
内面全反射を使用して核酸または被分析物質を検出する方法及び装置
|
US5543292A
(en)
*
|
1992-06-16 |
1996-08-06 |
Hitachi, Ltd. |
Process for the measurement of nucleic acids
|
US5795714A
(en)
*
|
1992-11-06 |
1998-08-18 |
Trustees Of Boston University |
Method for replicating an array of nucleic acid probes
|
US6436635B1
(en)
*
|
1992-11-06 |
2002-08-20 |
Boston University |
Solid phase sequencing of double-stranded nucleic acids
|
US5614402A
(en)
*
|
1992-12-07 |
1997-03-25 |
Third Wave Technologies, Inc. |
5' nucleases derived from thermostable DNA polymerase
|
CA2153387A1
(en)
|
1993-01-07 |
1994-07-21 |
Hubert Koester |
Dna sequencing by mass spectrometry
|
US6194144B1
(en)
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
US5605798A
(en)
*
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
KR960700349A
(ko)
*
|
1993-01-08 |
1996-01-19 |
다알렌 반스톤 |
체액 또는 조직으로부터 추출된 합성 올리고누클레오티드의 검출방법(detection of synthetic oligonucleotides extracted from body fluids or tissues)
|
US5679510A
(en)
*
|
1993-04-27 |
1997-10-21 |
Hybridon, Inc. |
Quantitative detection of specific nucleic acid sequences using lambdoid bacteriophages linked by oligonucleotides to solid support
|
JP2842758B2
(ja)
*
|
1993-05-10 |
1999-01-06 |
株式会社日立製作所 |
自動分析装置
|
US6225059B1
(en)
|
1993-11-01 |
2001-05-01 |
Nanogen, Inc. |
Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
|
US6331274B1
(en)
|
1993-11-01 |
2001-12-18 |
Nanogen, Inc. |
Advanced active circuits and devices for molecular biological analysis and diagnostics
|
US7314708B1
(en)
*
|
1998-08-04 |
2008-01-01 |
Nanogen, Inc. |
Method and apparatus for electronic synthesis of molecular structures
|
CA2179315A1
(en)
*
|
1993-12-17 |
1995-06-22 |
Roger S. Cubicciotti |
Nucleotide-directed assembly of bimolecular and multimolecular drugs and devices
|
US20050123926A1
(en)
*
|
1994-01-13 |
2005-06-09 |
Enzo Diagnostics, Inc., |
In vitro process for producing multiple nucleic acid copies
|
US20110097791A1
(en)
*
|
1999-04-16 |
2011-04-28 |
Engelhardt Dean L |
Novel process, construct and conjugate for producing multiple nucleic acid copies
|
US6986985B1
(en)
|
1994-01-13 |
2006-01-17 |
Enzo Life Sciences, Inc. |
Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
|
US5484702A
(en)
*
|
1994-01-27 |
1996-01-16 |
Research Foundation Of The State University Of New York At Buffalo |
Method for preselecting recombinant clones containing a specific nucleic acid sequence and subsequent transformation with preselected clones
|
WO1995025538A1
(en)
*
|
1994-03-18 |
1995-09-28 |
The General Hospital Corporation |
Cleaved amplified rflp detection methods
|
US6110709A
(en)
*
|
1994-03-18 |
2000-08-29 |
The General Hospital Corporation |
Cleaved amplified modified polymorphic sequence detection methods
|
US5714330A
(en)
*
|
1994-04-04 |
1998-02-03 |
Lynx Therapeutics, Inc. |
DNA sequencing by stepwise ligation and cleavage
|
US5552278A
(en)
*
|
1994-04-04 |
1996-09-03 |
Spectragen, Inc. |
DNA sequencing by stepwise ligation and cleavage
|
US5831065A
(en)
*
|
1994-04-04 |
1998-11-03 |
Lynx Therapeutics, Inc. |
Kits for DNA sequencing by stepwise ligation and cleavage
|
US6589736B1
(en)
|
1994-11-22 |
2003-07-08 |
The Trustees Of Boston University |
Photocleavable agents and conjugates for the detection and isolation of biomolecules
|
US5876924A
(en)
*
|
1994-06-22 |
1999-03-02 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method hybridization signal amplification method (HSAM)
|
US6593086B2
(en)
|
1996-05-20 |
2003-07-15 |
Mount Sinai School Of Medicine Of New York University |
Nucleic acid amplification methods
|
US20070269799A9
(en)
*
|
1994-06-22 |
2007-11-22 |
Zhang David Y |
Nucleic acid amplification methods
|
US5942391A
(en)
*
|
1994-06-22 |
1999-08-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method: ramification-extension amplification method (RAM)
|
USRE38442E1
(en)
*
|
1994-06-22 |
2004-02-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method hybridization signal amplification method (HSAM)
|
US5552471A
(en)
*
|
1994-08-17 |
1996-09-03 |
The Perkin-Elmer Corporation |
Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
|
US5597909A
(en)
*
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
US5580731A
(en)
*
|
1994-08-25 |
1996-12-03 |
Chiron Corporation |
N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
|
US6232465B1
(en)
|
1994-09-02 |
2001-05-15 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US5808045A
(en)
*
|
1994-09-02 |
1998-09-15 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US5763594A
(en)
*
|
1994-09-02 |
1998-06-09 |
Andrew C. Hiatt |
3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
|
US6214987B1
(en)
*
|
1994-09-02 |
2001-04-10 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
|
US5990300A
(en)
*
|
1994-09-02 |
1999-11-23 |
Andrew C. Hiatt |
Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US5872244A
(en)
*
|
1994-09-02 |
1999-02-16 |
Andrew C. Hiatt |
3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
|
US6013445A
(en)
*
|
1996-06-06 |
2000-01-11 |
Lynx Therapeutics, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
US6974666B1
(en)
|
1994-10-21 |
2005-12-13 |
Appymetric, Inc. |
Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
|
US5660979A
(en)
*
|
1994-11-04 |
1997-08-26 |
Akzo Nobel N.V. |
Detection of human retrovirus infection
|
US20030104361A1
(en)
|
1997-09-29 |
2003-06-05 |
Susan Weininger |
Method of detection of nucleic acids with a specific sequence composition
|
US5871902A
(en)
*
|
1994-12-09 |
1999-02-16 |
The Gene Pool, Inc. |
Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
|
EP1260593A3
(de)
*
|
1994-12-23 |
2003-12-03 |
Dade Behring Inc. |
Nachweis von Nukleinsäuren durch Nuklease-katalysierte Produktbildung
|
EP0724015B1
(de)
*
|
1995-01-12 |
2004-03-31 |
Toyo Boseki Kabushiki Kaisha |
Neue alkalische Phosphatase, deren Herstellung und Verwendung
|
US5559000A
(en)
*
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
US6428955B1
(en)
|
1995-03-17 |
2002-08-06 |
Sequenom, Inc. |
DNA diagnostics based on mass spectrometry
|
US8142708B2
(en)
*
|
1995-04-03 |
2012-03-27 |
Wisconsin Alumni Research Foundation |
Micro fluidic system for single molecule imaging
|
US7775368B2
(en)
*
|
1995-04-03 |
2010-08-17 |
Wisconsin Alumni Research Foundation |
Micro-channel long molecule manipulation system
|
JP4511636B2
(ja)
|
1995-04-03 |
2010-07-28 |
ウィスコンシン アルムニ リサーチ ファウンデーション |
顕微鏡的イメージングにより核酸の物理的特性を測定する方法
|
US20060063193A1
(en)
*
|
1995-04-11 |
2006-03-23 |
Dong-Jing Fu |
Solid phase sequencing of double-stranded nucleic acids
|
US7803529B1
(en)
*
|
1995-04-11 |
2010-09-28 |
Sequenom, Inc. |
Solid phase sequencing of biopolymers
|
US5750341A
(en)
*
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
US5830655A
(en)
*
|
1995-05-22 |
1998-11-03 |
Sri International |
Oligonucleotide sizing using cleavable primers
|
US5700642A
(en)
*
|
1995-05-22 |
1997-12-23 |
Sri International |
Oligonucleotide sizing using immobilized cleavable primers
|
US6027879A
(en)
*
|
1995-08-09 |
2000-02-22 |
The Regents Of The University Of California |
Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe
|
US6146854A
(en)
*
|
1995-08-31 |
2000-11-14 |
Sequenom, Inc. |
Filtration processes, kits and devices for isolating plasmids
|
US5747255A
(en)
*
|
1995-09-29 |
1998-05-05 |
Lynx Therapeutics, Inc. |
Polynucleotide detection by isothermal amplification using cleavable oligonucleotides
|
US6849398B1
(en)
|
1996-01-18 |
2005-02-01 |
The Scripps Research Institute |
Use of encoded reaction cassette
|
US6027890A
(en)
*
|
1996-01-23 |
2000-02-22 |
Rapigene, Inc. |
Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
|
US6613508B1
(en)
*
|
1996-01-23 |
2003-09-02 |
Qiagen Genomics, Inc. |
Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
|
EP0992511B1
(de)
*
|
1996-01-23 |
2009-03-11 |
Operon Biotechnologies, Inc. |
Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen
|
US6312893B1
(en)
*
|
1996-01-23 |
2001-11-06 |
Qiagen Genomics, Inc. |
Methods and compositions for determining the sequence of nucleic acid molecules
|
DE69739465D1
(de)
*
|
1996-01-23 |
2009-07-30 |
Operon Biotechnologies Inc |
Methoden zur Analyse von Nukleinsäure-Molekülen mittels Techniken zur Grössen-bestimmung
|
BR9707060A
(pt)
*
|
1996-01-23 |
1999-12-28 |
Rapigene Inc |
Métodos e composições para detectar o ligamento de par ligante usando indicador não-fluorescente.
|
CA2243560A1
(en)
*
|
1996-01-23 |
1997-07-31 |
Rapigene, Inc. |
Methods and compositions for determining the sequence of nucleic acid molecules
|
US7195871B2
(en)
*
|
1996-01-24 |
2007-03-27 |
Third Wave Technologies, Inc |
Methods and compositions for detecting target sequences
|
US7432048B2
(en)
*
|
1996-11-29 |
2008-10-07 |
Third Wave Technologies, Inc. |
Reactions on a solid surface
|
US6875572B2
(en)
|
1996-01-24 |
2005-04-05 |
Third Wave Technologies, Inc. |
Nucleic acid detection assays
|
US6090606A
(en)
*
|
1996-01-24 |
2000-07-18 |
Third Wave Technologies, Inc. |
Cleavage agents
|
US20080160524A1
(en)
*
|
1996-01-24 |
2008-07-03 |
Third Wave Technologies, Inc. |
Methods and Compositions for Detecting Target Sequences
|
US5985557A
(en)
*
|
1996-01-24 |
1999-11-16 |
Third Wave Technologies, Inc. |
Invasive cleavage of nucleic acids
|
US7122364B1
(en)
*
|
1998-03-24 |
2006-10-17 |
Third Wave Technologies, Inc. |
FEN endonucleases
|
US6706471B1
(en)
|
1996-01-24 |
2004-03-16 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
US7527928B2
(en)
*
|
1996-11-29 |
2009-05-05 |
Third Wave Technologies, Inc. |
Reactions on a solid surface
|
CA2243353C
(en)
*
|
1996-01-24 |
2010-03-30 |
Third Wave Technologies, Inc. |
Invasive cleavage of nucleic acids
|
WO1997027206A1
(en)
*
|
1996-01-26 |
1997-07-31 |
Codon Pharmaceuticals, Inc. |
Oligonucleotide analogs
|
US5824478A
(en)
*
|
1996-04-30 |
1998-10-20 |
Vysis, Inc. |
Diagnostic methods and probes
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
JP2002514046A
(ja)
*
|
1996-07-08 |
2002-05-14 |
バースタイン テクノロジーズ,インコーポレイティド |
切断可能なシグナル因子の装置および方法
|
US6342349B1
(en)
*
|
1996-07-08 |
2002-01-29 |
Burstein Technologies, Inc. |
Optical disk-based assay devices and methods
|
US6780982B2
(en)
*
|
1996-07-12 |
2004-08-24 |
Third Wave Technologies, Inc. |
Charge tags and the separation of nucleic acid molecules
|
US5858665A
(en)
*
|
1996-07-25 |
1999-01-12 |
Navix, Inc. |
Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
|
US5853990A
(en)
|
1996-07-26 |
1998-12-29 |
Edward E. Winger |
Real time homogeneous nucleotide assay
|
US6352827B1
(en)
*
|
1996-08-28 |
2002-03-05 |
President And Fellows Of Harvard College |
Detection of multiple nucleic acid sequences in a fluid sample
|
US5777324A
(en)
|
1996-09-19 |
1998-07-07 |
Sequenom, Inc. |
Method and apparatus for maldi analysis
|
US6140053A
(en)
*
|
1996-11-06 |
2000-10-31 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry via exonuclease degradation
|
US5900481A
(en)
*
|
1996-11-06 |
1999-05-04 |
Sequenom, Inc. |
Bead linkers for immobilizing nucleic acids to solid supports
|
US7285422B1
(en)
*
|
1997-01-23 |
2007-10-23 |
Sequenom, Inc. |
Systems and methods for preparing and analyzing low volume analyte array elements
|
US6024925A
(en)
|
1997-01-23 |
2000-02-15 |
Sequenom, Inc. |
Systems and methods for preparing low volume analyte array elements
|
EP1164203B1
(de)
|
1996-11-06 |
2007-10-10 |
Sequenom, Inc. |
DNA-Diagnostik mittels Massenspektrometrie
|
US6133436A
(en)
*
|
1996-11-06 |
2000-10-17 |
Sequenom, Inc. |
Beads bound to a solid support and to nucleic acids
|
DE69727489T2
(de)
|
1996-11-06 |
2004-11-25 |
Sequenom, Inc., San Diego |
Verfahren zur massenspektrometrie
|
ES2375764T3
(es)
|
1996-11-29 |
2012-03-06 |
Third Wave Technologies, Inc. |
Endonucleasas fen-1, mezclas y procedimientos de escisión.
|
US6706473B1
(en)
|
1996-12-06 |
2004-03-16 |
Nanogen, Inc. |
Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
|
DE69735445T2
(de)
*
|
1996-12-10 |
2006-08-10 |
Sequenom, Inc., San Diego |
Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
|
US5905024A
(en)
*
|
1996-12-17 |
1999-05-18 |
University Of Chicago |
Method for performing site-specific affinity fractionation for use in DNA sequencing
|
WO1998037238A2
(en)
*
|
1997-02-21 |
1998-08-27 |
Burstein Laboratories, Inc. |
Gene sequencer and methods
|
US5846726A
(en)
*
|
1997-05-13 |
1998-12-08 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
AU737771B2
(en)
*
|
1997-05-21 |
2001-08-30 |
Gesellschaft Fur Biotechnologische Forschung Mbh |
Method and kit for the detection of mutations in DNA's using restriction enzymes
|
US5928869A
(en)
*
|
1997-05-30 |
1999-07-27 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
DK0990047T3
(da)
*
|
1997-07-22 |
2003-09-15 |
Qiagen Genomics Inc |
Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometri
|
US6365731B1
(en)
|
1997-08-06 |
2002-04-02 |
Ambion, Inc. |
Stripping nucleic acids with iodine and sodium thiosulfate
|
US5955378A
(en)
*
|
1997-08-20 |
1999-09-21 |
Challener; William A. |
Near normal incidence optical assaying method and system having wavelength and angle sensitivity
|
US6207370B1
(en)
|
1997-09-02 |
2001-03-27 |
Sequenom, Inc. |
Diagnostics based on mass spectrometric detection of translated target polypeptides
|
US8182991B1
(en)
|
1997-11-26 |
2012-05-22 |
Third Wave Technologies, Inc. |
FEN-1 endonucleases, mixtures and cleavage methods
|
US6268131B1
(en)
|
1997-12-15 |
2001-07-31 |
Sequenom, Inc. |
Mass spectrometric methods for sequencing nucleic acids
|
GB9815163D0
(en)
*
|
1998-07-13 |
1998-09-09 |
Brax Genomics Ltd |
Compounds
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
CA2320462A1
(en)
*
|
1998-02-09 |
1999-08-12 |
Toyo Kohan Co., Ltd. |
Substrates for immobilizing and amplifying dna, dna-immobilized chips having dna immobilized on the substrates, and method for amplifying dna
|
US6723564B2
(en)
|
1998-05-07 |
2004-04-20 |
Sequenom, Inc. |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
|
US6221592B1
(en)
|
1998-10-20 |
2001-04-24 |
Wisconsin Alumi Research Foundation |
Computer-based methods and systems for sequencing of individual nucleic acid molecules
|
US6607888B2
(en)
|
1998-10-20 |
2003-08-19 |
Wisconsin Alumni Research Foundation |
Method for analyzing nucleic acid reactions
|
US20020025519A1
(en)
|
1999-06-17 |
2002-02-28 |
David J. Wright |
Methods and oligonucleotides for detecting nucleic acid sequence variations
|
US6201112B1
(en)
*
|
1999-07-22 |
2001-03-13 |
Agilent Technologies Inc. |
Method for 3′ end-labeling ribonucleic acids
|
US6528319B1
(en)
*
|
1999-09-02 |
2003-03-04 |
Amersham Biosciences Corp |
Method for anchoring oligonucleotides to a substrate
|
US6893819B1
(en)
*
|
2000-11-21 |
2005-05-17 |
Stratagene California |
Methods for detection of a nucleic acid by sequential amplification
|
US7118860B2
(en)
|
1999-10-29 |
2006-10-10 |
Stratagene California |
Methods for detection of a target nucleic acid by capture
|
US7838225B2
(en)
*
|
1999-10-29 |
2010-11-23 |
Hologic, Inc. |
Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
|
US7824859B2
(en)
*
|
1999-10-29 |
2010-11-02 |
Cytyc Corporation |
Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
|
JP2001204463A
(ja)
*
|
2000-01-27 |
2001-07-31 |
Toyo Kohan Co Ltd |
ヌクレオチド固定用担体
|
AU2001247697B2
(en)
*
|
2000-03-22 |
2006-06-22 |
Solulink, Incorporated |
Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
|
US8288322B2
(en)
|
2000-04-17 |
2012-10-16 |
Dyax Corp. |
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
|
ES2531551T3
(es)
*
|
2000-04-17 |
2015-03-17 |
Dyax Corp. |
Métodos para construir bibliotecas de presentación de paquetes genéticos para miembros de una familia diversa de péptido
|
ATE423221T1
(de)
*
|
2000-06-13 |
2009-03-15 |
Univ Boston |
Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
|
US20060057565A1
(en)
*
|
2000-09-11 |
2006-03-16 |
Jingyue Ju |
Combinatorial fluorescence energy transfer tags and uses thereof
|
US6627748B1
(en)
|
2000-09-11 |
2003-09-30 |
The Trustees Of Columbia University In The City Of New York |
Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
|
US7829348B2
(en)
*
|
2000-09-22 |
2010-11-09 |
Iowa State University Research Foundation, Inc. |
Raman-active reagents and the use thereof
|
AU2433602A
(en)
|
2000-09-25 |
2002-04-02 |
Picoliter Inc |
Acoustic ejection of fluids from a plurality of reservoirs
|
DE60138916D1
(de)
|
2000-09-26 |
2009-07-16 |
Boston Probes Inc |
Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
|
AU2001296645A1
(en)
|
2000-10-06 |
2002-04-15 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding dna and rna
|
US9708358B2
(en)
|
2000-10-06 |
2017-07-18 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
US20020142483A1
(en)
|
2000-10-30 |
2002-10-03 |
Sequenom, Inc. |
Method and apparatus for delivery of submicroliter volumes onto a substrate
|
AU2001297524A1
(en)
*
|
2000-11-15 |
2002-09-19 |
Third Wave Technologies, Inc. |
Fen endonucleases
|
WO2002061071A2
(en)
|
2000-12-18 |
2002-08-08 |
Dyax Corp. |
Focused libraries of genetic packages
|
KR20020063359A
(ko)
*
|
2001-01-27 |
2002-08-03 |
일렉트론 바이오 (주) |
핵산 및 올리거뉴클레오티드의 상보적 이중결합의 특정서열에 특이적으로 반응하는 절단기법을 이용한 핵산 혼성분석 방법 및 장치
|
ES2441412T3
(es)
*
|
2001-03-09 |
2014-02-04 |
Trovagene, Inc. |
Sondas conjugadas y detección óptica de analitos
|
AU2013205033B2
(en)
*
|
2001-04-17 |
2016-06-09 |
Takeda Pharmaceutical Company Limited |
Novel Methods of Constructing Libraries Comprising Displayed and/or Expressed Members of a Diverse Family of Peptides, Polypeptides or Proteins and the Novel Libraries
|
US6534646B2
(en)
*
|
2001-06-04 |
2003-03-18 |
Barrskogen, Inc. |
Oligonucleotide labeling reagents
|
US6893822B2
(en)
|
2001-07-19 |
2005-05-17 |
Nanogen Recognomics Gmbh |
Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
|
US20050147984A1
(en)
*
|
2001-08-31 |
2005-07-07 |
Clondiag Chip Technologies Gmbh |
Interaction detection on several probe arrays
|
AU2002364945A1
(en)
*
|
2001-10-25 |
2003-07-09 |
Neurogenetics, Inc. |
Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
|
US20030224380A1
(en)
*
|
2001-10-25 |
2003-12-04 |
The General Hospital Corporation |
Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
|
US20030170678A1
(en)
*
|
2001-10-25 |
2003-09-11 |
Neurogenetics, Inc. |
Genetic markers for Alzheimer's disease and methods using the same
|
US7057026B2
(en)
*
|
2001-12-04 |
2006-06-06 |
Solexa Limited |
Labelled nucleotides
|
GB0129012D0
(en)
|
2001-12-04 |
2002-01-23 |
Solexa Ltd |
Labelled nucleotides
|
DE10200374A1
(de)
*
|
2002-01-08 |
2003-07-24 |
Friz Biochem Gmbh |
Verfahren zur qualitativ und quantitativ vergleichenden Detektion chemischer Substanzen
|
DE10201463B4
(de)
|
2002-01-16 |
2005-07-21 |
Clondiag Chip Technologies Gmbh |
Reaktionsgefäß zur Durchführung von Array-Verfahren
|
DE10224825A1
(de)
*
|
2002-06-05 |
2003-12-24 |
Eppendorf Ag |
Verfahren zur Analyse von Biomolekülen
|
US7074597B2
(en)
*
|
2002-07-12 |
2006-07-11 |
The Trustees Of Columbia University In The City Of New York |
Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
|
US20040067532A1
(en)
*
|
2002-08-12 |
2004-04-08 |
Genetastix Corporation |
High throughput generation and affinity maturation of humanized antibody
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
US11008359B2
(en)
|
2002-08-23 |
2021-05-18 |
Illumina Cambridge Limited |
Labelled nucleotides
|
EP3002289B1
(de)
*
|
2002-08-23 |
2018-02-28 |
Illumina Cambridge Limited |
Modifizierte nukleotide zur polynukleotidsequenzierung
|
WO2004022578A2
(en)
*
|
2002-09-08 |
2004-03-18 |
Applera Corporation |
Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
|
AU2003297859A1
(en)
*
|
2002-12-13 |
2004-07-09 |
The Trustees Of Columbia University In The City Of New York |
Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
|
CA2520538C
(en)
|
2003-03-31 |
2014-04-29 |
F. Hoffmann-La Roche Ag |
Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
|
US7158353B2
(en)
*
|
2003-11-06 |
2007-01-02 |
Seagate Technology Llc |
Magnetoresistive sensor having specular sidewall layers
|
US7667024B2
(en)
*
|
2003-11-19 |
2010-02-23 |
Allelogic Biosciences Corp. |
Oligonucleotides labeled with a plurality of fluorophores
|
CA2557661A1
(en)
*
|
2004-02-28 |
2005-09-15 |
Chang-Ning J. Wang |
Nucleic acid complexes
|
EP2436778A3
(de)
*
|
2004-03-03 |
2012-07-11 |
The Trustees of Columbia University in the City of New York |
Photospaltbare fluoreszierende Nukleotide zur DNA-Sequenzierung auf einem durch ortsspezifische Kopplungschemie konstruierten Chip
|
WO2006073436A2
(en)
*
|
2004-04-29 |
2006-07-13 |
The Trustees Of Columbia University In The City Of New York |
Mass tag pcr for multiplex diagnostics
|
US7939251B2
(en)
|
2004-05-06 |
2011-05-10 |
Roche Molecular Systems, Inc. |
SENP1 as a marker for cancer
|
WO2005118871A1
(en)
*
|
2004-05-28 |
2005-12-15 |
The Arizona Board Of Regents |
Surface plasmon resonance sensor for detecting changes in polynucleotides mass
|
US7828954B2
(en)
*
|
2004-09-21 |
2010-11-09 |
Gamida For Life B.V. |
Electrode based patterning of thin film self-assembled nanoparticles
|
EP1672082B1
(de)
*
|
2004-10-08 |
2009-12-16 |
Sysmex Corporation |
Verfahren zum Nachweis einer Zielsubstanz unter Verwendung einer Nukleinsäuresonde
|
JP2008520616A
(ja)
*
|
2004-11-24 |
2008-06-19 |
アプラーゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング |
固相ペプチド合成および精製方法
|
EP1844162B1
(de)
|
2005-02-01 |
2014-10-15 |
Applied Biosystems, LLC |
vERFAHREN ZUR SEQUENZBESTIMMUNG IN EINEM POLYNUKLEOTID
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
WO2007002204A2
(en)
|
2005-06-21 |
2007-01-04 |
The Trustees Of Columbia University In The City Of New York |
Pyrosequencing methods and related compostions
|
GB0517097D0
(en)
|
2005-08-19 |
2005-09-28 |
Solexa Ltd |
Modified nucleosides and nucleotides and uses thereof
|
US20090088332A1
(en)
*
|
2005-11-21 |
2009-04-02 |
Jingyue Ju |
Multiplex Digital Immuno-Sensing Using a Library of Photocleavable Mass Tags
|
KR100652903B1
(ko)
*
|
2005-12-21 |
2006-12-04 |
한국과학기술연구원 |
초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
|
AU2007237909A1
(en)
*
|
2006-04-19 |
2007-10-25 |
Applied Biosystems, Llc. |
Reagents, methods, and libraries for gel-free bead-based sequencing
|
US7674924B2
(en)
|
2006-05-22 |
2010-03-09 |
Third Wave Technologies, Inc. |
Compositions, probes, and conjugates and uses thereof
|
EP2071927A2
(de)
|
2006-09-28 |
2009-06-24 |
Illumina, Inc. |
Zusammensetzungen und verfahren zur nukleotidsequenzierung
|
US7883869B2
(en)
|
2006-12-01 |
2011-02-08 |
The Trustees Of Columbia University In The City Of New York |
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
|
US20090017562A1
(en)
*
|
2007-03-13 |
2009-01-15 |
Iowa State University Research Foundation, Inc. |
Raman-active reagents
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
WO2009036379A2
(en)
*
|
2007-09-14 |
2009-03-19 |
Adimab, Inc. |
Rationally designed, synthetic antibody libraries and uses therefor
|
US20090180931A1
(en)
|
2007-09-17 |
2009-07-16 |
Sequenom, Inc. |
Integrated robotic sample transfer device
|
EP2940029B1
(de)
|
2007-10-19 |
2023-11-29 |
The Trustees of Columbia University in the City of New York |
Design und synthese von spaltbaren fluoreszierenden nukleotiden als reversible terminatoren zur dna-sequenzierung durch synthese
|
EP2725107B1
(de)
|
2007-10-19 |
2018-08-29 |
The Trustees of Columbia University in the City of New York |
DNA-Sequenzierung mit nichtfluoreszierenden, reversiblen Nukleotidterminatoren und spaltbaren, fluoreszierenden ddNTPs und Nukleinsäuren die Inosine mit reversiblen Terminatorgruppe
|
US20090215050A1
(en)
*
|
2008-02-22 |
2009-08-27 |
Robert Delmar Jenison |
Systems and methods for point-of-care amplification and detection of polynucleotides
|
WO2009114815A1
(en)
|
2008-03-13 |
2009-09-17 |
Dyax Corp |
Libraries of genetic packages comprising novel hc cdr3 designs
|
US20090253142A1
(en)
*
|
2008-03-15 |
2009-10-08 |
Hologic, Inc. |
Compositions and methods for analysis of nucleic acid molecules during amplification reactions
|
EP2281078B1
(de)
*
|
2008-04-24 |
2014-10-22 |
Dyax Corporation |
Bibliotheken von genetischen packungen, umfassend neue hc-cdr1, -cdr2, und -cdr3, und neue lc-cdr1-, -cdr2- und -cdr3-designs
|
US8208909B2
(en)
|
2008-06-02 |
2012-06-26 |
West Corporation |
System, apparatus and method for availing a mobile call of address information
|
CA2773564A1
(en)
*
|
2009-09-14 |
2011-03-17 |
Dyax Corp. |
Libraries of genetic packages comprising novel hc cdr3 designs
|
EP2534266B1
(de)
*
|
2010-02-12 |
2016-07-06 |
Saint Louis University |
Molekulare biosensoren zur signalverstärkung
|
EP2561098B1
(de)
*
|
2010-04-23 |
2015-09-09 |
Australian Centre for Plant Functional Genomics Pty Ltd. |
Durch verankerte enzyme vermittelte nukleinsäureerkennung
|
DK3741883T3
(da)
|
2010-07-16 |
2023-02-20 |
Adimab Llc |
Antistofbiblioteker
|
JP5916732B2
(ja)
*
|
2010-09-20 |
2016-05-11 |
シージーン アイエヌシー |
単一標識固定化プローブ及びエキソ核酸切断活性を利用した固相におけるターゲット核酸配列検出
|
EP2710144B1
(de)
|
2011-05-19 |
2020-10-07 |
Agena Bioscience, Inc. |
Verfahren zur multiplex-identifizierung von nukleinsäuren
|
DK2970356T3
(en)
|
2013-03-15 |
2018-08-27 |
Illumina Cambridge Ltd |
Modified nucleosides or nucleotides
|
US10648026B2
(en)
|
2013-03-15 |
2020-05-12 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
DK3030682T3
(da)
|
2013-08-05 |
2020-09-14 |
Twist Bioscience Corp |
De novo synthesized gene libraries
|
US10669304B2
(en)
|
2015-02-04 |
2020-06-02 |
Twist Bioscience Corporation |
Methods and devices for de novo oligonucleic acid assembly
|
WO2016172377A1
(en)
|
2015-04-21 |
2016-10-27 |
Twist Bioscience Corporation |
Devices and methods for oligonucleic acid library synthesis
|
CN107406882B
(zh)
|
2015-04-24 |
2022-03-01 |
基纳生物技术有限公司 |
用于次要等位基因和多态性的鉴定和定量的多重化方法
|
CN107787371B
(zh)
|
2015-04-24 |
2022-02-01 |
基纳生物技术有限公司 |
检测和定量次要变体的并行式方法
|
WO2017049231A1
(en)
|
2015-09-18 |
2017-03-23 |
Twist Bioscience Corporation |
Oligonucleic acid variant libraries and synthesis thereof
|
US11512347B2
(en)
|
2015-09-22 |
2022-11-29 |
Twist Bioscience Corporation |
Flexible substrates for nucleic acid synthesis
|
CA3006867A1
(en)
|
2015-12-01 |
2017-06-08 |
Twist Bioscience Corporation |
Functionalized surfaces and preparation thereof
|
EP3500672A4
(de)
|
2016-08-22 |
2020-05-20 |
Twist Bioscience Corporation |
De-novo-synthetisierte nukleinsäure-bibliotheken
|
US10417457B2
(en)
|
2016-09-21 |
2019-09-17 |
Twist Bioscience Corporation |
Nucleic acid based data storage
|
WO2018066713A1
(ja)
*
|
2016-10-07 |
2018-04-12 |
地方独立行政法人神奈川県立産業技術総合研究所 |
核酸の検出方法及びそのためのキット
|
EP3554514A4
(de)
|
2016-12-16 |
2020-08-05 |
Twist Bioscience Corporation |
Variante bibliotheken der immunologischen synapse und synthese davon
|
EP3586255A4
(de)
|
2017-02-22 |
2021-03-31 |
Twist Bioscience Corporation |
Nukleinsäurebasierte datenspeicherung
|
WO2018170169A1
(en)
|
2017-03-15 |
2018-09-20 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
AU2018284227A1
(en)
|
2017-06-12 |
2020-01-30 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
WO2018231864A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
KR20200047706A
(ko)
|
2017-09-11 |
2020-05-07 |
트위스트 바이오사이언스 코포레이션 |
Gpcr 결합 단백질 및 이의 합성 방법
|
SG11202003574TA
(en)
|
2017-10-20 |
2020-05-28 |
Twist Bioscience Corp |
Heated nanowells for polynucleotide synthesis
|
CA3088911A1
(en)
|
2018-01-04 |
2019-07-11 |
Twist Bioscience Corporation |
Dna-based digital information storage
|
WO2019222706A1
(en)
|
2018-05-18 |
2019-11-21 |
Twist Bioscience Corporation |
Polynucleotides, reagents, and methods for nucleic acid hybridization
|
WO2020176680A1
(en)
|
2019-02-26 |
2020-09-03 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for antibody optimization
|
US11492727B2
(en)
|
2019-02-26 |
2022-11-08 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for GLP1 receptor
|
CN114729342A
(zh)
|
2019-06-21 |
2022-07-08 |
特韦斯特生物科学公司 |
基于条形码的核酸序列装配
|