DE3855325T2 - Oxothiolane und Derivate, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Arzneimittel - Google Patents

Oxothiolane und Derivate, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Arzneimittel

Info

Publication number
DE3855325T2
DE3855325T2 DE3855325T DE3855325T DE3855325T2 DE 3855325 T2 DE3855325 T2 DE 3855325T2 DE 3855325 T DE3855325 T DE 3855325T DE 3855325 T DE3855325 T DE 3855325T DE 3855325 T2 DE3855325 T2 DE 3855325T2
Authority
DE
Germany
Prior art keywords
hydrogen
group
sec
aminoalkyl
hydroxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3855325T
Other languages
English (en)
Other versions
DE3855325D1 (de
Inventor
Abraham Fisher
Ishai Karton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
State of Israel
Original Assignee
State of Israel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by State of Israel filed Critical State of Israel
Publication of DE3855325D1 publication Critical patent/DE3855325D1/de
Application granted granted Critical
Publication of DE3855325T2 publication Critical patent/DE3855325T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE3855325T 1987-10-28 1988-10-26 Oxothiolane und Derivate, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Arzneimittel Expired - Lifetime DE3855325T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11447387A 1987-10-28 1987-10-28
US07/189,210 US4876260A (en) 1987-10-28 1988-05-02 Oxathiolanes

Publications (2)

Publication Number Publication Date
DE3855325D1 DE3855325D1 (de) 1996-07-04
DE3855325T2 true DE3855325T2 (de) 1996-10-10

Family

ID=26812231

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855325T Expired - Lifetime DE3855325T2 (de) 1987-10-28 1988-10-26 Oxothiolane und Derivate, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Arzneimittel

Country Status (13)

Country Link
US (1) US4876260A (de)
EP (1) EP0314444B1 (de)
JP (1) JP2753280B2 (de)
KR (1) KR910007979B1 (de)
AT (1) ATE138663T1 (de)
AU (1) AU608903B2 (de)
CA (1) CA1315791C (de)
DE (1) DE3855325T2 (de)
DK (1) DK175064B1 (de)
ES (1) ES2087854T3 (de)
IL (1) IL87834A (de)
NO (1) NO167806C (de)
NZ (1) NZ226415A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
JP2683783B2 (ja) * 1992-07-10 1997-12-03 雪印乳業株式会社 シェーグレン症候群治療剤
DE4343838C2 (de) * 1993-12-22 1998-07-09 Lohmann Therapie Syst Lts Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung
US6572880B2 (en) 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US6290986B1 (en) 1996-10-24 2001-09-18 Pharmaceutical Applications Associates, Llc Method and composition for transdermal administration of pharmacologic agents
US6479074B2 (en) 1996-10-24 2002-11-12 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
NZ500643A (en) 1997-05-30 2001-12-21 Neurosearch As Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators
US20040209849A1 (en) * 1998-11-27 2004-10-21 Sanochemia Pharmazeutika Aktiengesellschaft Use of effectors of the central cholinergic nervous system for treatment of delirium
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
US6433168B1 (en) 1999-07-26 2002-08-13 Sumika Fine Chemicals Co., Ltd. Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
EP2320661B8 (de) 2001-11-29 2015-09-02 Godo Kaisha IP Bridge 1 Entfernungsverfahren für die Codierungsverzerrung
MXPA04010921A (es) * 2002-05-03 2005-05-27 Israel Inst Biolog Res Metodos y composiciones para el tratamietno de trastornos del sistema nervioso central y periferico y compuestos novedosos utiles para los mismos.
JP2009541342A (ja) * 2006-06-20 2009-11-26 ワイス Ｋｖ１．５カリウムチャネル阻害剤
US8143400B2 (en) * 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
PE20110777A1 (es) * 2008-11-23 2011-10-29 Pfizer Nuevas lactamas como inhibidores de beta secretasa
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
BRPI1007350B8 (pt) 2009-01-26 2021-05-25 Israel Institute For Biological Res compostos espiro heterocíclicos bicíclicos
CN101798311A (zh) * 2010-04-07 2010-08-11 天津炜杰凯华科技有限公司 顺式西维美林的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2146962A1 (en) * 1971-07-28 1973-03-09 Yoshitomi Pharmaceutical Aza-spirodecanones - useful in treating gastric disorders
IL48453A (en) * 1975-11-11 1980-06-30 Purdue Frederick Co Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
IL48452A (en) * 1975-11-11 1979-07-25 Purdue Frederick Co Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
US4855290A (en) * 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
ZA868369B (en) * 1986-01-10 1987-11-25 Israel State Derivatives of quinuclidine
IL87234A (en) * 1987-08-13 1992-02-16 Israel Inst Biolog Res Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR890006641A (ko) 1989-06-15
NO167806B (no) 1991-09-02
NZ226415A (en) 1990-05-28
NO884790L (no) 1989-05-02
EP0314444A2 (de) 1989-05-03
EP0314444A3 (en) 1990-11-07
US4876260A (en) 1989-10-24
ATE138663T1 (de) 1996-06-15
ES2087854T3 (es) 1996-08-01
DE3855325D1 (de) 1996-07-04
JP2753280B2 (ja) 1998-05-18
AU2367188A (en) 1989-05-04
CA1315791C (en) 1993-04-06
NO167806C (no) 1991-12-11
NO884790D0 (no) 1988-10-27
EP0314444B1 (de) 1996-05-29
KR910007979B1 (ko) 1991-10-05
DK598688A (da) 1989-04-29
DK598688D0 (da) 1988-10-27
DK175064B1 (da) 2004-05-17
IL87834A0 (en) 1989-03-31
JPH0262883A (ja) 1990-03-02
IL87834A (en) 1992-05-25
AU608903B2 (en) 1991-04-18

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Legal Events

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