DE50212548D1 - Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall - Google Patents

Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall

Info

Publication number: DE50212548D1
Authority: DE; Germany
Prior art keywords: stroke; treatment; plasminogic; neurotoxic; activating factors
Prior art date: 2001-11-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE50212548T

Other languages

English (en)

Inventor

Mariola Soehngen

Wolfgang Soehngen

Wolf-Dieter Schleuning

Robert Medcalf

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

H Lundbeck AS

Original Assignee

Paion Deutschland GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-02

Filing date

2002-10-31

Publication date

2008-09-04

2002-10-31 Application filed by Paion Deutschland GmbH filed Critical Paion Deutschland GmbH

2008-09-04 Application granted granted Critical

2008-09-04 Publication of DE50212548D1 publication Critical patent/DE50212548D1/de

2022-11-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000003213 activating effect Effects 0.000 title abstract 2
231100000501 nonneurotoxic Toxicity 0.000 title 1
208000035404 Autolysis Diseases 0.000 abstract 2
206010057248 Cell death Diseases 0.000 abstract 2
102000003978 Tissue Plasminogen Activator Human genes 0.000 abstract 2
108090000373 Tissue Plasminogen Activator Proteins 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000028043 self proteolysis Effects 0.000 abstract 2
229960000187 tissue plasminogen activator Drugs 0.000 abstract 2
102000009123 Fibrin Human genes 0.000 abstract 1
108010073385 Fibrin Proteins 0.000 abstract 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
102000013566 Plasminogen Human genes 0.000 abstract 1
108010051456 Plasminogen Proteins 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000001966 cerebroprotective effect Effects 0.000 abstract 1
229950003499 fibrin Drugs 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229960005356 urokinase Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

DE50212548T 2001-11-02 2002-10-31 Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall Expired - Lifetime DE50212548D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10153601A DE10153601A1 (de)	2001-11-02	2001-11-02	DSPA zur Behandlung von Schlaganfall
EP01130006A EP1308166B1 (de)	2001-11-02	2001-12-17	Nicht-neurotoxische Plasminogen Aktivierende Faktoren zur Behandlung von Schlaganfällen
PCT/EP2002/012204 WO2003037363A2 (de)	2001-11-02	2002-10-31	Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall

Publications (1)

Publication Number	Publication Date
DE50212548D1 true DE50212548D1 (de)	2008-09-04

Family

ID=7704253

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE10153601A Ceased DE10153601A1 (de)	2001-11-02	2001-11-02	DSPA zur Behandlung von Schlaganfall
DE50115077T Expired - Lifetime DE50115077D1 (de)	2001-11-02	2001-12-17	Nicht-neurotoxische Plasminogen Aktivierende Faktoren zur Behandlung von Schlaganfällen
DE50212548T Expired - Lifetime DE50212548D1 (de)	2001-11-02	2002-10-31	Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DE10153601A Ceased DE10153601A1 (de)	2001-11-02	2001-11-02	DSPA zur Behandlung von Schlaganfall
DE50115077T Expired - Lifetime DE50115077D1 (de)	2001-11-02	2001-12-17	Nicht-neurotoxische Plasminogen Aktivierende Faktoren zur Behandlung von Schlaganfällen

Country Status (27)

Country	Link
US (7)	US20050048027A1 (de)
EP (4)	EP1308166B1 (de)
JP (2)	JP5004407B2 (de)
KR (3)	KR20070087248A (de)
CN (2)	CN101156948A (de)
AT (3)	ATE440614T1 (de)
AU (1)	AU2002350660C1 (de)
BR (1)	BR0213856A (de)
CA (1)	CA2465792C (de)
CY (3)	CY1108446T1 (de)
DE (3)	DE10153601A1 (de)
DK (3)	DK1308166T3 (de)
EA (3)	EA201000386A1 (de)
ES (3)	ES2332576T3 (de)
HK (1)	HK1057328A1 (de)
HR (1)	HRP20040383B1 (de)
HU (1)	HU230163B1 (de)
IL (1)	IL205695A0 (de)
MX (1)	MXPA04004155A (de)
NO (1)	NO329789B1 (de)
NZ (2)	NZ545414A (de)
PL (1)	PL208343B1 (de)
PT (3)	PT1308166E (de)
SG (1)	SG148034A1 (de)
SI (2)	SI1441757T1 (de)
WO (1)	WO2003037363A2 (de)
ZA (1)	ZA200403285B (de)

Families Citing this family (14)

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DE10153601A1 (de)	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
WO2004096267A1 (de) *	2003-05-02	2004-11-11	Paion Gmbh	Intravenöse injektion nicht-neurotoxischer plasminogen-aktivatoren zur behandlung von schlaganfall
US20060135425A1 (en) *	2003-05-02	2006-06-22	Paion Deutschland Gmbh	Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
NZ543367A (en) *	2003-05-02	2010-06-25	Paion Deutschland Gmbh	Plasminogen activating factors from DSPA for the treatment of stroke at a dosage of 62.5 to 230 micrograms/kg
US20080057050A1 (en) *	2003-05-02	2008-03-06	Paion Deutschland Gmbh	Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
EP1622640A1 (de) *	2003-05-05	2006-02-08	Paion Deutschland GmbH	Glutamat-rezeptor-antagonisten als neuroprotektiva
DE10342518A1 (de) *	2003-09-12	2005-05-12	Paion Gmbh	Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
JP2006241109A (ja) *	2005-03-04	2006-09-14	Paion Deutschland Gmbh	ヒトＰセレクチンおよびＤＳＰＡα１に対する抗体を含む融合タンパク質
AR068914A1 (es) *	2007-10-18	2009-12-16	Paion Deutschland Gmbh	Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
EP2558580A2 (de)	2010-04-16	2013-02-20	H. Lundbeck A/S	Verfahren zur herstellung von rekombinantem dspa-alpha1
CA2823491A1 (en) *	2011-01-05	2012-07-12	Thrombogenics Nv	Plasminogen and plasmin variants
US9644196B2 (en)	2011-08-12	2017-05-09	Thrombogenics Nv	Plasminogen and plasmin variants
US11613744B2 (en)	2018-12-28	2023-03-28	Vertex Pharmaceuticals Incorporated	Modified urokinase-type plasminogen activator polypeptides and methods of use
EP3902913A1 (de) *	2018-12-28	2021-11-03	Catalyst Biosciences, Inc.	Modifizierte urokinaseartige plasminogenaktivatorpolypeptide und verfahren zur verwendung

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DE10153601A1 (de)	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
WO2004096267A1 (de)	2003-05-02	2004-11-11	Paion Gmbh	Intravenöse injektion nicht-neurotoxischer plasminogen-aktivatoren zur behandlung von schlaganfall
NZ543367A (en)	2003-05-02	2010-06-25	Paion Deutschland Gmbh	Plasminogen activating factors from DSPA for the treatment of stroke at a dosage of 62.5 to 230 micrograms/kg
US20060135425A1 (en) *	2003-05-02	2006-06-22	Paion Deutschland Gmbh	Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
US20080057050A1 (en) *	2003-05-02	2008-03-06	Paion Deutschland Gmbh	Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
EP1622640A1 (de)	2003-05-05	2006-02-08	Paion Deutschland GmbH	Glutamat-rezeptor-antagonisten als neuroprotektiva
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DE10342518A1 (de)	2003-09-12	2005-05-12	Paion Gmbh	Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
AR068914A1 (es) *	2007-10-18	2009-12-16	Paion Deutschland Gmbh	Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia

2001
- 2001-11-02 DE DE10153601A patent/DE10153601A1/de not_active Ceased
- 2001-12-17 PT PT01130006T patent/PT1308166E/pt unknown
- 2001-12-17 EP EP01130006A patent/EP1308166B1/de not_active Expired - Lifetime
- 2001-12-17 DE DE50115077T patent/DE50115077D1/de not_active Expired - Lifetime
- 2001-12-17 AT AT01130006T patent/ATE440614T1/de active
- 2001-12-17 ES ES01130006T patent/ES2332576T3/es not_active Expired - Lifetime
- 2001-12-17 DK DK01130006T patent/DK1308166T3/da active
2002
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- 2002-10-31 CN CNA2007101051509A patent/CN101156948A/zh active Pending
- 2002-10-31 KR KR1020077017712A patent/KR20070087248A/ko active Application Filing
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- 2002-10-31 EP EP10011603A patent/EP2368567A1/de not_active Withdrawn
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2005
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2008
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2010
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Also Published As

Publication number	Publication date
US8071091B2 (en)	2011-12-06
PL208343B1 (pl)	2011-04-29
CN101156948A (zh)	2008-04-09
KR20050042234A (ko)	2005-05-06
HUP0402165A3 (en)	2010-01-28
EA200400624A1 (ru)	2004-10-28
HRP20040383B1 (en)	2012-08-31
US20090004176A1 (en)	2009-01-01
US20050048027A1 (en)	2005-03-03
CA2465792A1 (en)	2003-05-08
DK1441757T3 (da)	2008-11-17
WO2003037363A3 (de)	2003-09-18
NZ532903A (en)	2006-10-27
CN1592634A (zh)	2005-03-09
ES2332576T3 (es)	2010-02-09
NO329789B1 (no)	2010-12-20
EA200801714A1 (ru)	2008-12-30
HK1057328A1 (en)	2004-04-02
NO20042262L (no)	2004-06-01
AU2002350660B2 (en)	2008-04-10
ATE440614T1 (de)	2009-09-15
JP2009137983A (ja)	2009-06-25
PT1997510E (pt)	2012-05-21
NZ545414A (en)	2008-09-26
EP1308166B1 (de)	2009-08-26
SI1997510T1 (sl)	2012-06-29
EP2368567A1 (de)	2011-09-28
PL369872A1 (en)	2005-05-02
EP1441757B1 (de)	2008-07-23
EA201000386A1 (ru)	2011-06-30
CY1108446T1 (el)	2014-04-09
DE10153601A1 (de)	2003-05-22
US20060142195A1 (en)	2006-06-29
ZA200403285B (en)	2005-07-27
CN100446810C (zh)	2008-12-31
US8119597B2 (en)	2012-02-21
EA010858B1 (ru)	2008-12-30
EP1997510B1 (de)	2012-02-29
DE50115077D1 (de)	2009-10-08
DK1997510T3 (da)	2012-05-21
AU2002350660C1 (en)	2008-10-09
US20140199287A1 (en)	2014-07-17
PT1441757E (pt)	2008-11-03
MXPA04004155A (es)	2005-03-31
ES2311070T3 (es)	2009-02-01
KR20070087248A (ko)	2007-08-27
BR0213856A (pt)	2004-08-31
HUP0402165A2 (hu)	2005-01-28
IL205695A0 (en)	2010-11-30
HRP20040383A2 (en)	2005-08-31
NO20042262D0 (no)	2004-06-01
EP1308166A1 (de)	2003-05-07
DK1308166T3 (da)	2009-12-14
ATE547115T1 (de)	2012-03-15
KR100816221B1 (ko)	2008-03-24
US20090263373A1 (en)	2009-10-22
US20130039902A1 (en)	2013-02-14
CY1109648T1 (el)	2014-08-13
EP1441757A2 (de)	2004-08-04
HU230163B1 (hu)	2015-09-28
EP1997510A1 (de)	2008-12-03
US20170051268A1 (en)	2017-02-23
CA2465792C (en)	2014-04-01
CY1112957T1 (el)	2016-04-13
JP2005519025A (ja)	2005-06-30
WO2003037363A2 (de)	2003-05-08
EA013707B1 (ru)	2010-06-30
JP5004407B2 (ja)	2012-08-22
SG148034A1 (en)	2008-12-31
EP1997510A8 (de)	2011-04-13
KR20090128583A (ko)	2009-12-15
ATE401910T1 (de)	2008-08-15
PT1308166E (pt)	2009-11-27
SI1441757T1 (sl)	2009-02-28
ES2382224T3 (es)	2012-06-06

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