DE540573T1 - Bestimmung von freiem und komplexiertem prostat-spezifisches antigen. - Google Patents

Bestimmung von freiem und komplexiertem prostat-spezifisches antigen.

Info

Publication number
DE540573T1
DE540573T1 DE0540573T DE91913019T DE540573T1 DE 540573 T1 DE540573 T1 DE 540573T1 DE 0540573 T DE0540573 T DE 0540573T DE 91913019 T DE91913019 T DE 91913019T DE 540573 T1 DE540573 T1 DE 540573T1
Authority
DE
Germany
Prior art keywords
psa
free
complex
antiging
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0540573T
Other languages
English (en)
Inventor
Hans Lilja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20380033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE540573(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of DE540573T1 publication Critical patent/DE540573T1/de
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57438Specifically defined cancers of liver, pancreas or kidney
DE0540573T 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostat-spezifisches antigen. Pending DE540573T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002480A SE9002480D0 (sv) 1990-07-23 1990-07-23 Assay of free and complexed prostate-specific antigen
PCT/FI1991/000223 WO1992001936A1 (en) 1990-07-23 1991-07-22 Assay of free and complexed prostate-specific antigen (psa)

Publications (1)

Publication Number Publication Date
DE540573T1 true DE540573T1 (de) 1995-09-28

Family

ID=20380033

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69117292T Expired - Lifetime DE69117292T3 (de) 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostata-spezifischem antigen
DE0540573T Pending DE540573T1 (de) 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostat-spezifisches antigen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69117292T Expired - Lifetime DE69117292T3 (de) 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostata-spezifischem antigen

Country Status (10)

Country Link
US (4) US5501983A (de)
EP (1) EP0540573B2 (de)
JP (1) JP2669566B2 (de)
AT (1) ATE134448T1 (de)
DE (2) DE69117292T3 (de)
DK (1) DK0540573T4 (de)
ES (1) ES2070107T5 (de)
GR (1) GR3019888T3 (de)
SE (1) SE9002480D0 (de)
WO (1) WO1992001936A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965379A (en) * 1991-07-19 1999-10-12 Cytimmune Sciences Inc. Method for measuring endogenous cytokines
GB9309966D0 (en) 1993-05-14 1993-06-30 Nordion Int Inc Detection of prostrate-specific antigen in breast tumors
GB9314623D0 (en) 1993-07-14 1993-08-25 Nordion Int Inc Localization and therapy with agents directed against prostate specific antigen in breast cancer
EP0635575A1 (de) 1993-07-22 1995-01-25 Wallac Oy Monoklonale Antikörper gegen Epitope in freiem uber nicht in Alpha-1-antichymotrypsin komplexiertem Prostata spezifisches Antigen
EP0652014A1 (de) * 1993-11-10 1995-05-10 National Institute Of Immunology Behandlung von Prostatahypertrophie
US5599677A (en) * 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
GB9415489D0 (en) * 1994-08-01 1994-09-21 Nordion Int Inc Detection of prostate-specific antigen in amniotic fluid
EP0725139A3 (de) * 1995-02-03 1997-11-26 Bayer Corporation Rekombinantes prostat-spezifisches Antigen und seiner Verwendung als Immunoassay-Kalibrator
US5698402A (en) * 1995-02-23 1997-12-16 Dianon Systems, Inc. Methods for diagnosing benign prostatic hyperplasia
US5614372A (en) * 1995-02-24 1997-03-25 Lilja; Hans Early detection of prostate cancer (CAP) by employing prostate specific antigen (PSA) and human glandular kallikrein (hGK-1)
US5654161A (en) * 1995-05-12 1997-08-05 Chiron Diagnostics Corporation Method for diagnosing prostate cancer
US5807978A (en) * 1995-06-07 1998-09-15 Kokolus; William J. Immunogenic peptides of prostate specific antigen
US5800347A (en) * 1995-11-03 1998-09-01 The General Hospital Corporation ROC method for early detection of disease
CA2229427A1 (en) * 1995-09-12 1997-03-20 The General Hospital Corporation Method for early detection of ovarian cancer
US5710007A (en) * 1995-09-29 1998-01-20 Luderer; Albert A. Methods for diagnosing prostatic adenocarcinoma
WO1997014416A1 (en) * 1995-10-18 1997-04-24 Merck & Co., Inc. Conjugates useful in the treatment of benign prostatic hyperplasia
EP0789032A2 (de) * 1996-02-01 1997-08-13 Bayer Corporation Verfahren zur Herstellung eines monoklonalen Antikörpers, der zu einer equimolären Responz gegen eine freie und komplexierte Analyseprobe in einem monoklonalen/polyklonalen Sandwichimmuntest
US6143509A (en) * 1996-02-06 2000-11-07 Abbott Laboratories Prostate specific antigen peptides and uses thereof
JP2000510949A (ja) * 1996-04-26 2000-08-22 チルドレンズ メディカル センター コーポレーション 組織のリモデリングに関連した状態のための非観血的酵素スクリーン
AU775537B2 (en) * 1996-04-26 2004-08-05 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US6811995B1 (en) 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
AU4086397A (en) * 1996-09-06 1998-03-26 Centocor Inc. Monoclonal antibodies specific for prostate specific antigen and methods of detecting prostate specific antigen
DE19641560A1 (de) 1996-10-09 1998-04-16 Boehringer Mannheim Gmbh Monoklonale Antikörper gegen einen Komplex aus humanem ACT und einer Serinprotease
US6177404B1 (en) 1996-10-15 2001-01-23 Merck & Co., Inc. Conjugates useful in the treatment of benign prostatic hyperplasia
US6107103A (en) * 1996-10-15 2000-08-22 Procyon Bropharma Inc. Assay for PSP94 protein
US5840501A (en) * 1996-10-25 1998-11-24 Bayer Corporation Determination of cPSA
IL121659A (en) * 1996-10-25 2000-07-16 Bayer Ag Method for determining CPSA in a blood sample
US5856182A (en) * 1996-11-18 1999-01-05 Beckman Coulter, Inc. Monoclonal antibodies specific for the PSA-ACT complex
US6548260B1 (en) * 1997-01-21 2003-04-15 Bayer Corporation Detection of PSA-α2-macroglobulin complex in a biological fluid
US6309816B1 (en) * 1997-04-16 2001-10-30 Horus Therapeutics, Inc. Methods for diagnosing cancer by measuring creatine kinase
DE19717436C2 (de) * 1997-04-25 2001-02-15 Biomac Gmbh Verfahren zur exakten Bestimmung von Prostata-spezifischem Antigen in Körperflüssigkeiten
US7288636B2 (en) * 1997-04-30 2007-10-30 Hybritech Incorporated Forms of prostate specific antigens and methods for their detection
US6670196B1 (en) * 1997-05-14 2003-12-30 Biosite, Inc. Rapid evaluation of the ratio of biological molecules
US6649420B1 (en) * 1997-08-26 2003-11-18 Thomas L. Cantor Methods and devices for detecting no-complexed prostate specific I antigen
US5994085A (en) * 1997-08-26 1999-11-30 Cantor; Thomas L. Methods and devices for detecting non-complexed prostate specific antigen
US6300088B1 (en) 1997-11-24 2001-10-09 Duke University Method of detecting prostate specific antigen
DE19814915A1 (de) 1998-04-03 1999-10-07 Roche Diagnostics Gmbh Immunologisches Verfahren zur Bestimmung von PSA
FI981185A (fi) * 1998-05-28 1999-11-29 Stenman Ulf Haakan Uusi diagnostinen menetelmä
FI981186A (fi) * 1998-05-28 1999-11-29 Stenman Ulf Haakan Uusi immunomääritys ja sen käyttö diagnostiikassa
US7226731B1 (en) 1998-07-24 2007-06-05 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services PB 39, a gene dysregulated in prostate cancer, and uses thereof
EP1100903A1 (de) * 1998-07-24 2001-05-23 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Pb 39, ein dysreguliertes gen in prostatakrebs und deren verwendung
WO2000009691A2 (en) 1998-08-10 2000-02-24 Urogenesys, Inc. Bpc-1: a secreted brain specific protein expressed and secreted by prostate and bladder cancer cells
IL146093A0 (en) 1999-04-20 2002-07-25 Target Discovery Inc Method of separating a polypeptide or protein from a solution containing a plurality thereof
US6423503B1 (en) * 1999-04-30 2002-07-23 Hybritech Incorporated Forms of free prostate-specific antigen (PSA) and their association with prostate tissues from prostate peripheral zone and transition zone
US6893818B1 (en) * 1999-10-28 2005-05-17 Agensys, Inc. Gene upregulated in cancers of the prostate
FR2807438B1 (fr) * 2000-04-10 2004-09-17 Bio Merieux Nouveaux anticorps reconnaissant specifiquement le psa libre inactif, et leurs applications
GB0012718D0 (en) * 2000-05-24 2000-07-19 Angeletti P Ist Richerche Bio Conjugates of aminodrugs
FR2810114B1 (fr) * 2000-06-13 2002-08-23 Bio Merieux Methode, procede, test immunologique et kit de diagnostic d'un adenocarcinome de la prostate ou d'une hypertrophie benigne de la prostate
EP2075582A3 (de) 2000-07-12 2010-01-06 Agensys, Inc. Neuartiges Tumor-Antigen zur Diagnose und Therapie von Blasen-, Eierstock-, Lungen-, und Nierenkrebs
US6379550B1 (en) 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
DE60107022T2 (de) 2000-07-24 2005-11-24 Health Research Inc. Verfahren zur Detektion von Prostata-spezifischem Membran-Antigen in Serum
US6984494B2 (en) * 2000-08-15 2006-01-10 Genentech, Inc. Analytical method
WO2002016593A2 (en) 2000-08-22 2002-02-28 Agensys, Inc. Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
WO2002018578A2 (en) 2000-08-28 2002-03-07 Agensys, Inc. Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer
US6764825B1 (en) * 2000-10-13 2004-07-20 Tang J. Wang Methods and device for detecting prostate specific antigen (PSA)
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
EP2287186B1 (de) 2001-09-06 2014-12-31 Agensys, Inc. Nucleinsäure und entsprechendes Protein, STEAP-1, bei der Behandlung und zum Nachweis von Krebs
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US7534580B2 (en) * 2002-05-01 2009-05-19 Ambrilia Biopharma Inc. PSP94 diagnostic reagents and assays
US20040081653A1 (en) 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
US20040176577A1 (en) * 2002-09-10 2004-09-09 Eva Rojer Immunoassays for specific determination of SCCA isoforms
ES2463420T3 (es) * 2002-11-01 2014-05-27 Iris International, Inc. Inmuno-PCR sándwich por desplazamiento
JP2006508163A (ja) 2002-11-27 2006-03-09 アジェンシス, インコーポレイテッド 癌の処置および検出において有用な24p4c12と称される、核酸および対応タンパク質
EP2343315A3 (de) 2003-02-10 2011-11-23 Agensys, Inc. Nukleinsäure und entsprechendes Protein mit der Bezeichnung 158P1D7, das sich für die Behandlung und den Nachweis von Blasenkrebs und anderen Krebserkrankungen eignet
WO2004094652A2 (en) * 2003-04-22 2004-11-04 Neurobiotex, Inc. Zinc-based screening test and kit for early diagnosis of prostate cancer
EP2319524B1 (de) 2003-05-30 2013-08-21 Agensys, Inc. Prostatstammzellenantigen-Varianten und Untersequenzen davon
JP4651663B2 (ja) 2004-05-28 2011-03-16 アジェンシス,インコーポレイテッド Pscaタンパク質に結合する抗体および関連分子
DE102004027429B4 (de) 2004-06-04 2018-09-13 Siemens Healthcare Diagnostics Gmbh Verfahren zur Anwendung von auf Markerwerten basierenden Dichtekarten bei der Diagnose von Patienten mit Krankheiten insbesondere von Tumoren
DK1842226T3 (da) * 2004-11-03 2010-10-18 Iris Molecular Diagnostics Inc Homogen analytpåvisning
JP5037350B2 (ja) * 2004-11-03 2012-09-26 アイリス モレキュラー ダイアグノスティクス, インコーポレイテッド 親和性分離のための微粒気泡
US8663600B2 (en) * 2005-02-17 2014-03-04 Diaprost Ab Diagnosis of prostate cancer
US20080125582A1 (en) * 2006-10-13 2008-05-29 Bio-Rad Laboratories, Inc. Methods and compositions for stabilizing prostate specific antigen
US20090062624A1 (en) * 2007-04-26 2009-03-05 Thomas Neville Methods and systems of delivering a probability of a medical condition
ES2687620T3 (es) 2007-05-04 2018-10-26 Opko Diagnostics, Llc Dispositivo y método para análisis en sistemas microfluídicos
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
US8362325B2 (en) 2007-10-03 2013-01-29 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
AU2009215799B2 (en) * 2008-02-21 2013-08-22 Iris International Inc. Method for early determination of recurrence after therapy for prostate cancer
WO2009148803A2 (en) * 2008-05-15 2009-12-10 Soar Biodynamics, Ltd. Methods and systems for integrated health systems
US20100168621A1 (en) * 2008-12-23 2010-07-01 Neville Thomas B Methods and systems for prostate health monitoring
WO2010078554A1 (en) 2009-01-05 2010-07-08 Bio-Rad Laboratories, Inc. Process design using mass spectrometry
WO2010087999A1 (en) 2009-02-02 2010-08-05 Claros Diagnostics, Inc. Structures for controlling light interaction with microfluidic devices
EP2239675A1 (de) 2009-04-07 2010-10-13 BIOCRATES Life Sciences AG Verfahren zur In-vitro-Diagnose einer komplexen Krankheit
CN102346536A (zh) * 2010-07-29 2012-02-08 元太科技工业股份有限公司 省电触控电子书
JP6110786B2 (ja) 2011-03-28 2017-04-05 積水メディカル株式会社 Psaの測定方法及びその試薬
US20140308204A1 (en) 2011-10-25 2014-10-16 Memorial Sloan Kettering Cancer Center Free psa antibodies as diagnostics, prognostics and therapeutics for prostate cancer
BR112014013853A2 (pt) 2011-12-09 2020-01-14 Ceres Inc uso de um ácido nucleico isolado, método de obtenção de uma célula vegetal transgênica, método de obtenção de uma planta transgênica, método de produção de uma planta, método de produção de biomassa, método de processamento de biomassa, método de alteração da composição de biomassa, método de modulação de composição de biomassa, método de produção de um produto de forragem
CN104364788B (zh) 2012-03-05 2018-02-06 阿克蒂克合伙公司 预测前列腺癌风险及前列腺腺体体积的装置
SG11201608035UA (en) 2014-03-28 2016-10-28 Opko Diagnostics Llc Compositions and methods related to diagnosis of prostate cancer
DK3253800T3 (da) 2015-03-27 2021-05-31 Opko Diagnostics Llc Prostata antigen standarder og bruge deraf
CN108802392A (zh) * 2018-08-29 2018-11-13 上海市东方医院 一种用于诊断前列腺癌的层析试纸条及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446122A (en) * 1979-12-28 1984-05-01 Research Corporation Purified human prostate antigen
WO1981001849A1 (en) * 1979-12-28 1981-07-09 Research Corp Purified human prostate antigen
US4690890A (en) * 1984-04-04 1987-09-01 Cetus Corporation Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay
AU602861B2 (en) * 1985-03-29 1990-11-01 Hybritech Incorporated Processes for the stabilization of prostate specific antigen in natural matrices
JPH0690203B2 (ja) * 1985-08-23 1994-11-14 中外製薬株式会社 前立腺特異抗原とα▲下1▼−アンチトリプシン複合体の定量方法
US5599677A (en) * 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides

Also Published As

Publication number Publication date
SE9002480D0 (sv) 1990-07-23
ATE134448T1 (de) 1996-03-15
ES2070107T3 (es) 1996-04-16
GR3019888T3 (en) 1996-08-31
EP0540573B2 (de) 2003-11-19
DE69117292D1 (de) 1996-03-28
US5939533A (en) 1999-08-17
WO1992001936A1 (en) 1992-02-06
EP0540573A1 (de) 1993-05-12
JPH06502719A (ja) 1994-03-24
US5912158A (en) 1999-06-15
DE69117292T2 (de) 1996-07-18
ES2070107T5 (es) 2004-05-16
JP2669566B2 (ja) 1997-10-29
EP0540573B1 (de) 1996-02-21
US20020123616A1 (en) 2002-09-05
ES2070107T1 (es) 1995-06-01
DK0540573T3 (da) 1996-04-09
DE69117292T3 (de) 2004-06-03
US5501983A (en) 1996-03-26
DK0540573T4 (da) 2004-04-05

Similar Documents

Publication Publication Date Title
DE69117292D1 (de) Bestimmung von freiem und komplexiertem prostat-spezifisches antigen
Haglund Tumour marker antigen CA125 in pancreatic cancer: a comparison with CA19-9 and CEA
Darras et al. Measurement of urokinase-type plasminogen activator (u-PA) with an enzyme-linked immunosorbent assay (ELISA) based on three murine monoclonal antibodies
DE3887675D1 (de) Antikörper.
DK0914155T3 (da) Monoklonale antistoffer, der er spepcifikke for det ekstracellulære domæne af prostataspecifikt membran-antigen
NO166465C (no) Fremgangsmaate for bestemmelse av sekvensen av monomerer.
DK0710253T3 (da) Antistoffer, der er specifikke mod human prostatakirtel-kallikrein
DE69128543T2 (de) Monoklonale antikörper der maus
NO974534D0 (no) Bestemmelse av cPSA
Watanabe et al. Enzyme immunoassay for human ferritin.
ES2033823T3 (es) Ensayo en cuanto a cancer de mama humano.
FI922017A0 (fi) Immunbestaemningar och monoklonala antikroppar foer protrombinaktiveringspeptider och degradations- produkter av dessa.
DK0455707T3 (da) Blodkoagulationsfaktor betaXIIa monoklonalt antistof og immunassay
SE8004542L (sv) Diagnostiskt test
Perey et al. Elevated CA125 levels in patients with metastatic breast carcinoma.
ATE229037T1 (de) Monoklonaler antikörper gegen denthrombin- antithrombin iii-komplex und dessen verwendung in immunoassays
IT1264083B1 (it) Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.
Gao et al. Detection of soluble urokinase receptor by immunoradiometric assay and its application in tumor patients
Pelzer et al. Enzyme immunoassay for determination of human thrombin/antithrombin III complex
Bogdanowicz et al. Evaluation of prostate-specific antigen and prostatic acid phosphatase in untreated prostatic carcinoma and benign prostatic hyperplasia
JPS55135752A (en) Determination method of immunogloblin e in human blood by enzyme immunity measuring method
FI943921A0 (fi) Bestaemning av fri och komplexbunden trypsinogen-2
JPS56150356A (en) Immunologic measuring method
FI922480A0 (fi) Diagnostiskt foerfarande.