DE59108153D1 - Aus Polyaldehyden aufgebaute gasenthaltende Mikropartikel als Kontrastmittel - Google Patents

Aus Polyaldehyden aufgebaute gasenthaltende Mikropartikel als Kontrastmittel

Info

Publication number
DE59108153D1
DE59108153D1 DE59108153T DE59108153T DE59108153D1 DE 59108153 D1 DE59108153 D1 DE 59108153D1 DE 59108153 T DE59108153 T DE 59108153T DE 59108153 T DE59108153 T DE 59108153T DE 59108153 D1 DE59108153 D1 DE 59108153D1
Authority
DE
Germany
Prior art keywords
contrast agents
polyaldehydes
gas
appropriate
containing microparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59108153T
Other languages
English (en)
Inventor
Georg Dr Roessling
Celal Dr Albayrak
Matthias Dr Rothe
Joachim Dr Siegert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE59108153T priority Critical patent/DE59108153D1/de
Application granted granted Critical
Publication of DE59108153D1 publication Critical patent/DE59108153D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G6/00—Condensation polymers of aldehydes or ketones only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE59108153T 1990-02-09 1991-02-11 Aus Polyaldehyden aufgebaute gasenthaltende Mikropartikel als Kontrastmittel Expired - Lifetime DE59108153D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59108153T DE59108153D1 (de) 1990-02-09 1991-02-11 Aus Polyaldehyden aufgebaute gasenthaltende Mikropartikel als Kontrastmittel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4004430A DE4004430A1 (de) 1990-02-09 1990-02-09 Aus polyaldehyden aufgebaute kontrastmittel
DE59108153T DE59108153D1 (de) 1990-02-09 1991-02-11 Aus Polyaldehyden aufgebaute gasenthaltende Mikropartikel als Kontrastmittel

Publications (1)

Publication Number Publication Date
DE59108153D1 true DE59108153D1 (de) 1996-10-17

Family

ID=6400056

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4004430A Withdrawn DE4004430A1 (de) 1990-02-09 1990-02-09 Aus polyaldehyden aufgebaute kontrastmittel
DE59108153T Expired - Lifetime DE59108153D1 (de) 1990-02-09 1991-02-11 Aus Polyaldehyden aufgebaute gasenthaltende Mikropartikel als Kontrastmittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4004430A Withdrawn DE4004430A1 (de) 1990-02-09 1990-02-09 Aus polyaldehyden aufgebaute kontrastmittel

Country Status (17)

Country Link
US (1) US5501863A (de)
EP (1) EP0441468B1 (de)
JP (1) JP3363912B2 (de)
AT (1) ATE142507T1 (de)
AU (1) AU649996B2 (de)
CA (1) CA2036107A1 (de)
DE (2) DE4004430A1 (de)
DK (1) DK0441468T3 (de)
ES (1) ES2094192T3 (de)
FI (1) FI910596A (de)
GR (1) GR3021206T3 (de)
HU (1) HUT61490A (de)
IE (1) IE76315B1 (de)
NO (1) NO300916B1 (de)
NZ (1) NZ237060A (de)
PT (1) PT96691B (de)
ZA (1) ZA91961B (de)

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NO910510L (no) 1991-08-12
FI910596A (fi) 1991-08-10
EP0441468A3 (en) 1992-05-27
AU7098291A (en) 1991-10-17
NZ237060A (en) 1994-11-25
AU649996B2 (en) 1994-06-09
EP0441468B1 (de) 1996-09-11
HU910427D0 (en) 1991-08-28
ES2094192T3 (es) 1997-01-16
DE4004430A1 (de) 1991-08-14
ZA91961B (en) 1991-11-27
ATE142507T1 (de) 1996-09-15
JP3363912B2 (ja) 2003-01-08
IE76315B1 (en) 1997-10-22
FI910596A0 (fi) 1991-02-07
PT96691B (pt) 1998-07-31
US5501863A (en) 1996-03-26
NO910510D0 (no) 1991-02-08
IE910434A1 (en) 1991-08-14
NO300916B1 (no) 1997-08-18
PT96691A (pt) 1991-10-31
JPH059132A (ja) 1993-01-19
HUT61490A (en) 1993-01-28
EP0441468A2 (de) 1991-08-14
DK0441468T3 (de) 1997-02-10
CA2036107A1 (en) 1991-08-10
GR3021206T3 (en) 1996-12-31

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