DE59108591D1 - Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren - Google Patents

Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren

Info

Publication number
DE59108591D1
DE59108591D1 DE59108591T DE59108591T DE59108591D1 DE 59108591 D1 DE59108591 D1 DE 59108591D1 DE 59108591 T DE59108591 T DE 59108591T DE 59108591 T DE59108591 T DE 59108591T DE 59108591 D1 DE59108591 D1 DE 59108591D1
Authority
DE
Germany
Prior art keywords
electrophoretic separation
separation device
separation process
electrophoretic
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59108591T
Other languages
English (en)
Inventor
Andreas Dr Manz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeptosens AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of DE59108591D1 publication Critical patent/DE59108591D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
DE59108591T 1991-12-06 1991-12-06 Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren Expired - Fee Related DE59108591D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91810952A EP0544969B1 (de) 1991-12-06 1991-12-06 Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren

Publications (1)

Publication Number Publication Date
DE59108591D1 true DE59108591D1 (de) 1997-04-10

Family

ID=8208910

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59108591T Expired - Fee Related DE59108591D1 (de) 1991-12-06 1991-12-06 Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren

Country Status (4)

Country Link
US (1) US5296114A (de)
EP (1) EP0544969B1 (de)
JP (1) JPH05302912A (de)
DE (1) DE59108591D1 (de)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5935401A (en) * 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
EP0620432B1 (de) * 1993-04-15 2004-08-25 Zeptosens AG Verfahren zur Steuerung der Probeneinführung bei Mikrosäulentrennungstechniken und Probenentnahmevorrichtungen
US5328578A (en) * 1993-06-15 1994-07-12 Hewlett-Packard Company Capillary electrophoresis with tracking separation field
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6319472B1 (en) 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US6375899B1 (en) 1993-11-01 2002-04-23 Nanogen, Inc. Electrophoretic buss for transport of charged materials in a multi-chamber system
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
DE59410283D1 (de) * 1993-11-11 2003-06-18 Aclara Biosciences Inc Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
JP3190347B2 (ja) * 1993-11-29 2001-07-23 株式会社東レリサーチセンター 電気泳動分取装置
EP0670489A3 (de) * 1994-03-03 1996-03-06 Ciba Geigy Ag Vorrichtung und Verfahren zur Trennung fluider Substanzen.
AU2550395A (en) * 1994-06-02 1996-01-04 Perkin-Elmer Corporation, The Method and apparatus for automated carbohydrate mapping and sequencing
US5580435A (en) * 1994-06-10 1996-12-03 The Board Of Trustees Of The Leland Stanford Junior University System for detecting components of a sample in electrophoretic separation
US6403367B1 (en) * 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6071394A (en) 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US7857957B2 (en) * 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5846396A (en) * 1994-11-10 1998-12-08 Sarnoff Corporation Liquid distribution system
US5985119A (en) * 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
US5632876A (en) * 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
JP4026724B2 (ja) * 1995-01-27 2007-12-26 ノースイースタン ユニバーシティー 毛管電気泳動のためのポリビニルアルコール（ｐｖａ）をベースとする共有結合の安定した親水性コーティング
US6120665A (en) * 1995-06-07 2000-09-19 Chiang; William Yat Chung Electrokinetic pumping
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5879632A (en) * 1996-04-09 1999-03-09 Sarnoff Corporation Apportioning system
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
KR100596953B1 (ko) * 1996-07-03 2006-08-30 칼리퍼 라이프 사이언시즈, 인크. 전기적변수에의한유체-함유구조물내의전기삼투압또는전기영동력의가변제어를위한장치및방법
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) * 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US5858194A (en) * 1996-07-18 1999-01-12 Beckman Instruments, Inc. Capillary, interface and holder
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6110343A (en) * 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
US6465257B1 (en) 1996-11-19 2002-10-15 Caliper Technologies Corp. Microfluidic systems
US6056859A (en) * 1997-02-12 2000-05-02 Lockheed Martin Energy Research Corporation Method and apparatus for staining immobilized nucleic acids
WO1998049344A1 (en) 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6159353A (en) * 1997-04-30 2000-12-12 Orion Research, Inc. Capillary electrophoretic separation system
US6093330A (en) * 1997-06-02 2000-07-25 Cornell Research Foundation, Inc. Microfabrication process for enclosed microstructures
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US6368871B1 (en) * 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
EP1032824A4 (de) 1997-10-15 2003-07-23 Aclara Biosciences Inc Laminierte mikrostrukturierte vorrichtung und zugehöriges herstellungsverfahren
US6685809B1 (en) * 1999-02-04 2004-02-03 Ut-Battelle, Llc Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
WO1999040434A1 (en) 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7497994B2 (en) * 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6123798A (en) * 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
US6180536B1 (en) 1998-06-04 2001-01-30 Cornell Research Foundation, Inc. Suspended moving channels and channel actuators for microfluidic applications and method for making
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6682942B1 (en) * 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6245227B1 (en) 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
CN1312474C (zh) * 1998-09-17 2007-04-25 阿德文生物科学公司 集成的化学分析系统
US6062261A (en) * 1998-12-16 2000-05-16 Lockheed Martin Energy Research Corporation MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6633031B1 (en) * 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
WO2001050499A1 (en) 1999-12-30 2001-07-12 Advion Biosciences, Inc. Multiple electrospray device, systems and methods
WO2001051918A1 (en) * 2000-01-12 2001-07-19 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US6596988B2 (en) 2000-01-18 2003-07-22 Advion Biosciences, Inc. Separation media, multiple electrospray nozzle system and method
AU2001234997B2 (en) * 2000-02-11 2006-07-27 Monogram Biosciences, Inc. Microfluid device with sample injector and method of use
US6537433B1 (en) 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
IL152634A0 (en) * 2000-05-04 2003-06-24 Univ Yale High density protein arrays for screening of protein activity
MXPA02002500A (es) * 2000-07-07 2004-09-10 Baxter Int Sistema medico, metodo y aparato utilizando sensores micro-electromecanicos.
US7294247B1 (en) 2000-10-25 2007-11-13 Xiamen University Electrophoretic separating device and method for using the device
ATE432466T1 (de) * 2000-10-31 2009-06-15 Caliper Life Sciences Inc Mikrofluidisches verfahren für in-situ- materialkonzentration
US6681788B2 (en) * 2001-01-29 2004-01-27 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
DE10113257C1 (de) 2001-03-19 2002-11-14 Inst Mikrotechnik Mainz Gmbh Elektrophoresevorrichtung und ihre Verwendung
WO2002086333A1 (en) * 2001-04-25 2002-10-31 President And Fellows Of Harvard College Fluidic switches and method for controlling flow in fluidic systems
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US7014705B2 (en) * 2001-06-08 2006-03-21 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
WO2002101127A1 (en) * 2001-06-08 2002-12-19 Syrrx, Inc. In situ crystal growth and analysis
US6719840B2 (en) * 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
US6837926B2 (en) 2001-06-08 2005-01-04 Syrrx, Inc. Device for detecting precipitate formation in microvolumes
US6837927B2 (en) 2001-06-08 2005-01-04 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force
US6797056B2 (en) 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6811609B2 (en) 2001-06-08 2004-11-02 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force in different directions
US6994749B2 (en) 2001-06-08 2006-02-07 Syrrx, Inc. Microfluidic device for parallel delivery and mixing of fluids
US6780240B2 (en) 2001-06-08 2004-08-24 Syrrx, Inc. Method for causing fluid movement by centrifugal force
US6803568B2 (en) * 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US7105810B2 (en) * 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
US7252928B1 (en) 2002-03-12 2007-08-07 Caliper Life Sciences, Inc. Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
WO2004013290A2 (en) * 2002-08-05 2004-02-12 Invitrogen Corporation Compositions and methods for molecular biology
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
CA2508358A1 (en) * 2002-12-03 2004-06-17 Genetronics, Inc. Large-scale electroporation plates, systems, and methods of use
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20050016851A1 (en) * 2003-07-24 2005-01-27 Jensen Klavs F. Microchemical method and apparatus for synthesis and coating of colloidal nanoparticles
US7537807B2 (en) * 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
US8974652B2 (en) * 2004-05-28 2015-03-10 Board Of Regents, The University Of Texas System Programmable fluidic processors
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US7211184B2 (en) * 2004-08-04 2007-05-01 Ast Management Inc. Capillary electrophoresis devices
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7591883B2 (en) * 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
EP1859330B1 (de) * 2005-01-28 2012-07-04 Duke University Vorrichtungen und verfahren zur manipulation von tropfen auf einer leiterplatte
US20090155894A1 (en) * 2005-10-17 2009-06-18 Soper Steven A Electrokinetic Thermal Cycler and Reactor
US8268246B2 (en) * 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
AR080285A1 (es) * 2010-12-14 2012-03-28 Comision Nac De En Atomica Dispositivo de fluidica para electroforesis de moleculas.
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
WO2018032458A1 (en) * 2016-08-18 2018-02-22 Shenzhen Genorivision Technology Co. Ltd. An electrophoresis chip with an integrated optical sensor
WO2021026172A1 (en) 2019-08-05 2021-02-11 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2365284C2 (de) * 1973-12-31 1975-10-23 Medac Gesellschaft Fuer Klinische Spezialpraeparate Mbh, 2000 Hamburg Kammer und Verfahren für die Durchführung des zweiten Kreuz-Elektrophoreseschrittes
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
EP0376611A3 (de) * 1988-12-30 1992-07-22 The Board Of Trustees Of The Leland Stanford Junior University Elektroforetische Vorrichtung

Also Published As

Publication number Publication date
JPH05302912A (ja) 1993-11-16
EP0544969A1 (de) 1993-06-09
US5296114A (en) 1994-03-22
EP0544969B1 (de) 1997-03-05

Similar Documents

Publication Publication Date Title
DE59108591D1 (de) Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
DE69329267T2 (de) Bildverarbeitungsvorrichtung und Bildverarbeitungsverfahren
DE69225964D1 (de) Messverfahren und gerät
DE69331967D1 (de) Gefässstent und zugehörige einführungsvorrichtung
BR9400698A (pt) Dispositivo separador
DE69312645D1 (de) Dokumentenvereinzelvorrichtung
DE69422130D1 (de) Osteometrie und osteometrische vorrichtung
DE68926386D1 (de) Bildkodiervorrichtung und Bildkodierverfahren
DE69304281D1 (de) Gerät zum trennen von feststoffen und flüssigkeiten
DE69125315D1 (de) Kodierverfahren und Kodiervorrichtung
NO955353L (no) Separasjonsanordning
ITTO930246A0 (it) Dispositivo singolarizzatore
DE69434714D1 (de) Elektrophotografisches Gerät und Prozesseinheit
DE59403560D1 (de) Trennelement und Vorrichtung mit Trennelement
DE69213992D1 (de) Elektrofotografisches Verfahren und Gerät
DE69320882T2 (de) Entwicklungsgerät und -verfahren
DE69211086T2 (de) Messverfahren und Messgerät
DE69309572D1 (de) Auftragsverfahren und -vorrichtung
DE69124185D1 (de) Ausgabeverfahren und Gerät
DK25693D0 (da) Skilleapparat
DE69117787T2 (de) Zeichenverarbeitungsverfahren und Gerät
FI946027A0 (fi) Keräys- ja erotuslaite
KR920015145U (ko) 협잡물 분리 처리장치
NO304680B1 (no) Separasjonsanordning
DE69227709D1 (de) Bildverarbeitungsgerät und Bildverarbeitungsverfahren

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ZEPTOSENS AG, WITTERSWIL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8339 Ceased/non-payment of the annual fee