DE59204339D1 - Derivate der 4-hydroxy-buttersäure. - Google Patents

Derivate der 4-hydroxy-buttersäure.

Info

Publication number
DE59204339D1
DE59204339D1 DE59204339T DE59204339T DE59204339D1 DE 59204339 D1 DE59204339 D1 DE 59204339D1 DE 59204339 T DE59204339 T DE 59204339T DE 59204339 T DE59204339 T DE 59204339T DE 59204339 D1 DE59204339 D1 DE 59204339D1
Authority
DE
Germany
Prior art keywords
hydroxy
derivatives
butteric acid
acid
butteric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59204339T
Other languages
English (en)
Inventor
Gernot Koehler
Anita Koehler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Franz Koehler Chemie GmbH
Original Assignee
Dr Franz Koehler Chemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Franz Koehler Chemie GmbH filed Critical Dr Franz Koehler Chemie GmbH
Priority to DE59204339T priority Critical patent/DE59204339D1/de
Application granted granted Critical
Publication of DE59204339D1 publication Critical patent/DE59204339D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
DE59204339T 1991-04-29 1992-04-27 Derivate der 4-hydroxy-buttersäure. Expired - Lifetime DE59204339D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59204339T DE59204339D1 (de) 1991-04-29 1992-04-27 Derivate der 4-hydroxy-buttersäure.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4113984A DE4113984C2 (de) 1991-04-29 1991-04-29 Salze der 4-Hydroxy-Buttersäure
DE59204339T DE59204339D1 (de) 1991-04-29 1992-04-27 Derivate der 4-hydroxy-buttersäure.
PCT/DE1992/000336 WO1992019581A1 (de) 1991-04-29 1992-04-27 Derivate der 4-hydroxy-buttersäure

Publications (1)

Publication Number Publication Date
DE59204339D1 true DE59204339D1 (de) 1995-12-21

Family

ID=6430605

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4113984A Expired - Lifetime DE4113984C2 (de) 1991-04-29 1991-04-29 Salze der 4-Hydroxy-Buttersäure
DE59204339T Expired - Lifetime DE59204339D1 (de) 1991-04-29 1992-04-27 Derivate der 4-hydroxy-buttersäure.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4113984A Expired - Lifetime DE4113984C2 (de) 1991-04-29 1991-04-29 Salze der 4-Hydroxy-Buttersäure

Country Status (7)

Country Link
US (2) US5380937A (de)
EP (1) EP0536369B1 (de)
JP (1) JP3377525B2 (de)
AT (1) ATE130290T1 (de)
DE (2) DE4113984C2 (de)
ES (1) ES2079865T3 (de)
WO (1) WO1992019581A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058023B1 (es) * 1992-10-29 1995-10-01 Koehler Chemie Dr Franz Derivados del acido 4-hidroxi-butirico.
AU779354B2 (en) 1998-12-23 2005-01-20 Orphan Medical, Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
EP1316309A1 (de) * 1998-12-23 2003-06-04 Orphan Medical Inc. Mikrobenbeständige und stabilisierte Lösungen die gamma-Hydroxybuttersäuresalze zur Behandlung von Narkolepsie enthalten
US6548569B1 (en) * 1999-03-25 2003-04-15 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6623730B1 (en) 1999-09-14 2003-09-23 Tepha, Inc. Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
ES2383673T3 (es) * 2000-09-22 2012-06-25 Jpi Commercial, Llc Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos
US6703216B2 (en) 2002-03-14 2004-03-09 The Regents Of The University Of California Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB)
ES2819189T3 (es) 2003-05-08 2021-04-15 Tepha Inc Tejidos y fibras médicos de polihidroxialcanoato
JP2007528853A (ja) * 2003-07-08 2007-10-18 テファ， インコーポレイテッド 徐放性薬物送達のためのポリ−４−ヒドロキシブチレートマトリックス
CA2536510C (en) * 2003-08-22 2011-01-18 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
PL1778305T3 (pl) * 2004-08-03 2011-04-29 Tepha Inc Szwy z polihydroksyalkanianów nieulegające zwijaniu się
JP2008528204A (ja) * 2005-01-28 2008-07-31 テファ， インコーポレイテッド ポリ−４−ヒドロキシブチレート粒子を使用した塞栓形成
US7838556B2 (en) * 2006-02-21 2010-11-23 University Of Maryland, Baltimore Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
ES2332190T3 (es) * 2006-05-05 2010-01-28 Givaudan Nederland Services B.V. Composicion para mejorar el gusto.
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8778398B2 (en) 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US8771735B2 (en) 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
US8461197B2 (en) 2009-04-23 2013-06-11 Concert Pharmaceuticals, Inc. 4-hydroxybutyric acid analogs
US20120076865A1 (en) 2010-03-24 2012-03-29 Jazz Pharmaceuticals, Inc. Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances
ES2804540T3 (es) * 2011-02-14 2021-02-08 Concert Pharmaceuticals Inc Análogos deuterados de ácido 4–hidroxibutírico
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
US9050302B2 (en) 2013-03-01 2015-06-09 Jazz Pharmaceuticals Ireland Limited Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
WO2016025329A1 (en) 2014-08-15 2016-02-18 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
KR20210094513A (ko) 2018-11-19 2021-07-29 재즈 파마슈티칼즈 아일랜드 리미티드 알코올-내성 약물 제형
CA3127871A1 (en) 2019-03-01 2020-09-10 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2631284A1 (de) * 1976-07-12 1978-01-26 Henkel Kgaa Kosmetische mittel mit einem gehalt an haut-feuchthaltemitteln
US4227979A (en) * 1977-10-05 1980-10-14 Ppg Industries, Inc. Radiation-curable coating compositions containing amide acrylate compounds
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
US4448905A (en) * 1982-09-30 1984-05-15 Gaf Corporation Alcohol substituted amides as chain extenders for polyurethanes
US4549010A (en) * 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US5506268A (en) * 1993-06-11 1996-04-09 Nps Pharmaceuticals, Inc. Use of isovaleramide as a mild anxiolytic and sedative agent

Also Published As

Publication number Publication date
JP3377525B2 (ja) 2003-02-17
WO1992019581A1 (de) 1992-11-12
EP0536369B1 (de) 1995-11-15
US5753708A (en) 1998-05-19
US5380937A (en) 1995-01-10
ATE130290T1 (de) 1995-12-15
EP0536369A1 (de) 1993-04-14
DE4113984C2 (de) 2002-05-08
ES2079865T3 (es) 1996-01-16
DE4113984A1 (de) 1992-11-05
JPH05508422A (ja) 1993-11-25

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