DE59408715D1 - Cyclische Adhäsionsinhibitoren - Google Patents
Cyclische AdhäsionsinhibitorenInfo
- Publication number
- DE59408715D1 DE59408715D1 DE59408715T DE59408715T DE59408715D1 DE 59408715 D1 DE59408715 D1 DE 59408715D1 DE 59408715 T DE59408715 T DE 59408715T DE 59408715 T DE59408715 T DE 59408715T DE 59408715 D1 DE59408715 D1 DE 59408715D1
- Authority
- DE
- Germany
- Prior art keywords
- lys
- alanine
- asp
- atoms
- prodn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE59408715T DE59408715D1 (de) | 1993-04-01 | 1994-03-21 | Cyclische Adhäsionsinhibitoren |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4310643A DE4310643A1 (de) | 1993-04-01 | 1993-04-01 | Cyclische Adhäsionsinhibitoren |
DE59408715T DE59408715D1 (de) | 1993-04-01 | 1994-03-21 | Cyclische Adhäsionsinhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
DE59408715D1 true DE59408715D1 (de) | 1999-10-14 |
Family
ID=6484433
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4310643A Withdrawn DE4310643A1 (de) | 1993-04-01 | 1993-04-01 | Cyclische Adhäsionsinhibitoren |
DE59408715T Expired - Lifetime DE59408715D1 (de) | 1993-04-01 | 1994-03-21 | Cyclische Adhäsionsinhibitoren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4310643A Withdrawn DE4310643A1 (de) | 1993-04-01 | 1993-04-01 | Cyclische Adhäsionsinhibitoren |
Country Status (20)
Country | Link |
---|---|
US (2) | US5849692A (de) |
EP (1) | EP0632053B1 (de) |
JP (1) | JP3694332B2 (de) |
KR (1) | KR100304201B1 (de) |
CN (1) | CN1056851C (de) |
AT (1) | ATE184288T1 (de) |
AU (1) | AU684489B2 (de) |
CA (1) | CA2120303C (de) |
CZ (1) | CZ286768B6 (de) |
DE (2) | DE4310643A1 (de) |
DK (1) | DK0632053T3 (de) |
ES (1) | ES2138632T3 (de) |
GR (1) | GR3032074T3 (de) |
HU (1) | HUT69726A (de) |
NO (1) | NO313756B1 (de) |
PL (1) | PL178791B1 (de) |
RU (1) | RU2130030C1 (de) |
SK (1) | SK281828B6 (de) |
TW (1) | TW343198B (de) |
UA (1) | UA34436C2 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
DE4415310A1 (de) * | 1994-04-30 | 1995-11-02 | Merck Patent Gmbh | Cyclopeptide |
US7053041B1 (en) | 1996-05-31 | 2006-05-30 | The Scripps Research Institute | Methods and compositions useful for inhibition of αvβ5mediated angiogenesis |
DE19534016A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Biotinderivate |
DE19534177A1 (de) * | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
DE19538741A1 (de) * | 1995-10-18 | 1997-04-24 | Merck Patent Gmbh | Cyclopeptidderivate |
DE19613933A1 (de) * | 1996-04-06 | 1997-10-09 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
RU2194528C2 (ru) | 1996-05-31 | 2002-12-20 | Дзе Скриппс Рисерч Инститьют | Способы и композиции, используемые для ингибирования ангиогенеза |
DE19736772A1 (de) * | 1997-08-23 | 1999-02-25 | Merck Patent Gmbh | Cyclopeptidderivate |
CA2356748A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia |
UA71608C2 (en) * | 1999-03-11 | 2004-12-15 | Merck Patent Gmbh | A method for producing the cyclic pentapeptide |
DE19933173A1 (de) | 1999-07-15 | 2001-01-18 | Merck Patent Gmbh | Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶ |
US6359015B1 (en) | 2000-02-28 | 2002-03-19 | The United States Of America As Represented By The Department Of Veterans Affairs | Method for antagonizing inhibition effects of alcohol on cell adhesion |
US6624187B1 (en) * | 2000-06-12 | 2003-09-23 | Health Research, Inc. | Long wave length absorbing bacteriochlorin alkyl ether analogs |
DE10040105A1 (de) | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften |
FR2814744B1 (fr) * | 2000-10-04 | 2002-11-29 | Commissariat Energie Atomique | Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese |
CN1507354A (zh) * | 2001-03-02 | 2004-06-23 | ͨ��ҽ�ƹ�˾ | 通过给予整合蛋白αvβ3拮抗剂并与其它预防或治疗药剂配合来预防或者治疗炎性疾病或自身免疫疾病的方法 |
US7879267B2 (en) * | 2001-08-02 | 2011-02-01 | J&J Vision Care, Inc. | Method for coating articles by mold transfer |
WO2003075741A2 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | METHODS OF PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN αvβ3 ANTAGONIST IN COMBINATION WITH AN HMG-CoA REDUCTASE INHIBITOR OR A BISPHOSPHONATE |
CA2478239A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
JP2005535572A (ja) * | 2002-04-12 | 2005-11-24 | メディミューン,インコーポレーテッド | 組換え抗インターロイキン−9抗体 |
GB0217017D0 (en) * | 2002-07-23 | 2002-08-28 | Bioacta Ltd | Peptide 2 |
ITRM20020402A1 (it) * | 2002-07-29 | 2004-01-29 | Sigma Tau Ind Farmaceuti | Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine. |
US6977272B2 (en) * | 2002-10-16 | 2005-12-20 | President And Fellows Of Harvard College | Method for antagonizing inhibition effects of alcohol on cell adhesion |
CA2514653A1 (en) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
US7354584B2 (en) | 2003-04-11 | 2008-04-08 | Medimmune, Inc. | Recombinant IL-9 antibodies |
US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
ITRM20040239A1 (it) * | 2004-05-13 | 2004-08-13 | Sigma Tau Ind Farmaceuti | Derivati ciclopeptidici ad attivita' antintegrine. |
AU2005299355A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
EP2043603A4 (de) | 2006-07-11 | 2010-10-27 | Arubor Corp | Prävention und therapie von rhinosinusitis mit proinflammatorischen zytokinhemmern |
LT2068889T (lt) | 2006-08-10 | 2020-02-10 | Roy C. Levitt | Anakinra, naudojama bronchiolito obliteranso sindromo gydymui |
US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
ES2394377T3 (es) | 2006-11-10 | 2013-01-31 | Cara Therapeutics, Inc. | Amidas de péptidos sintéticos |
US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
WO2009124754A1 (en) * | 2008-04-08 | 2009-10-15 | Merck Patent Gmbh | Compositions containing cyclic peptides and methods of use |
BRPI0920108A2 (pt) | 2008-10-23 | 2016-12-13 | Steba Biotech N V | peptídomimético cíclico contendo argina, glicina, ácido aspártico (rgd), conjugado de peptidomimético cíclico contendo rgd, composição farmacêutica, conjugado e uso do mesmo. |
CN101906141B (zh) * | 2009-06-02 | 2013-04-17 | 首都医科大学 | 一类肽链与双脂肪醇链的偶联物及其制备方法和应用 |
CN101906144B (zh) * | 2009-06-03 | 2013-06-19 | 首都医科大学 | 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用 |
RU2655763C2 (ru) * | 2016-10-24 | 2018-05-29 | Общество С Ограниченной Ответственностью "Айвикс" | Фармацевтическая композиция и способ лечения женских сексуальных дисфункций |
RU2626002C1 (ru) | 2016-10-24 | 2017-07-21 | Общество С Ограниченной Ответственностью "Айвикс" | Новая группа пептидов для лечения женской сексуальной дисфункции |
US10494403B2 (en) | 2018-03-06 | 2019-12-03 | Ciphore Biomed Technology Limited Company | Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4472305A (en) * | 1983-05-17 | 1984-09-18 | Sterling Drug Inc. | Hexapeptide amides |
JP2945680B2 (ja) * | 1988-09-09 | 1999-09-06 | 旭硝子株式会社 | ペプチド誘導体およびその用途 |
US5192746A (en) * | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
JPH04264097A (ja) * | 1991-02-16 | 1992-09-18 | Asahi Glass Co Ltd | ペプチド誘導体およびその用途 |
HUT63609A (en) * | 1992-03-10 | 1993-09-28 | Sandoz Ag | Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds |
UA43823C2 (uk) * | 1992-07-06 | 2002-01-15 | Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН |
US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
-
1993
- 1993-04-01 DE DE4310643A patent/DE4310643A1/de not_active Withdrawn
-
1994
- 1994-03-02 UA UA94005107A patent/UA34436C2/uk unknown
- 1994-03-21 EP EP94104396A patent/EP0632053B1/de not_active Expired - Lifetime
- 1994-03-21 DE DE59408715T patent/DE59408715D1/de not_active Expired - Lifetime
- 1994-03-21 DK DK94104396T patent/DK0632053T3/da active
- 1994-03-21 AT AT94104396T patent/ATE184288T1/de active
- 1994-03-21 ES ES94104396T patent/ES2138632T3/es not_active Expired - Lifetime
- 1994-03-25 CZ CZ1994704A patent/CZ286768B6/cs not_active IP Right Cessation
- 1994-03-29 NO NO19941152A patent/NO313756B1/no not_active IP Right Cessation
- 1994-03-30 CN CN94103298A patent/CN1056851C/zh not_active Expired - Lifetime
- 1994-03-30 AU AU59185/94A patent/AU684489B2/en not_active Expired
- 1994-03-30 TW TW083102761A patent/TW343198B/zh active
- 1994-03-30 CA CA002120303A patent/CA2120303C/en not_active Expired - Lifetime
- 1994-03-31 KR KR1019940006639A patent/KR100304201B1/ko not_active IP Right Cessation
- 1994-03-31 PL PL94302854A patent/PL178791B1/pl unknown
- 1994-03-31 SK SK383-94A patent/SK281828B6/sk unknown
- 1994-03-31 JP JP09682994A patent/JP3694332B2/ja not_active Expired - Lifetime
- 1994-03-31 HU HU9400937A patent/HUT69726A/hu unknown
- 1994-03-31 RU RU94011276A patent/RU2130030C1/ru active
-
1996
- 1996-03-15 US US08/616,770 patent/US5849692A/en not_active Expired - Lifetime
-
1998
- 1998-10-01 US US09/164,585 patent/US6169072B1/en not_active Expired - Lifetime
-
1999
- 1999-12-08 GR GR990403165T patent/GR3032074T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
TW343198B (en) | 1998-10-21 |
NO941152L (no) | 1994-10-03 |
CN1056851C (zh) | 2000-09-27 |
KR100304201B1 (ko) | 2001-11-30 |
CA2120303A1 (en) | 1994-10-02 |
RU2130030C1 (ru) | 1999-05-10 |
CZ70494A3 (en) | 1995-01-18 |
CZ286768B6 (en) | 2000-07-12 |
JP3694332B2 (ja) | 2005-09-14 |
PL178791B1 (pl) | 2000-06-30 |
HUT69726A (en) | 1995-09-28 |
NO313756B1 (no) | 2002-11-25 |
EP0632053A2 (de) | 1995-01-04 |
JPH06329698A (ja) | 1994-11-29 |
GR3032074T3 (en) | 2000-03-31 |
AU684489B2 (en) | 1997-12-18 |
US6169072B1 (en) | 2001-01-02 |
DE4310643A1 (de) | 1994-10-06 |
SK38394A3 (en) | 1995-02-08 |
EP0632053A3 (de) | 1995-02-15 |
CA2120303C (en) | 2007-05-01 |
DK0632053T3 (da) | 2000-03-13 |
US5849692A (en) | 1998-12-15 |
CN1099760A (zh) | 1995-03-08 |
EP0632053B1 (de) | 1999-09-08 |
NO941152D0 (no) | 1994-03-29 |
AU5918594A (en) | 1994-10-06 |
ATE184288T1 (de) | 1999-09-15 |
UA34436C2 (uk) | 2001-03-15 |
HU9400937D0 (en) | 1994-06-28 |
SK281828B6 (sk) | 2001-08-06 |
ES2138632T3 (es) | 2000-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |