DE59811296D1 - Pentopyranosyl-nucleosid, seine herstellung und verwendung - Google Patents

Pentopyranosyl-nucleosid, seine herstellung und verwendung

Info

Publication number
DE59811296D1
DE59811296D1 DE59811296T DE59811296T DE59811296D1 DE 59811296 D1 DE59811296 D1 DE 59811296D1 DE 59811296 T DE59811296 T DE 59811296T DE 59811296 T DE59811296 T DE 59811296T DE 59811296 D1 DE59811296 D1 DE 59811296D1
Authority
DE
Germany
Prior art keywords
pentopyranosyl
nucleic acid
reactive group
biomolecule
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59811296T
Other languages
English (en)
Inventor
Christian Miculka
Norbert Windhab
Tilmann Brandstetter
Gerhard Burdinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Nanogen Recognomics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanogen Recognomics GmbH filed Critical Nanogen Recognomics GmbH
Priority to DE59811296T priority Critical patent/DE59811296D1/de
Application granted granted Critical
Publication of DE59811296D1 publication Critical patent/DE59811296D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/724Devices having flexible or movable element
    • Y10S977/727Devices having flexible or movable element formed from biological material
    • Y10S977/728Nucleic acids, e.g. DNA or RNA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/797Lipid particle
    • Y10S977/798Lipid particle having internalized material
    • Y10S977/799Containing biological material
    • Y10S977/80Nucleic acid, e.g. DNA or RNA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/832Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/835Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
    • Y10S977/836Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial having biological reactive capability
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/84Manufacture, treatment, or detection of nanostructure
    • Y10S977/894Manufacture, treatment, or detection of nanostructure having step or means utilizing biological growth
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/84Manufacture, treatment, or detection of nanostructure
    • Y10S977/895Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y10S977/896Chemical synthesis, e.g. chemical bonding or breaking
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/914Protein engineering
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/925Bioelectrical
DE59811296T 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung Expired - Lifetime DE59811296D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59811296T DE59811296D1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19741715A DE19741715A1 (de) 1997-09-22 1997-09-22 Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE59811296T DE59811296D1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
PCT/EP1998/005997 WO1999015539A2 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung

Publications (1)

Publication Number Publication Date
DE59811296D1 true DE59811296D1 (de) 2004-06-03

Family

ID=7843183

Family Applications (4)

Application Number Title Priority Date Filing Date
DE19741715A Withdrawn DE19741715A1 (de) 1997-09-22 1997-09-22 Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE59811296T Expired - Lifetime DE59811296D1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
DE59807330T Expired - Lifetime DE59807330D1 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids
DE59810856T Expired - Lifetime DE59810856D1 (de) 1997-09-22 1998-09-21 Verwendung eines konjugates enthaltend ein pentopyranosyl-nucleotid zur herstellung eines arrays

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19741715A Withdrawn DE19741715A1 (de) 1997-09-22 1997-09-22 Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE59807330T Expired - Lifetime DE59807330D1 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids
DE59810856T Expired - Lifetime DE59810856D1 (de) 1997-09-22 1998-09-21 Verwendung eines konjugates enthaltend ein pentopyranosyl-nucleotid zur herstellung eines arrays

Country Status (10)

Country Link
US (8) US6506896B1 (de)
EP (3) EP1017703B1 (de)
JP (3) JP4674965B2 (de)
KR (3) KR20010024202A (de)
AT (3) ATE260290T1 (de)
AU (3) AU757983B2 (de)
BR (3) BR9812501A (de)
CA (3) CA2303784A1 (de)
DE (4) DE19741715A1 (de)
WO (3) WO1999015541A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741739B4 (de) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
DE19741738A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
DE19815901A1 (de) * 1998-04-08 1999-10-14 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden
DE19837387A1 (de) 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US20010049111A1 (en) * 1999-08-13 2001-12-06 Norbert Windhab Methods, procedures, and formats for using microelectronic array devices to perform multiplex immunoassay analyses
DE10010118A1 (de) * 2000-03-03 2001-09-20 Henkel Kgaa Beschichtungssystem auf der Basis von Pyranosyl-Nukleinsäuren
DE10111681A1 (de) * 2001-03-09 2002-10-02 Nanogen Recognomics Gmbh Verbessertes Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
WO2004087931A1 (en) * 2003-04-03 2004-10-14 Korea Advanced Institute Of Science And Technology Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
US20070286863A1 (en) * 2006-05-17 2007-12-13 Christopher Sinal CMKLR regulation of adipogenesis and adipocyte metabolic function
JP5126706B2 (ja) * 2007-02-16 2013-01-23 独立行政法人農業・食品産業技術総合研究機構 2以上の水酸基を有する化合物のライブラリー合成方法
RU2015151857A (ru) 2008-12-02 2019-01-15 Уэйв Лайф Сайенсес Джапан, Инк. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
EP2593892A1 (de) * 2010-07-16 2013-05-22 Elitech Holding B.V. Orthogonale nukleinsäureaffinitätspaare
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
MX347361B (es) 2011-07-19 2017-04-12 Wave Life Sciences Ltd Metodos para la sintesis de acidos nucleicos funcionalizados.
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
US9982257B2 (en) 2012-07-13 2018-05-29 Wave Life Sciences Ltd. Chiral control
US9598458B2 (en) 2012-07-13 2017-03-21 Wave Life Sciences Japan, Inc. Asymmetric auxiliary group
WO2014175974A2 (en) 2013-03-13 2014-10-30 Elitech Holding B.V. Artificial nucleic acids
EP3095460A4 (de) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chirales nukleinsäureadjuvans mit antiallergischer wirkung und antiallergikum
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
CA2936712A1 (en) 2014-01-16 2015-07-23 Meena Chiral design
US10870845B2 (en) 2014-07-01 2020-12-22 Global Life Sciences Solutions Operations UK Ltd Methods for capturing nucleic acids
US10472620B2 (en) 2014-07-01 2019-11-12 General Electric Company Method, substrate and device for separating nucleic acids
US9593368B2 (en) 2014-07-01 2017-03-14 General Electric Company Methods for amplifying nucleic acids on substrates
CN107556355B (zh) * 2016-06-30 2021-10-22 上海兆维科技发展有限公司 一种核苷双亚磷酰胺及其制备方法

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2644817A (en) * 1949-10-28 1953-07-07 Merck & Co Inc 1-glycosido-5, 6 dimethyl benzimidazoles and process therefor
GB690119A (en) * 1950-07-13 1953-04-15 British Drug Houses Ltd Improvements in or relating to the manufacture of heterocyclic compounds
US2719843A (en) * 1951-10-24 1955-10-04 Davoll John Method of synthesizing nucleosides and analogous compounds and compounds prepared thereby
GB866815A (en) * 1957-06-14 1961-05-03 Pfizer & Co C Piperazine salts
US2993039A (en) * 1959-11-06 1961-07-18 Upjohn Co Preparing nu-glycosides of aldose and ketose sugars
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3752804A (en) 1969-06-14 1973-08-14 Takeda Chemical Industries Ltd 2-allyloxyinosine-5'-phosphate and physiologically acceptable salts thereof
JPS5036087A (de) * 1973-07-13 1975-04-04
JPS5821005B2 (ja) * 1974-08-26 1983-04-26 株式会社クボタ 球状黒鉛鋳鉄製造における黒鉛球状化剤
US3995190A (en) * 1974-09-19 1976-11-30 Butler, Binion, Rice, Cook & Knapp Mobile ion film memory
US4283773A (en) * 1977-08-30 1981-08-11 Xerox Corporation Programmable master controller communicating with plural controllers
US4225410A (en) * 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
JPS55153796A (en) * 1979-05-21 1980-11-29 Meiji Seika Kaisha Ltd 5-fluorouracil nucleoside and its preparation
US4352795A (en) 1981-01-29 1982-10-05 Warner-Lambert Company 7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production
JPS57146796A (en) * 1981-03-09 1982-09-10 Haruo Ogura Glycoside derivative
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4476301A (en) * 1982-04-29 1984-10-09 Centre National De La Recherche Scientifique Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4580895A (en) * 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
CA1242486A (en) * 1983-11-25 1988-09-27 John J. Comfort Automatic test equipment
US4661451A (en) * 1984-02-06 1987-04-28 Ortho Diagnostic Systems, Inc. Methods for immobilizing and translocating biological cells
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
DE3434039A1 (de) * 1984-09-17 1986-03-27 Behringwerke Ag, 3550 Marburg Glycopeptide, verfahren zu ihrer herstellung und ihre verwendung
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4584075A (en) * 1984-11-26 1986-04-22 Ionics Incorporated Process and apparatus for electrically desorbing components selectively sorbed on an electrolytically conducting barrier
GB8432118D0 (en) 1984-12-19 1985-01-30 Malcolm A D B Sandwich hybridisation technique
US4594135A (en) * 1985-02-20 1986-06-10 Ionics Incorporated Process and apparatus for electrically desorbing components selectively sorbed on granules
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
JPH0337770Y2 (de) 1985-03-30 1991-08-09
DE3513168A1 (de) * 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4816418A (en) * 1985-07-22 1989-03-28 Sequoia-Turner Corporation Method and apparatus for performing automated, multi-sequential immunoassays
EP0213825A3 (de) * 1985-08-22 1989-04-26 Molecular Devices Corporation Chemisch-modulierte Mehrfachkapazitanz
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
EP0228075B1 (en) 1986-01-03 1991-04-03 Molecular Diagnostics, Inc. Eucaryotic genomic dna dot-blot hybridization method
US5242797A (en) * 1986-03-21 1993-09-07 Myron J. Block Nucleic acid assay method
US5125748A (en) * 1986-03-26 1992-06-30 Beckman Instruments, Inc. Optical detection module for use in an automated laboratory work station
FR2604438B1 (fr) * 1986-09-26 1988-12-23 Centre Nat Rech Scient Nouveaux conjugues de couplage entre des sequences d'arn ou d'adn et une proteine, leur procede de preparation et leur application biologique
US4918056A (en) * 1986-10-14 1990-04-17 Health Research, Inc. (Roswell Park Division) 2-substituted arabinopyranosyl nucleosides and nucleotides
DE3750503T2 (de) * 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
US4859538A (en) * 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
US4885211A (en) * 1987-02-11 1989-12-05 Eastman Kodak Company Electroluminescent device with improved cathode
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
YU57087A (en) 1987-04-01 1990-08-31 Centar Za Genticko Inzenjerstv Process for obtaining genome by hebridization and oligonucleotidic tests
US5114674A (en) 1987-05-01 1992-05-19 Biotronic Systems Corporation Added array of molecular chains for interfering with electrical fields
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5074977A (en) * 1987-05-05 1991-12-24 The Washington Technology Center Digital biosensors and method of using same
JP2682859B2 (ja) 1987-07-27 1997-11-26 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション レセプター膜
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
JP3012244B2 (ja) * 1987-09-21 2000-02-21 ジェン―プローブ インコーポレイテッド ヌクレオチドプローブ用非ヌクレオチド連結試薬
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5075077A (en) * 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
WO1990001564A1 (en) 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
US5096669A (en) * 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US5849482A (en) 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5219726A (en) * 1989-06-02 1993-06-15 The Salk Institute For Biological Studies Physical mapping of complex genomes
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE3924454A1 (de) * 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
US5681941A (en) * 1990-01-11 1997-10-28 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5750015A (en) * 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
JPH05507025A (ja) * 1990-04-11 1993-10-14 ルドヴィグ・インスティテュート・フォー・キャンサー・リサーチ 逐次的化学反応が可能な方法および装置
US5166063A (en) * 1990-06-29 1992-11-24 Eli Lilly And Company Immobolization of biomolecules by enhanced electrophoretic precipitation
WO1992004470A1 (en) 1990-09-12 1992-03-19 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US5527670A (en) * 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
GB2247889A (en) 1990-09-12 1992-03-18 Scient Generics Ltd DNA denaturation by an electric potential
US5227265A (en) * 1990-11-30 1993-07-13 Eastman Kodak Company Migration imaging system
US5679757A (en) 1990-12-12 1997-10-21 The Regents Of The University Of California Highly organic solvent soluble, water insoluble electroluminescent polyphenylene vinylenes having pendant steroid groups and products and uses thereof
WO1992019960A1 (en) * 1991-05-09 1992-11-12 Nanophore, Inc. Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5349203A (en) * 1991-12-09 1994-09-20 Mitsubishi Denki Kabushiki Kaisha Organic electric-field switching device
JPH05236997A (ja) * 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
GB9207086D0 (en) * 1992-03-31 1992-05-13 Sharp Kk Improvements relating to information technology
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
EP1223173B1 (de) * 1992-07-23 2005-07-13 Isis Pharmaceuticals, Inc. Neue 2'-O-Alkyl-Nukleoside und -Phosphoramidite, Verfahren zu ihrer Herstellung und ihre Verwendungen
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5433819A (en) * 1993-05-26 1995-07-18 Pressac, Inc. Method of making circuit boards
US5789167A (en) * 1993-09-10 1998-08-04 Genevue, Inc. Optical detection of position of oligonucleotides on large DNA molecules
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5445525A (en) * 1994-05-12 1995-08-29 Intel Corporation Interconnection scheme for integrated circuit card with auxiliary contacts
WO1997027317A1 (en) * 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
ATE284894T1 (de) * 1994-10-24 2005-01-15 Genencor Int L-pyranosyl-nukleoside
US5718915A (en) * 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5464517A (en) * 1995-01-30 1995-11-07 Bio-Rad Laboratories Electrophoresis in low conductivity buffers
US5602262A (en) * 1995-02-03 1997-02-11 Eli Lilly And Company Process for the preparation of 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
EP0739898B1 (de) * 1995-03-13 2001-09-26 Aventis Pharma Deutschland GmbH Phosphonomonoesternnukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
WO1996039414A1 (en) * 1995-06-01 1996-12-12 Hybridon, Inc. Novel base protecting groups for oligonucleotide synthesis
KR19990028344A (ko) * 1995-06-23 1999-04-15 로버터 에이.커리 치료 화합물
WO1997005156A1 (en) 1995-07-27 1997-02-13 Carsten Behrens A new achiral linker reagent for the incorporation of multiple amino groups into oligonucleotides
US5912340A (en) 1995-10-04 1999-06-15 Epoch Pharmaceuticals, Inc. Selective binding complementary oligonucleotides
AU7286696A (en) * 1995-10-13 1997-05-07 F. Hoffmann-La Roche Ag Antisense oligomers
GB9602028D0 (en) 1996-02-01 1996-04-03 Amersham Int Plc Nucleoside analogues
US5660701A (en) * 1996-02-29 1997-08-26 Bio-Rad Laboratories, Inc. Protein separations by capillary electrophoresis using amino acid-containing buffers
DE19651560A1 (de) * 1996-12-11 1998-06-18 Hoechst Ag Neue funktionelle supramolekulare Nanosysteme
JPH10306907A (ja) * 1997-05-06 1998-11-17 Kobe Steel Ltd 流動層熱分解方法及び熱分解炉並びに被燃焼物処理装置
NZ501415A (en) * 1997-06-10 2001-10-26 Glaxo Group Ltd Benzimidazole derivatives (optionally with saccharide substituents) useful for the treatment or prophylaxis of viral infections (particularly herpes, cytomegalovirus and Hepatitis B) or for the treatment or prophylaxis of restenosis
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741738A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
EP1210607A4 (de) * 1999-08-13 2004-12-22 Nanogen Inc Mikroelektronische, molekulare deskriptor-feldvorrichtung, methoden, verfahren und formate zur kombinatorischen auswahl von intermolekularen ligandbindenden strukturen und zur überprüfung von medikamenten

Also Published As

Publication number Publication date
US6608186B1 (en) 2003-08-19
ATE260290T1 (de) 2004-03-15
BR9812501A (pt) 2000-12-12
EP1017703A2 (de) 2000-07-12
CA2302414A1 (en) 1999-04-01
US6506896B1 (en) 2003-01-14
CA2303784A1 (en) 1999-04-01
EP1017703B1 (de) 2004-04-28
ATE265462T1 (de) 2004-05-15
JP4674964B2 (ja) 2011-04-20
ATE233272T1 (de) 2003-03-15
US6613894B1 (en) 2003-09-02
EP1019423A2 (de) 2000-07-19
JP4601817B2 (ja) 2010-12-22
KR100571299B1 (ko) 2006-04-17
AU1024699A (en) 1999-04-12
WO1999015541A2 (de) 1999-04-01
JP2001517675A (ja) 2001-10-09
US20090221793A1 (en) 2009-09-03
US7777024B2 (en) 2010-08-17
KR20010030656A (ko) 2001-04-16
CA2303229A1 (en) 1999-04-01
EP1017704A2 (de) 2000-07-12
DE59810856D1 (de) 2004-04-01
US20060270840A1 (en) 2006-11-30
WO1999015539A2 (de) 1999-04-01
JP2001517674A (ja) 2001-10-09
US7501506B2 (en) 2009-03-10
AU757983B2 (en) 2003-03-13
CA2303229C (en) 2009-12-01
EP1019423B1 (de) 2003-02-26
WO1999015540A3 (de) 1999-06-10
WO1999015539A3 (de) 1999-06-17
DE59807330D1 (de) 2003-04-03
US20040198966A1 (en) 2004-10-07
US20050053945A1 (en) 2005-03-10
EP1017704B1 (de) 2004-02-25
BR9812381A (pt) 2002-04-30
US20030039997A1 (en) 2003-02-27
WO1999015540A2 (de) 1999-04-01
AU1024599A (en) 1999-04-12
DE19741715A1 (de) 1999-03-25
KR20010030659A (ko) 2001-04-16
KR20010024202A (ko) 2001-03-26
BR9812376A (pt) 2000-12-12
JP4674965B2 (ja) 2011-04-20
WO1999015541A3 (de) 1999-06-17
JP2001517676A (ja) 2001-10-09
AU9627198A (en) 1999-04-12
AU751058B2 (en) 2002-08-08
US7153955B2 (en) 2006-12-26

Similar Documents

Publication Publication Date Title
DE59811296D1 (de) Pentopyranosyl-nucleosid, seine herstellung und verwendung
CA2184005A1 (en) Novel phosphoramidate and phophorothioamidate oligomeric compounds
NO992167D0 (no) Preparater og fremgangsmÕter for immobilisering av nukleinsyrer til faste bµrere
ATE425987T1 (de) Gereinigtes antigen fur die alzheimer krankheit und verfahren zu dessen herstellung und verwendung
DK0462145T3 (da) Covalente konjugater mellem lipid og oligonucleotid
CY1108716T1 (el) Μεθοδος διαγνωσεως της νοσου του alzheimer με βαση μια μορφη μεταγραφης γονιδιου.
FI103809B1 (fi) In vitro -menetelmä templaattien tuottamiseksi DNA-sekventointia varten
ATE284417T1 (de) Polymermodifizierte anionische stärke, verfahren zu ihrer herstellung und ihre verwendung
EP0369566A3 (de) Bifunktionelle chimäre Antikörper
ATE234869T1 (de) Verfahren zur herstellung von geträgertem metallocen-katalysator und olefin- polymerisationsverfahren unter dessen verwendung
EP1348712A4 (de) L-nukleinsäurederivate und verfahren zu deren synthese
ATE541558T1 (de) Photoaktivierbare zusammensetzung und ihre verwendung
ATE79121T1 (de) Iodierte polymere, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel.
MX9800967A (es) Compuestos quimicos.
ATE321768T1 (de) Linker-nucleosid, seine herstellung und verwendung
NO20002214L (no) FremgangsmÕte for syntese av pyrrolaminer
DE69835954D1 (de) Herstellung von polyorganophosphazenen mit bestimmtem molekulargewicht
TR200003291T2 (tr) İzomerden arınmış, çok ikameli aza-halkalı bileşimlerin üretilmelerine yönelik yöntem.
ATE552263T1 (de) 3'-desoxypentopyranosyl-nucleinsäure und ihre herstellung
ATE105293T1 (de) Phosphortrilactame und verfahren zu deren herstellung.
DE50214965D1 (de) Reaktive azofarbstoffe, verfahren zu ihrer herstellung und ihre verwendung
HUP9801666A2 (hu) Eljárás ciano-formiát-észter-származék előállítására
IL81434A0 (en) Sor gene product from human t-cell lymphotropic virus type iii
Andrew LINKING MANPOWER PLANNING AND MANAGEMENT DEVELOPMENT
ATE326482T1 (de) Anti-petasin-antikörper, verfahren zu ihrer herstellung und ihre verwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS S.A., PARIS, FR

8328 Change in the person/name/address of the agent

Representative=s name: ACKERMANN, J., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW.,