DE60016415D1 - Genetisches versuchssystem - Google Patents

Genetisches versuchssystem

Info

Publication number
DE60016415D1
DE60016415D1 DE60016415T DE60016415T DE60016415D1 DE 60016415 D1 DE60016415 D1 DE 60016415D1 DE 60016415 T DE60016415 T DE 60016415T DE 60016415 T DE60016415 T DE 60016415T DE 60016415 D1 DE60016415 D1 DE 60016415D1
Authority
DE
Germany
Prior art keywords
samples
reagents
glass slide
openings
slide member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60016415T
Other languages
English (en)
Other versions
DE60016415T2 (de
Inventor
D Juncosa
Rene Bongard
Johannes Dapprich
Richard Scribner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Cellmark Inc
Original Assignee
Orchid Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Biosciences Inc filed Critical Orchid Biosciences Inc
Application granted granted Critical
Publication of DE60016415D1 publication Critical patent/DE60016415D1/de
Publication of DE60016415T2 publication Critical patent/DE60016415T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
DE60016415T 1999-05-27 2000-05-11 Genetisches versuchssystem Expired - Fee Related DE60016415T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/321,170 US6225109B1 (en) 1999-05-27 1999-05-27 Genetic analysis device
US321170 1999-05-27
PCT/US2000/013100 WO2000073766A1 (en) 1999-05-27 2000-05-11 Genetic assay system

Publications (2)

Publication Number Publication Date
DE60016415D1 true DE60016415D1 (de) 2005-01-05
DE60016415T2 DE60016415T2 (de) 2005-05-19

Family

ID=23249497

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60016415T Expired - Fee Related DE60016415T2 (de) 1999-05-27 2000-05-11 Genetisches versuchssystem

Country Status (8)

Country Link
US (2) US6225109B1 (de)
EP (1) EP1196755B1 (de)
JP (1) JP2003501620A (de)
AT (1) ATE284027T1 (de)
AU (1) AU777018B2 (de)
CA (1) CA2374928A1 (de)
DE (1) DE60016415T2 (de)
WO (1) WO2000073766A1 (de)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6270730B1 (en) * 1998-06-16 2001-08-07 Northwest Engineering Inc. Multi-well rotary synthesizer
AU3508600A (en) * 1999-02-26 2000-09-14 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7115423B1 (en) * 1999-10-22 2006-10-03 Agilent Technologies, Inc. Fluidic structures within an array package
US20030170659A1 (en) * 2000-01-24 2003-09-11 Ingeneus Corporation Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding
US6982147B2 (en) * 2000-01-24 2006-01-03 Ingeneus Corporation Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
US7001740B2 (en) * 2000-11-08 2006-02-21 Surface Logix, Inc. Methods of arraying biological materials using peelable and resealable devices
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
US6803205B2 (en) * 2000-11-08 2004-10-12 Surface Logix, Inc. Methods of measuring enzyme activity using peelable and resealable devices
US6967074B2 (en) * 2000-11-08 2005-11-22 Surface Logix, Inc. Methods of detecting immobilized biomolecules
US7371563B2 (en) * 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US7351575B2 (en) * 2000-11-08 2008-04-01 Surface Logix, Inc. Methods for processing biological materials using peelable and resealable devices
US7378280B2 (en) * 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7776571B2 (en) * 2000-12-12 2010-08-17 Autogenomics, Inc. Multi-substrate biochip unit
JP4797196B2 (ja) * 2001-02-14 2011-10-19 株式会社 フューエンス マイクロチップ
US7223363B2 (en) * 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US7297518B2 (en) * 2001-03-12 2007-11-20 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
US6960437B2 (en) * 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
EP2169383A1 (de) * 2001-06-15 2010-03-31 Bayer Technology Services GmbH Körper für Durchflussküvetten und deren Verwendung
US20050158845A1 (en) * 2001-08-06 2005-07-21 Wikswo John P. Device and methods for measuring the response of a least one cell to a medium
US6682702B2 (en) 2001-08-24 2004-01-27 Agilent Technologies, Inc. Apparatus and method for simultaneously conducting multiple chemical reactions
US7118910B2 (en) 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same
JP4566509B2 (ja) * 2001-12-28 2010-10-20 株式会社エンプラス プラスチックプレート及びプラスチックプレート組立体
US6773677B2 (en) * 2002-01-09 2004-08-10 Caliper Life Sciences, Inc. Slide cassette for fluidic injection
US7731909B1 (en) * 2002-01-22 2010-06-08 Grace Bio-Labs, Inc. Reaction surface array diagnostic apparatus
US7736594B1 (en) * 2002-01-22 2010-06-15 Grace Bio-Labs, Inc. Reaction surface array diagnostic apparatus
JP2005521425A (ja) 2002-04-01 2005-07-21 フルイディグム コーポレイション 微小流体粒子分析システム
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
JP2005532043A (ja) * 2002-04-11 2005-10-27 シークエノム， インコーポレイテッド 固相支持体上で化学反応を実行するための方法および装置
US20030235521A1 (en) * 2002-06-21 2003-12-25 Shea Laurence R. Array assay devices and methods of using the same
US7220573B2 (en) * 2002-06-21 2007-05-22 Agilent Technologies, Inc. Array assay devices and methods of using the same
JP2005531001A (ja) * 2002-06-24 2005-10-13 フルイディグム コーポレイション 再循環流体ネットワークおよびその使用法
US7442342B2 (en) * 2002-06-26 2008-10-28 Ge Healthcare Bio-Sciences Ab Biochip holder and method of collecting fluid
JP4057967B2 (ja) * 2002-07-31 2008-03-05 株式会社東芝 塩基配列自動解析装置
US7745203B2 (en) * 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
US7202398B2 (en) * 2002-08-16 2007-04-10 E. I. Du Pont De Nemours And Company Chalcone isomerase
US7143785B2 (en) 2002-09-25 2006-12-05 California Institute Of Technology Microfluidic large scale integration
EP1546412B1 (de) 2002-10-02 2014-05-21 California Institute Of Technology MIKROFLUIDISCHE NUKLEINSûUREANALYSE
CA2503797A1 (en) * 2002-11-08 2004-05-27 Irm, Llc Systems and methods of sorting samples
WO2004087323A1 (en) * 2003-03-28 2004-10-14 Mergen Ltd. Multi-array systems and methods of use thereof
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
EP1628753A1 (de) * 2003-05-30 2006-03-01 Applera Corporation Apparatur und verfahren zur hybridisierung und spr detektion
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
WO2005003769A1 (ja) * 2003-07-04 2005-01-13 Kubota Corporation バイオチップ
US20050026299A1 (en) * 2003-07-31 2005-02-03 Arindam Bhattacharjee Chemical arrays on a common carrier
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005052578A1 (ja) * 2003-11-28 2005-06-09 Olympus Corporation 生体関連物質の検査装置とその反応ステージ
KR100695123B1 (ko) 2003-12-03 2007-03-14 삼성전자주식회사 Ｔｍ에 따라 기판상에 고정화된 프로브 폴리뉴클레오티드군을 2이상 포함하는 폴리뉴클레오티드 어레이 및 그를이용하는 표적 핵산 검출 방법
US20050135974A1 (en) * 2003-12-18 2005-06-23 Harvey Michael A. Device for preparing multiple assay samples using multiple array surfaces
WO2005073408A2 (en) * 2004-01-23 2005-08-11 Pyxis Genomics, Inc. Small segments of dna determine animal identity and source
WO2005080605A2 (en) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
US8034306B1 (en) * 2004-02-20 2011-10-11 Grace Bio-Labs, Inc. Reaction surface array diagnostic apparatus including a flexible microtitre plate
DE102004022483B4 (de) * 2004-05-07 2006-05-04 P.A.L.M. Microlaser Technologies Ag Halter für eine Aufnahmevorrichtung zum Aufnehmen von biologischen Objekten
JP4627455B2 (ja) * 2004-05-18 2011-02-09 三菱レイヨン株式会社 Ｄｎａマイクロアレイ処理装置
US20050277122A1 (en) * 2004-06-14 2005-12-15 Fredrick Joseph P Devices and methods for contacting fluid with a chemical array
JP2006153785A (ja) * 2004-12-01 2006-06-15 Hitachi Ltd 溶液攪拌装置及び分析システム
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
TW200722524A (en) * 2005-12-13 2007-06-16 Zen U Biotechnology Co Ltd The device of determining the activity value of nattokinase
US7815868B1 (en) * 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US20090186775A1 (en) * 2008-01-15 2009-07-23 Empire Genomics, Llc Organization Method and device for dual array hybridization karyotype analysis
WO2009137244A1 (en) * 2008-04-15 2009-11-12 Charles River Laboratories, Inc. Cartridge and method for sample analysis
DE102008025992B4 (de) * 2008-05-30 2011-01-27 Siemens Healthcare Diagnostics Gmbh Titerplatte und Verfahren zur Detektion eines Analyten
CN101368206B (zh) * 2008-07-16 2012-08-22 深圳华因康基因科技有限公司 测序反应小室、基因测序反应台及基因测序设备
US20100227327A1 (en) * 2008-08-08 2010-09-09 Xiaoliang Sunney Xie Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
US20100036110A1 (en) * 2008-08-08 2010-02-11 Xiaoliang Sunney Xie Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
KR101578153B1 (ko) * 2008-08-26 2015-12-17 삼성전자주식회사 슬라이드 반응 장치
DE102008053270A1 (de) 2008-10-27 2010-05-12 Medizinische Hochschule Hannover Vorrichtung und Verfahren zur Analyse von Zellen
KR20100090955A (ko) * 2009-02-09 2010-08-18 삼성전자주식회사 혼성화 챔버 및 이를 이용한 혼성화 방법
TW201234011A (en) 2010-11-01 2012-08-16 Nanoink Inc High-throughput slide processing apparatus
WO2012061308A1 (en) 2010-11-01 2012-05-10 Nanoink, Inc. High-throughput assay methods and articles
CN105973805B (zh) * 2011-01-10 2019-06-18 伊鲁米那股份有限公司 用于生物或化学分析的样品的成像方法
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012122379A2 (en) * 2011-03-08 2012-09-13 Colorado State University Research Foundation Microfluidic cytochemical staining system
CN104080958A (zh) 2011-10-19 2014-10-01 纽亘技术公司 用于定向核酸扩增和测序的组合物和方法
GB2513793B (en) 2012-01-26 2016-11-02 Nugen Tech Inc Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
EP2861787B1 (de) 2012-06-18 2017-09-20 Nugen Technologies, Inc. Zusammensetzungen und verfahren zur negativen auswahl von unerwünschten nukleinsäuresequenzen
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
GB2519255B (en) 2013-02-01 2016-01-06 Univ California Methods for genome assembly and haplotype phasing
WO2014144092A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
CA2929596C (en) 2013-11-13 2022-07-05 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
WO2015089243A1 (en) 2013-12-11 2015-06-18 The Regents For Of The University Of California Methods for labeling dna fragments to recontruct physical linkage and phase
WO2015131107A1 (en) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
WO2016019360A1 (en) 2014-08-01 2016-02-04 Dovetail Genomics Llc Tagging nucleic acids for sequence assembly
CN107075581B (zh) 2014-08-06 2022-03-18 纽亘技术公司 由靶向测序进行数字测量
EP3259696A1 (de) 2015-02-17 2017-12-27 Dovetail Genomics LLC Nukleinsäuresequenzanordnung
US11807896B2 (en) 2015-03-26 2023-11-07 Dovetail Genomics, Llc Physical linkage preservation in DNA storage
US10384207B2 (en) 2015-07-21 2019-08-20 Neuro Probe Incorporated Assay apparatus and methods
CN108368542B (zh) 2015-10-19 2022-04-08 多弗泰尔基因组学有限责任公司 用于基因组组装、单元型定相以及独立于靶标的核酸检测的方法
JP7441003B2 (ja) 2016-02-23 2024-02-29 ダブテイル ゲノミクス エルエルシー ゲノムアセンブリのためのフェージングされたリードセットの生成とハプロタイプフェージング
EP3954771A1 (de) 2016-05-13 2022-02-16 Dovetail Genomics, LLC Rückgewinnung von long-range-bindungsinformationen aus konservierten proben
US11083907B2 (en) 2016-08-01 2021-08-10 Neuropair, Inc. Superparamagnetic particle scaffold for regenerating damaged neural tissue
US10190155B2 (en) 2016-10-14 2019-01-29 Nugen Technologies, Inc. Molecular tag attachment and transfer
EP3600663A1 (de) * 2017-03-31 2020-02-05 Forward Biotech, Inc. Vorrichtung zur messung von fluidvolumen
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
CA3090102A1 (en) 2018-01-31 2019-08-08 Dovetail Genomics, Llc Sample prep for dna linkage recovery
JP2022512328A (ja) 2018-12-07 2022-02-03 エレメント バイオサイエンシーズ，インク． フローセルデバイスおよびその使用
US11053540B1 (en) 2020-01-17 2021-07-06 Element Biosciences, Inc. High performance fluorescence imaging module for genomic testing assay
US11198121B1 (en) 2020-06-10 2021-12-14 Element Biosciences, Inc. Flow cell systems and devices
WO2022132782A1 (en) * 2020-12-15 2022-06-23 Colgate-Palmolive Company Microfluidic device for testing aqueous samples containing biomaterials

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753776A (en) * 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US6176962B1 (en) * 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
JP2763468B2 (ja) * 1992-12-25 1998-06-11 株式会社日立製作所 光散乱を用いた液体内の粒子分類装置
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix Inc Verfahren und Vorrichtung zum Verpacken von Chips
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
GB9506312D0 (en) 1995-03-28 1995-05-17 Medical Res Council Improvements in or relating to sample processing
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
DE59712460D1 (de) * 1996-11-18 2005-12-01 Novartis Ag Messvorrichtung mit einem planaren optischen wellenleiter
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US6322683B1 (en) * 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
DE10014204C2 (de) * 2000-03-22 2002-08-14 Max Planck Gesellschaft Mikrohybridisierungskammer

Also Published As

Publication number Publication date
EP1196755B1 (de) 2004-12-01
WO2000073766A1 (en) 2000-12-07
AU777018B2 (en) 2004-09-30
JP2003501620A (ja) 2003-01-14
DE60016415T2 (de) 2005-05-19
ATE284027T1 (de) 2004-12-15
US20010051113A1 (en) 2001-12-13
AU5010400A (en) 2000-12-18
EP1196755A4 (de) 2002-08-14
US6720143B2 (en) 2004-04-13
US6225109B1 (en) 2001-05-01
EP1196755A1 (de) 2002-04-17
CA2374928A1 (en) 2000-12-07

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