DE60024133D1 - Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form - Google Patents

Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form

Info

Publication number
DE60024133D1
DE60024133D1 DE60024133T DE60024133T DE60024133D1 DE 60024133 D1 DE60024133 D1 DE 60024133D1 DE 60024133 T DE60024133 T DE 60024133T DE 60024133 T DE60024133 T DE 60024133T DE 60024133 D1 DE60024133 D1 DE 60024133D1
Authority
DE
Germany
Prior art keywords
calcium salt
crystalline form
hemi calcium
based preparation
trihydrate hemi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60024133T
Other languages
English (en)
Other versions
DE60024133T2 (de
Inventor
William Tully
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Science and Technology Ireland Ltd
Original Assignee
Warner Lambert Research and Development Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11042528&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60024133(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Research and Development Ireland Ltd filed Critical Warner Lambert Research and Development Ireland Ltd
Application granted granted Critical
Publication of DE60024133D1 publication Critical patent/DE60024133D1/de
Publication of DE60024133T2 publication Critical patent/DE60024133T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
DE60024133T 1999-12-17 2000-12-18 Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form Expired - Fee Related DE60024133T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/IE99/00132 1999-12-17
IE9900132 1999-12-17
PCT/IE2000/000150 WO2001044180A1 (en) 1999-12-17 2000-12-18 A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt

Publications (2)

Publication Number Publication Date
DE60024133D1 true DE60024133D1 (de) 2005-12-22
DE60024133T2 DE60024133T2 (de) 2006-08-03

Family

ID=11042528

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60024133T Expired - Fee Related DE60024133T2 (de) 1999-12-17 2000-12-18 Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form

Country Status (13)

Country Link
US (1) US6600051B2 (de)
EP (2) EP1237865B1 (de)
JP (1) JP2003517038A (de)
AT (1) ATE309985T1 (de)
AU (1) AU776613B2 (de)
CA (1) CA2388226A1 (de)
DE (1) DE60024133T2 (de)
ES (1) ES2252088T3 (de)
HU (1) HUP0203708A3 (de)
IL (2) IL149087A0 (de)
MX (1) MXPA02004078A (de)
WO (1) WO2001044180A1 (de)
ZA (1) ZA200203648B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ294695B6 (cs) 1995-07-17 2005-02-16 Warner-Lambert Company Krystalická forma II atorvastatinu nebo jeho hydrátu, farmaceutický přípravek obsahující tuto krystalickou formu II atorvastatinu a její použití v lékařství
US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
CN1524073A (zh) * 2001-06-29 2004-08-25 ����-�����ع�˾ ′R-(R*,R*)-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-(苯基氨基）羰基-1H-吡咯-1-庚酸钙盐（2∶1）（阿托伐他汀）
US7074818B2 (en) * 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
WO2003070702A1 (en) * 2002-02-15 2003-08-28 Teva Pharmaceutical Industries Ltd. Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation, as well as novel processes for preparing atorvastatin hemi-calcium forms i, viii and ix
EP1465901A4 (de) 2002-02-19 2006-02-01 Teva Pharma Verfahren zur desolvatation von atorvastatin hemi-kalzium solvaten und von im wesentlichen lösungsmittelfreiem atorvastatin hemi-kalzium
EP1424324A1 (de) * 2002-11-28 2004-06-02 Teva Pharmaceutical Industries Limited Kristalline Form F von Atorvastatin
CA2508871C (en) * 2002-11-28 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline form f of atorvastatin hemi-calcium salt
ES2739493T3 (es) 2004-05-05 2020-01-31 Pfizer Prod Inc Formas de sal de de atorvastatina con benetamina
MX2007000582A (es) * 2004-07-16 2007-03-30 Lek Pharmaceuticals Productos de degradacion oxidativa de atorvastatin calcio.
JP2008530146A (ja) * 2005-12-13 2008-08-07 テバ ファーマシューティカル インダストリーズ リミティド アトルバスタチン・ヘミカルシウムの結晶形及びその調製方法
US8486500B2 (en) * 2007-06-20 2013-07-16 Coating Excellence International Llc Flat bottom bag
GR1006173B (el) * 2007-12-21 2008-11-26 Ανωνυμος Φαρμακευτικη-Χημικη Βιομηχανια Medichromα.Ε. Χημικη συνθεση του (3r, 5r) - διυδροξυ - 7 - [2-(4-φθοροφαινυλ) - 5 - σοπροπυλ - 3 - φαινυλ - 4 - φαινυλκαρβαμοϋλο - πυρρολυλο - τριενυδρο - επτανοϊκου ασβεστιου, εφαρμογη φαρμακευτικου σκευασματος και παραγωγικη διαδικασια
CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5216174A (en) 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5245047A (en) 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5149837A (en) 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5124482A (en) 1988-02-22 1992-06-23 Warner-Lambert Company Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5248793A (en) 1990-10-17 1993-09-28 Warner-Lambert Company Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5103024A (en) 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
CZ294695B6 (cs) * 1995-07-17 2005-02-16 Warner-Lambert Company Krystalická forma II atorvastatinu nebo jeho hydrátu, farmaceutický přípravek obsahující tuto krystalickou formu II atorvastatinu a její použití v lékařství
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
IL127058A (en) 1996-07-29 2001-07-24 Warner Lambert Co Process for the synthesis of protected esters of acid (S) - 4,3 dehydroxybutyric
ATE360608T1 (de) 1997-12-19 2007-05-15 Pfizer Ireland Pharmaceuticals Verfahren zur herstellung von 1,3-diolen

Also Published As

Publication number Publication date
HUP0203708A2 (hu) 2003-03-28
HUP0203708A3 (en) 2003-11-28
US6600051B2 (en) 2003-07-29
DE60024133T2 (de) 2006-08-03
IL149087A0 (en) 2002-11-10
WO2001044180A1 (en) 2001-06-21
MXPA02004078A (es) 2002-10-11
IL149087A (en) 2006-12-31
EP1237865A1 (de) 2002-09-11
US20020156294A1 (en) 2002-10-24
AU776613B2 (en) 2004-09-16
EP1584616A1 (de) 2005-10-12
ATE309985T1 (de) 2005-12-15
EP1237865B1 (de) 2005-11-16
JP2003517038A (ja) 2003-05-20
CA2388226A1 (en) 2001-06-21
AU2544001A (en) 2001-06-25
ES2252088T3 (es) 2006-05-16
ZA200203648B (en) 2003-02-10

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee