DE60024133D1 - Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form - Google Patents
Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner formInfo
- Publication number
- DE60024133D1 DE60024133D1 DE60024133T DE60024133T DE60024133D1 DE 60024133 D1 DE60024133 D1 DE 60024133D1 DE 60024133 T DE60024133 T DE 60024133T DE 60024133 T DE60024133 T DE 60024133T DE 60024133 D1 DE60024133 D1 DE 60024133D1
- Authority
- DE
- Germany
- Prior art keywords
- calcium salt
- crystalline form
- hemi calcium
- based preparation
- trihydrate hemi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE9900132 | 1999-12-17 | ||
WOPCT/IE99/00132 | 1999-12-17 | ||
PCT/IE2000/000150 WO2001044180A1 (en) | 1999-12-17 | 2000-12-18 | A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60024133D1 true DE60024133D1 (de) | 2005-12-22 |
DE60024133T2 DE60024133T2 (de) | 2006-08-03 |
Family
ID=11042528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60024133T Expired - Fee Related DE60024133T2 (de) | 1999-12-17 | 2000-12-18 | Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form |
Country Status (13)
Country | Link |
---|---|
US (1) | US6600051B2 (de) |
EP (2) | EP1237865B1 (de) |
JP (1) | JP2003517038A (de) |
AT (1) | ATE309985T1 (de) |
AU (1) | AU776613B2 (de) |
CA (1) | CA2388226A1 (de) |
DE (1) | DE60024133T2 (de) |
ES (1) | ES2252088T3 (de) |
HU (1) | HUP0203708A3 (de) |
IL (2) | IL149087A0 (de) |
MX (1) | MXPA02004078A (de) |
WO (1) | WO2001044180A1 (de) |
ZA (1) | ZA200203648B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1148049E (pt) | 1995-07-17 | 2005-02-28 | Warner Lambert Co | Formas cristalinas de hemi-sal de calcio do acido [r-(r*,r*)]-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil)-1h-pirrole-1-heptanoico (atorvastatina) |
US7411075B1 (en) | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
US7501450B2 (en) | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
CA2450111C (en) * | 2001-06-29 | 2006-02-07 | Warner-Lambert Company Llc | Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin) |
US7074818B2 (en) * | 2001-07-30 | 2006-07-11 | Dr. Reddy's Laboratories Limited | Crystalline forms VI and VII of Atorvastatin calcium |
US20060020137A1 (en) * | 2001-11-29 | 2006-01-26 | Limor Tessler | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
MXPA04007939A (es) * | 2002-02-15 | 2004-11-26 | Teva Pharma | Formas cristalinas novedosas de hemi-calcio de atorvastatina y procesos para su preparacion; procesos novedosos para la preparacion de hemi-calcio de atorvastatina en sus formas i, viii i ix. |
CN100379723C (zh) | 2002-02-19 | 2008-04-09 | 特瓦制药工业有限公司 | 阿托伐他汀半钙脱溶剂的方法和基本上不含有机溶剂的阿托伐他汀半钙 |
WO2004050618A2 (en) * | 2002-11-28 | 2004-06-17 | Teva Pharmaceutical Industries Ltd. | Crystalline form f of atorvastatin hemi-calcium salt |
EP1424324A1 (de) * | 2002-11-28 | 2004-06-02 | Teva Pharmaceutical Industries Limited | Kristalline Form F von Atorvastatin |
ES2739493T3 (es) | 2004-05-05 | 2020-01-31 | Pfizer Prod Inc | Formas de sal de de atorvastatina con benetamina |
ES2586561T3 (es) * | 2004-07-16 | 2016-10-17 | Lek Pharmaceuticals D.D. | Productos de degradación oxidativa de atorvastatina calcio |
TW200745026A (en) * | 2005-12-13 | 2007-12-16 | Teva Pharma | Crystal form of atorvastatin hemi-calcium and processes for preparation thereof |
US8486500B2 (en) * | 2007-06-20 | 2013-07-16 | Coating Excellence International Llc | Flat bottom bag |
GR1006173B (el) * | 2007-12-21 | 2008-11-26 | Ανωνυμος Φαρμακευτικη-Χημικη Βιομηχανια Medichromα.Ε. | Χημικη συνθεση του (3r, 5r) - διυδροξυ - 7 - [2-(4-φθοροφαινυλ) - 5 - σοπροπυλ - 3 - φαινυλ - 4 - φαινυλκαρβαμοϋλο - πυρρολυλο - τριενυδρο - επτανοϊκου ασβεστιου, εφαρμογη φαρμακευτικου σκευασματος και παραγωγικη διαδικασια |
CN103483238B (zh) * | 2013-08-20 | 2014-12-31 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钙三水合物的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
US5124482A (en) | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
US5216174A (en) | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5149837A (en) | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
PT1148049E (pt) * | 1995-07-17 | 2005-02-28 | Warner Lambert Co | Formas cristalinas de hemi-sal de calcio do acido [r-(r*,r*)]-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil)-1h-pirrole-1-heptanoico (atorvastatina) |
HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
US6087511A (en) * | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
CN1093126C (zh) | 1996-07-29 | 2002-10-23 | 沃尼尔·朗伯公司 | 合成被保护的(s)-3,4-二羟基丁酸酯的改进方法 |
AU755543B2 (en) | 1997-12-19 | 2002-12-12 | Warner-Lambert Export Limited | Process for the synthesis of 1,3-diols |
-
2000
- 2000-12-18 EP EP00988991A patent/EP1237865B1/de not_active Expired - Lifetime
- 2000-12-18 JP JP2001545268A patent/JP2003517038A/ja active Pending
- 2000-12-18 EP EP05076123A patent/EP1584616A1/de not_active Withdrawn
- 2000-12-18 AU AU25440/01A patent/AU776613B2/en not_active Ceased
- 2000-12-18 DE DE60024133T patent/DE60024133T2/de not_active Expired - Fee Related
- 2000-12-18 WO PCT/IE2000/000150 patent/WO2001044180A1/en active IP Right Grant
- 2000-12-18 MX MXPA02004078A patent/MXPA02004078A/es active IP Right Grant
- 2000-12-18 IL IL14908700A patent/IL149087A0/xx active IP Right Grant
- 2000-12-18 AT AT00988991T patent/ATE309985T1/de not_active IP Right Cessation
- 2000-12-18 ES ES00988991T patent/ES2252088T3/es not_active Expired - Lifetime
- 2000-12-18 CA CA002388226A patent/CA2388226A1/en not_active Abandoned
- 2000-12-18 HU HU0203708A patent/HUP0203708A3/hu unknown
-
2002
- 2002-04-11 IL IL149087A patent/IL149087A/en not_active IP Right Cessation
- 2002-05-08 ZA ZA200203648A patent/ZA200203648B/en unknown
- 2002-06-14 US US10/172,051 patent/US6600051B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU776613B2 (en) | 2004-09-16 |
US20020156294A1 (en) | 2002-10-24 |
EP1237865A1 (de) | 2002-09-11 |
WO2001044180A1 (en) | 2001-06-21 |
MXPA02004078A (es) | 2002-10-11 |
ES2252088T3 (es) | 2006-05-16 |
EP1237865B1 (de) | 2005-11-16 |
ZA200203648B (en) | 2003-02-10 |
CA2388226A1 (en) | 2001-06-21 |
DE60024133T2 (de) | 2006-08-03 |
US6600051B2 (en) | 2003-07-29 |
EP1584616A1 (de) | 2005-10-12 |
AU2544001A (en) | 2001-06-25 |
IL149087A (en) | 2006-12-31 |
JP2003517038A (ja) | 2003-05-20 |
HUP0203708A3 (en) | 2003-11-28 |
IL149087A0 (en) | 2002-11-10 |
ATE309985T1 (de) | 2005-12-15 |
HUP0203708A2 (hu) | 2003-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |