DE60027171D1 - Nanopartikelzusammensetzungen enthaltend amorphes cyclosporin und deren herstellungsverfahren und verwendungsverfahren - Google Patents
Nanopartikelzusammensetzungen enthaltend amorphes cyclosporin und deren herstellungsverfahren und verwendungsverfahrenInfo
- Publication number
- DE60027171D1 DE60027171D1 DE60027171T DE60027171T DE60027171D1 DE 60027171 D1 DE60027171 D1 DE 60027171D1 DE 60027171 T DE60027171 T DE 60027171T DE 60027171 T DE60027171 T DE 60027171T DE 60027171 D1 DE60027171 D1 DE 60027171D1
- Authority
- DE
- Germany
- Prior art keywords
- cyclosporine
- amorphic
- production process
- compositions containing
- nanoparticle compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US392557 | 1989-08-11 | ||
US09/392,557 US6656504B1 (en) | 1999-09-09 | 1999-09-09 | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
PCT/US2000/024505 WO2001017546A1 (en) | 1999-09-09 | 2000-09-07 | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60027171D1 true DE60027171D1 (de) | 2006-05-18 |
DE60027171T2 DE60027171T2 (de) | 2007-01-04 |
Family
ID=23551058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60027171T Expired - Lifetime DE60027171T2 (de) | 1999-09-09 | 2000-09-07 | Nanopartikelzusammensetzungen enthaltend amorphes cyclosporin und deren herstellungsverfahren und verwendungsverfahren |
Country Status (8)
Country | Link |
---|---|
US (1) | US6656504B1 (de) |
EP (1) | EP1210104B1 (de) |
JP (2) | JP2003508492A (de) |
AT (1) | ATE322281T1 (de) |
AU (1) | AU7119500A (de) |
CA (1) | CA2384670C (de) |
DE (1) | DE60027171T2 (de) |
WO (1) | WO2001017546A1 (de) |
Families Citing this family (78)
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US8293277B2 (en) | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
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US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US7998507B2 (en) | 2000-09-21 | 2011-08-16 | Elan Pharma International Ltd. | Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
MXPA04002446A (es) | 2001-09-26 | 2004-07-23 | Baxter Int | Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente. |
US20050191359A1 (en) * | 2001-09-28 | 2005-09-01 | Solubest Ltd. | Water soluble nanoparticles and method for their production |
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US20050227911A1 (en) * | 2001-09-28 | 2005-10-13 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules |
DE10151392A1 (de) * | 2001-10-18 | 2003-05-08 | Bayer Cropscience Ag | Pulverförmige Feststoff-Formulierungen |
DE10154464B4 (de) * | 2001-11-08 | 2005-10-20 | Max Delbrueck Centrum | Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol |
US7700851B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
ATE464880T1 (de) | 2002-02-04 | 2010-05-15 | Elan Pharma Int Ltd | Arzneistoffnanopartikel mit lysozym- oberflächenstabilisator |
WO2003080027A1 (en) * | 2002-03-20 | 2003-10-02 | Elan Pharma International, Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
AU2003230692A1 (en) * | 2002-03-20 | 2003-10-08 | Elan Pharma International Ltd. | Nanoparticulate compositions of map kinase inhibitors |
US7101576B2 (en) * | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
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WO2004006959A1 (en) * | 2002-07-16 | 2004-01-22 | Elan Pharma International, Ltd | Liquid dosage compositions of stable nanoparticulate active agents |
DE10248619A1 (de) * | 2002-10-18 | 2004-04-29 | Bayer Ag | Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden |
JP4469846B2 (ja) * | 2003-01-31 | 2010-06-02 | エラン ファーマ インターナショナル,リミティド | ナノ粒子状トピラメート製剤 |
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US8512727B2 (en) * | 2003-03-03 | 2013-08-20 | Alkermes Pharma Ireland Limited | Nanoparticulate meloxicam formulations |
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ATE415946T1 (de) * | 2003-08-08 | 2008-12-15 | Elan Pharma Int Ltd | Neue metaxalon-zusammensetzungen |
ES2366646T3 (es) * | 2003-11-05 | 2011-10-24 | Elan Pharma International Limited | Composiciones en forma de nanopartículas que tienen un péptido como estabilizante superficial. |
KR20130030305A (ko) * | 2004-11-16 | 2013-03-26 | 엘란 파마 인터내셔널 리미티드 | 주사가능한 나노입자형 올란자핀 제형 |
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CN101180038A (zh) * | 2005-03-23 | 2008-05-14 | 伊兰制药国际有限公司 | 纳米颗粒皮质类固醇和抗组胺药制剂 |
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US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
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US7202209B2 (en) | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
US7297679B2 (en) * | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
US7501393B2 (en) * | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
CA2622758A1 (en) | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
US7745400B2 (en) | 2005-10-14 | 2010-06-29 | Gregg Feinerman | Prevention and treatment of ocular side effects with a cyclosporin |
US8367112B2 (en) * | 2006-02-28 | 2013-02-05 | Alkermes Pharma Ireland Limited | Nanoparticulate carverdilol formulations |
US20080299210A1 (en) * | 2006-04-13 | 2008-12-04 | Min Wei | Stable nanosized amorphous drug |
US20080181957A1 (en) * | 2006-06-23 | 2008-07-31 | Min Wei | Increased amorphous stability of poorly water soluble drugs by nanosizing |
TWI434926B (zh) * | 2006-12-11 | 2014-04-21 | Alcon Res Ltd | 眼用組成物中聚氧化乙烯-聚氧化丁烯(peo-pbo)嵌段共聚物之使用 |
US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
US8703204B2 (en) | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
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DE102007048705A1 (de) * | 2007-10-11 | 2009-04-16 | Bayer Healthcare Ag | Amorphe Formulierung |
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EA201270050A1 (ru) | 2009-06-19 | 2012-05-30 | Сан Фарма Адвансед Ресёрч Компани Лтд. | Нанодисперсия лекарственного средства и способ ее получения |
TWI547522B (zh) * | 2009-07-07 | 2016-09-01 | 愛爾康研究有限公司 | 環氧乙烷環氧丁烷嵌段共聚物組成物 |
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EP3334416A1 (de) | 2015-08-11 | 2018-06-20 | Eyesiu Medicines B.V. | Pegyliertes lipidnanoteilchen mit bioaktiver lipophiler verbindung |
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-
1999
- 1999-09-09 US US09/392,557 patent/US6656504B1/en not_active Expired - Fee Related
-
2000
- 2000-09-07 EP EP00959965A patent/EP1210104B1/de not_active Expired - Lifetime
- 2000-09-07 DE DE60027171T patent/DE60027171T2/de not_active Expired - Lifetime
- 2000-09-07 AU AU71195/00A patent/AU7119500A/en not_active Abandoned
- 2000-09-07 AT AT00959965T patent/ATE322281T1/de not_active IP Right Cessation
- 2000-09-07 JP JP2001521335A patent/JP2003508492A/ja active Pending
- 2000-09-07 CA CA2384670A patent/CA2384670C/en not_active Expired - Fee Related
- 2000-09-07 WO PCT/US2000/024505 patent/WO2001017546A1/en active IP Right Grant
-
2010
- 2010-08-24 JP JP2010186933A patent/JP2011006450A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US6656504B1 (en) | 2003-12-02 |
JP2003508492A (ja) | 2003-03-04 |
JP2011006450A (ja) | 2011-01-13 |
AU7119500A (en) | 2001-04-10 |
EP1210104A1 (de) | 2002-06-05 |
WO2001017546A1 (en) | 2001-03-15 |
CA2384670C (en) | 2011-01-04 |
CA2384670A1 (en) | 2001-03-15 |
DE60027171T2 (de) | 2007-01-04 |
ATE322281T1 (de) | 2006-04-15 |
EP1210104B1 (de) | 2006-04-05 |
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