DE60033658D1 - Behandlung von prostata-krebs mit anti-erbb2 antikörpern - Google Patents

Behandlung von prostata-krebs mit anti-erbb2 antikörpern

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Publication number
DE60033658D1
DE60033658D1 DE60033658T DE60033658T DE60033658D1 DE 60033658 D1 DE60033658 D1 DE 60033658D1 DE 60033658 T DE60033658 T DE 60033658T DE 60033658 T DE60033658 T DE 60033658T DE 60033658 D1 DE60033658 D1 DE 60033658D1
Authority
DE
Germany
Prior art keywords
prostate cancer
treatment
erbb2 antibodies
erbb2
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60033658T
Other languages
English (en)
Other versions
DE60033658T2 (de
Inventor
Mark X Sliwkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE60033658D1 publication Critical patent/DE60033658D1/de
Application granted granted Critical
Publication of DE60033658T2 publication Critical patent/DE60033658T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
DE60033658T 1999-06-25 2000-06-23 Behandlung von prostata-krebs mit anti-erbb2 antikörpern Expired - Lifetime DE60033658T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14131599P 1999-06-25 1999-06-25
US141315P 1999-06-25
PCT/US2000/017423 WO2001000238A1 (en) 1999-06-25 2000-06-23 TREATING PROSTATE CANCER WITH ANTI-ErbB2 ANTIBODIES

Publications (2)

Publication Number Publication Date
DE60033658D1 true DE60033658D1 (de) 2007-04-12
DE60033658T2 DE60033658T2 (de) 2007-11-22

Family

ID=22495163

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60033658T Expired - Lifetime DE60033658T2 (de) 1999-06-25 2000-06-23 Behandlung von prostata-krebs mit anti-erbb2 antikörpern

Country Status (18)

Country Link
US (2) US20060083739A1 (de)
EP (1) EP1189634B1 (de)
JP (2) JP4579471B2 (de)
KR (1) KR100754049B1 (de)
CN (1) CN100381172C (de)
AT (1) ATE355079T1 (de)
AU (1) AU779209B2 (de)
BR (1) BR0012195A (de)
CA (1) CA2383493C (de)
CY (1) CY1107637T1 (de)
DE (1) DE60033658T2 (de)
DK (1) DK1189634T3 (de)
ES (1) ES2282120T3 (de)
IL (1) IL147017A0 (de)
MX (1) MXPA01013395A (de)
PT (1) PT1189634E (de)
WO (1) WO2001000238A1 (de)
ZA (1) ZA200110088B (de)

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US20060083739A1 (en) 2006-04-20
AU779209B2 (en) 2005-01-13
ES2282120T3 (es) 2007-10-16
IL147017A0 (en) 2002-08-14
KR20020069104A (ko) 2002-08-29
JP4579471B2 (ja) 2010-11-10
JP2009269928A (ja) 2009-11-19
US20090087432A1 (en) 2009-04-02
WO2001000238A1 (en) 2001-01-04
KR100754049B1 (ko) 2007-08-31
CY1107637T1 (el) 2013-04-18
EP1189634B1 (de) 2007-02-28
MXPA01013395A (es) 2003-09-04
AU5499200A (en) 2001-01-31
CA2383493A1 (en) 2001-01-04
ZA200110088B (en) 2002-08-26
CN1379684A (zh) 2002-11-13
CA2383493C (en) 2010-08-10
DE60033658T2 (de) 2007-11-22
BR0012195A (pt) 2002-07-23
PT1189634E (pt) 2007-06-06
DK1189634T3 (da) 2007-06-25
EP1189634A1 (de) 2002-03-27
ATE355079T1 (de) 2006-03-15
JP2003503361A (ja) 2003-01-28
CN100381172C (zh) 2008-04-16

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