DE60036137D1 - Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung - Google Patents

Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung

Info

Publication number
DE60036137D1
DE60036137D1 DE60036137T DE60036137T DE60036137D1 DE 60036137 D1 DE60036137 D1 DE 60036137D1 DE 60036137 T DE60036137 T DE 60036137T DE 60036137 T DE60036137 T DE 60036137T DE 60036137 D1 DE60036137 D1 DE 60036137D1
Authority
DE
Germany
Prior art keywords
formulation
agent
immunosuppression
labrasol
preservative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036137T
Other languages
English (en)
Other versions
DE60036137T2 (de
Inventor
Saibal Chakravorty
Prasad Bharti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RPG Life Sciences Ltd
Original Assignee
RPG Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RPG Life Sciences Ltd filed Critical RPG Life Sciences Ltd
Application granted granted Critical
Publication of DE60036137D1 publication Critical patent/DE60036137D1/de
Publication of DE60036137T2 publication Critical patent/DE60036137T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
DE60036137T 2000-09-18 2000-09-18 Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung Expired - Lifetime DE60036137T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2000/000091 WO2002022158A1 (en) 2000-09-18 2000-09-18 Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities

Publications (2)

Publication Number Publication Date
DE60036137D1 true DE60036137D1 (de) 2007-10-04
DE60036137T2 DE60036137T2 (de) 2008-05-15

Family

ID=11076272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036137T Expired - Lifetime DE60036137T2 (de) 2000-09-18 2000-09-18 Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung

Country Status (12)

Country Link
US (1) US7056530B1 (de)
EP (1) EP1333851B1 (de)
AT (1) ATE370744T1 (de)
AU (2) AU2001225459B2 (de)
BR (1) BR0013813A (de)
CA (1) CA2422580C (de)
DE (1) DE60036137T2 (de)
ES (1) ES2292496T3 (de)
MX (1) MXPA02004900A (de)
PT (1) PT1333851E (de)
SI (1) SI1333851T1 (de)
WO (1) WO2002022158A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1728982A (zh) * 2002-10-31 2006-02-01 阿尔扎公司 可增加疏水性药物生物利用度的药物制剂
GB0308734D0 (en) 2003-04-15 2003-05-21 Axcess Ltd Uptake of macromolecules
GB0308732D0 (en) * 2003-04-15 2003-05-21 Axcess Ltd Absorption enhancers
GB0603252D0 (en) 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
US20130266615A1 (en) * 2012-04-10 2013-10-10 Bin Wu Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
CN114010597B (zh) * 2021-11-25 2023-05-16 广州白云山汉方现代药业有限公司 一种特殊油脂比例的棓丙酯脂肪乳注射液及其制备方法
CN114246827B (zh) * 2022-01-04 2023-04-11 中山大学 一种鱼油微乳制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870062A (en) 1956-04-27 1959-01-20 Scherer Corp R P Gelatin composition for capsules
DE2907460A1 (de) 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
KR0148748B1 (ko) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
FR2705568B1 (fr) * 1993-05-27 1995-08-18 Carilene Laboratoires Utilisation de lipides peroxydés pour la préparation d'une composition pharmaceutique destinées au traitement par application locale des télangiectasies.
DE69435104D1 (de) 1993-09-28 2008-07-31 Scherer Gmbh R P Herstellung von Weichgelatinekapseln
MY129435A (en) * 1994-10-26 2007-04-30 Novartis Ag Pharmaceutical microemulsion preconcentrates
KR0167613B1 (ko) * 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
ES2227700T3 (es) * 1996-06-19 2005-04-01 Novartis Ag Preparados de capsulas blandas que contienen ciclosporina.
KR100587551B1 (ko) * 1997-12-10 2006-06-08 싸이클로스포린 테라퓨틱스 리미티드 오메가-3 지방산 오일을 함유하는 약학 조성물
PT982035E (pt) 1998-08-18 2004-08-31 Panacea Biotec Ltd Composicao de ciclosporina compreendendo um veiculo hidrofilo
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions

Also Published As

Publication number Publication date
SI1333851T1 (sl) 2008-02-29
AU2001225459C1 (en) 2002-03-26
PT1333851E (pt) 2007-11-26
CA2422580C (en) 2011-05-17
ES2292496T3 (es) 2008-03-16
AU2545901A (en) 2002-03-26
DE60036137T2 (de) 2008-05-15
MXPA02004900A (es) 2003-10-24
BR0013813A (pt) 2002-04-30
EP1333851A1 (de) 2003-08-13
EP1333851B1 (de) 2007-08-22
US7056530B1 (en) 2006-06-06
WO2002022158A1 (en) 2002-03-21
AU2001225459B2 (en) 2005-12-22
CA2422580A1 (en) 2002-03-21
ATE370744T1 (de) 2007-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803