DE60036700D1 - Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden - Google Patents

Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden

Info

Publication number
DE60036700D1
DE60036700D1 DE60036700T DE60036700T DE60036700D1 DE 60036700 D1 DE60036700 D1 DE 60036700D1 DE 60036700 T DE60036700 T DE 60036700T DE 60036700 T DE60036700 T DE 60036700T DE 60036700 D1 DE60036700 D1 DE 60036700D1
Authority
DE
Germany
Prior art keywords
nucleotine
bind
antiproliferative activity
rich oligonucleotides
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036700T
Other languages
English (en)
Other versions
DE60036700T2 (de
Inventor
Donald M Miller
Paula J Bates
John O Trent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antisoma Research Ltd
Original Assignee
Antisoma Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antisoma Research Ltd filed Critical Antisoma Research Ltd
Publication of DE60036700D1 publication Critical patent/DE60036700D1/de
Application granted granted Critical
Publication of DE60036700T2 publication Critical patent/DE60036700T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/15Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/151Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/18Type of nucleic acid acting by a non-sequence specific mechanism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
DE60036700T 1999-04-08 2000-04-07 Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden Expired - Lifetime DE60036700T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12831699P 1999-04-08 1999-04-08
US128316P 1999-04-08
US14982399P 1999-08-19 1999-08-19
US149823P 1999-08-19
PCT/US2000/009311 WO2000061597A1 (en) 1999-04-08 2000-04-07 Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin

Publications (2)

Publication Number Publication Date
DE60036700D1 true DE60036700D1 (de) 2007-11-22
DE60036700T2 DE60036700T2 (de) 2008-07-24

Family

ID=26826478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036700T Expired - Lifetime DE60036700T2 (de) 1999-04-08 2000-04-07 Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden

Country Status (12)

Country Link
US (2) US7314926B1 (de)
EP (1) EP1181304B1 (de)
JP (1) JP2002541264A (de)
AT (1) ATE375358T1 (de)
AU (1) AU775412B2 (de)
CA (1) CA2370000A1 (de)
CY (1) CY1106991T1 (de)
DE (1) DE60036700T2 (de)
DK (1) DK1181304T3 (de)
ES (1) ES2296615T3 (de)
PT (1) PT1181304E (de)
WO (1) WO2000061597A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110178161A1 (en) * 1999-04-08 2011-07-21 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (de) 1999-04-08 2007-10-10 Antisoma Research Limited Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden
US7544767B2 (en) * 2002-04-05 2009-06-09 Burnham Institute For Medical Research HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
US7541150B2 (en) * 2002-04-08 2009-06-02 University Of Louisville Research Foundation, Inc Method for the diagnosis and prognosis of malignant diseases
US7357928B2 (en) 2002-04-08 2008-04-15 University Of Louisville Research Foundation, Inc. Method for the diagnosis and prognosis of malignant diseases
US20050187176A1 (en) * 2003-10-10 2005-08-25 Bates Paula J. Method for inhibiting NF-kappa B signaling and use to treat or prevent human diseases
FR2900341B1 (fr) 2006-04-27 2012-09-14 Centre Nat Rech Scient Utilisation de ligands synthetiques multivalents de la nucleoline de surface pour le traitement du cancer
WO2007137000A2 (en) 2006-05-16 2007-11-29 The Arizona Board Of Regents On Behalf Of The University Of Arizona Combination cancer chemotherapy
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
JP2011511051A (ja) * 2008-02-05 2011-04-07 アンティソマ リサーチ リミテッド 生物学的物質およびそれらの使用
GB2460086A (en) * 2008-05-16 2009-11-18 Antisoma Res Ltd Treatment of paediatric cancers
CA2724818C (en) 2008-05-22 2015-06-16 Centre National De La Recherche Scientifique (Cnrs) New optically pure compounds for improved therapeutic efficiency
WO2010030849A1 (en) * 2008-09-12 2010-03-18 University Of Louisville Research Foundation, Inc. Compositions and methods for treating cancer,inhibiting proliferation, and inducing cell death
KR100998365B1 (ko) * 2009-06-29 2010-12-06 압타바이오 주식회사 치료 효능이 있는 변형핵산 및 구아노신을 함유하는 올리고뉴클레오티드 변형체
WO2011062997A2 (en) 2009-11-17 2011-05-26 Musc Foundation For Research Development Human monoclonal antibodies to human nucleolin
US20130065227A1 (en) * 2010-03-04 2013-03-14 Paula J. Bates Methods of increasing macropinocytosis in cancer cells
WO2011133142A1 (en) * 2010-04-20 2011-10-27 University Of Louisville Treatment of vhl-negative tumors
WO2012045750A2 (en) 2010-10-04 2012-04-12 Centre National De La Recherche Scientifique (Cnrs) Compositions comprising multivalent synthetic ligands of surface nucleolin and glycosaminoglycans
US9452219B2 (en) 2011-06-02 2016-09-27 University Of Louisville Research Foundation, Inc. Anti-nucleolin agent-conjugated nanoparticles
EP2814498B1 (de) * 2012-02-16 2017-05-10 The Governing Council Of The University Of Toronto Guanosinreiche oligonucleotidzusammensetzungen und verwendungen zur behandlung von rsv-infektion
WO2013129603A1 (ja) * 2012-02-28 2013-09-06 国立大学法人東京農工大学 Tdp-43細胞内存在量関連疾患の認定方法
US9982257B2 (en) 2012-07-13 2018-05-29 Wave Life Sciences Ltd. Chiral control
EP2982756A1 (de) * 2014-08-04 2016-02-10 Berlin Cures Holding AG Aptamere zur Verwendung gegen Erkrankungen im Zusammenhang mit Autoantikörpern
WO2016179394A1 (en) 2015-05-05 2016-11-10 Malik Mohammad Tariq Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents
CA3009378A1 (en) 2015-12-23 2017-06-29 Queensland University Of Technology Nucleic acid oligomers and uses therefor
EP3468605A4 (de) 2016-06-08 2020-01-08 President and Fellows of Harvard College Manipulierter viraler vektor zur reduzierung von induktion von entzündungs- und immunreaktionen
EP3493852A1 (de) 2016-08-02 2019-06-12 University of Louisville Research Foundation, Inc. Gezielte nanotröpfchenemulsionen zur behandlung von krebs
KR20190065139A (ko) 2017-12-01 2019-06-11 압타바이오 주식회사 혈액암 치료제
CA3179430A1 (en) 2020-05-19 2021-11-25 Jaeil Kim Novel nucleolin-binding peptide and use thereof

Family Cites Families (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US5359047A (en) 1988-09-22 1994-10-25 Massachusetts Institute Of Technology Nucleic acids encoding DNA structure-specific recognition protein and uses therefor
US5705334A (en) 1988-09-22 1998-01-06 Massachusetts Institute Of Technology Uses for DNA structure-specific recognition protein
US5495070A (en) 1988-10-04 1996-02-27 Agracetus, Inc. Genetically engineering cotton plants for altered fiber
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
CA2006008C (en) * 1988-12-20 2000-02-15 Donald J. Kessler Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5714575A (en) 1989-02-13 1998-02-03 The University Of Medicine And Dentistry Of New Jersey Nucleic acids sequence, stress-induced proteins and uses thereof
US5561222A (en) 1989-11-15 1996-10-01 Duke University RNA-binding proteins useful for the control of cellular genetic processing and expression
US5212058A (en) 1990-05-09 1993-05-18 Massachusetts Institute Of Technology Nucleic acid encoding ubiquitin-specific proteases
DE4021571A1 (de) 1990-07-06 1992-01-16 Boehringer Mannheim Gmbh N-methylhydantoinase, kloniert
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
US5310892A (en) 1990-12-10 1994-05-10 The Rockefeller University Nucleic acid sequence which codes for and expresses human fibrillarin and uses thereof
US5470971A (en) 1991-03-11 1995-11-28 The University Of Medicine And Dentistry Of New Jersey Stress-induced proteins, genes coding therefor, transformed cells of organisms, methods and applications
US5612201A (en) 1991-05-23 1997-03-18 Ludwig Institute For Cancer Research Isolated nucleic acid molecules useful in determining expression of a tumor rejection antigen precursor
US6235525B1 (en) 1991-05-23 2001-05-22 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof
US5925729A (en) 1991-05-23 1999-07-20 Ludwig Institute For Cancer Research Tumor rejection antigen precursors, tumor rejection antigens and uses thereof
US5342774A (en) 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5624818A (en) 1991-09-09 1997-04-29 Fred Hutchinson Cancer Research Center Nucleic acids encoding regulatory proteins that dimerize with Mad or Max
US5262409A (en) 1991-10-11 1993-11-16 Fred Hutchinson Cancer Research Center Binary tumor therapy
US5376546A (en) 1991-11-04 1994-12-27 Xoma Corporation Analogs of ribosome-inactivating proteins
US5688511A (en) 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
US6153408A (en) 1991-11-15 2000-11-28 Institut Pasteur And Institut National De La Sante Et De La Recherche Medicale Altered major histocompatibility complex (MHC) determinant and methods of using the determinant
US5499967A (en) * 1992-02-27 1996-03-19 Societe Anonyme Dite: Laboratoires D'hygiene Societe Anonyme Dite: Et De Dietetique (L.H.D.) Transdermal drug delivery device with waveshape generator
US6093399A (en) 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US6036955A (en) 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US6235313B1 (en) * 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5444149A (en) 1992-05-11 1995-08-22 Duke University Methods and compositions useful in the recognition, binding and expression of ribonucleic acids involved in cell growth, neoplasia and immunoregulation
US5686306A (en) 1992-05-13 1997-11-11 Board Of Regents, The University Of Texas System Methods and reagents for lengthening telomeres
US5645986A (en) 1992-05-13 1997-07-08 Board Of Reagents, The University Of Texas System Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5837453A (en) 1992-05-13 1998-11-17 Geron Corporation Telomerase activity assays
US5523389A (en) 1992-09-29 1996-06-04 Isis Pharmaceuticals, Inc. Inhibitors of human immunodeficiency virus
US5834247A (en) 1992-12-09 1998-11-10 New England Biolabs, Inc. Modified proteins comprising controllable intervening protein sequences or their elements methods of producing same and methods for purification of a target protein comprised by a modified protein
US6323185B1 (en) * 1993-04-23 2001-11-27 The United States Of America As Represented By The Department Of Health And Human Services Anti-viral guanosine-rich oligonucleotides and method of treating HIV
US5567604A (en) * 1993-04-23 1996-10-22 Aronex Pharmaceuticals, Inc. Anti-viral guanosine-rich oligonucleotides
US6288042B1 (en) 1993-04-23 2001-09-11 Aronex Pharmaceuticals, Inc. Anti-viral guanosine-rich tetrad forming oligonucleotides
US5443962A (en) 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US6017536A (en) 1993-06-07 2000-01-25 Trimeris, Inc. Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
US5614503A (en) 1993-11-12 1997-03-25 Aronex Pharmaceuticals, Inc. Amphipathic nucleic acid transporter
US5863726A (en) 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
US5804380A (en) 1993-11-12 1998-09-08 Geron Corporation Telomerase activity assays
US5449758A (en) 1993-12-02 1995-09-12 Life Technologies, Inc. Protein size marker ladder
US5625031A (en) 1994-02-08 1997-04-29 Bristol-Myers Squibb Company Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
US5643778A (en) 1994-02-17 1997-07-01 The Wistar Institute Of Anatomy & Biology RNA editing enzyme and methods of use thereof
US5763174A (en) 1994-02-17 1998-06-09 The Wistar Institute Of Anatomy & Biology RNA editing enzyme and methods of use thereof
US5594120A (en) 1994-02-18 1997-01-14 Brigham And Women's Hospital, Inc. Integrin alpha subunit
US6037329A (en) 1994-03-15 2000-03-14 Selective Genetics, Inc. Compositions containing nucleic acids and ligands for therapeutic treatment
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US6183751B1 (en) * 1994-08-18 2001-02-06 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's Sarcoma virus sequences and uses thereof
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US5631146A (en) 1995-01-19 1997-05-20 The General Hospital Corporation DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates and methods for isolation thereof
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
DE19502912A1 (de) 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilisierte Oligonucleotide
US5643890A (en) 1995-01-31 1997-07-01 The Board Of Regents Of The University Of Nebraska Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
US5932556A (en) 1995-09-17 1999-08-03 Tam; Robert C Methods and compositions for regulation of CD28 expression
US5624799A (en) 1995-02-13 1997-04-29 The Burnham Institute Cancer-associated mar binding protein
US6020139A (en) 1995-04-25 2000-02-01 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
DE69629563T2 (de) 1995-05-03 2004-07-22 The President And Fellows Of Harvard College, Cambridge Bestimmung der funktion von calcineurin in immunosuppression und neurotoxizität
US5843732A (en) 1995-06-06 1998-12-01 Nexstar Pharmaceuticals, Inc. Method and apparatus for determining consensus secondary structures for nucleic acid sequences
US5741677A (en) 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
US5763178A (en) 1995-06-07 1998-06-09 Trevigen, Inc. Oscillating signal amplifier for nucleic acid detection
US5656430A (en) 1995-06-07 1997-08-12 Trevigen, Inc. Oscillating signal amplifier for nucleic acid detection
WO1997002279A1 (en) 1995-07-06 1997-01-23 Ctrc Research Foundation Methods and compositions for modulation and inhibition of telomerase
US5968506A (en) 1995-08-04 1999-10-19 Geron Corporation Purified telomerase
US5783398A (en) 1995-09-15 1998-07-21 Merck & Co., Inc. High throughput assay using fusion proteins
US5776696A (en) 1995-09-15 1998-07-07 Merck & Co., Inc. High throughput assay using fusion proteins
US5854223A (en) 1995-10-06 1998-12-29 The Trustees Of Columbia University In The City Of New York S-DC28 as an antirestenosis agent after balloon injury
US5861498A (en) 1995-11-01 1999-01-19 Thomas Jefferson University Nucleotides encoding immunophilin FKBP46 and fragments thereof
JP3089350B2 (ja) 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
US6214805B1 (en) * 1996-02-15 2001-04-10 The United States Of America As Represented By The Department Of Health And Human Services RNase L activators and antisense oligonucleotides effective to treat RSV infections
DK0885002T3 (da) 1996-03-04 2011-08-22 Penn State Res Found Materialer og fremgangsmåder til forøgelse af cellulær internalisering
US6331617B1 (en) 1996-03-21 2001-12-18 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6030955A (en) 1996-03-21 2000-02-29 The Trustees Of Columbia University In The City Of New York And Imclone Systems, Inc. Methods of affecting intracellular phosphorylation of tyrosine using phosphorothioate oligonucleotides, and antiangiogenic and antiproliferative uses thereof
US5734040A (en) 1996-03-21 1998-03-31 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6274313B1 (en) 1996-03-21 2001-08-14 Pioneer-Hybrid International, Inc. Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
EP0932698A1 (de) 1996-03-26 1999-08-04 Lynx Therapeutics, Inc. Oligonukleotide zusammenstellungen zur behandlung von menschlichem melanom
CA2175435A1 (en) 1996-04-30 1997-10-31 Joseph Lam Proteins involved in the synthesis and assembly of o-antigen in pseudomonas aeruginosa
US6027881A (en) 1996-05-08 2000-02-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence
US5756710A (en) 1996-06-05 1998-05-26 The Trustees Of Columbia University In City Of New York Phosphorothioate oligonucleotides that bind to the V3-loop and uses thereof
US5792613A (en) 1996-06-12 1998-08-11 The Curators Of The University Of Missouri Method for obtaining RNA aptamers based on shape selection
US5780447A (en) 1996-06-14 1998-07-14 St. Jude Children's Research Hospital Recombinant adeno-associated viral vectors
US6348586B1 (en) * 1996-07-25 2002-02-19 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's sarcoma virus sequences and uses thereof
US6107029A (en) 1996-07-31 2000-08-22 Message Pharmaceticals, Inc. Universal method for detecting interactions between RNA molecules and RNA binding proteins
US5691145A (en) 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
CN102021153B (zh) 1996-10-01 2016-05-25 杰龙公司 人类的端粒酶催化亚单位
US5898860A (en) * 1996-10-01 1999-04-27 Leibold; William Steven System and method for automatically generating a control drawing for a real-time process control system
US5849564A (en) 1996-11-29 1998-12-15 The Trustees Of Columbia University In The City Of New York Polypeptides from Kaposi's sarcoma-associated herpesvirus, DNA encoding same and uses thereof
AU6646398A (en) 1996-12-31 1998-07-31 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US6416959B1 (en) * 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
US6126965A (en) 1997-03-21 2000-10-03 Georgetown University School Of Medicine Liposomes containing oligonucleotides
FR2763943B1 (fr) 1997-05-28 1999-07-09 Rhone Poulenc Rorer Sa Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
US6028058A (en) 1997-07-21 2000-02-22 Ciblex Corporation Methods and compositions for regulating nuclear trafficking of proteins
WO1999016871A2 (en) 1997-09-22 1999-04-08 Max-Planck-Gesellschaft Zur Forderung Der Wissensc Nucleic acid catalysts with endonuclease activity
US6025194A (en) 1997-11-19 2000-02-15 Geron Corporation Nucleic acid sequence of senescence asssociated gene
US6455250B1 (en) 1997-12-11 2002-09-24 The Regents Of The University Of California Endonuclease compositions and methods of use
US5989860A (en) 1997-12-12 1999-11-23 Incyte Pharmaceuticals, Inc. Human isomerase homologs
US5932475A (en) 1997-12-12 1999-08-03 Incyte Pharmaceuticals, Inc. Human nucleolin-like protein
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6376226B1 (en) * 1998-01-09 2002-04-23 Thomas Jefferson University Recombinant, active caspases and uses thereof
US6071732A (en) 1998-01-29 2000-06-06 The Board Of Regents Of The University Of Oklahoma Tyrosylprotein sulfotransferases, nucleic acids encoding tyrosylprotein sulfotransferases, and methods of use thereof
US6255055B1 (en) * 1998-03-09 2001-07-03 Wisconsin Alumni Research Foundation c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence
US6332897B1 (en) 1998-03-27 2001-12-25 Glaxo Wellcome Inc. Assay methods
US6180348B1 (en) * 1998-04-20 2001-01-30 Weihua Li Method of isolating target specific oligonucleotide ligands
US6017709A (en) 1998-04-29 2000-01-25 University Of Houston DNA replication templates stabilized by guanine quartets
US6171843B1 (en) * 1998-06-01 2001-01-09 Incyte Pharmaceuticals, Inc. Human peptidyl-prolyl isomerases
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社B&Cラボラトリーズ 皮膚の老化度の測定方法および測定用キット
WO2000011446A2 (en) * 1998-08-21 2000-03-02 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
US6331396B1 (en) 1998-09-23 2001-12-18 The Cleveland Clinic Foundation Arrays for identifying agents which mimic or inhibit the activity of interferons
US6465176B1 (en) 1998-10-02 2002-10-15 Message Pharmaceuticals, Inc. Method for identifying compounds RNA/RNA binding protein interactions
US6423493B1 (en) * 1998-10-26 2002-07-23 Board Of Regents The University Of Texas System Combinatorial selection of oligonucleotide aptamers
US6426231B1 (en) * 1998-11-18 2002-07-30 The Texas A&M University System Analyte sensing mediated by adapter/carrier molecules
US6177254B1 (en) * 1998-12-15 2001-01-23 Jerome Bernard Rattner Nucleolus autoantigenic marker for systemic lupus erthyematosus
US5948680A (en) 1998-12-17 1999-09-07 Isis Pharmaceuticals Inc. Antisense inhibition of Elk-1 expression
US6335170B1 (en) * 1999-02-22 2002-01-01 Torben F. Orntoft Gene expression in bladder tumors
KR20020000554A (ko) 1999-03-29 2002-01-05 윌슨, 로엔스 알. 백혈병 치료방법
US6383752B1 (en) * 1999-03-31 2002-05-07 Hybridon, Inc. Pseudo-cyclic oligonucleobases
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (de) 1999-04-08 2007-10-10 Antisoma Research Limited Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden
US20080318889A1 (en) 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318890A1 (en) 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
DE60001531T2 (de) * 1999-04-23 2003-10-02 Molecular Probes Inc Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen
US6316200B1 (en) 2000-06-08 2001-11-13 Becton, Dickinson And Company Probes and methods for detection of nucleic acids
US6200746B1 (en) * 1999-08-25 2001-03-13 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
US6420122B1 (en) * 1999-09-27 2002-07-16 Massachusetts Institute Of Technology Methods of screening for agents that inhibit aggregation of polypeptides
US6379888B1 (en) * 1999-09-27 2002-04-30 Becton, Dickinson And Company Universal probes and methods for detection of nucleic acids
US6165789A (en) 1999-10-27 2000-12-26 Isis Pharmaceuticals, Inc. Antisense modulation of hnRNP A1 expression
US6165786A (en) 1999-11-03 2000-12-26 Isis Pharmaceuticals, Inc. Antisense modulation of nucleolin expression
EP1867718B1 (de) 1999-12-13 2010-01-20 Bioniche Life Sciences Inc. Therapeutisch nützliche synthetische Oligonukleotide
US6291187B1 (en) 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
US7541150B2 (en) * 2002-04-08 2009-06-02 University Of Louisville Research Foundation, Inc Method for the diagnosis and prognosis of malignant diseases
US7357928B2 (en) 2002-04-08 2008-04-15 University Of Louisville Research Foundation, Inc. Method for the diagnosis and prognosis of malignant diseases
DE60331310D1 (de) 2002-06-26 2010-04-01 Univ Louisville Res Found Verfahren zum apoptosenachweis
US20050187176A1 (en) 2003-10-10 2005-08-25 Bates Paula J. Method for inhibiting NF-kappa B signaling and use to treat or prevent human diseases
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
JP2011511051A (ja) 2008-02-05 2011-04-07 アンティソマ リサーチ リミテッド 生物学的物質およびそれらの使用

Also Published As

Publication number Publication date
EP1181304A4 (de) 2002-10-02
ATE375358T1 (de) 2007-10-15
WO2000061597A1 (en) 2000-10-19
JP2002541264A (ja) 2002-12-03
PT1181304E (pt) 2008-01-23
EP1181304B1 (de) 2007-10-10
ES2296615T3 (es) 2008-05-01
US7314926B1 (en) 2008-01-01
WO2000061597A9 (en) 2001-11-29
DE60036700T2 (de) 2008-07-24
US20090326047A1 (en) 2009-12-31
AU4212900A (en) 2000-11-14
CA2370000A1 (en) 2000-10-19
EP1181304A1 (de) 2002-02-27
US8648051B2 (en) 2014-02-11
AU775412B2 (en) 2004-07-29
DK1181304T3 (da) 2008-02-11
CY1106991T1 (el) 2012-09-26

Similar Documents

Publication Publication Date Title
DE60036700D1 (de) Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden
ATE347360T1 (de) Verfahren zur induktion von krebszellentod und tumorregression
DK0544713T3 (da) Oligonukleutider til modulering af virkningerne af cytomegalovirusinfektioner
ATE555202T1 (de) Verfahren zur lieferung von rna-interferenz und verwendungen damit
DE60013591D1 (de) Screening nach modulatoren der funktion von immunstimulatorischer dna
DE602004015811D1 (de) Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden
ATE312202T1 (de) Menschliche rnase h und entsprechende oligonukleotidverbindungen
DE60134866D1 (de) Verwendung von imidazochinolinaminen als adjuvantien in dna-impfung
ATE498685T1 (de) Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
DK1053313T3 (da) Optimerede antisense oligonucleotider komplementære til DNA methyltransferase-sekvenser
ATE431746T1 (de) Verwendung cd28 spezifischer monoklonaler antikörper zur stimulation von blutzellen, welche kein cd28 tragen
DE60125055D1 (de) Verfahren zur zuführung von umschlägen
ATE465261T1 (de) Integrin-gekoppelte kinase, ihre hemmstoffe und deren gebrauch für verfahren zur therapeutischen behandlung; gentherapie und bereitstellung von hemmstoffen, die als pseudosubstrate wirken
DK1692517T3 (da) Anvendelse af ADAM 12 til diagnosticering af præeklampsi
ATE310510T1 (de) Transdermales therapeutisches system zur abgabe von lerisetron
PT1153015E (pt) Pirimidina-2,4,6-trionas uteis como inibidores de metaloproteinases matriciais
DE50009838D1 (de) Humanes antibiotisches protein
DE60141221D1 (de) Verfahren zur genexpressionsanalyse
IL145826A0 (en) Quantitative assay for expression of genes in microarray
DK1618195T3 (da) Fremgangsmåde til selektiv inhibering af humant N-myc-gen i N-myc-udtrykkende tumorer via antisense- og antigen-peptidnucleinsyrer (PNA)
DE69936141D1 (de) Verwendung von dna-pk
ATE301664T1 (de) Boronsäurehaltige reagenzien und oligonukleotide
ATE364180T1 (de) Screeningverfahren mit bnpi und dnpi
DE50113417D1 (de) Zellbindende nukleinsäuremoleküle (aptamere)
DE1229138T1 (de) Verbesserungen von Verfahren zur Erwärmung von Stahlbändern in senkrechten Öfen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 1181304

Country of ref document: EP

Representative=s name: HENKEL, BREUER & PARTNER, 80333 MUENCHEN, DE