DE60039727D1 - Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid - Google Patents

Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid

Info

Publication number
DE60039727D1
DE60039727D1 DE60039727T DE60039727T DE60039727D1 DE 60039727 D1 DE60039727 D1 DE 60039727D1 DE 60039727 T DE60039727 T DE 60039727T DE 60039727 T DE60039727 T DE 60039727T DE 60039727 D1 DE60039727 D1 DE 60039727D1
Authority
DE
Germany
Prior art keywords
glyceride
composition containing
new composition
bicyclic compound
bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039727T
Other languages
English (en)
Inventor
Ryuji Ueno
Tsuyoshi Habe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
Sucampo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22573018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60039727(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sucampo GmbH filed Critical Sucampo GmbH
Application granted granted Critical
Publication of DE60039727D1 publication Critical patent/DE60039727D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
DE60039727T 1999-10-15 2000-10-13 Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid Expired - Lifetime DE60039727D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15954999P 1999-10-15 1999-10-15

Publications (1)

Publication Number Publication Date
DE60039727D1 true DE60039727D1 (de) 2008-09-11

Family

ID=22573018

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60039727T Expired - Lifetime DE60039727D1 (de) 1999-10-15 2000-10-13 Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid
DE60010913T Expired - Lifetime DE60010913T2 (de) 1999-10-15 2000-10-13 Bizyklische Verbindungen, Zusammenstellung und Verfahren zu ihrer Stabilisierung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60010913T Expired - Lifetime DE60010913T2 (de) 1999-10-15 2000-10-13 Bizyklische Verbindungen, Zusammenstellung und Verfahren zu ihrer Stabilisierung

Country Status (26)

Country Link
US (5) US6583174B1 (de)
EP (2) EP1426361B2 (de)
JP (2) JP4332316B2 (de)
KR (1) KR100830061B1 (de)
CN (1) CN1268623C (de)
AR (3) AR026046A1 (de)
AT (2) ATE402925T2 (de)
AU (2) AU780342B2 (de)
BR (1) BRPI0014869B8 (de)
CA (1) CA2385732C (de)
CZ (1) CZ303625B6 (de)
DE (2) DE60039727D1 (de)
DK (2) DK1220849T3 (de)
ES (2) ES2221859T3 (de)
HK (2) HK1045693B (de)
HU (2) HU230484B1 (de)
IL (2) IL148803A0 (de)
MX (1) MXPA02003756A (de)
NO (1) NO330258B1 (de)
NZ (1) NZ518020A (de)
PT (2) PT1426361E (de)
RU (1) RU2695274C3 (de)
TR (1) TR200201032T2 (de)
TW (1) TWI281918B (de)
WO (1) WO2001027099A2 (de)
ZA (1) ZA200202312B (de)

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ATE402925T2 (de) * 1999-10-15 2008-08-15 Sucampo Ag Neue zusammensetzung enthaltend eine bicyclische verbindung und ein glycerid
US6414016B1 (en) 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
TWI331920B (en) 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
FR2842810B1 (fr) * 2002-07-25 2006-01-27 Inst Nat Sciences Appliq Nouveaux composes gem difluores, leur procedes de preparation et leurs applications.
PT1562604E (pt) * 2002-10-23 2012-04-09 Sucampo Ag Compostos de prostaglandina para o tratamento de obesidade
ES2591252T3 (es) * 2002-12-27 2016-11-25 Sucampo Ag Derivados de prostaglandinas para tratar el síndrome de colon irritable y/o la dispepsia funcional
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI348386B (en) * 2003-08-12 2011-09-11 R Tech Ueno Ltd Composition and method for promoting hair growth
TWI387454B (zh) 2004-09-02 2013-03-01 Sucampo Ag 治療胃腸道疾病之方法及組成物
NZ562763A (en) * 2005-04-12 2010-12-24 Sucampo Ag Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
CN104983712A (zh) 2006-01-24 2015-10-21 株式会社·R-技术上野 软明胶胶囊制剂
WO2007086541A2 (en) 2006-01-24 2007-08-02 R-Tech Ueno, Ltd. Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
CA2819844C (en) * 2006-02-07 2015-09-15 R-Tech Ueno, Ltd. Prostaglandin derivatives
US20090030072A1 (en) 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
US20090012165A1 (en) 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
CN101808623B (zh) 2007-07-19 2013-08-14 株式会社·R-技术上野 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法
US20090082442A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched lubiprostone
CN101318948B (zh) 2008-04-01 2011-04-27 上海天伟生物制药有限公司 鲁比前列酮晶体、其制备方法及用途
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
NZ597626A (en) 2009-07-28 2013-03-28 Ono Pharmaceutical Co Bicyclic compound and use thereof for medical purposes
CA2774021A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of opioid receptor antagonist for gastrointestinal tract disorders
CA2779736A1 (en) * 2009-11-03 2011-05-12 Bernard Charles Sherman Stable pharmaceutical formulations comprising lubiprostone
US9150537B2 (en) 2011-01-27 2015-10-06 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
WO2012102357A1 (ja) 2011-01-27 2012-08-02 小野薬品工業株式会社 二環式化合物およびその医薬用途
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
EP3277274A4 (de) 2015-04-01 2018-12-05 Cedars-Sinai Medical Center Antimethanogene lovastatin-analoga oder -derivate und verwendungen davon
US10899729B2 (en) 2016-06-30 2021-01-26 Ono Pharmaceutical Co.. Ltd. Method for producing bicyclic compound
WO2018065826A1 (en) 2016-10-06 2018-04-12 Sucampo Ag Multilayer beads for pharmaceutical use
JPWO2019221215A1 (ja) * 2018-05-18 2021-05-27 ニプロ株式会社 ルビプロストン含有粒子状医薬組成物

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Also Published As

Publication number Publication date
HU229547B1 (en) 2014-01-28
TR200201032T2 (tr) 2002-08-21
MXPA02003756A (es) 2005-09-08
PT1426361E (pt) 2008-10-08
NO20021736D0 (no) 2002-04-12
US6583174B1 (en) 2003-06-24
AR089848A2 (es) 2014-09-24
BRPI0014869B1 (pt) 2017-06-13
EP1426361B1 (de) 2008-07-30
US7417067B2 (en) 2008-08-26
WO2001027099A3 (en) 2001-10-25
ATE267189T1 (de) 2004-06-15
WO2001027099A2 (en) 2001-04-19
US20080255227A1 (en) 2008-10-16
HK1045693B (zh) 2005-01-21
ES2309410T3 (es) 2008-12-16
KR20020068521A (ko) 2002-08-27
ES2309410T5 (es) 2015-03-17
HUP0203746A2 (hu) 2003-03-28
DE60010913T2 (de) 2005-06-09
NZ518020A (en) 2004-02-27
EP1220849A2 (de) 2002-07-10
PT1220849E (pt) 2004-10-29
TWI281918B (en) 2007-06-01
IL148803A (en) 2006-07-05
US20040235885A1 (en) 2004-11-25
EP1426361A1 (de) 2004-06-09
HK1045693A1 (en) 2002-12-06
CZ303625B6 (cs) 2013-01-16
KR100830061B1 (ko) 2008-05-16
BR0014869A (pt) 2002-06-25
RU2002112984A (ru) 2004-01-20
CZ20021037A3 (cs) 2002-09-11
RU2695274C9 (ru) 2020-01-22
AR109354A2 (es) 2018-11-21
EP1220849B1 (de) 2004-05-19
AU2004242503A1 (en) 2005-01-27
US20120095090A1 (en) 2012-04-19
CA2385732A1 (en) 2001-04-19
AU7685600A (en) 2001-04-23
DK1220849T3 (da) 2004-09-27
DE60010913D1 (de) 2004-06-24
US8088934B2 (en) 2012-01-03
AU780342B2 (en) 2005-03-17
AR026046A1 (es) 2002-12-26
JP2003511445A (ja) 2003-03-25
AU2004242503B2 (en) 2007-06-21
AU2004242503C1 (en) 2005-01-27
ATE402925T2 (de) 2008-08-15
CN1268623C (zh) 2006-08-09
NO330258B1 (no) 2011-03-14
JP4332316B2 (ja) 2009-09-16
US8097649B1 (en) 2012-01-17
ZA200202312B (en) 2002-12-24
NO20021736L (no) 2002-04-12
JP2009235079A (ja) 2009-10-15
CN1379769A (zh) 2002-11-13
HU230484B1 (hu) 2016-07-28
DK1426361T3 (da) 2008-11-17
DK1426361T4 (en) 2015-03-16
BRPI0014869B8 (pt) 2021-05-25
RU2695274C2 (ru) 2019-07-22
HK1066792A1 (en) 2005-04-01
RU2695274C3 (ru) 2020-11-09
HUP1300369A2 (de) 2003-03-28
EP1426361B2 (de) 2015-02-25
CA2385732C (en) 2009-02-10
IL148803A0 (en) 2002-09-12
ES2221859T3 (es) 2005-01-16
HUP0203746A3 (en) 2005-02-28

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Legal Events

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8363 Opposition against the patent