DE60039729D1 - N-(8,8,8-Trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol zur Behandlung von Hepatitis-Virus-Infektionen - Google Patents
N-(8,8,8-Trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol zur Behandlung von Hepatitis-Virus-InfektionenInfo
- Publication number
- DE60039729D1 DE60039729D1 DE60039729T DE60039729T DE60039729D1 DE 60039729 D1 DE60039729 D1 DE 60039729D1 DE 60039729 T DE60039729 T DE 60039729T DE 60039729 T DE60039729 T DE 60039729T DE 60039729 D1 DE60039729 D1 DE 60039729D1
- Authority
- DE
- Germany
- Prior art keywords
- dideoxy
- imino
- treatment
- glucitol
- trifluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11985699P | 1999-02-12 | 1999-02-12 | |
US11972299P | 1999-02-12 | 1999-02-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60039729D1 true DE60039729D1 (de) | 2008-09-11 |
Family
ID=26817632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60039729T Expired - Lifetime DE60039729D1 (de) | 1999-02-12 | 2000-02-14 | N-(8,8,8-Trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol zur Behandlung von Hepatitis-Virus-Infektionen |
Country Status (10)
Country | Link |
---|---|
US (3) | US6545021B1 (de) |
EP (1) | EP1165080A2 (de) |
JP (1) | JP2002536407A (de) |
AT (1) | ATE402701T1 (de) |
AU (1) | AU3595500A (de) |
CA (1) | CA2362914C (de) |
DE (1) | DE60039729D1 (de) |
ES (1) | ES2311921T3 (de) |
HK (1) | HK1043311A1 (de) |
WO (1) | WO2000047198A2 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
EP1173161A2 (de) | 1999-02-12 | 2002-01-23 | G.D. SEARLE & CO. | Verwendung von glucamin derivaten zur behandlung von hepatitis infektionen |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
ES2302697T3 (es) | 1999-08-10 | 2008-08-01 | The Chancellor, Masters And Scholars Of The University Of Oxford | Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales. |
JP2003522791A (ja) * | 2000-02-14 | 2003-07-29 | ファルマシア コーポレイション | 肝炎ウイルス感染症治療用n‐置換‐1,5‐ジデオキシ‐1,5‐イミノ‐d‐グルシトール化合物の使用 |
KR20090089922A (ko) | 2000-10-18 | 2009-08-24 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
US20040067877A1 (en) * | 2002-08-01 | 2004-04-08 | Schinazi Raymond F. | 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections |
CA2500940A1 (en) * | 2002-09-23 | 2004-06-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Use of iminosugar derivatives to inhibit ion channel activity |
US20090111812A1 (en) * | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
EP2932982B1 (de) * | 2005-05-17 | 2018-10-03 | Amicus Therapeutics, Inc. | Verfahren zur Behandlung der Pompe-Krankheit mit 1-desoxynojirimycin und Derivaten |
CN102727437A (zh) | 2006-08-02 | 2012-10-17 | 牛津大学院长校长专家委员会 | 病毒感染的脂质体治疗 |
EP2054076A2 (de) * | 2006-08-21 | 2009-05-06 | United Therapeutics Corporation | Kombinationstherapie zur behandlung von virusinfektionen |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
JP2011518124A (ja) * | 2008-03-26 | 2011-06-23 | ユニバーシティ・オブ・オックスフォード | 小胞体ターゲッティングリポソーム |
WO2010027996A1 (en) * | 2008-09-02 | 2010-03-11 | Institute For Hepatitis And Virus Research | Novel imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity |
AT507745B1 (de) * | 2008-12-16 | 2012-01-15 | Forschungsholding Tu Graz Gmbh | Fluorophile glykosidasehemmer |
US8450345B2 (en) | 2009-02-23 | 2013-05-28 | The Chancellor, Masters And Scholars Of The University Of Oxford | Iminosugars and methods of treating viral diseases |
CN102625660B (zh) * | 2009-02-24 | 2015-03-11 | 联合治疗公司 | 亚氨基糖以及治疗沙粒病毒感染的方法 |
CA2757026A1 (en) * | 2009-03-27 | 2010-09-30 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
CN102639133B (zh) | 2009-06-12 | 2015-03-11 | 联合治疗公司 | 亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法 |
ES2466027T3 (es) * | 2009-09-04 | 2014-06-09 | United Therapeutics Corporation | Procedimiento para el tratamiento de infecciones por ortomixovirus |
EP2473493B1 (de) * | 2009-09-04 | 2014-04-30 | United Therapeutics Corporation | Verfahren zur behandlung von poxvirusinfektionen |
ES2527623T3 (es) * | 2009-09-04 | 2015-01-27 | United Therapeutics Corporation | Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus |
KR20210062731A (ko) | 2012-03-07 | 2021-05-31 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물 |
EP2858642A4 (de) | 2012-06-06 | 2015-12-02 | Unither Virology Llc | Neuartige iminozucker und deren anwendungen |
AP2016009125A0 (en) | 2013-09-16 | 2016-04-30 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
EP3105235B1 (de) * | 2014-02-12 | 2019-11-06 | Amicus Therapeutics, Inc. | Zuckerderivate mit schwefelhaltigen gruppen und verfahren zur herstellung davon und verfahren zur verwendung davon zur behandlung von mps iiic |
SG10202003753PA (en) | 2014-09-30 | 2020-05-28 | Amicus Therapeutics Inc | Highly potent acid alpha-glucosidase with enhanced carbohydrates |
EP3215499B1 (de) | 2014-11-05 | 2021-01-20 | Emergent Virology LLC | Iminozucker zur verwendung in der behandlung von virenerkrankungen |
MY198085A (en) | 2015-12-30 | 2023-07-31 | Amicus Therapeutics Inc | Augmented acid alpha-glucosidase for the treatment of pompe disease |
WO2017173059A1 (en) | 2016-03-30 | 2017-10-05 | Amicus Therapeutics, Inc. | Method for selection of high m6p recombinant proteins |
WO2017173060A1 (en) | 2016-03-30 | 2017-10-05 | Amicus Therapeutics, Inc. | Formulations comprising recombinant acid alpha-glucosidase |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU33730B (en) | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
GB1555654A (en) | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
US4065562A (en) | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
US4012448A (en) | 1976-01-15 | 1977-03-15 | Stanford Research Institute | Synthesis of adriamycin and 7,9-epiadriamycin |
NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
JPS5562004A (en) | 1978-11-02 | 1980-05-10 | Kureha Chem Ind Co Ltd | Control agent against plant viral disease |
US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
DE3049446A1 (de) | 1980-12-30 | 1982-07-29 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 1,5-didesoxy-1,5-imino-d-glucitol und dessen n-derivaten |
ZA822995B (en) | 1981-05-21 | 1983-12-28 | Wyeth John & Brother Ltd | Slow release pharmaceutical composition |
US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
ATE126696T1 (de) | 1985-12-23 | 1995-09-15 | Hutchinson Fred Cancer Res | Regulierung der retroviralen replikation, infektion und pathogenese. |
GB2186485B (en) | 1986-02-13 | 1988-09-07 | Ethical Pharma Ltd | Slow release formulation |
DE3611841A1 (de) | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
US5039667A (en) * | 1987-08-07 | 1991-08-13 | The Governors Of The University Of Alberta | Antiviral therapy for hepatitis B with 2',3'-dideoxypurine nucleosides |
US4848430A (en) * | 1987-09-28 | 1989-07-18 | Leski Lenet | Tire snow belt |
DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
IE81173B1 (en) | 1987-12-21 | 2000-05-31 | Monsanto Co | Use of the N-n-butyl derivative of desoxynojirimycin in the manufacture of a medicament inhibiting HIV-virus |
US4849430A (en) | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
FI101344B (fi) | 1988-03-31 | 1998-06-15 | Tanabe Seiyaku Co | Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta |
US5041441A (en) | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
EP0350012A3 (de) | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antivirale Zusammensetzung |
US5144037A (en) | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
US5221746A (en) | 1988-11-03 | 1993-06-22 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
US5310745A (en) | 1988-11-03 | 1994-05-10 | G. D. Searle & Co. | Antiviral compounds |
US4957926A (en) | 1988-12-22 | 1990-09-18 | Monsanto Company | Method of treating herpesviruses |
US5132291A (en) * | 1989-01-24 | 1992-07-21 | Gensia Pharmaceuticals, Inc. | Antivirals and methods for increasing the antiviral activity of azt |
US5011829A (en) | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
EP0491041A4 (en) * | 1989-09-07 | 1993-03-03 | Nippon Shinyaku Company, Limited | Antiviral drug |
US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
DE4009561A1 (de) | 1990-03-24 | 1991-09-26 | Bayer Ag | Neue desoxynojirimycinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5536732A (en) | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5151519A (en) | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
ATE137266T1 (de) | 1990-09-20 | 1996-05-15 | Monsanto Co | Verfahren zur herstellung von n-substituiertem 1- deoxynojirimycin |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5190765A (en) | 1991-06-27 | 1993-03-02 | Alza Corporation | Therapy delayed |
DE4307883A1 (en) | 1992-03-12 | 1993-09-23 | Westarp Martin Egon Dr Med | Use of anti-retroviral substances - to treat motor-neuronal diseases |
IL105090A (en) | 1992-03-18 | 1998-08-16 | Us Bioscience | Acid N) phosphonoacetyl (Aspartic L in a broad spectrum antiviral agent |
ZA931934B (en) | 1992-03-18 | 1993-03-18 | Us Bioscience | Compostitions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals |
US5331096A (en) | 1992-04-01 | 1994-07-19 | G. D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
US5258518A (en) | 1992-04-01 | 1993-11-02 | G. D. Searle & Co. | 2-substituted tertiary carbinol derivatives of deoxynojirimycin |
US5261724A (en) * | 1992-04-03 | 1993-11-16 | Grammer Ag | Sprung seat |
EP0655457A1 (de) | 1992-08-14 | 1995-05-31 | Nippon Shinyaku Company, Limited | Moranolinderivat |
US5265356A (en) * | 1992-10-14 | 1993-11-30 | Winter Kent L | Snowplow and hydraulic system for same |
FR2700267B1 (fr) | 1993-01-13 | 1995-03-17 | Oreal | N-acyl amino déoxy alditols, et leur utilisation dans des compositions cosmétiques ou dermopharmaceutiques. |
EP0691327B1 (de) | 1993-03-17 | 1999-07-21 | Kao Corporation | Aminderivate und sie enthaltende dermatologische zubereitungen |
US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
WO1995006061A1 (en) | 1993-08-20 | 1995-03-02 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
US5750648A (en) * | 1993-08-20 | 1998-05-12 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
US6093702A (en) | 1993-12-20 | 2000-07-25 | The United States Of America As Represented By The Department Of Health And Human Services | Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread |
CA2181033C (en) * | 1994-01-13 | 2007-09-04 | Timothy M. Block | Use of n-alkyl derivatives of 1,5-dideoxy-1,5-imino-d-glucitol for the treatment of hepatitis b virus infections |
WO1995022975A1 (en) | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
US5451679A (en) | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
US5491261A (en) * | 1994-07-01 | 1996-02-13 | Ciba-Geigy Corporation | Poly-perfluoroalkyl-substituted alcohols and acids, and derivatives thereof |
US5622342A (en) * | 1994-10-26 | 1997-04-22 | Mills; James E. | Versatile apparatus for supporting cameras, spotting scopes and other devices |
US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
FR2731150B1 (fr) | 1995-03-03 | 1997-04-18 | Oreal | Utilisation de composes amphiphiles en tant qu'agent epaississant de milieux non aqueux |
US5763470A (en) | 1995-06-07 | 1998-06-09 | Sugen Inc. | Benzopyran compounds and methods for their use |
EP1655033A1 (de) * | 1995-06-07 | 2006-05-10 | Emory University | Nucleoside mit anti-hepatitis B virus Wirksamkeit |
WO1997000881A1 (en) | 1995-06-22 | 1997-01-09 | Nippon Shinyaku Co., Ltd. | Moranoline derivatives |
US5905068A (en) * | 1996-09-24 | 1999-05-18 | Abbott Laboratories | Retroviral protease inhibiting compounds |
ATE295732T1 (de) * | 1997-02-14 | 2005-06-15 | Searle Llc | Verwendung von n-substituierten 1,5-dideoxy-1,5- imino-d-glucitol verbindungen in der kombinationstherapie der vom hepatitisvirus verursachten infektionen |
US20030100532A1 (en) * | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
KR20010033028A (ko) * | 1997-12-11 | 2001-04-25 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 막-관련 바이러스 복제의 억제 |
US6689759B1 (en) * | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
ATE331515T1 (de) * | 1998-02-12 | 2006-07-15 | Searle Llc | Verwendung von n-substituirten-1,5-dideoxy-1,5- imino-d-glucitolen zur behandlung von hepatitis infektionen |
US20040132161A1 (en) * | 1998-04-20 | 2004-07-08 | Finkel Terri H. | Methods and compositions for increasing CD4lymphocyte immune responsiveness |
EP1173161A2 (de) * | 1999-02-12 | 2002-01-23 | G.D. SEARLE & CO. | Verwendung von glucamin derivaten zur behandlung von hepatitis infektionen |
US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
-
2000
- 2000-02-14 DE DE60039729T patent/DE60039729D1/de not_active Expired - Lifetime
- 2000-02-14 WO PCT/US2000/003768 patent/WO2000047198A2/en not_active Application Discontinuation
- 2000-02-14 EP EP00914585A patent/EP1165080A2/de not_active Withdrawn
- 2000-02-14 JP JP2000598151A patent/JP2002536407A/ja active Pending
- 2000-02-14 ES ES05027240T patent/ES2311921T3/es not_active Expired - Lifetime
- 2000-02-14 CA CA002362914A patent/CA2362914C/en not_active Expired - Fee Related
- 2000-02-14 AT AT05027240T patent/ATE402701T1/de not_active IP Right Cessation
- 2000-02-14 AU AU35955/00A patent/AU3595500A/en not_active Abandoned
- 2000-02-14 US US09/503,945 patent/US6545021B1/en not_active Expired - Lifetime
-
2002
- 2002-06-28 HK HK02104874.1A patent/HK1043311A1/zh unknown
-
2003
- 2003-01-14 US US10/341,717 patent/US20030220299A1/en not_active Abandoned
-
2006
- 2006-06-22 US US11/472,542 patent/US20060264468A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2362914A1 (en) | 2000-08-17 |
US20030220299A1 (en) | 2003-11-27 |
ATE402701T1 (de) | 2008-08-15 |
AU3595500A (en) | 2000-08-29 |
JP2002536407A (ja) | 2002-10-29 |
WO2000047198A3 (en) | 2001-02-15 |
ES2311921T3 (es) | 2009-02-16 |
US6545021B1 (en) | 2003-04-08 |
WO2000047198A2 (en) | 2000-08-17 |
HK1043311A1 (zh) | 2002-09-13 |
US20060264468A1 (en) | 2006-11-23 |
EP1165080A2 (de) | 2002-01-02 |
CA2362914C (en) | 2009-04-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60039729D1 (de) | N-(8,8,8-Trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol zur Behandlung von Hepatitis-Virus-Infektionen | |
ATE331515T1 (de) | Verwendung von n-substituirten-1,5-dideoxy-1,5- imino-d-glucitolen zur behandlung von hepatitis infektionen | |
EA200300819A1 (ru) | Производные нуклеозидов в качестве ингибиторов рнк-зависимой рнк вирусной полимеразы | |
MY151199A (en) | Substituted diphenyl heterocycles useful for treating hcv infection | |
ATE491459T1 (de) | Modifizierte nukleoside zur behandlung von virusinfektionen und abnormaler zellulärer proliferation | |
EA200201279A1 (ru) | Способы и композиции для лечения вирусного гепатита c | |
DE69925256D1 (de) | Trisubstituierte 1,3,5-triazine derivate zur behandlung von hiv infektionen | |
BR0307712A (pt) | Composto, composição e uso dos mesmos no tratamento de infecções por flaviviridae e proliferação celular anormal | |
WO2003105770A3 (en) | CARBOCYCLIC NUCLEOSIDE DERIVATIVES FOR USE AS VIRAL RNA-DEPENDENT RNA POLYMERASE INHIBITORS | |
DE69830241D1 (de) | Verwendung von n-substituierten 1,5-dideoxy-1,5-imino-d-glucitol verbindungen in der kombinationstherapie der vom hepatitisvirus verursachten infektionen | |
WO2001008672A3 (en) | Glucamine compounds for treating hepatitis virus infections | |
ATE498398T1 (de) | Cycloalkyl-heterozyklen zur behandlung des hepatitis-c-virus | |
HUP0400500A2 (hu) | Vírusos fertőzések kezelése Levovirin TM alkalmazásával | |
DE69838980D1 (de) | Kombination von product r mit einem antiviralen mittel in der behandlung von hiv infektionen | |
ATE274513T1 (de) | Verbindungen und verfahren zur behandlung von schmerz | |
CO5210951A1 (es) | Mezclas fungicidas sinergicas de una azolopirimidina y una fenoxiamida inhibidora de la biosisntesis de melanina | |
KR960021043A (ko) | 스코폴레틴을 포함하는 b형 간염 치료제 | |
ZA908933B (en) | Prevention of glycoprotein enveloped virus infectivity by quinolyloxazole-2-ones | |
MY141975A (en) | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |