DE60112050D1 - Rekombinantes influenza a virus - Google Patents

Rekombinantes influenza a virus

Info

Publication number
DE60112050D1
DE60112050D1 DE60112050T DE60112050T DE60112050D1 DE 60112050 D1 DE60112050 D1 DE 60112050D1 DE 60112050 T DE60112050 T DE 60112050T DE 60112050 T DE60112050 T DE 60112050T DE 60112050 D1 DE60112050 D1 DE 60112050D1
Authority
DE
Germany
Prior art keywords
gene
virus
relates
influenza
modification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60112050T
Other languages
English (en)
Other versions
DE60112050T2 (de
Inventor
Boris Ferko
Andre Egorov
Regina Voglauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polymun Scientific Immunbiologische Forschung GmbH
Original Assignee
Polymun Scientific Immunbiologische Forschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polymun Scientific Immunbiologische Forschung GmbH filed Critical Polymun Scientific Immunbiologische Forschung GmbH
Publication of DE60112050D1 publication Critical patent/DE60112050D1/de
Application granted granted Critical
Publication of DE60112050T2 publication Critical patent/DE60112050T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
DE60112050T 2000-03-02 2001-03-02 Rekombinantes influenza a virus Expired - Lifetime DE60112050T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00104338 2000-03-02
EP00104338 2000-03-02
PCT/EP2001/002392 WO2001064860A2 (en) 2000-03-02 2001-03-02 Recombinant influenza a viruses

Publications (2)

Publication Number Publication Date
DE60112050D1 true DE60112050D1 (de) 2005-08-25
DE60112050T2 DE60112050T2 (de) 2006-04-27

Family

ID=8168006

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60112050T Expired - Lifetime DE60112050T2 (de) 2000-03-02 2001-03-02 Rekombinantes influenza a virus

Country Status (7)

Country Link
US (1) US6800288B2 (de)
EP (1) EP1259629B1 (de)
AT (1) ATE299943T1 (de)
AU (2) AU5035201A (de)
DE (1) DE60112050T2 (de)
RU (1) RU2280690C2 (de)
WO (1) WO2001064860A2 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2334895C (en) 1998-06-12 2016-01-19 Mount Sinai School Of Medicine Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
WO2001077394A1 (en) 2000-04-10 2001-10-18 Mount Sinai School Of Medicine Of New York University Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
CN103540568A (zh) 2002-04-26 2014-01-29 米迪缪尼有限公司 制备流感病毒的多质粒系统
US7465456B2 (en) * 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
WO2004111249A2 (en) * 2003-06-13 2004-12-23 Polymun Scientific Immunbiologische Forschung Gmbh Protein constructs containing caspase recognition sites
US7566458B2 (en) * 2003-06-16 2009-07-28 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
US7037707B2 (en) * 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
WO2005062820A2 (en) 2003-12-23 2005-07-14 Medimmune Vaccines, Inc Multi plasmid system for the production of influenza virus
JP4980895B2 (ja) 2004-05-25 2012-07-18 メディミューン，エルエルシー インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
CN102727880A (zh) 2004-06-01 2012-10-17 西奈山医学院 遗传工程猪流感病毒及其应用
WO2006013367A2 (en) * 2004-08-04 2006-02-09 Medical Research Council Chimeric heamaglutinin proteins and uses thereof
EP1855713B1 (de) * 2005-02-15 2016-04-27 Mount Sinai School of Medicine Gentechnisch hergestellter pferde-influenza-virus und seine verwendungen
CA2600730C (en) 2005-03-08 2014-11-25 Medimmune, Inc. Influenza hemagglutinin and neuraminidase variants
AT502275B8 (de) * 2005-08-08 2007-08-15 Greenhills Biotechnology Res D Immunantwort-induzierende zusammensetzungen
KR101492643B1 (ko) 2005-12-02 2015-02-12 이칸 스쿨 오브 메디슨 엣 마운트 시나이 비-천연 표면 단백질을 제시하는 키메라 바이러스 및 그의용도
WO2008133701A1 (en) * 2006-07-21 2008-11-06 Medimmune, Llc. Methods and compositions for increasing replication capacity of an influenza virus
CN101983069B (zh) * 2006-08-09 2014-07-16 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体
EP2415783B1 (de) 2006-10-16 2016-12-14 Genelux Corporation Modifizierte Impfstoffvirusstämme zur Verwendung in einem Diagnose- und Therapieverfahren
WO2008150496A2 (en) * 2007-05-31 2008-12-11 Genelux Corporation Assay for sensitivity to chemotherapeutic agents
CA2690627C (en) 2007-06-15 2014-12-02 Genelux Corporation Microorganisms for imaging and/or treatment of tumors
JP5666905B2 (ja) 2007-06-18 2015-02-12 メディミューン，エルエルシー ヘマグルチニンポリペプチド中に変化を有するインフルエンザｂウイルス
EP2048237A1 (de) * 2007-10-05 2009-04-15 Avir Green Hills Biotechnology Research Development Trade Ag Replikationsdefizienter Influenza-Virus zur Expression heterologer Sequenzen
TWI437036B (zh) * 2008-01-31 2014-05-11 Sumitomo Chemical Co 粒狀組成物及其製造方法
CA2730408A1 (en) * 2008-07-11 2010-01-14 Chin-Fen Yang Influenza hemagglutinin and neuraminidase variants
CN102361649A (zh) 2009-02-12 2012-02-22 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体
WO2011014504A1 (en) 2009-07-27 2011-02-03 Mount Sinai School Of Medicine Of New York University Recombinant influenza virus vectors and uses thereof
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
EP2697368B1 (de) 2011-04-15 2019-06-05 Genelux Corporation Klonale stämme von abgeschwächten vaccinia-viren und verwendungsverfahren davon
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
CA2789539A1 (en) 2011-09-12 2013-03-12 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (de) 2011-10-27 2013-05-01 Christopher L. Parks Von einem eingehüllten Virus abgeleitete Virenpartikel
KR101426407B1 (ko) * 2011-11-10 2014-08-07 서울대학교산학협력단 고생산성, 고면역원성, 및 무병원성 인플루엔자 바이러스 제작용 재조합 발현 벡터
WO2013138522A2 (en) 2012-03-16 2013-09-19 Genelux Corporation Methods for assessing effectiveness and monitoring oncolytic virus treatment
WO2013158265A1 (en) 2012-04-20 2013-10-24 Genelux Corporation Imaging methods for oncolytic virus therapy
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
US20140140959A1 (en) 2012-10-05 2014-05-22 Aladar A. Szalay Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (de) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
CN105849270B (zh) * 2013-10-28 2020-02-28 蓝天疫苗有限责任公司 用于病毒疗法的新型流感病毒载体
US10238700B2 (en) 2014-01-02 2019-03-26 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
WO2016137929A1 (en) 2015-02-26 2016-09-01 Boehringer Ingelheim Vetmedica Gmbh Bivalent swine influenza virus vaccine
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3072901A1 (de) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
RU2628690C2 (ru) * 2015-11-06 2017-08-21 Общество С Ограниченной Ответственностью 'Фарминтерпрайсез' Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний
RU2660562C2 (ru) * 2016-03-30 2018-07-06 Общество с ограниченной ответственностью "ФАРМИНТЕРПРАЙСЕЗ БИОТЕХ" Аттенуированный гриппозный вектор и мукозальная универсальная гриппозная вакцина на его основе
EA037571B1 (ru) * 2015-11-06 2021-04-15 Общество с ограниченной ответственностью "ФАРМИНТЕРПРАЙСЕЗ БИОТЕХ" Аттенуированный вирус гриппа а, аттенуированный грипозный вектор, фармацевтическая композиция и их применение для профилактики или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний
RU2706544C1 (ru) * 2018-12-28 2019-11-19 Общество с ограниченной ответственностью "Нанолек" Концентрат вакцины от гриппа и способ его получения
RU2706191C1 (ru) * 2018-12-28 2019-11-14 Общество с ограниченной ответственностью "Нанолек" Поливалентная вакцина против гриппа
RU2701959C1 (ru) * 2018-12-28 2019-10-02 Общество с ограниченной ответственностью "Нанолек" Способ контроля получения продукта вакцина от гриппа
RU2701953C1 (ru) * 2018-12-28 2019-10-02 Общество с ограниченной ответственностью "Нанолек" Способ получения поливалентной вакцины от гриппа
CN113481171B (zh) * 2021-06-21 2022-10-18 武汉大学 一种携带hiv-1基因的重组流感病毒株及其制备方法与应用
US20240033347A1 (en) 2022-07-08 2024-02-01 Viromissile, Inc. Oncolytic vaccinia viruses and recombinant viruses and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843724A (en) * 1995-04-27 1998-12-01 Rutgers University Chimeric nucleic acids and proteins for inhibiting HIV-1 expression
CA2334895C (en) * 1998-06-12 2016-01-19 Mount Sinai School Of Medicine Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
AU748416B2 (en) * 1998-06-12 2002-06-06 Andrej Egorov Interferon inducing genetically engineered attenuated viruses

Also Published As

Publication number Publication date
EP1259629B1 (de) 2005-07-20
AU5035201A (en) 2001-09-12
RU2002126205A (ru) 2004-03-10
EP1259629A2 (de) 2002-11-27
RU2280690C2 (ru) 2006-07-27
AU2001250352B2 (en) 2006-01-12
WO2001064860A2 (en) 2001-09-07
ATE299943T1 (de) 2005-08-15
US20030147916A1 (en) 2003-08-07
US6800288B2 (en) 2004-10-05
WO2001064860A3 (en) 2002-02-21
DE60112050T2 (de) 2006-04-27

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Legal Events

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