DE60130544D1 - Embolische zusammensetzungen - Google Patents

Embolische zusammensetzungen

Info

Publication number
DE60130544D1
DE60130544D1 DE60130544T DE60130544T DE60130544D1 DE 60130544 D1 DE60130544 D1 DE 60130544D1 DE 60130544 T DE60130544 T DE 60130544T DE 60130544 T DE60130544 T DE 60130544T DE 60130544 D1 DE60130544 D1 DE 60130544D1
Authority
DE
Germany
Prior art keywords
embolic
crosslinked
compositions
macromers
embolic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60130544T
Other languages
English (en)
Other versions
DE60130544T2 (de
Inventor
Dennis W Goupil
Hassan Chaouk
Troy Holland
Bruktawit T Asfaw
Stephen D Goodrich
Lucas Latini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocompatibles UK Ltd
Original Assignee
Biocure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocure Inc filed Critical Biocure Inc
Publication of DE60130544D1 publication Critical patent/DE60130544D1/de
Application granted granted Critical
Publication of DE60130544T2 publication Critical patent/DE60130544T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
    • C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • C08F271/02—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00 on to polymers of monomers containing heterocyclic nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F277/00—Macromolecular compounds obtained by polymerising monomers on to polymers of carbocyclic or heterocyclic monomers as defined respectively in group C08F32/00 or in group C08F34/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/14—Polymers provided for in subclass C08G
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/08—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
DE60130544T 2000-03-13 2001-03-13 Embolische zusammensetzungen Expired - Lifetime DE60130544T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18897500P 2000-03-13 2000-03-13
US188975P 2000-03-13
US25469700P 2000-12-11 2000-12-11
US254697P 2000-12-11
PCT/US2001/007940 WO2001068720A1 (en) 2000-03-13 2001-03-13 Embolic compositions

Publications (2)

Publication Number Publication Date
DE60130544D1 true DE60130544D1 (de) 2007-10-31
DE60130544T2 DE60130544T2 (de) 2008-06-26

Family

ID=26884649

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60130544T Expired - Lifetime DE60130544T2 (de) 2000-03-13 2001-03-13 Embolische zusammensetzungen

Country Status (8)

Country Link
US (6) US6676971B2 (de)
EP (1) EP1263803B1 (de)
JP (1) JP4871476B2 (de)
AT (1) ATE373682T1 (de)
AU (2) AU4566001A (de)
CA (1) CA2403218C (de)
DE (1) DE60130544T2 (de)
WO (1) WO2001068720A1 (de)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
JP4871476B2 (ja) 2000-03-13 2012-02-08 バイオコンパティブルズ ユーケー リミテッド 塞栓組成物
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
US8697137B2 (en) 2000-03-24 2014-04-15 Biosphere Medical, Inc. Methods of using microspheres for active embolization
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
JP2004504887A (ja) * 2000-08-02 2004-02-19 アエスクラップ　アーゲー　ウント　コー　カーゲー 医療技術製品、その製造方法、およびその外科用用途
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2002072166A1 (en) * 2001-03-13 2002-09-19 Biocure, Inc. Compositions for drug delivery
WO2002089676A2 (en) * 2001-05-04 2002-11-14 Concentric Medical Hydrogel filament vaso-occlusive device
US20030014075A1 (en) * 2001-07-16 2003-01-16 Microvention, Inc. Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation
AU2002359410A1 (en) * 2001-11-16 2003-06-10 Biocure, Inc. Methods for initiating in situ formation of hydrogels
US7645259B2 (en) * 2002-02-01 2010-01-12 Vascular Designs, Inc. Multi-function catheter and use thereof
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof
US8062251B2 (en) * 2002-02-01 2011-11-22 Vascular Designs, Inc. Multi-function catheter and use thereof
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7207996B2 (en) 2002-04-04 2007-04-24 Vascular Control Systems, Inc. Doppler directed suturing and compression device and method
US6713646B2 (en) 2002-04-12 2004-03-30 Biosphere Medical Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
US7105031B2 (en) * 2002-04-26 2006-09-12 Medtronic Vascular, Inc. Balloon-tipped, multi-lumen catheter for endoluminal repair of endoluminal leaks in aortic or aorto-iliac endoluminal grafts
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
WO2003105917A2 (en) 2002-06-12 2003-12-24 Scimed Life Systems, Inc. Bulking agents
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US6884905B2 (en) 2002-07-23 2005-04-26 Biosphere Medical Degradable carbamate-containing bis(acryloyl) crosslinkers, and degradable crosslinked hydrogels comprising them
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
WO2004028569A1 (en) * 2002-09-25 2004-04-08 Biocompatibles Uk Limited Polymer compositions for administration to animals
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US20040161466A1 (en) * 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
DE602004014101D1 (de) * 2003-02-12 2008-07-10 Biocompatibles Uk Ltd Zusammensetzungen für die chemoembolotherapie solider tumoren
CN1747721A (zh) * 2003-02-12 2006-03-15 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
US20060057198A1 (en) * 2003-02-21 2006-03-16 Biocompatibles Uk Limited Drug delivery from embolic agents
WO2004084703A2 (en) * 2003-03-24 2004-10-07 Biosphere Medical, Inc. Temporary embolization using inverse thermosensitive polymers
WO2004087007A2 (en) * 2003-03-25 2004-10-14 Biocure, Inc. Hydrogel string medical device
US20040202694A1 (en) * 2003-04-11 2004-10-14 Vascular Control Systems, Inc. Embolic occlusion of uterine arteries
US7396540B2 (en) * 2003-04-25 2008-07-08 Medtronic Vascular, Inc. In situ blood vessel and aneurysm treatment
US7022747B2 (en) 2003-04-29 2006-04-04 Basf Corporation Method for creating microsphere polymers and particles
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
WO2005025456A1 (en) * 2003-09-02 2005-03-24 University Of Florida Polymeric reconstrainable, repositionable, detachable, percutaneous endovascular stentgraft
US20050107867A1 (en) * 2003-11-17 2005-05-19 Taheri Syde A. Temporary absorbable venous occlusive stent and superficial vein treatment method
ES2404682T3 (es) 2003-12-11 2013-05-28 Isto Technologies Inc. Sistema de cartílago particulado
JP2007517614A (ja) * 2004-01-07 2007-07-05 ボストン サイエンティフィック サンタ ローザ コーポレイション 身体内腔の閉塞方法、閉塞合成物および機器
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
DE102004014633A1 (de) * 2004-03-22 2005-10-13 Aesculap Ag & Co. Kg Zusammensetzung zur Adhäsionsprophylaxe
US8067073B2 (en) * 2004-03-25 2011-11-29 Boston Scientific Scimed, Inc. Thermoplastic medical device
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
JP4655505B2 (ja) * 2004-04-28 2011-03-23 東レ株式会社 架橋生分解性粒子およびその製造方法
WO2005107747A2 (en) * 2004-05-06 2005-11-17 Bioresponse, Llc Diindolymethane formulations for the treatment of leiomyomas
US20050266043A1 (en) * 2004-05-27 2005-12-01 Medtronic Vascular, Inc. Methods and compounds for treatment of aneurysmal tissue
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
JP2008510021A (ja) * 2004-06-29 2008-04-03 バイオキュア・インコーポレーテッド バイオマテリアル
US20070258939A1 (en) * 2004-08-03 2007-11-08 Biocamparibles Uk Limited Drug Delivery from Embolic Agents
US20070281028A1 (en) * 2004-08-04 2007-12-06 Biocompatibles Uk Limited Drug Delivery of a Cox Inhibitor from Embolic Agents
US20060045900A1 (en) * 2004-08-27 2006-03-02 Robert Richard Embolization
WO2006026412A2 (en) * 2004-08-31 2006-03-09 Vnus Medical Technologies, Inc. Apparatus and material composition for permanent occlusion of a hollow anatomical structure
AU2005298344B2 (en) 2004-10-25 2011-02-10 Varian Medical Systems, Inc. Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
WO2006047748A2 (en) * 2004-10-26 2006-05-04 Cordis Neurovascular, Inc. Method of delivering embolic particles to an aneurysm
US7201918B2 (en) * 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
WO2006062871A2 (en) * 2004-12-08 2006-06-15 Pervasis Therapeutics, Inc. Materials and methods for minimally-invasive administration of a cell-containing flowable composition
CN102772824A (zh) * 2004-12-08 2012-11-14 渗透治疗有限公司 增强血管通路的方法和组合物
CA2593084C (en) * 2004-12-30 2014-03-18 Bioresponse, Llc Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
WO2006078841A1 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
CN101146484B (zh) * 2005-01-25 2015-04-08 泰科医疗集团有限合伙公司 用于永久性闭塞中空解剖结构的结构
US20060178696A1 (en) * 2005-02-04 2006-08-10 Porter Stephen C Macroporous materials for use in aneurysms
US20100080757A1 (en) * 2005-02-08 2010-04-01 Haaga John R Method of detecting abnormal tissue
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
DE602006014814D1 (de) * 2005-04-21 2010-07-22 Massachusetts Inst Technology Materialien und verfahren zur änderung einer immunreaktion auf exogene und endogene immunogene, einschliesslich genidentischer und nicht-genidentischer zellen, gewebe oder organe
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
KR101429774B1 (ko) * 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
EP1901680B1 (de) * 2005-06-21 2015-04-15 Shire Regenerative Medicine, Inc. Kryokonservierung von biokompatiblem material
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
WO2007004484A1 (ja) * 2005-07-01 2007-01-11 The Nippon Synthetic Chemical Industry Co., Ltd. 血管一時塞栓剤用ｐｖａ粒子、その製造方法、および血管一時塞栓剤
WO2007025290A2 (en) * 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants and methods for repair, replacement and treatment of joint disease
US20070078480A1 (en) * 2005-10-04 2007-04-05 Boston Scientific Scimed, Inc. Self-expanding biodegradable or water-soluble vaso-occlusive devices
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
JP2009513265A (ja) * 2005-10-26 2009-04-02 バイオキュア・インコーポレーテッド 膨潤可能な物品を有するヒドロゲル椎間板移植片
US20100204783A1 (en) * 2005-12-06 2010-08-12 Helen Marie Nugent Methods and compositions for enhancing vascular access
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20070149641A1 (en) * 2005-12-28 2007-06-28 Goupil Dennis W Injectable bone cement
US20080305176A1 (en) * 2006-01-24 2008-12-11 Biocompatibles Uk Limited Process For Loading Polymer Particles With Drug
WO2007090130A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US9017361B2 (en) 2006-04-20 2015-04-28 Covidien Lp Occlusive implant and methods for hollow anatomical structure
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
BRPI0711784B8 (pt) 2006-06-15 2021-06-22 Microvention Inc dispositivo de embolização construído de polímero expansível e seu método de preparação
WO2008002482A2 (en) * 2006-06-23 2008-01-03 Surmodics, Inc. Hydrogel-based joint repair system and method
US8586621B2 (en) 2006-10-27 2013-11-19 Michael A. Zeligs Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
WO2008057580A2 (en) * 2006-11-07 2008-05-15 Pervasis Therapeutics, Inc. Materials and methods for treating and managing angiogenesis-mediated diseases
US7720533B2 (en) * 2006-12-20 2010-05-18 Zimmer Orthobiologicals, Inc. Apparatus and method for delivering a biocompatible material to a surgical site
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
CA2684040C (en) 2007-04-12 2016-12-06 Isto Technologies, Inc. Method of forming an implant using a mold that mimics the shape of the tissue defect site and implant formed therefrom
US20080255678A1 (en) * 2007-04-13 2008-10-16 Cully Edward H Medical apparatus and method of making the same
US9642693B2 (en) * 2007-04-13 2017-05-09 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
US9717584B2 (en) * 2007-04-13 2017-08-01 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
US20080287633A1 (en) * 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
ATE545441T1 (de) * 2007-06-13 2012-03-15 Pervasis Therapeutics Inc Verfahren und vorrichtungen zur minimal invasiven abgabe von zellhaltigen fliessfähigen zusammensetzungen
CN101842061A (zh) 2007-06-25 2010-09-22 微排放器公司 自扩展假体
US8480651B2 (en) * 2007-08-02 2013-07-09 Covidien Lp Cannula system
US7887846B2 (en) * 2007-08-07 2011-02-15 E. I. Du Pont De Nemours And Company Process for preparation of swellable and degradable microspheres
JP5179308B2 (ja) * 2007-10-03 2013-04-10 株式会社クラレ ポリビニルアセタール
WO2009046281A2 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Injectable particles
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US20090123519A1 (en) * 2007-11-12 2009-05-14 Surmodics, Inc. Swellable hydrogel matrix and methods
CA2709379C (en) * 2007-12-21 2016-08-16 Microvention, Inc. Hydrogel filaments for biomedical uses
CN102015012A (zh) * 2008-02-29 2011-04-13 普拉罗美德公司 通过加热热敏聚合物进行的局部栓塞
US20110087207A1 (en) * 2008-02-29 2011-04-14 Pluromed, Inc. Local embolization using thermosensitive polymers
US20090226531A1 (en) * 2008-03-07 2009-09-10 Allergan, Inc. Methods and composition for intraocular delivery of therapeutic sirna
WO2009120265A2 (en) 2008-03-25 2009-10-01 Boston Scientific Scimed, Inc. Compositions and methods for delivery of embolics
WO2009124148A1 (en) * 2008-04-04 2009-10-08 Curaseal, Inc. Implantable fistula closure device
US8246876B2 (en) * 2008-08-18 2012-08-21 Cook Medical Technologies Llc Embolization particles and method for making same
CN102202582B (zh) 2008-09-04 2014-07-30 库拉希尔公司 用于肠瘘治疗的可充胀装置
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US8470013B2 (en) * 2008-10-20 2013-06-25 Imds Corporation Systems and methods for aneurysm treatment and vessel occlusion
US20110212179A1 (en) * 2008-10-30 2011-09-01 David Liu Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
US20120123355A1 (en) * 2009-07-30 2012-05-17 Cook Medical Technologied Erodible embolization material
US20110065809A1 (en) * 2009-09-15 2011-03-17 Medtronic, Inc. Polymerization of Multifunctional Azides, and Polymers Therefrom
JP2013505791A (ja) 2009-09-24 2013-02-21 マイクロベンション インコーポレイテッド 医学的使用のための注射用ヒドロゲル繊維
KR101745748B1 (ko) 2009-10-26 2017-06-12 마이크로벤션, 인코포레이티드 팽창성 중합체로부터 제작된 색전술 장치
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
CN102695500A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 多糖基水凝胶
CN102883752B (zh) * 2010-01-13 2016-03-02 G·比索夫 用于制备临时肠道堵塞的组合物
US7955301B1 (en) 2010-01-27 2011-06-07 Warsaw Orthopedic, Inc. Injection shut off valve with pressure actuator for delivery of compositions
US9486500B2 (en) 2010-01-28 2016-11-08 Warsaw Orthopedic, Inc. Osteoimplant and methods for making
US9125902B2 (en) * 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
US9592243B2 (en) 2011-04-25 2017-03-14 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for treatment of an injury
US9511077B2 (en) 2011-04-25 2016-12-06 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for wound healing
US9211116B2 (en) 2011-06-16 2015-12-15 Curaseal Inc. Fistula treatment devices and related methods
JP6127042B2 (ja) 2011-06-17 2017-05-10 キュラシール インコーポレイテッド 瘻孔処置用デバイスと方法
US10137280B2 (en) 2011-06-30 2018-11-27 Incube Labs, Llc System and method for treatment of hemorrhagic stroke
AT511671A1 (de) * 2011-07-13 2013-01-15 Bischof Georg Dr Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers
US8956682B2 (en) 2012-04-02 2015-02-17 Surmodics, Inc. Hydrophilic polymeric coatings for medical articles with visualization moiety
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
JP6480327B2 (ja) 2012-06-14 2019-03-06 マイクロベンション インコーポレイテッドＭｉｃｒｏｖｅｎｔｉｏｎ， Ｉｎｃ． ポリマー治療組成物
CA2887604C (en) 2012-10-15 2021-05-18 Microvention, Inc. Liquid embolic compositions and uses thereof for treating vascular conditions
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
CN105517580A (zh) * 2013-03-15 2016-04-20 马修·R·德勒埃 可成像栓塞微球
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
WO2015148859A1 (en) 2014-03-26 2015-10-01 Venclose, Inc. Venous disease treatment
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
JP6599361B2 (ja) 2014-04-29 2019-10-30 マイクロベンション インコーポレイテッド 活性剤を含むポリマー
US9764122B2 (en) 2014-07-25 2017-09-19 Warsaw Orthopedic, Inc. Drug delivery device and methods having an occluding member
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US10456235B2 (en) 2015-03-02 2019-10-29 Accurate Medical Therapeutics Ltd. Embolization particulates for occluding a blood vessel
EP3277198B1 (de) 2015-04-01 2023-10-25 Boston Scientific Scimed, Inc. Systeme zur bereitstellung von gelembolie
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
PL3291820T3 (pl) 2015-05-06 2023-08-21 Zoetis Services Llc Preparat hydrożelowy o łagodnej przyczepności
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
GB201515602D0 (en) * 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
US20170216346A1 (en) * 2016-01-28 2017-08-03 Cook Medical Technologies Llc Injectable compositions and methods of use thereof
USD802756S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
US11712418B2 (en) 2017-05-26 2023-08-01 Bruin Biosciences, Inc. Chemoembolization agents
US10576182B2 (en) 2017-10-09 2020-03-03 Microvention, Inc. Radioactive liquid embolic
CN107812232A (zh) * 2017-11-08 2018-03-20 华威（深圳）医疗器械有限责任公司 可显影羧基改性聚乙烯醇微球栓塞剂及其制备工艺
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
EP3793622A1 (de) * 2018-05-15 2021-03-24 Incept, LLC Emboliezusammensetzungen und verfahren
CN112423739A (zh) 2018-05-16 2021-02-26 斯贝洛克斯公司 过敏性鼻炎药物输送植入物
GB201810784D0 (en) * 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Radiopaque polymers
WO2020003147A2 (en) 2018-06-29 2020-01-02 Biocompatibles Uk Limited Radiopaque polymers
CN113272347A (zh) * 2018-11-21 2021-08-17 株式会社可乐丽 单分散性水凝胶颗粒
US20210022743A1 (en) * 2019-07-22 2021-01-28 Boston Scientific Scimed, Inc. In vivo crosslinking of embolic hydrogels using bioorthogonal click chemistry
JPWO2021199883A1 (de) * 2020-03-31 2021-10-07
US20230293553A1 (en) * 2020-07-06 2023-09-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polymeric carriers for delivery of therapeutic agents
EP4192435A1 (de) * 2020-09-04 2023-06-14 Blackswan Vascular, Inc. Flüssige emboliezusammensetzungen mit gesteuerter freisetzung von röntgendichten und therapeutischen verbindungen und verfahren zur verwendung davon
WO2023287727A1 (en) 2021-07-12 2023-01-19 Boston Scientific Scimed, Inc. Radiopaque compositions
US20230037198A1 (en) * 2021-07-29 2023-02-02 Varian Medical Systems, Inc. Apparatuses and methods for producing embolic particles with activated loading sites
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
CN116115818A (zh) * 2021-11-12 2023-05-16 刘庄 活性金属微球、基于活性金属微球的复合栓塞剂及其应用
US20230201122A1 (en) 2021-12-23 2023-06-29 Boston Scientific Medical Device Limited Chemoembolic compositions and methods of treatment using them
CN115501378B (zh) * 2022-09-23 2023-08-22 江南大学 一种改性聚乙烯醇栓塞微球及其制备方法

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1566330A (en) * 1977-02-16 1980-04-30 Farmaceutici Italia Anthracycline glycosides
JPS6317904A (ja) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
JPS63242272A (ja) * 1987-03-31 1988-10-07 テルモ株式会社 バルーンカテーテルのバルーン拡張用組成物
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
DE3841401A1 (de) 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
ATE130517T1 (de) 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
JP2576292B2 (ja) * 1991-01-29 1997-01-29 株式会社日立製作所 復水器及びそれを用いた発電プラント
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
TW272976B (de) * 1993-08-06 1996-03-21 Ciba Geigy Ag
US5394727A (en) * 1993-08-18 1995-03-07 Aluminum Company Of America Method of forming a metal container body
CA2202511A1 (en) 1994-10-12 1996-04-25 Laurence A. Roth Targeted delivery via biodegradable polymers
AU4438696A (en) * 1995-02-03 1996-08-21 Novartis Ag Crosslinked polymers
DE69521025T2 (de) 1995-03-07 2001-10-04 Menlo Care Inc Mittel zur Verbesserung der Schliessmuskelfunktion mit kontrollierter Ausdehnung
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
ATE235268T1 (de) 1995-07-27 2003-04-15 Micro Therapeutics Inc Neue embolisierende zusammensetzungen
US5667767A (en) 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5580568A (en) 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
EP0842209B1 (de) 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5833652A (en) 1995-09-18 1998-11-10 Y. Pierre Gobin Component mixing catheter
EP0876165B1 (de) 1995-12-18 2006-06-21 Angiotech BioMaterials Corp. Vernetzten polymerisatmassen und verfahren für ihre verwendung
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5702361A (en) * 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5902599A (en) 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
EP0902687A1 (de) 1996-03-11 1999-03-24 Focal, Inc. Verabreichung von radionukliden und radiopfarmazeutika in einem polymer
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
CA2260047A1 (en) 1996-07-29 1998-02-05 Micro Therapeutics, Inc. Novel methods for embolizing vascular sites with an embolizing composition comprising dimethylsulfoxide
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
AR008108A1 (es) * 1996-08-01 1999-12-09 Novartis Ag Un metodo para formar un articulo polimerico absorbente de radiacion, un articulo polimerico asi formado, y un metodo para formar un tintepolimerico
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5925683A (en) 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US5785642A (en) 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
WO1998017200A1 (en) 1996-10-18 1998-04-30 Micro Therapeutics, Inc. Method for treating urinary reflux
US5981826A (en) 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
JP2001510151A (ja) 1997-07-18 2001-07-31 インファイムド，インク． 生理活性物質の制御放出のための生分解性マクロマー
US6265509B1 (en) * 1997-07-30 2001-07-24 Novartis Ag Crosslinked polymers
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
WO1999012577A1 (en) * 1997-09-05 1999-03-18 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising a contrast agent for chemoembolization
US6037366A (en) 1997-09-11 2000-03-14 Prohold Medical Technologies, Inc. Composition for creating vascular occlusions
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
JP5095049B2 (ja) 1998-03-06 2012-12-12 バイオスフィアー メディカル，インク． 組織バルキング、および胃食道逆流疾患、尿失禁、皮膚のしわの治療のための移植可能な粒子
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
ATE502670T1 (de) 1998-08-14 2011-04-15 Incept Llc Apparat für die in-situ-bildung von hydrogelen
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6231613B1 (en) 1998-12-15 2001-05-15 Enteric Medical Technologies, Inc. Methods for soft tissue augmentation in mammals
DE69922050T2 (de) 1999-02-05 2005-11-10 The Regents Of The University Of California, Oakland Thermoreversibles polymer für intralumenalimplantate
WO2000050103A1 (en) 1999-02-25 2000-08-31 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US6303100B1 (en) 1999-03-19 2001-10-16 Micro Therapeutics, Inc. Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms
US6203779B1 (en) 1999-03-19 2001-03-20 Charlie Ricci Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
EP1173517A4 (de) 1999-04-26 2006-06-28 California Inst Of Techn Hydrogele die sich in situ formen
DK1218437T3 (da) 1999-08-27 2009-10-19 Angiodevice Internat Gmbh Præparater, som danner interpenetrerende polymernetværk, til anvendelse som medicinske tætningsmidler med höj styrke
WO2001017574A1 (en) 1999-09-10 2001-03-15 Focal, Inc. Hydrogels for orthopedic repair
JP2003516810A (ja) * 1999-11-15 2003-05-20 バイオキュア・インコーポレーテッド 分解性ポリ（ビニルアルコール）ヒドロゲル
KR100335866B1 (ko) 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
WO2001055360A1 (en) 2000-01-28 2001-08-02 Infimed Therapeutics, Inc. Slow release protein polymers
JP4871476B2 (ja) * 2000-03-13 2012-02-08 バイオコンパティブルズ ユーケー リミテッド 塞栓組成物
AU2001247507A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable microspheres for tissue construction
EP1274472A2 (de) 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injizierbare und schwellfähige mikrokügelchen zur gewebeverstärkung
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US8697137B2 (en) 2000-03-24 2014-04-15 Biosphere Medical, Inc. Methods of using microspheres for active embolization
AU2000269277A1 (en) 2000-08-23 2002-03-04 Eidgenossische Technische Hochschule Zurich Novel polymer compounds

Also Published As

Publication number Publication date
AU4566001A (en) 2001-09-24
US8221735B2 (en) 2012-07-17
CA2403218A1 (en) 2001-09-20
JP2003527402A (ja) 2003-09-16
AU2001245660B2 (en) 2006-06-15
USRE47121E1 (en) 2018-11-13
US20010036451A1 (en) 2001-11-01
WO2001068720A1 (en) 2001-09-20
JP4871476B2 (ja) 2012-02-08
USRE47873E1 (en) 2020-02-25
US20090209658A1 (en) 2009-08-20
EP1263803B1 (de) 2007-09-19
DE60130544T2 (de) 2008-06-26
ATE373682T1 (de) 2007-10-15
EP1263803A1 (de) 2002-12-11
US6676971B2 (en) 2004-01-13
CA2403218C (en) 2011-10-18
USRE48302E1 (en) 2020-11-10
US20030223956A1 (en) 2003-12-04

Similar Documents

Publication Publication Date Title
ATE373682T1 (de) Embolische zusammensetzungen
DE60115212D1 (de) Biomedizinische artikel aus hydrogel
ATE520721T1 (de) Wässrige gelartige zusammensetzungen auf basis von blockcopolymeren mit hydrophilen und hydrophoben blöcken
CA2323925A1 (en) Crosslinkable macromers bearing initiator groups
BR0106238B1 (pt) massa para moldagem com boa capacidade de moldagem por sopro, bem como uso da referida massa de moldagem e artigo moldado que a contÉm.
ATE517932T1 (de) Aus der schmelze verarbeitbare polymerzusammensetzung, die fluorpolymer mit langkettenverzweigungen enthält
BR0214136A (pt) Polìmeros de enxerto, processo para a preparação e uso dos mesmos
WO2004070772A3 (de) Carbazol-enthaltende konjugierte polymere und blends, deren darstellung und verwendung
TW200631604A (en) Ophthalmic compositions comprising polyether substituted polymers
ATE400352T1 (de) Herstellung von polymergegenständen mit hydrophiler oberfläche
WO2006130575A3 (en) Polymer-containing detergent compositions and their use
DE60134147D1 (de) Träger in partikelform zur verbesserung der oral- absorption von wikstoffen
BR0110067A (pt) Composição polimérica para canos
ATE410473T1 (de) Polymerstrukturen mit einem hydrophil/lipophil- system
ATE362776T1 (de) Quellbare hydrogelbildende polymere mit geringem feinstaubanteil
MY149404A (en) Polyvinyl ether compound
AR020532A1 (es) Hidrogeles opticamente transparentes y procesos para su produccion.
IL115181A (en) Contrast agent consisting of repeating biodegradable units its use and preparation
EP1543845A3 (de) Verdichtungsmittel und ölbehandelte Zellulosefaser
EP1325949A3 (de) Verwendung fluorierter Flüssigkeiten
PL366468A1 (en) Stabilizer compositions for halogenated polymers, the use thereof and polymers containing said compositions
DE60006951D1 (de) Verfahren zur herstellung von alkylierten diphenylaminzusammensetzungen
ATE325828T1 (de) Polymerträger mit polyoxalkylenen
ATE362512T1 (de) Stickstoffhaltige polymere umfassende reinigungsmittelzusammensetzung
TW200502303A (en) Acrylic elastomer composition

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOCOMPATIBLES UK LTD., FARNHAM, SURREY, GB