DE60135352D1 - Vorrichtung zur intraokularen wirkstoffverabreichung - Google Patents

Vorrichtung zur intraokularen wirkstoffverabreichung

Info

Publication number
DE60135352D1
DE60135352D1 DE60135352T DE60135352T DE60135352D1 DE 60135352 D1 DE60135352 D1 DE 60135352D1 DE 60135352 T DE60135352 T DE 60135352T DE 60135352 T DE60135352 T DE 60135352T DE 60135352 D1 DE60135352 D1 DE 60135352D1
Authority
DE
Germany
Prior art keywords
delivery
occular
intra
substances
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60135352T
Other languages
English (en)
Inventor
Signe Varner
Eugene Dejuan Jr
Terry Shelly
Aaron Barnes
Mark Humayun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of DE60135352D1 publication Critical patent/DE60135352D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE60135352T 2000-08-30 2001-06-22 Vorrichtung zur intraokularen wirkstoffverabreichung Expired - Lifetime DE60135352D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22893400P 2000-08-30 2000-08-30
PCT/US2001/020119 WO2002017831A2 (en) 2000-08-30 2001-06-22 Devices for intraocular drug delivery

Publications (1)

Publication Number Publication Date
DE60135352D1 true DE60135352D1 (de) 2008-09-25

Family

ID=22859147

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60135352T Expired - Lifetime DE60135352D1 (de) 2000-08-30 2001-06-22 Vorrichtung zur intraokularen wirkstoffverabreichung

Country Status (11)

Country Link
US (3) US6719750B2 (de)
EP (2) EP1313415B1 (de)
JP (1) JP4471568B2 (de)
AT (2) ATE547080T1 (de)
AU (3) AU2001271417B2 (de)
CA (1) CA2420038C (de)
DE (1) DE60135352D1 (de)
DK (1) DK1313415T3 (de)
ES (1) ES2312456T3 (de)
PT (1) PT1313415E (de)
WO (1) WO2002017831A2 (de)

Families Citing this family (295)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW586934B (en) * 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
US9295581B2 (en) * 1999-01-05 2016-03-29 Second Sight Medical Products, Inc. Medical tack with a variable effective length
US7943162B2 (en) * 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
ATE547080T1 (de) 2000-08-30 2012-03-15 Univ Johns Hopkins Vorrichtungen zur intraokularen arzneimittelabgabe
JP4657577B2 (ja) * 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド 眼への適用および他への適用のための可撓性マイクロチップデバイス
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6875165B2 (en) * 2001-02-22 2005-04-05 Retinalabs, Inc. Method of radiation delivery to the eye
EP1404297B1 (de) 2001-06-12 2011-04-27 The Johns Hopkins University School Of Medicine Reservoirvorrichtung für die intraokulare arzneimittelabgabe
ES2271278T3 (es) * 2001-06-18 2007-04-16 Durect Corporation Dispositivo para administrar microdosis de agentes en el oido.
EP1409065B1 (de) * 2001-07-23 2007-01-17 Alcon, Inc. Vorrichtung zur freisetzung eines ophthalmischen arzneimittels
AU2002319606B2 (en) * 2001-07-23 2006-09-14 Alcon, Inc. Ophthalmic drug delivery device
CA2473355C (en) * 2002-01-18 2012-01-03 Michael E. Snyder Sustained release ophthalmological device and method of making and using the same
US7108685B2 (en) * 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
AU2003217531A1 (en) * 2002-05-02 2003-11-17 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
DK1519681T3 (da) * 2002-07-09 2007-04-10 Aecc Entpr Ltd Fremgangsmåde til billeddannelse af den relative bevægelse af skeletstykker
US7008403B1 (en) * 2002-07-19 2006-03-07 Cognitive Ventures Corporation Infusion pump and method for use
EP1539066B1 (de) * 2002-09-17 2012-11-07 Iscience Surgical Corporation Gerät zur chirurgischen umleitung von wässrigen körperflüssigkeiten
US20050143363A1 (en) * 2002-09-29 2005-06-30 Innorx, Inc. Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases
US20060265043A1 (en) * 2002-09-30 2006-11-23 Evgenia Mandrusov Method and apparatus for treating vulnerable plaque
US7326238B1 (en) 2002-09-30 2008-02-05 Abbott Cardiovascular Systems Inc. Method and apparatus for treating vulnerable plaque
US7008411B1 (en) * 2002-09-30 2006-03-07 Advanced Cardiovascular Systems, Inc. Method and apparatus for treating vulnerable plaque
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
CA2524271C (en) * 2003-05-02 2012-09-04 Surmodics, Inc. Controlled release bioactive agent delivery device
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US20040225250A1 (en) * 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US20040265356A1 (en) * 2003-06-30 2004-12-30 Bausch & Lomb Incorporated Drug delivery device
ZA200508654B (en) * 2003-07-10 2007-01-31 Alcon Inc Ophthalmic drug delivery device
ES2388138T3 (es) * 2003-08-27 2012-10-09 Ophthotech Corporation Terapia de combinación para tratamiento de trastornos neovasculares oculares
AU2004274026A1 (en) * 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US7431709B2 (en) * 2003-12-05 2008-10-07 Innfocus, Llc Glaucoma implant device
US20050148948A1 (en) * 2003-12-19 2005-07-07 Caputa Steven G. Sutureless ophthalmic drug delivery system and method
IL159818A0 (en) * 2004-01-12 2004-06-20 Nulens Ltd Intraocular structure
US7976520B2 (en) * 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US20050222613A1 (en) * 2004-02-05 2005-10-06 Edwin Ryan Wound closure device and method for vitrectomy
BRPI0507690A (pt) * 2004-02-12 2007-07-24 Neovista Inc métodos e aparelho para a braquiterapia intra-ocular
US7563222B2 (en) * 2004-02-12 2009-07-21 Neovista, Inc. Methods and apparatus for intraocular brachytherapy
WO2005099787A1 (en) * 2004-04-06 2005-10-27 Surmodics, Inc. Coating compositions for bioactive agents
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
AU2005240073A1 (en) * 2004-04-29 2005-11-17 Iscience Surgical Corporation Apparatus and method for ocular treatment
US20100173866A1 (en) * 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
CA2564806A1 (en) * 2004-04-29 2005-11-17 Iscience Surgical Corporation Apparatus and method for surgical enhancement of aqueous humor drainage
US8119154B2 (en) * 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US20050267520A1 (en) 2004-05-12 2005-12-01 Modesitt D B Access and closure device and method
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
AU2005269988B2 (en) * 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
US20060110428A1 (en) * 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US7678133B2 (en) 2004-07-10 2010-03-16 Arstasis, Inc. Biological tissue closure device and method
US7117870B2 (en) * 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US9138228B2 (en) 2004-08-11 2015-09-22 Emory University Vascular conduit device and system for implanting
WO2006023130A2 (en) * 2004-08-12 2006-03-02 Surmodics, Inc. Biodegradable controlled release bioactive agent delivery device
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
WO2006057859A1 (en) * 2004-11-24 2006-06-01 Therakine Corporation An implant for intraocular drug delivery
US20060134168A1 (en) 2004-12-07 2006-06-22 Chappa Ralph A Coatings with crystallized active agent(s) and methods
WO2006068898A1 (en) * 2004-12-22 2006-06-29 Bausch & Lomb Incorporated Reusable drug delivery device
US20060198868A1 (en) * 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
US20060147491A1 (en) * 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
EP1883398A4 (de) * 2005-02-01 2012-06-06 Osteobiologics Inc Verfahren und vorrichtung zur selektiven zugabe eines bioaktiven wirkstoffes zu einem mehrphasenimplantat
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
KR101387456B1 (ko) 2005-02-09 2014-04-21 산텐 세이야꾸 가부시키가이샤 질환 또는 상태의 치료를 위한 액체 제제
US20060233858A1 (en) * 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
US20070077270A1 (en) * 2005-03-28 2007-04-05 Clemson University Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
WO2006110487A1 (en) * 2005-04-08 2006-10-19 Surmodics, Inc. Sustained release implants for subretinal delivery
US20060259008A1 (en) * 2005-04-27 2006-11-16 Allergan, Inc. Apparatus and methods useful for intravitreal injection of drugs
US20060258994A1 (en) * 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
CN101217916B (zh) 2005-05-12 2013-04-10 阿尔斯塔西斯公司 穿刺和闭合装置以及方法
US20070027452A1 (en) * 2005-05-18 2007-02-01 Varner Signe E Insertion instrument for non-linear medical devices
US20080207499A1 (en) * 2005-06-29 2008-08-28 Gaetano Barile Rage-related methods for treating and preventing diabetic retinopathy
DE602006008632D1 (de) * 2005-07-11 2009-10-01 Dsm Ip Assets Bv Gerollter draht zur kontrollierten freisetzung von arzneimitteln an das auge
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070060887A1 (en) * 2005-08-22 2007-03-15 Marsh David A Ophthalmic injector
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
CN101309709A (zh) * 2005-09-21 2008-11-19 苏尔莫迪克斯公司 包含天然生物可降解的多糖的涂层和物品
EP1926504B1 (de) * 2005-09-21 2010-01-13 SurModics, Inc. In situ okklusionszusammensetzungen mit natürlichen biologisch abbaubaren polysacchariden
US20080167600A1 (en) * 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
WO2007059144A1 (en) * 2005-11-15 2007-05-24 Surmodics, Inc. Ultrasonic nozzles for applying two-component coatings
WO2007059208A2 (en) 2005-11-15 2007-05-24 Neovista Inc. Methods and apparatus for intraocular brachytherapy
MX2008006379A (es) 2005-11-29 2009-03-03 Smithkline Beecham Corp Metodo de tratamiento.
WO2007084418A2 (en) * 2006-01-13 2007-07-26 Surmodics, Inc. Microparticle containing matrices for drug delivery
US9084662B2 (en) * 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
DE602007014007D1 (de) * 2006-01-17 2011-06-01 Nulens Ltd Intraokularer arzneispender
GB0600903D0 (en) * 2006-01-17 2006-02-22 Cancer Rec Tech Ltd Treatment of cancer
EP3632385A1 (de) * 2006-01-17 2020-04-08 Novartis AG Glaukombehandlungsvorrichtung
EP2001438A2 (de) 2006-02-09 2008-12-17 Macusight, Inc. Stabile formulierungen sowie verfahren zu ihrer herstellung und verwendung
EP1998829B1 (de) 2006-03-14 2011-02-09 University Of Southern California Mems-Vorrichtung zur Wirkstofffreisetzung
DK2001466T3 (en) 2006-03-23 2016-02-29 Santen Pharmaceutical Co Ltd LOW-DOSAGE RAPAMYCINE FOR TREATMENT OF VASCULAR PERMEABILITY-RELATED DISEASES
US8676293B2 (en) * 2006-04-13 2014-03-18 Aecc Enterprises Ltd. Devices, systems and methods for measuring and evaluating the motion and function of joint structures and associated muscles, determining suitability for orthopedic intervention, and evaluating efficacy of orthopedic intervention
US7981096B2 (en) * 2006-05-12 2011-07-19 David Castillejos Optic nerve head implant and medication delivery system
US7674243B2 (en) * 2006-05-17 2010-03-09 Alcon Inc. Ophthalmic injection device using piezoelectric array
US20070270750A1 (en) * 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US20070268340A1 (en) * 2006-05-17 2007-11-22 Bruno Dacquay Ophthalmic Injection System and Method Using Piezoelectric Array
US7811252B2 (en) * 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US7815603B2 (en) * 2006-05-17 2010-10-19 Alcon Research, Ltd. Ophthalmic injection method
US7887521B2 (en) * 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US7862540B2 (en) * 2006-05-17 2011-01-04 Alcon Research, Ltd. Ophthalmic injection device using shape memory alloy
US8668676B2 (en) * 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US20070293873A1 (en) * 2006-06-19 2007-12-20 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
EP2037882B1 (de) * 2006-06-28 2014-12-10 SurModics, Inc. Kombination aus abbaubaren und nichtabbaubaren matrizen zur wirkstofffreisetzung
JP2009542671A (ja) * 2006-06-28 2009-12-03 サーモディクス，インコーポレイティド 微粒子を含む活性剤溶出マトリックス
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US20080097335A1 (en) * 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
WO2008022258A2 (en) * 2006-08-16 2008-02-21 Surmodics, Inc. Methods and materials for increasing the adhesion of elution control matrices to substrates
WO2008027371A2 (en) * 2006-08-29 2008-03-06 Surmodics, Inc. Low profile bioactive agent delivery device
WO2008039749A2 (en) * 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
US20080125712A1 (en) * 2006-09-26 2008-05-29 Alcon Manufacturing, Ltd. Ophthalmic injection system
US20080097379A1 (en) * 2006-09-26 2008-04-24 Alcon Manufacturing, Ltd. Ophthalmic injection method
US20080075779A1 (en) * 2006-09-27 2008-03-27 Chappa Ralph A Additives And Methods For Enhancing Active Agent Elution Kinetics
US20080097390A1 (en) * 2006-09-27 2008-04-24 Alcon Manufacturing, Ltd. Spring actuated delivery system
US20080089923A1 (en) * 2006-09-29 2008-04-17 Burkstrand Michael J Biodegradable ocular implants and methods for treating ocular conditions
KR20090067218A (ko) * 2006-10-16 2009-06-24 알콘 리서치, 리미티드 일회용 단부를 구비하는 안과용 핸드 피스의 작동 방법
EP2063829B1 (de) * 2006-10-16 2010-12-08 Alcon Research, Ltd. Universelle aufladbare baugruppe mit eingeschränkter wiederverwendbarkeit für ein ophthalmisches handstück
US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US9022970B2 (en) * 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US7831309B1 (en) 2006-12-06 2010-11-09 University Of Southern California Implants based on bipolar metal oxide semiconductor (MOS) electronics
US20080147021A1 (en) * 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
US20090005869A1 (en) * 2006-12-15 2009-01-01 University Of Virginia Patent Foundation Device which Attaches into a Joint and Carries a Payload of Controlled Release Drugs and Related Method thereof
WO2008076544A2 (en) * 2006-12-18 2008-06-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
US7846123B2 (en) 2007-04-24 2010-12-07 Emory University Conduit device and system for implanting a conduit device in a tissue wall
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
WO2009012406A1 (en) 2007-07-17 2009-01-22 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities reference to priority document
US7740619B2 (en) 2007-08-01 2010-06-22 Alcon Research, Ltd. Spring driven ophthalmic injection device with safety actuator lockout feature
US20090036842A1 (en) * 2007-08-03 2009-02-05 Raffi Pinedjian Consumable Activation Lever For Injection Device
US20090099481A1 (en) * 2007-10-10 2009-04-16 Adam Deitz Devices, Systems and Methods for Measuring and Evaluating the Motion and Function of Joints and Associated Muscles
US20090105744A1 (en) * 2007-10-17 2009-04-23 Modesitt D Bruce Methods for forming tracts in tissue
JP5330401B2 (ja) 2007-11-08 2013-10-30 アリメラ・サイエンシーズ，インコーポレーテッド 眼のための埋め込み装置、及びその装置を備えるキット
EP2666510B1 (de) 2007-12-20 2017-10-18 University Of Southern California Vorrichtung zur kontrollierten Abgabe von Therapeutika
US20090192493A1 (en) * 2008-01-03 2009-07-30 University Of Southern California Implantable drug-delivery devices, and apparatus and methods for refilling the devices
US8602959B1 (en) 2010-05-21 2013-12-10 Robert Park Methods and devices for delivery of radiation to the posterior portion of the eye
US9056201B1 (en) 2008-01-07 2015-06-16 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US10022558B1 (en) 2008-01-07 2018-07-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
KR101634983B1 (ko) * 2008-01-07 2016-07-01 살루타리스 메디컬 디바이스즈, 인코퍼레이티드 눈의 후부에 대한 방사선의 전달을 위한 외안의 최소한의 수술 방법 및 장치
US9873001B2 (en) 2008-01-07 2018-01-23 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US20110207987A1 (en) * 2009-11-02 2011-08-25 Salutaris Medical Devices, Inc. Methods And Devices For Delivering Appropriate Minimally-Invasive Extraocular Radiation
US8608632B1 (en) 2009-07-03 2013-12-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye
WO2009091812A2 (en) * 2008-01-14 2009-07-23 Surmodics, Inc. Devices and methods for elution of nucleic acid delivery complexes
WO2009097468A2 (en) 2008-01-29 2009-08-06 Kliman Gilbert H Drug delivery devices, kits and methods therefor
US20100152646A1 (en) * 2008-02-29 2010-06-17 Reshma Girijavallabhan Intravitreal injection device and method
US20090227938A1 (en) * 2008-03-05 2009-09-10 Insitu Therapeutics, Inc. Wound Closure Devices, Methods of Use, and Kits
WO2009126830A2 (en) * 2008-04-09 2009-10-15 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
US8496954B2 (en) * 2008-04-18 2013-07-30 Surmodics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
EP2296630A2 (de) * 2008-05-07 2011-03-23 SurModics, Inc. Abgabe von nukleinsäurekomplexen aus teilchen
CN103394142B (zh) 2008-05-08 2015-08-19 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
CN104353150A (zh) 2008-05-08 2015-02-18 迷你泵有限责任公司 可植入泵和用于可植入泵的插管
US8231609B2 (en) * 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
AU2009256236A1 (en) 2008-06-04 2009-12-10 Neovista, Inc. Handheld radiation delivery system for advancing a radiation source wire
EP3298995A1 (de) 2008-06-25 2018-03-28 Novartis AG Augenimplantat mit formänderungsfähigkeiten
EP2312993A4 (de) * 2008-07-21 2015-03-11 Arstasis Inc Vorrichtungen, verfahren und kits zur bildung von gewebetrakten
AU2009274128A1 (en) * 2008-07-21 2010-01-28 Arstasis, Inc. Devices and methods for forming tracts in tissue
US8459310B2 (en) * 2008-07-24 2013-06-11 Surmodics, Inc. Systems and methods for filling medical device lumen
WO2010062394A2 (en) 2008-11-26 2010-06-03 Surmodics, Inc. Implantable ocular drug delivery device and methods
WO2010071844A1 (en) * 2008-12-19 2010-06-24 Qlt Plug Delivery, Inc Substance delivering punctum implants and methods
US20100174272A1 (en) * 2009-01-02 2010-07-08 Weiner Alan L In-situ refillable ophthalmic implant
USD691270S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691269S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691268S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
USD691267S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
US8545554B2 (en) * 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US20100191177A1 (en) * 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
JP5524983B2 (ja) 2009-01-28 2014-06-18 トランセンド・メディカル・インコーポレイテッド インプラントシステム
PL2391419T3 (pl) 2009-01-29 2019-12-31 Forsight Vision4, Inc. Dostarczanie leku do tylnego odcinka
US20100191168A1 (en) 2009-01-29 2010-07-29 Trustees Of Tufts College Endovascular cerebrospinal fluid shunt
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
EP2396070A4 (de) 2009-02-12 2012-09-19 Incept Llc Wirkstofffreisetzung mit hydrogel-plugs
EP2408409B8 (de) * 2009-03-16 2016-06-08 Endoshape, Inc. Zuverlässig fixierte ophtalmologische formgedächtnisimplantate
US8372036B2 (en) 2009-05-06 2013-02-12 Alcon Research, Ltd. Multi-layer heat assembly for a drug delivery device
CN102802541A (zh) * 2009-05-15 2012-11-28 阿尔斯塔西斯公司 在组织中形成管道的装置、方法和成套用具
CA2763522A1 (en) 2009-06-02 2010-12-09 Surmodics, Inc. Silane-functionalized hydrophobic .alpha.(1.fwdarw.-4)glucopyranose polymers and polymeric matrices for implantation or injection
ES2921527T3 (es) 2009-06-03 2022-08-29 Forsight Vision5 Inc Administración de fármaco en segmento anterior
EP2724739B1 (de) 2009-07-30 2015-07-01 Tandem Diabetes Care, Inc. Tragbares Infusionspumpensystem
EP2467797B1 (de) 2009-08-18 2017-07-19 MiniPumps, LLC Elektrolytische arzneimittelverabreichungspumpe mit adaptiver steuerung
US20110054445A1 (en) * 2009-09-02 2011-03-03 Board Of Regents, The University Of Texas System Devices and Methods for Treatment of Eye Disease
US8545431B2 (en) * 2009-09-21 2013-10-01 Alcon Research, Ltd. Lumen clearing valve for glaucoma drainage device
US8721580B2 (en) * 2009-09-21 2014-05-13 Alcon Research, Ltd. Power saving glaucoma drainage device
US8419673B2 (en) 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
US8257295B2 (en) 2009-09-21 2012-09-04 Alcon Research, Ltd. Intraocular pressure sensor with external pressure compensation
US20110208215A1 (en) * 2009-09-22 2011-08-25 Modesitt D Bruce Devices, methods, and kits for forming tracts in tissue
US9138163B2 (en) 2009-09-25 2015-09-22 Ortho Kinematics, Inc. Systems and devices for an integrated imaging system with real-time feedback loop and methods therefor
WO2011041517A1 (en) 2009-09-30 2011-04-07 Surmodics, Inc. Hydrophobic polysaccharides with silyl ether linkages having enhanced degradation and medical articles made therefrom
US20120232102A1 (en) 2009-09-30 2012-09-13 Chun-Fang Xu Methods Of Administration And Treatment
US20110166555A1 (en) * 2009-09-30 2011-07-07 Jianbo Zhou Carrier for an insertable medical device, insertion tools, methods of use, and kits
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US20110159098A1 (en) * 2009-12-30 2011-06-30 Surmodics, Inc. Stabilization and delivery of nucleic acid complexes
US20110184310A1 (en) * 2010-01-27 2011-07-28 Joe Denton Brown Method of heating a shape memory alloy of a surgical instrument
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
WO2011123180A1 (en) 2010-04-03 2011-10-06 Praful Doshi Medical devices including medicaments and methods of making and using same
NZ629829A (en) 2010-04-30 2015-11-27 Alexion Pharma Inc Anti-c5a antibodies and methods for using the antibodies
EP3861969A1 (de) 2010-08-05 2021-08-11 ForSight Vision4, Inc. Injektorvorrichtung zur arzneimittelabgabe
WO2012019139A1 (en) * 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
SI2600812T1 (sl) * 2010-08-05 2021-12-31 ForSight Vision4, Inc., Naprava za zdravljenje očesa
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US20120100187A1 (en) 2010-10-26 2012-04-26 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
WO2012065006A2 (en) 2010-11-11 2012-05-18 Forsight Vision4, Inc. Methods and apparatus to determine porous structures for drug delivery
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
JP6130302B2 (ja) 2011-01-28 2017-05-17 アピカ カーディオヴァスキュラー リミテッド 組織壁の刺し傷を封止するシステム
EP2670346A2 (de) 2011-02-01 2013-12-11 Georgia Tech Research Corporation Systeme zur implantierung und verwendung einer leitung in einer gewebewand
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
WO2012131583A2 (en) * 2011-03-27 2012-10-04 Microsert Ltd. Miniature implanted drug delivery devices and inserter systems for introducing such devices
EP4249059A3 (de) 2011-06-28 2023-11-29 ForSight Vision4, Inc. Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge
WO2013027107A1 (en) * 2011-08-23 2013-02-28 Simcha Milo Device for creating temporary access and then closure
RU2740680C2 (ru) 2011-09-14 2021-01-19 Форсайт Вижн5, Инк. Глазное вкладочное устройство и способы
EP2755546A4 (de) * 2011-09-15 2015-08-12 Yoseph Yaacobi Systeme und verfahren zur behandlung von ohrerkrankungen
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
SI2755600T1 (sl) 2011-09-16 2021-08-31 Forsight Vision4, Inc. Naprava za izmenjavo tekočine
US8585631B2 (en) 2011-10-18 2013-11-19 Alcon Research, Ltd. Active bimodal valve system for real-time IOP control
US8840578B2 (en) 2011-12-09 2014-09-23 Alcon Research, Ltd. Multilayer membrane actuators
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US9622910B2 (en) 2011-12-12 2017-04-18 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven values
WO2013090231A1 (en) 2011-12-13 2013-06-20 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
US9339187B2 (en) 2011-12-15 2016-05-17 Alcon Research, Ltd. External pressure measurement system and method for an intraocular implant
US9241829B2 (en) 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US20130317481A1 (en) 2012-05-25 2013-11-28 Arstasis, Inc. Vascular access configuration
ES2706059T3 (es) 2012-05-25 2019-03-27 Novartis Ag Composición farmacéutica acuosa que contiene un agente terapéutico biológico y derivado de L-arginina y una inyección que incluye la composición
US20130317438A1 (en) 2012-05-25 2013-11-28 Arstasis, Inc. Vascular access configuration
MX351261B (es) 2012-06-01 2017-10-06 Surmodics Inc Aparato y método para recubrir catéteres con globo.
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
EP2895123B1 (de) 2012-09-17 2017-06-07 Novartis Ag Expandierende augenimplantatvorrichtungen
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
PT2911623T (pt) 2012-10-26 2019-11-21 Forsight Vision5 Inc Sistema oftálmico para libertação prolongada de fármaco no olho
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
US9295389B2 (en) 2012-12-17 2016-03-29 Novartis Ag Systems and methods for priming an intraocular pressure sensor in an intraocular implant
US9572712B2 (en) 2012-12-17 2017-02-21 Novartis Ag Osmotically actuated fluidic valve
US9528633B2 (en) 2012-12-17 2016-12-27 Novartis Ag MEMS check valve
EP2948104B1 (de) 2013-01-25 2019-07-24 Apica Cardiovascular Limited Systeme für perkutanen zugang sowie stabilisierung und verschluss von organen
AU2014236455B2 (en) 2013-03-14 2018-07-12 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CA2907114C (en) * 2013-03-15 2021-07-13 Optimedica Corporation Microfemtotomy methods and systems
JP6302992B2 (ja) 2013-03-15 2018-03-28 エーピーケー アドバンスド メディカル テクノロジーズ，インコーポレイテッド 組織壁に移植するためのコネクタ
EP4302736A3 (de) 2013-03-28 2024-04-03 ForSight Vision4, Inc. Ophthalmisches implantat zur abgabe von therapeutischen substanzen
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
CN105431204A (zh) 2013-07-12 2016-03-23 奥普索特克公司 用于治疗或预防眼科病的方法
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
US9283115B2 (en) 2013-08-26 2016-03-15 Novartis Ag Passive to active staged drainage device
US9289324B2 (en) 2013-08-26 2016-03-22 Novartis Ag Externally adjustable passive drainage device
EP3041524A4 (de) * 2013-09-06 2017-06-14 The Regents of the University of Colorado, a body corporate Intraokulare wirkstofffreisetzung und filtervorrichtung sowie verfahren zur verwendung davon
US11219552B2 (en) 2013-09-06 2022-01-11 The Regents Of The University Of Colorado, A Body Corporate Intraocular filter device and methods of using same
US9737696B2 (en) 2014-01-15 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
JP6637430B2 (ja) 2014-01-15 2020-01-29 タフツ メディカル センター, インク.Tufts Medical Center, Inc. 血管内脳脊髄液シャント
NZ711451A (en) 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
US9603742B2 (en) 2014-03-13 2017-03-28 Novartis Ag Remote magnetic driven flow system
US9681983B2 (en) 2014-03-13 2017-06-20 Novartis Ag Debris clearance system for an ocular implant
USD760381S1 (en) 2014-06-25 2016-06-28 Donald Fox Orbital injection cannula
US10258503B2 (en) 2014-07-15 2019-04-16 Forsight Vision4, Inc. Ocular implant delivery device and method
MY182793A (en) 2014-08-08 2021-02-05 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
EP3212250A4 (de) 2014-10-31 2018-07-11 Thoratec Corporation Apikale verbinder und instrumente zur verwendung in einer herzwand
JP6586172B2 (ja) 2014-10-31 2019-10-02 セレバスク, エルエルシーCereVasc, LLC 水頭症の治療方法およびシステム
US10500091B2 (en) 2014-11-10 2019-12-10 Forsight Vision4, Inc. Expandable drug delivery devices and methods of use
US9655777B2 (en) 2015-04-07 2017-05-23 Novartis Ag System and method for diagphragm pumping using heating element
EP3283004A4 (de) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Augeneinsatzzusammensetzung aus einem semikristallinen oder kristallinen pharmazeutischen wirkstoff
US20160354161A1 (en) 2015-06-05 2016-12-08 Ortho Kinematics, Inc. Methods for data processing for intra-operative navigation systems
US10182939B2 (en) 2015-09-16 2019-01-22 Novartis Ag Hydraulic injector and methods for intra-ocular lens insertion
US10272230B2 (en) 2015-10-30 2019-04-30 Cerevasc, Llc Systems and methods for treating hydrocephalus
CN108430405B (zh) 2015-11-20 2021-04-13 弗赛特影像4股份有限公司 用于缓释药物递送装置的多孔结构
AU2016361579B2 (en) 2015-11-25 2022-08-04 Incept, Llc Shape changing drug delivery devices and methods
US11617680B2 (en) 2016-04-05 2023-04-04 Forsight Vision4, Inc. Implantable ocular drug delivery devices
USD814637S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD815285S1 (en) 2016-05-11 2018-04-10 Salutaris Medical Devices, Inc. Brachytherapy device
USD814638S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD808529S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
USD808528S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
EA202090247A1 (ru) 2017-07-14 2020-05-12 Цитомкс Терапьютикс, Инк. Антитела против cd166 и их применения
US11365241B2 (en) 2017-07-27 2022-06-21 Alexion Pharmaceuticals, Inc. High concentration anti-C5 antibody formulations
CN107519532B (zh) * 2017-08-25 2020-10-02 唐山市工人医院 一种弹性假体材料及其制备方法
WO2019103906A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
EP3501433A1 (de) * 2017-12-21 2019-06-26 Universiteit Maastricht Vorrichtung zur handhabung eines stabförmigen elements zum einfügen in oder entfernen aus dem auge eines patienten
EP3762083A1 (de) 2018-03-08 2021-01-13 CereVasc, Inc. Systeme und verfahren zur minimal-invasiven wirkstoffabgabe an einen subarachnoidraum
US11690807B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
SG11202005949UA (en) 2018-05-24 2020-07-29 Celanese Eva Performance Polymers Corp Implantable device for sustained release of a macromolecular drug compound
US20200100941A1 (en) 2018-08-25 2020-04-02 Thad Anthony Labbe Ophthalmic surgical instruments for removal of lens materials and methods of use
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
BR112021012172A2 (pt) 2018-12-12 2021-08-31 Kite Pharma, Inc. Receptores de antígenos quiméricos e de célula t e métodos de uso
CN109431678B (zh) * 2018-12-17 2021-05-28 中国医学科学院北京协和医院 经巩膜药物传输系统
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2021217024A1 (en) 2020-04-24 2021-10-28 Millennium Pharmaceuticals, Inc. Anti-cd19 antibodies and uses thereof
WO2022159723A1 (en) 2021-01-22 2022-07-28 Shifamed Holdings, Llc Adjustable shunting systems with plate assemblies, and associated systems and methods
CN117425673A (zh) 2021-04-09 2024-01-19 武田药品工业株式会社 靶向补体因子d的抗体和其用途
EP4330283A1 (de) 2021-04-26 2024-03-06 Millennium Pharmaceuticals, Inc. Anti-adgre2-antikörper und verwendungen davon
KR20240004286A (ko) 2021-04-26 2024-01-11 밀레니엄 파머슈티컬스 인코퍼레이티드 항 Clec12A 항체 및 이의 용도
AU2022372894A1 (en) 2021-10-20 2024-04-18 Takeda Pharmaceutical Company Limited Compositions targeting bcma and methods of use thereof

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US273410A (en) 1883-03-06 Gelatine eye-disk
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US4069307A (en) 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4144317A (en) 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4014334A (en) * 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4206756A (en) * 1977-03-23 1980-06-10 Murray Grossan Jet ear irrigation system
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4304765A (en) 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4678466A (en) * 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US4451254A (en) * 1982-03-15 1984-05-29 Eli Lilly And Company Implant system
CA1232814A (en) 1983-09-16 1988-02-16 Hidetoshi Sakamoto Guide wire for catheter
US4892736A (en) 1983-10-07 1990-01-09 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4764377A (en) 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4701180A (en) * 1986-02-19 1987-10-20 Kelly L Thomas Implanted anchor and insert with analog display
US4665905A (en) 1986-06-09 1987-05-19 Brown Charles S Dynamic elbow and knee extension brace
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5989579A (en) 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
WO1989005664A1 (en) 1987-12-17 1989-06-29 Allied-Signal Inc. Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4936825A (en) * 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
KR0185215B1 (ko) 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5364343A (en) * 1991-03-06 1994-11-15 D.D. S.R.L. Irrigation device for use in ear canals for therapeutic or hygienic purposes
US5246867A (en) 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
DK0797988T3 (da) 1993-07-19 2009-05-11 Univ British Columbia Anti-angiogene præparater og fremgangsmåder til anvendelse deraf
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5472436A (en) 1994-07-26 1995-12-05 Fremstad; Daria A. Ocular appliance for delivering medication
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
IL113723A (en) * 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
ZA97976B (en) 1996-04-05 1997-08-18 Alza Corp Uniform drug delivery theraphy.
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5997517A (en) 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
DK0973499T3 (da) * 1997-03-31 2003-11-17 Alza Corp Implanterbart diffusionsafgivelsessystem
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
IL129951A0 (en) 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
ES2232005T3 (es) 1997-08-11 2005-05-16 Allergan, Inc. Dispositivo de implante biodegradable esteril que contiene retinoide con biocompatibilidad mejorada y metodo de preparacion.
US6306166B1 (en) 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US5972027A (en) * 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
KR100289471B1 (ko) 1998-01-19 2001-09-17 김충섭 휀타닐계마취제의이식형서방성제제
US20020188037A1 (en) 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
ATE219693T1 (de) 1998-04-27 2002-07-15 Surmodics Inc Bioaktive wirkstoffe freisetzende beschichtungen
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US6263880B1 (en) * 1998-06-22 2001-07-24 Neovasys, Inc. Method of enhancing blood flow in tissue
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
NZ509797A (en) 1998-07-10 2003-11-28 Univ Sydney Prophylactic treatments of neovascularisation in macular degeneration using a steroid
US6378526B1 (en) * 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6399655B1 (en) 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US20040121014A1 (en) 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6309660B1 (en) 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6264971B1 (en) 1999-11-04 2001-07-24 Btg International Limited Ocular insert
US6706023B1 (en) * 1999-12-03 2004-03-16 Bionix Development Corporation Device for irrigation of a blind orifice
US6245100B1 (en) 2000-02-01 2001-06-12 Cordis Corporation Method for making a self-expanding stent-graft
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
WO2001068766A2 (en) * 2000-03-13 2001-09-20 The Dow Chemical Company Flame retardant, high impact monovinylidene aromatic polymer composition
US6478776B1 (en) * 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6451373B1 (en) 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
ATE547080T1 (de) 2000-08-30 2012-03-15 Univ Johns Hopkins Vorrichtungen zur intraokularen arzneimittelabgabe
ATE367836T1 (de) 2000-10-31 2007-08-15 Cook Inc Beschichtete, implantierbare medizinische geräte
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
JP2004523275A (ja) 2000-12-22 2004-08-05 アバンテク バスキュラー コーポレーション 治療能力のある薬剤の送達
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
EP1404297B1 (de) 2001-06-12 2011-04-27 The Johns Hopkins University School Of Medicine Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US7485113B2 (en) 2001-06-22 2009-02-03 Johns Hopkins University Method for drug delivery through the vitreous humor
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
US6764470B2 (en) * 2001-12-03 2004-07-20 Roland P. Dimick Ear plug medication administration device
CA2494186A1 (en) 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a poly(ethylene-co-(meth)acrylate), medical device, and method
US20050143363A1 (en) 2002-09-29 2005-06-30 Innorx, Inc. Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases
US7654997B2 (en) * 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat

Also Published As

Publication number Publication date
AU2007200057A1 (en) 2007-01-25
WO2002017831A3 (en) 2002-07-11
EP1992317A3 (de) 2009-01-21
WO2002017831A2 (en) 2002-03-07
ATE404140T1 (de) 2008-08-15
PT1313415E (pt) 2008-11-25
EP1992317A2 (de) 2008-11-19
AU2007200057B2 (en) 2008-09-18
JP4471568B2 (ja) 2010-06-02
JP2004524866A (ja) 2004-08-19
US6719750B2 (en) 2004-04-13
AU2001271417B2 (en) 2006-10-05
ATE547080T1 (de) 2012-03-15
US20020026176A1 (en) 2002-02-28
DK1313415T3 (da) 2008-10-13
ES2312456T3 (es) 2009-03-01
AU7141701A (en) 2002-03-13
EP1992317B1 (de) 2012-02-29
CA2420038A1 (en) 2002-03-07
CA2420038C (en) 2010-11-09
US20040133155A1 (en) 2004-07-08
US20050059956A1 (en) 2005-03-17
US8096972B2 (en) 2012-01-17
EP1313415A2 (de) 2003-05-28
EP1313415B1 (de) 2008-08-13

Similar Documents

Publication Publication Date Title
DE60135352D1 (de) Vorrichtung zur intraokularen wirkstoffverabreichung
DE60239868D1 (de) Reservoirvorrichtung für die intraokulare arzneimittelabgabe
CY1112271T1 (el) Διαδερμικα συστηματα οπιοειδων περισταλτικα της απροσφορης χρησης
WO2003082188A3 (en) Methods and drug delivery systems for the treatment of orofacial diseases
ATE504308T1 (de) Antimikrobielle kationische peptide und diese enthaltende formulierungen
HUP0401568A2 (hu) Periokuláris vagy subconjunctivális adagolásra alkalmas szemészeti depó készítmények
TNSN08079A1 (en) Pharmaceutical compositions for the treatment of inner ear disorders
DE60228293D1 (de) Implantierbare vorrichtungen zur behandlung von schmerzen durch abgabe von fentanyl und fentanyl-verwandten
GB0223040D0 (en) Therapeutic compounds
HUP0203590A2 (hu) Gyógyszerkészítmény a csonttömeg csökkenésével járó betegségek kezelésére
ATE316786T1 (de) Behandlung von mukositis
GB0108592D0 (en) Therapeutic agents
HK1085386A1 (en) Pharmaceuticals comprising shikonins active constituent
HK1069785A1 (en) Superoxide dismutase mimics for the treatment of ocular disorders and diseases
MXPA04000124A (es) Composicion farmaceutica para la terapia de cistitis intersticial.
DE60140318D1 (de) Konfiguration implantierter vorrichtungen
WO2002079235A3 (en) Compositions and methods for modulating guanylyl cyclase signaling receptor (gc-c) activity and for treating meniere's disease
GB0306977D0 (en) Device
ATE550039T1 (de) Mittel zur behandlung von glomerulären erkrankungen
WO2002069979A3 (en) Pharmaceutical formulation comprising r-salmeterol and fluticasone propionate
DE60138385D1 (de) Heilmittel zur behandlung von erkrankungen des sehnervs
DE60231785D1 (de) Gelierbare, biokompatible und implantierbare zusammensetzung
ATE487482T1 (de) Superoxid-dismutase-mimika zur behandlungvon augenstörungen und erkrankungen
RU2001112156A (ru) Активно действующее вещество для профилактики и лечения заболеваний желудочно-кишечного тракта
ATE386524T1 (de) Wässrige lösungen von moxaverin zur behandlung der erektilen dysfunktion

Legal Events

Date Code Title Description
8364 No opposition during term of opposition