DE60136926D1 - Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält - Google Patents
Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthältInfo
- Publication number
- DE60136926D1 DE60136926D1 DE60136926T DE60136926T DE60136926D1 DE 60136926 D1 DE60136926 D1 DE 60136926D1 DE 60136926 T DE60136926 T DE 60136926T DE 60136926 T DE60136926 T DE 60136926T DE 60136926 D1 DE60136926 D1 DE 60136926D1
- Authority
- DE
- Germany
- Prior art keywords
- cyclodextrin
- glycopeptide antibiotic
- composition containing
- disclosed
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nanotechnology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20117800P | 2000-05-02 | 2000-05-02 | |
US21314600P | 2000-06-22 | 2000-06-22 | |
US21341700P | 2000-06-22 | 2000-06-22 | |
US21342800P | 2000-06-22 | 2000-06-22 | |
US21341500P | 2000-06-22 | 2000-06-22 | |
US21341000P | 2000-06-22 | 2000-06-22 | |
US22672700P | 2000-08-18 | 2000-08-18 | |
PCT/US2001/014000 WO2001082971A2 (en) | 2000-05-02 | 2001-05-01 | Cyclodextrin containing glycopeptide antibiotic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60136926D1 true DE60136926D1 (de) | 2009-01-22 |
Family
ID=27569291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60136926T Expired - Lifetime DE60136926D1 (de) | 2000-05-02 | 2001-05-01 | Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält |
Country Status (12)
Country | Link |
---|---|
US (5) | US6858584B2 (de) |
EP (1) | EP1278549B1 (de) |
JP (2) | JP4870314B2 (de) |
CN (1) | CN1223378C (de) |
AT (1) | ATE416791T1 (de) |
AU (1) | AU2001259306A1 (de) |
BR (1) | BR0110530A (de) |
CA (2) | CA2408008C (de) |
DE (1) | DE60136926D1 (de) |
ES (1) | ES2316445T3 (de) |
SI (1) | SI1278549T1 (de) |
WO (1) | WO2001082971A2 (de) |
Families Citing this family (47)
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WO2001082971A2 (en) | 2000-05-02 | 2001-11-08 | Theravance, Inc. | Cyclodextrin containing glycopeptide antibiotic compositions |
UA75083C2 (uk) | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
TWI312785B (en) | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
TWI275594B (en) | 2001-08-24 | 2007-03-11 | Theravance Inc | Process for preparing vancomycin phosphonate derivatives |
US7499410B2 (en) * | 2001-12-26 | 2009-03-03 | Cisco Technology, Inc. | Fibre channel switch that enables end devices in different fabrics to communicate with one another while retaining their unique fibre channel domain—IDs |
US7599360B2 (en) * | 2001-12-26 | 2009-10-06 | Cisco Technology, Inc. | Methods and apparatus for encapsulating a frame for transmission in a storage area network |
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US7916628B2 (en) * | 2004-11-01 | 2011-03-29 | Cisco Technology, Inc. | Trunking for fabric ports in fibre channel switches and attached devices |
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US7649844B2 (en) * | 2004-12-29 | 2010-01-19 | Cisco Technology, Inc. | In-order fibre channel packet delivery |
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DK2337575T3 (en) | 2008-08-30 | 2016-05-23 | Medicines Co | A method of treatment with single doses of oritavancin |
JP2012525391A (ja) | 2009-04-28 | 2012-10-22 | ターガンタ セラピューティクス コーポレイション | オリタバンシンを用いた細菌感染の治療方法 |
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EP2496237A2 (de) * | 2009-11-06 | 2012-09-12 | Chelsea Therapeutics, Inc. | Enzymhemmende verbindungen |
US20110237609A1 (en) * | 2010-03-29 | 2011-09-29 | Chelsea Therapeutics, Inc. | Antifolate compositions |
WO2012078708A1 (en) | 2010-12-07 | 2012-06-14 | Chelsea Therapeutics, Inc. | Combination comprising methotrexate and an antifolate compound |
ES2949169T3 (es) | 2013-08-26 | 2023-09-26 | Melinta Therapeutics Inc | Procedimientos para tratar la bacteriemia y la osteomielitis utilizando oritavancina |
US9697843B2 (en) | 2014-04-30 | 2017-07-04 | Qualcomm Incorporated | High band excitation signal generation |
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WO2017179003A1 (en) | 2016-04-15 | 2017-10-19 | Lupin Limited | Topical compositions for ophthalmic and otic use |
CN107325159A (zh) * | 2016-04-29 | 2017-11-07 | 中国科学院上海药物研究所 | 一类万古霉素衍生物、其制备方法、药物组合物和用途 |
EA201892413A1 (ru) | 2016-05-09 | 2019-05-31 | Кселлия Фармасьютикалз Апс | Стабилизированные препараты гликопептидного антибиотика |
CN110198959B (zh) | 2017-01-03 | 2023-03-28 | 北卡罗米纳大学查佩尔希尔分校 | 释放一氧化氮的海藻酸盐作为可生物降解抗菌支架和相关方法 |
CA3055474A1 (en) | 2017-03-28 | 2018-10-04 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto |
CN111511350B (zh) | 2017-07-07 | 2023-10-13 | 埃皮辛特瑞柯斯公司 | 用于治疗剂的肠胃外施用的组合物 |
CN107987131B (zh) * | 2017-11-16 | 2021-03-09 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的化合物、其制备方法和应用 |
EP3762039A4 (de) | 2018-03-06 | 2021-12-22 | The University of North Carolina at Chapel Hill | Stickoxidfreisetzende cyclodextrin als biologisch abbaubare antibakterielle gerüste und zugehörige verfahren |
EA202092635A1 (ru) | 2018-06-13 | 2021-03-23 | Дибли Аг | Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet |
CN113383019B (zh) | 2018-12-28 | 2023-11-17 | 北卡罗来纳大学教堂山分校 | 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法 |
US20220133844A1 (en) | 2020-10-30 | 2022-05-05 | Somerset Therapeutics, Llc | Glycopeptide antibiotics liquid formulations and methods and uses thereof |
EP4014965A1 (de) | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Wässrige lösung |
EP4014969A1 (de) | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Wässrige lösung |
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-
2001
- 2001-05-01 WO PCT/US2001/014000 patent/WO2001082971A2/en active Application Filing
- 2001-05-01 DE DE60136926T patent/DE60136926D1/de not_active Expired - Lifetime
- 2001-05-01 CA CA2408008A patent/CA2408008C/en not_active Expired - Lifetime
- 2001-05-01 ES ES01932810T patent/ES2316445T3/es not_active Expired - Lifetime
- 2001-05-01 BR BR0110530-2A patent/BR0110530A/pt not_active Application Discontinuation
- 2001-05-01 AT AT01932810T patent/ATE416791T1/de not_active IP Right Cessation
- 2001-05-01 EP EP01932810A patent/EP1278549B1/de not_active Expired - Lifetime
- 2001-05-01 AU AU2001259306A patent/AU2001259306A1/en not_active Abandoned
- 2001-05-01 CA CA2726789A patent/CA2726789A1/en not_active Abandoned
- 2001-05-01 US US09/846,893 patent/US6858584B2/en not_active Expired - Lifetime
- 2001-05-01 SI SI200130903T patent/SI1278549T1/sl unknown
- 2001-05-01 JP JP2001579844A patent/JP4870314B2/ja not_active Expired - Lifetime
- 2001-05-01 CN CNB018104746A patent/CN1223378C/zh not_active Expired - Lifetime
-
2004
- 2004-08-31 US US10/931,122 patent/US7067483B2/en not_active Expired - Lifetime
- 2004-08-31 US US10/930,585 patent/US7026288B2/en not_active Expired - Lifetime
-
2006
- 2006-04-25 US US11/410,597 patent/US7544364B2/en not_active Expired - Lifetime
-
2008
- 2008-04-03 JP JP2008097622A patent/JP2008231109A/ja active Pending
-
2009
- 2009-04-29 US US12/431,940 patent/US8158580B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP4870314B2 (ja) | 2012-02-08 |
EP1278549A2 (de) | 2003-01-29 |
ES2316445T3 (es) | 2009-04-16 |
SI1278549T1 (sl) | 2009-04-30 |
US20060194717A1 (en) | 2006-08-31 |
US6858584B2 (en) | 2005-02-22 |
US20020077280A1 (en) | 2002-06-20 |
CN1223378C (zh) | 2005-10-19 |
US20050026820A1 (en) | 2005-02-03 |
US7067483B2 (en) | 2006-06-27 |
US7026288B2 (en) | 2006-04-11 |
CA2408008A1 (en) | 2001-11-08 |
CA2408008C (en) | 2011-01-18 |
WO2001082971A3 (en) | 2002-05-23 |
ATE416791T1 (de) | 2008-12-15 |
US8158580B2 (en) | 2012-04-17 |
EP1278549B1 (de) | 2008-12-10 |
US7544364B2 (en) | 2009-06-09 |
US20050032676A1 (en) | 2005-02-10 |
WO2001082971A2 (en) | 2001-11-08 |
AU2001259306A1 (en) | 2001-11-12 |
CA2726789A1 (en) | 2001-11-08 |
JP2008231109A (ja) | 2008-10-02 |
US20100081609A1 (en) | 2010-04-01 |
CN1441680A (zh) | 2003-09-10 |
JP2003531869A (ja) | 2003-10-28 |
BR0110530A (pt) | 2003-04-08 |
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