DE60137203D1 - Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung - Google Patents

Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung

Info

Publication number
DE60137203D1
DE60137203D1 DE60137203T DE60137203T DE60137203D1 DE 60137203 D1 DE60137203 D1 DE 60137203D1 DE 60137203 T DE60137203 T DE 60137203T DE 60137203 T DE60137203 T DE 60137203T DE 60137203 D1 DE60137203 D1 DE 60137203D1
Authority
DE
Germany
Prior art keywords
glass particles
ferrimagnetic
porous
ferro
porous ferric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60137203T
Other languages
English (en)
Inventor
Philippe Sauer
Bernd Springer
Thomas Manz
Christoph Ritt
Roland Fabis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen GmbH
Original Assignee
Qiagen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22708215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60137203(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Qiagen GmbH filed Critical Qiagen GmbH
Application granted granted Critical
Publication of DE60137203D1 publication Critical patent/DE60137203D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2993Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2993Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996Glass particles or spheres
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2998Coated including synthetic resin or polymer
DE60137203T 2000-03-24 2001-03-22 Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung Expired - Lifetime DE60137203D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19209300P 2000-03-24 2000-03-24
PCT/EP2001/003294 WO2001071732A2 (de) 2000-03-24 2001-03-22 Porous ferro- or ferrimagnetic glass particles for isolating molecules

Publications (1)

Publication Number Publication Date
DE60137203D1 true DE60137203D1 (de) 2009-02-12

Family

ID=22708215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60137203T Expired - Lifetime DE60137203D1 (de) 2000-03-24 2001-03-22 Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung

Country Status (8)

Country Link
US (3) US7183002B2 (de)
EP (1) EP1266385B1 (de)
JP (2) JP4907030B2 (de)
AT (1) ATE419629T1 (de)
AU (2) AU2001263800B2 (de)
CA (1) CA2400724C (de)
DE (1) DE60137203D1 (de)
WO (1) WO2001071732A2 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001263800B2 (en) * 2000-03-24 2006-03-09 Qiagen Gmbh Porous ferro- or ferrimagnetic glass particles for isolating molecules
GB0116359D0 (en) * 2001-07-04 2001-08-29 Genovision As Preparation of polymer particles
US7192560B2 (en) 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US7347976B2 (en) 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
DE10201084A1 (de) * 2002-01-14 2003-07-24 Bayer Ag Siliziumhaltige Magnetpartikel, Verfahren zu deren Herstellung und Verwendung der Partikel
GB0215185D0 (en) 2002-07-01 2002-08-07 Genovision As Binding a target substance
JP5129926B2 (ja) * 2002-12-12 2013-01-30 インテグリス・インコーポレーテッド 多孔質焼結コンポジット材料
US7981600B2 (en) 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
US20050059054A1 (en) 2003-07-25 2005-03-17 Richard Conrad Methods and compositions for preparing RNA from a fixed sample
WO2005026129A1 (en) 2003-09-15 2005-03-24 Gpc Biotech Ag Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
DE10355409A1 (de) * 2003-11-25 2005-06-30 Magnamedics Gmbh Sphärische, magnetische Silicagel-Träger mit vergrößerter Oberfläche für die Aufreinigung von Nukleinsäuren
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7727710B2 (en) 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
EP1715953A1 (de) * 2004-02-18 2006-11-02 Applera Corporation Polyelektrolytbeschichtete grössenausschlussionenaustauscherteilchen
AU2005200670B2 (en) * 2004-02-20 2007-05-03 F. Hoffmann-La Roche Ag Adsorption of nucleic acids to a solid phase
EP1690938A1 (de) * 2005-02-11 2006-08-16 Qiagen GmbH Verfahren zur Isolierung von Nukleinsäuren, wobei die Nukleinsäuren bei erhöhter Temperatur an einer Matrix immobilisiert werden
JP5007920B2 (ja) * 2005-08-31 2012-08-22 日立金属株式会社 核酸抽出方法、がん細胞検出方法および磁気ビーズ
JP4297148B2 (ja) 2006-09-22 2009-07-15 ソニー株式会社 核酸回収装置及び核酸回収方法
DE102006054173A1 (de) * 2006-11-16 2008-05-21 Qiagen Gmbh Verfahren zur Herstellung von magnetischen Kieselsäurepartikeln
EP1995316A1 (de) 2007-05-25 2008-11-26 Qiagen GmbH Verfahren zur schonenden Zellaufreinigung, Zellgewinnung und Transfektion von Zellen
CN101279246B (zh) * 2007-12-28 2011-07-27 华侨大学 一种嗜硫性磁性复合微球的制备方法和用此复合微球分离免疫球蛋白g的方法
KR101053023B1 (ko) * 2008-02-14 2011-08-01 (주)바이오니아 구형 실리카 자성입자 및 이의 제조방법
US20090218711A1 (en) * 2008-02-28 2009-09-03 David Dasher Method of increasing ceramic paste stiffening/gelation temperature by using a salt and precursor batch
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
DE102008026058A1 (de) 2008-05-30 2009-12-03 Qiagen Gmbh Lyse, Binde- und/oder Waschreagenz verwendbar zur Isolierung und/oder Reinigung von Nukleinsäuren
EP2264168B1 (de) 2009-06-18 2014-12-17 Qiagen GmbH Verfahren zur Isolierung von Nukleinsäuren
TWI407994B (zh) 2009-10-22 2013-09-11 Ind Tech Res Inst 分離核酸的方法、試劑及套組
EP2345719A1 (de) 2010-01-18 2011-07-20 Qiagen GmbH Verfahren zur Isolierung kleiner RNA
RU2444011C1 (ru) * 2010-07-06 2012-02-27 Учреждение Российской академии медицинских наук научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН (НИИВС им. И.И. Мечникова РАМН) Способ выявления кишечных вирусов в воде
EP2407540A1 (de) 2010-07-15 2012-01-18 Qiagen GmbH Verfahren zur Reinigung von Nukleinsäure
DE102010039232B4 (de) 2010-08-12 2013-02-21 Dennert Poraver Gmbh Verfahren zur Herstellung von magnetischem Blähglasgranulat
DE102010034083A1 (de) 2010-08-12 2012-02-16 Süd-Chemie AG Magnetische Glaspartikel zum Einsatz in Biogasanlagen, Fermentations- und Separationsprozessen
CN102179230B (zh) * 2011-04-01 2012-09-19 中国科学院生态环境研究中心 一种赋磁二氧化硅气凝胶的制备方法
WO2013004710A2 (en) 2011-07-04 2013-01-10 Qiagen Gmbh Reagent usable for the isolation and/or purification of nucleic acids
EP2742152B1 (de) 2011-08-12 2017-04-12 Qiagen GmbH Verfahren zur isolierung von nukleinsäuren
DE102012201774A1 (de) 2012-02-07 2013-08-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Magnetisch abtrennbare Mikropartikel mit einer silikatischen Hülle, Verfahren zu ihrer Herstellung sowie ihre Verwendung
EP2634254A1 (de) 2012-02-29 2013-09-04 QIAGEN GmbH Verfahren zur Isolierung von Nukleinsäuren aus Nahrungsmittelproben
CN104350152B (zh) * 2012-06-01 2017-08-11 欧米伽生物技术公司 选择性核酸片段回收
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
EP2888354B1 (de) 2012-08-21 2020-04-01 Qiagen GmbH Stabilisierung von viruspartikeln und viralen nukleinsäuren in einer biologischen probe
WO2014029791A1 (en) 2012-08-21 2014-02-27 Qiagen Gmbh Method for isolating nucleic acids from a formaldehyde releaser stabilized sample
AU2013310861B2 (en) 2012-09-03 2019-02-14 Qiagen Gmbh Method for isolating RNA including small RNA with high yield
EP2931661B1 (de) * 2012-12-11 2017-11-08 Qiagen GmbH Herstellung von kieselerdepartikeln
US10745686B2 (en) 2013-02-08 2020-08-18 Qiagen Gmbh Method for separating DNA by size
US9803230B2 (en) 2013-03-15 2017-10-31 Abbott Molecular Inc. One-step procedure for the purification of nucleic acids
JP6469108B2 (ja) 2013-11-19 2019-02-13 三星電子株式会社Samsung Electronics Co.,Ltd. ルミネッセンス粒子、これを含む材料および製品、ならびに方法
CN103903827B (zh) * 2014-03-20 2018-01-23 哈尔滨益材新材料有限公司 一种磁性二氧化硅复合微球的制备方法及其应用
CN103908945B (zh) * 2014-03-31 2015-09-16 洛阳惠尔纳米科技有限公司 一种核酸提取磁珠的制备方法及应用
CN104465008A (zh) * 2014-11-18 2015-03-25 成都理想财富投资咨询有限公司 一种用于dna纯化的磁流体的制备方法
FR3031063B1 (fr) 2014-12-30 2017-02-10 Biomerieux Sa Complexe multicouches, procede de fabrication et utilisation du complexe
EP3059312A1 (de) 2015-02-20 2016-08-24 QIAGEN GmbH Nukleinsäureextraktionsverfahren
KR101646610B1 (ko) 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
EP3303582A1 (de) 2015-06-01 2018-04-11 Qiagen GmbH Elektrophoreseunterstütztes verfahren und vorrichtung zur reinigung eines geladenen zielmoleküls aus einer probe
US10711265B2 (en) 2015-06-01 2020-07-14 Qiagen Gmbh Electrophoresis assisted method for purifying a target nucleic acid using a delayed elution approach
EP3303630B1 (de) 2015-06-05 2022-01-05 Qiagen GmbH Verfahren zum trennen von dns anhand der grösse
CA2982706A1 (en) 2015-06-09 2016-12-15 Biocartis N.V. Automatable method for nucleic acid isolation
CN108138366A (zh) 2015-07-23 2018-06-08 比奥卡尔齐斯股份有限公司 优化的临床样品测序
US20180135040A1 (en) 2016-02-16 2018-05-17 Life Magnetics, Inc. Methods for separating nucleic acids with graphene coated magnetic beads
CN110312808A (zh) 2016-06-30 2019-10-08 拜欧亿思有限公司 双链核酸信号探针以及利用上述双链核酸信号探针的靶分子检测方法
DE102016121483B4 (de) 2016-11-09 2020-06-18 Axagarius Gmbh & Co. Kg Partikelförmiges Feststoff-Kompositmaterial zur Nukleinsäureaufreinigung, enthaltend magnetische Nanopartikel , Verfahren zu dessen Herstellung und dessen Verwendung
ES2904624T3 (es) 2016-12-15 2022-04-05 Qiagen Gmbh Método para aislar ácido nucleico altamente puro con partículas magnéticas
CN111148834A (zh) 2017-09-27 2020-05-12 凯杰有限公司 以高收率分离rna的方法
TR201903564A2 (tr) 2019-03-08 2019-03-21 Safas Saf Plastik Sanayi Ve Ticaret Anonim Sirketi Stres ve ağri azaltici bi̇r malzeme olarak magneti̇t parti̇külleri̇ i̇çeren sürekli̇ blok esnek poli̇üretan köpük üretmek i̇çi̇n yöntem
US11104961B2 (en) 2020-01-13 2021-08-31 Fluent Biosciences Inc. Single cell sequencing
CA3175931A1 (en) 2020-03-16 2021-09-23 Fluent Biosciences Inc. Multi-omic analysis in monodisperse droplets
US20230223175A1 (en) * 2020-04-03 2023-07-13 Norwegian University Of Science And Technology Methods and products for isolating nucleic acids
CN112563016A (zh) * 2020-12-23 2021-03-26 四川迈克生物新材料技术有限公司 核酸提取用磁性微球的制备方法、所制备的产品及用途
CA3209578A1 (en) * 2021-01-25 2022-07-28 Fluent Biosciences Inc. Emulsification with magnetic hydrogels
CN112891986B (zh) * 2021-01-30 2022-05-03 哈尔滨工业大学 一种集成封闭式核酸自动提取装置
US20230139535A1 (en) * 2021-10-19 2023-05-04 Phenomenex, Inc. Systems and methods of simple and automatable protein digestion using magnetic beads

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549524A (en) * 1965-11-10 1970-12-22 Wolfgang Haller Material and method for performing steric separations
US3758284A (en) * 1970-12-17 1973-09-11 W Haller Porous material and method of making the same
US4169804A (en) 1976-08-19 1979-10-02 Minnesota Mining And Manufacturing Company Magnetically responsive composite microparticle
US4126437A (en) * 1976-12-02 1978-11-21 Xerox Corporation Magnetic glass carrier materials
US4335094A (en) 1979-01-26 1982-06-15 Mosbach Klaus H Magnetic polymer particles
JPS55147143A (en) * 1979-03-29 1980-11-15 Toyo Eng Corp Agitation method
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
US4395271A (en) 1979-04-13 1983-07-26 Corning Glass Works Method for making porous magnetic glass and crystal-containing structures
US4233169A (en) * 1979-04-13 1980-11-11 Corning Glass Works Porous magnetic glass structure
FR2461521A1 (fr) * 1979-07-20 1981-02-06 Anvar Fluides magnetiques, notamment ferrofluides, et procede pour leur obtention
EP0030086B2 (de) * 1979-11-13 1990-03-14 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Vereinigung von Reaktionsbehältern, Teile für ihre Herstellung und manuelles Immunoassayverfahren
JPS5676510A (en) * 1979-11-28 1981-06-24 Tdk Corp Manufacture of magnetic recording material
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
GB8317228D0 (en) * 1983-06-24 1983-07-27 Exxon Research Engineering Co Magnetizable adsorbents
US4523996A (en) * 1984-02-22 1985-06-18 Westinghouse Electric Corp. Method of separating cationic from anionic beads in mixed resin beds
JPS6139509A (ja) * 1984-07-31 1986-02-25 Japan Synthetic Rubber Co Ltd 超微粒酸化鉄含有物およびその製造方法
DE3582649D1 (de) * 1984-11-01 1991-05-29 Technicon Instr Magnetisch empfindlicher reagenstraeger und verfahren zur herstellung.
US5512332A (en) 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US4988618A (en) * 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
US4895650A (en) * 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
ATE117829T1 (de) * 1988-05-24 1995-02-15 Anagen Uk Ltd Magnetisch anziehbare teilchen und herstellungsverfahren.
NL8900725A (nl) 1989-03-23 1990-10-16 Az Univ Amsterdam Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur.
US5523231A (en) 1990-02-13 1996-06-04 Amersham International Plc Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules
GB9003253D0 (en) 1990-02-13 1990-04-11 Amersham Int Plc Precipitating polymers
US5610274A (en) * 1991-11-20 1997-03-11 Cpg, Inc. Production and use of magnetic porous inorganic materials
US5734020A (en) * 1991-11-20 1998-03-31 Cpg, Inc. Production and use of magnetic porous inorganic materials
GB9223334D0 (en) 1992-11-06 1992-12-23 Hybaid Ltd Magnetic solid phase supports
DE4307262A1 (de) 1993-03-02 1994-09-08 Christian Bergemann Magnetisches polymeres Siliciumdioxid
DE4321904B4 (de) 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
JPH07235407A (ja) * 1994-02-22 1995-09-05 Hitachi Ltd 磁気粒子
GB9411572D0 (en) 1994-06-09 1994-08-03 Amersham Int Plc Magnetic bead precipitation method
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
JP2965131B2 (ja) * 1995-07-07 1999-10-18 東洋紡績株式会社 核酸結合用磁性担体およびそれを用いる核酸単離方法
US5904848A (en) * 1996-02-21 1999-05-18 Cpg, Inc. Controlled pore glass-synthetic resin membrane
JPH1081507A (ja) * 1996-09-05 1998-03-31 Mizusawa Ind Chem Ltd 磁性体非晶質シリカ複合粒子及びその製造方法
DE19638591A1 (de) 1996-09-20 1998-04-02 Merck Patent Gmbh Kugelförmige magnetische Partikel
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
HU225261B1 (en) * 1997-01-21 2006-08-28 Grace W R & Co Silica adsorbent on magnetic substrate
JP3735990B2 (ja) * 1997-01-28 2006-01-18 東ソー株式会社 磁性シリカゲルの製造方法
WO1998051435A1 (en) 1997-05-14 1998-11-19 Weixin Tang Fully-coated, uniform-sized metallic particles
JPH11262387A (ja) * 1998-03-16 1999-09-28 Toyobo Co Ltd 核酸結合性磁性担体およびそれを用いた核酸単離方法
US20020104801A1 (en) * 1998-04-06 2002-08-08 Nicolas Voute Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles
GB9812800D0 (en) * 1998-06-12 1998-08-12 Rolic Ag Optically active compounds
JP2000256388A (ja) * 1999-03-10 2000-09-19 Jsr Corp 核酸結合用磁性シリカ粒子および核酸単離方法
US6296934B1 (en) * 1999-03-12 2001-10-02 E.I. Du Pont De Nemours And Company Glitter containing filaments for use in brushes
AU2001263800B2 (en) * 2000-03-24 2006-03-09 Qiagen Gmbh Porous ferro- or ferrimagnetic glass particles for isolating molecules
US6607667B2 (en) * 2000-11-28 2003-08-19 W. R. Grace & Co.-Conn. Method for adsorbing substances using silica adsorbent on magnetic substrate

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US7922917B2 (en) 2011-04-12
US20070080316A1 (en) 2007-04-12
JP2012106241A (ja) 2012-06-07
US7183002B2 (en) 2007-02-27
US20110186524A1 (en) 2011-08-04
AU6380001A (en) 2001-10-03
WO2001071732A2 (de) 2001-09-27
CA2400724A1 (en) 2001-09-27
WO2001071732A3 (de) 2002-01-03
AU2001263800B2 (en) 2006-03-09
US8202427B2 (en) 2012-06-19
EP1266385B1 (de) 2008-12-31
CA2400724C (en) 2009-11-24
EP1266385A2 (de) 2002-12-18
JP2003528455A (ja) 2003-09-24
JP4907030B2 (ja) 2012-03-28
WO2001071732B1 (de) 2002-02-28
US20030148101A1 (en) 2003-08-07
ATE419629T1 (de) 2009-01-15

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