DE60143523D1 - Feldeffekt-transistorbauelement für die ultraschnelle nukleinsäurensequenzierung - Google Patents

Feldeffekt-transistorbauelement für die ultraschnelle nukleinsäurensequenzierung

Info

Publication number
DE60143523D1
DE60143523D1 DE60143523T DE60143523T DE60143523D1 DE 60143523 D1 DE60143523 D1 DE 60143523D1 DE 60143523 T DE60143523 T DE 60143523T DE 60143523 T DE60143523 T DE 60143523T DE 60143523 D1 DE60143523 D1 DE 60143523D1
Authority
DE
Germany
Prior art keywords
nucleic acid
field effect
effect transistor
acid sequencing
transistor component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60143523T
Other languages
English (en)
Inventor
Jon Sauer
Zeghbroeck Bart Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eagle Research and Development LLC
Original Assignee
Eagle Research and Development LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eagle Research and Development LLC filed Critical Eagle Research and Development LLC
Application granted granted Critical
Publication of DE60143523D1 publication Critical patent/DE60143523D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/0001—Technical content checked by a classifier
    • H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Junction Field-Effect Transistors (AREA)
DE60143523T 2000-04-24 2001-04-24 Feldeffekt-transistorbauelement für die ultraschnelle nukleinsäurensequenzierung Expired - Lifetime DE60143523D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19913000P 2000-04-24 2000-04-24
US21768100P 2000-07-12 2000-07-12
US09/653,543 US6413792B1 (en) 2000-04-24 2000-08-31 Ultra-fast nucleic acid sequencing device and a method for making and using the same
PCT/US2001/013104 WO2001081908A1 (en) 2000-04-24 2001-04-24 Field effect transistor device for ultra-fast nucleic acid sequencing

Publications (1)

Publication Number Publication Date
DE60143523D1 true DE60143523D1 (de) 2011-01-05

Family

ID=27393987

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60143523T Expired - Lifetime DE60143523D1 (de) 2000-04-24 2001-04-24 Feldeffekt-transistorbauelement für die ultraschnelle nukleinsäurensequenzierung

Country Status (7)

Country Link
US (2) US6413792B1 (de)
EP (2) EP2278317B1 (de)
JP (5) JP4758047B2 (de)
AT (1) ATE489621T1 (de)
AU (1) AU2001255604A1 (de)
DE (1) DE60143523D1 (de)
WO (1) WO2001081908A1 (de)

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206568B2 (en) * 1999-06-22 2012-06-26 President And Fellows Of Harvard College Material deposition techniques for control of solid state aperture surface properties
US20060292041A1 (en) * 2000-03-23 2006-12-28 Dugas Matthew P Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples
US6616895B2 (en) * 2000-03-23 2003-09-09 Advanced Research Corporation Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples
US8232582B2 (en) * 2000-04-24 2012-07-31 Life Technologies Corporation Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en) * 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US7001792B2 (en) * 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6482639B2 (en) * 2000-06-23 2002-11-19 The United States Of America As Represented By The Secretary Of The Navy Microelectronic device and method for label-free detection and quantification of biological and chemical molecules
GB0105831D0 (en) 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
US8114591B2 (en) 2001-03-09 2012-02-14 Dna Electronics Ltd. Sensing apparatus and method
AU2002307371B2 (en) 2001-04-20 2008-04-03 Pennsylvania State University Methods for nucleic acid manipulation
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8017150B2 (en) * 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20050019784A1 (en) * 2002-05-20 2005-01-27 Xing Su Method and apparatus for nucleic acid sequencing and identification
GB0211564D0 (en) * 2002-05-21 2002-06-26 Tournaz Technology Ltd Reference circuit
WO2004079354A1 (ja) * 2003-03-07 2004-09-16 Matsushita Electric Industrial Co., Ltd. 細胞外電位測定デバイスおよびその製造方法
EP2365325A1 (de) * 2002-06-05 2011-09-14 Panasonic Corporation Vorrichtung zur Messung des extrazellulären Potentials und Verfahren zu Herstellung der Vorrichtung
JP4449519B2 (ja) * 2004-03-22 2010-04-14 パナソニック株式会社 細胞外電位測定デバイスおよびその製造方法
US8202439B2 (en) * 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
WO2004035211A1 (en) * 2002-10-15 2004-04-29 Advanced Research Corporation Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples
US20070042366A1 (en) * 2003-02-28 2007-02-22 Brown University Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same
NL1022855C2 (nl) * 2003-03-05 2004-09-07 Univ Delft Tech Werkwijze en inrichting voor het gecontroleerd vervaardigen van openingen op nanometerschaal.
US7250115B2 (en) 2003-06-12 2007-07-31 Agilent Technologies, Inc Nanopore with resonant tunneling electrodes
DE10329820B3 (de) * 2003-06-26 2005-01-13 Technische Universität Dresden Bio-Chip mit mehreren DNA-Zellen
US7347921B2 (en) 2003-07-17 2008-03-25 Agilent Technologies, Inc. Apparatus and method for threading a biopolymer through a nanopore
US7138672B2 (en) 2003-09-25 2006-11-21 Agilent Technologies, Inc. Apparatus and method for making a tensile diaphragm with an insert
US6846702B1 (en) 2003-10-24 2005-01-25 Agilent Technologies, Inc. Nanopore chip with N-type semiconductor
US7279337B2 (en) * 2004-03-10 2007-10-09 Agilent Technologies, Inc. Method and apparatus for sequencing polymers through tunneling conductance variation detection
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
JP3874772B2 (ja) * 2004-07-21 2007-01-31 株式会社日立製作所 生体関連物質測定装置及び測定方法
US7972858B2 (en) 2004-08-13 2011-07-05 President And Fellows Of Harvard College Ultra high-throughput opti-nanopore DNA readout platform
US20060086626A1 (en) * 2004-10-22 2006-04-27 Joyce Timothy H Nanostructure resonant tunneling with a gate voltage source
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
WO2007084163A2 (en) * 2005-04-06 2007-07-26 President And Fellows Of Harvard College Molecular characterization with carbon nanotube control
TW200741960A (en) * 2005-05-13 2007-11-01 Cambrios Technologies Corp Seed layers, cap layers, and thin films and methods of making thereof
US8677377B2 (en) 2005-09-08 2014-03-18 Apple Inc. Method and apparatus for building an intelligent automated assistant
WO2007041621A2 (en) * 2005-10-03 2007-04-12 Xingsheng Sean Ling Hybridization assisted nanopore sequencing
US7835870B2 (en) * 2005-11-01 2010-11-16 Georgia Institute Of Technology Methods and systems for evaluating the length of elongated elements
US8889348B2 (en) * 2006-06-07 2014-11-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by nanopore using modified nucleotides
RU2009102155A (ru) 2006-06-30 2010-08-10 Апплера Корпорейшн (Us) Способы анализирования связывающих взаимодействий
US9318108B2 (en) 2010-01-18 2016-04-19 Apple Inc. Intelligent automated assistant
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
JP5622392B2 (ja) 2006-12-14 2014-11-12 ライフ テクノロジーズ コーポレーション 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US9034637B2 (en) * 2007-04-25 2015-05-19 Nxp, B.V. Apparatus and method for molecule detection using nanopores
US9121843B2 (en) 2007-05-08 2015-09-01 Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
WO2008157640A2 (en) 2007-06-18 2008-12-24 Illumina, Inc. Microfabrication methods for the optimal patterning of substrates
US8698481B2 (en) 2007-09-12 2014-04-15 President And Fellows Of Harvard College High-resolution molecular sensor
WO2009046094A1 (en) 2007-10-01 2009-04-09 Nabsys, Inc. Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment
EP2205765B1 (de) * 2007-10-02 2012-09-12 President and Fellows of Harvard College Erfassung, neuerfassung und einfangen von molekülen mit einer nanopore
WO2009045473A2 (en) * 2007-10-02 2009-04-09 President And Fellows Of Harvard College Carbon nanotube synthesis for nanopore devices
US8996376B2 (en) 2008-04-05 2015-03-31 Apple Inc. Intelligent text-to-speech conversion
WO2010008480A2 (en) 2008-06-25 2010-01-21 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
WO2010044932A2 (en) * 2008-07-11 2010-04-22 Cornell University Nanofluidic channels with integrated charge sensors and methods based thereon
JP5717634B2 (ja) 2008-09-03 2015-05-13 ナブシス， インコーポレイテッド 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
KR101118461B1 (ko) * 2008-10-10 2012-03-06 나노칩스 (주) 초고속 고감도 dna 염기서열 분석 시스템
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
WO2010111605A2 (en) * 2009-03-27 2010-09-30 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US8455260B2 (en) * 2009-03-27 2013-06-04 Massachusetts Institute Of Technology Tagged-fragment map assembly
US8926904B2 (en) 2009-05-12 2015-01-06 Daniel Wai-Cheong So Method and apparatus for the analysis and identification of molecules
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US8246799B2 (en) * 2009-05-28 2012-08-21 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US10241644B2 (en) 2011-06-03 2019-03-26 Apple Inc. Actionable reminder entries
US10241752B2 (en) 2011-09-30 2019-03-26 Apple Inc. Interface for a virtual digital assistant
US8864969B2 (en) 2009-06-25 2014-10-21 The Board Of Trustees Of The Leland Stanford Junior University Electro-diffusion enhanced bio-molecule charge detection using electrostatic interaction
EP2483680A4 (de) 2009-09-30 2014-01-01 Quantapore Inc Ultraschnelle sequenzierung biologischer polymere mithilfe einer markierten nanopore
CN101694474B (zh) * 2009-10-22 2012-10-10 浙江大学 一种纳米孔电学传感器
CN102741430B (zh) 2009-12-01 2016-07-13 牛津楠路珀尔科技有限公司 生化分析仪器、用于进行生化分析的第一模块以及相关方法
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8682667B2 (en) 2010-02-25 2014-03-25 Apple Inc. User profiling for selecting user specific voice input processing information
WO2011108540A1 (ja) 2010-03-03 2011-09-09 国立大学法人大阪大学 ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置
US8039250B2 (en) * 2010-03-15 2011-10-18 International Business Machines Corporation Piezoelectric-based nanopore device for the active control of the motion of polymers through the same
US8603303B2 (en) * 2010-03-15 2013-12-10 International Business Machines Corporation Nanopore based device for cutting long DNA molecules into fragments
US9482615B2 (en) 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
CA2798635A1 (en) * 2010-05-06 2011-11-10 Ibis Biosciences, Inc. Integrated sample preparation systems and stabilized enzyme mixtures
US9670243B2 (en) 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US9164070B2 (en) 2010-06-30 2015-10-20 Life Technologies Corporation Column adc
US20120001646A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Methods and apparatus for testing isfet arrays
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
JP5876044B2 (ja) 2010-07-03 2016-03-02 ライフ テクノロジーズ コーポレーション 低濃度ドープドレインを有する化学的感応性センサ
JP5427722B2 (ja) * 2010-07-28 2014-02-26 株式会社日立ハイテクノロジーズ ナノポア式分析装置及び試料分析用チャンバ
JP5459554B2 (ja) * 2010-09-15 2014-04-02 株式会社リコー センサデバイス
EP2617061B1 (de) 2010-09-15 2021-06-30 Life Technologies Corporation Verfahren und vorrichtung zur analytmessung
CN105911126B (zh) 2010-09-24 2018-12-18 生命科技公司 匹配的晶体管对电路
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
WO2012042226A2 (en) 2010-10-01 2012-04-05 Oxford Nanopore Technologies Limited Biochemical analysis apparatus and rotary valve
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
WO2012067911A1 (en) 2010-11-16 2012-05-24 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
KR20120065792A (ko) * 2010-12-13 2012-06-21 삼성전자주식회사 나노 센서 및 그의 제조 방법
CN103370425B (zh) 2010-12-17 2019-03-19 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
CN107083421A (zh) 2010-12-17 2017-08-22 纽约哥伦比亚大学理事会 使用经修饰的核苷酸和纳米孔检测的dna边合成边测序
US9121059B2 (en) 2010-12-22 2015-09-01 Genia Technologies, Inc. Nanopore-based single molecule characterization
US9581563B2 (en) 2011-01-24 2017-02-28 Genia Technologies, Inc. System for communicating information from an array of sensors
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
US8852407B2 (en) 2011-01-28 2014-10-07 International Business Machines Corporation Electron beam sculpting of tunneling junction for nanopore DNA sequencing
US8986524B2 (en) 2011-01-28 2015-03-24 International Business Machines Corporation DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA
US20120193231A1 (en) 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
US9362568B2 (en) 2011-02-18 2016-06-07 The Board Of Trustees Of The Leland Stanford Junior University Battery with hybrid electrocatalysts
CN108051578B (zh) * 2011-04-04 2020-07-24 哈佛大学校长及研究员协会 通过局部电位测量进行的纳米孔感测
US9147505B2 (en) 2011-11-02 2015-09-29 Ut-Battelle, Llc Large area controlled assembly of transparent conductive networks
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
JP2013156167A (ja) * 2012-01-30 2013-08-15 Osaka Univ 物質の移動速度の制御方法および制御装置、並びに、これらの利用
EP3540077B1 (de) * 2012-02-16 2021-01-27 Genia Technologies, Inc. Verfahren zur erzeugung von doppelschichten zur verwendung mit nanoporensensoren
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
US10029915B2 (en) 2012-04-04 2018-07-24 International Business Machines Corporation Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores
EP2836604B1 (de) 2012-04-09 2021-09-15 The Trustees of Columbia University in the City of New York Verfahren zur herstellung von nanoporen und verwendungen davon
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
EP2839029B1 (de) 2012-04-19 2017-11-15 Life Technologies Corporation Verfahren zur durchführung von digitaler pcr
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9721563B2 (en) 2012-06-08 2017-08-01 Apple Inc. Name recognition system
JP2015525077A (ja) 2012-06-15 2015-09-03 ジェニア・テクノロジーズ・インコーポレイテッド チップの構成および高精度な核酸配列決定
WO2013191793A1 (en) 2012-06-20 2013-12-27 The Trustees Of Columbia University In The City Of New York Nucleic acid sequencing by nanopore detection of tag molecules
EP2887058B1 (de) 2012-08-17 2017-11-29 Quantum Biosystems Inc. Probenanalyseverfahren
KR20140028602A (ko) * 2012-08-29 2014-03-10 삼성전자주식회사 그래핀을 포함하는 나노 센서 및 이의 제조 방법
US9547647B2 (en) 2012-09-19 2017-01-17 Apple Inc. Voice-based media searching
US9718711B2 (en) 2012-10-01 2017-08-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatuses for filtering water fluid by screening ionic minerals
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
JP6282036B2 (ja) 2012-12-27 2018-02-21 クオンタムバイオシステムズ株式会社 物質の移動速度の制御方法および制御装置
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
WO2014113557A1 (en) 2013-01-18 2014-07-24 Nabsys, Inc. Enhanced probe binding
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US10066260B2 (en) 2013-03-14 2018-09-04 Life Technologies Corporation Matrix arrays and methods for making same
CN105051525B (zh) 2013-03-15 2019-07-26 生命科技公司 具有薄导电元件的化学设备
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
EP2971051A4 (de) 2013-03-15 2017-03-01 The Trustees of Columbia University in the City of New York Verfahren zur erkennung mehrerer vordefinierter verbindungen in einer probe
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
US9046511B2 (en) 2013-04-18 2015-06-02 International Business Machines Corporation Fabrication of tunneling junction for nanopore DNA sequencing
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
EP3004378B1 (de) 2013-05-24 2017-12-20 Illumina Cambridge Limited Pyrophosphorolytische sequenzierung mit nanoporen
CA2910019A1 (en) 2013-05-24 2014-11-27 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed fret detection
WO2014197334A2 (en) 2013-06-07 2014-12-11 Apple Inc. System and method for user-specified pronunciation of words for speech synthesis and recognition
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9188578B2 (en) 2013-06-19 2015-11-17 Globalfoundries Inc. Nanogap device with capped nanowire structures
US9182369B2 (en) 2013-06-19 2015-11-10 Globalfoundries Inc. Manufacturable sub-3 nanometer palladium gap devices for fixed electrode tunneling recognition
KR20160079780A (ko) 2013-09-18 2016-07-06 퀀텀 바이오시스템즈 가부시키가이샤 생체분자를 서열화하는 디바이스들, 시스템들 및 방법들
JP2015077652A (ja) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 ナノギャップ電極およびその製造方法
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
CN109797199A (zh) 2013-10-23 2019-05-24 吉尼亚科技公司 使用纳米孔的高速分子感测
US9322062B2 (en) 2013-10-23 2016-04-26 Genia Technologies, Inc. Process for biosensor well formation
JP6153856B2 (ja) * 2013-12-05 2017-06-28 株式会社日立ハイテクノロジーズ 生体分子特性解析チップ及びその製造方法
CA2943952A1 (en) 2014-03-24 2015-10-01 The Trustees Of Columbia University In The City Of New York Chemical methods for producing tagged nucleotides
US9970914B1 (en) * 2014-04-04 2018-05-15 The United States Of America As Represented By The Administrator Of National Aeronautics And Space Administration Gas sensors with contact pads
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
US9338493B2 (en) 2014-06-30 2016-05-10 Apple Inc. Intelligent automated assistant for TV user interactions
US9668121B2 (en) 2014-09-30 2017-05-30 Apple Inc. Social reminders
EP3204519B1 (de) 2014-10-10 2020-04-29 Quantapore Inc. Analyse nanoporenbasierter polymere mit gegenseitig löschenden fluoreszenzmarkern
CA2964790C (en) 2014-10-24 2023-02-21 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
EP3234575B1 (de) 2014-12-18 2023-01-25 Life Technologies Corporation Vorrichtung zur messung von analyten unter verwendung von grossflächigen fet-arrays
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
KR102593647B1 (ko) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 트랜스미터 구성을 갖춘 높은 데이터율 집적 회로
US10567477B2 (en) 2015-03-08 2020-02-18 Apple Inc. Virtual assistant continuity
CN112892628B (zh) 2015-04-03 2023-08-15 雅培制药有限公司 用于样品分析的装置和方法
CN107690582B (zh) 2015-04-03 2023-10-20 雅培制药有限公司 用于样品分析的装置和方法
US9578173B2 (en) * 2015-06-05 2017-02-21 Apple Inc. Virtual assistant aided communication with 3rd party service in a communication session
WO2017004463A1 (en) 2015-07-01 2017-01-05 Abbott Laboratories Devices and methods for sample analysis
US10671428B2 (en) 2015-09-08 2020-06-02 Apple Inc. Distributed personal assistant
US11010550B2 (en) 2015-09-29 2021-05-18 Apple Inc. Unified language modeling framework for word prediction, auto-completion and auto-correction
US10366158B2 (en) 2015-09-29 2019-07-30 Apple Inc. Efficient word encoding for recurrent neural network language models
US10691473B2 (en) 2015-11-06 2020-06-23 Apple Inc. Intelligent automated assistant in a messaging environment
US10049668B2 (en) 2015-12-02 2018-08-14 Apple Inc. Applying neural network language models to weighted finite state transducers for automatic speech recognition
US10223066B2 (en) 2015-12-23 2019-03-05 Apple Inc. Proactive assistance based on dialog communication between devices
US10446143B2 (en) 2016-03-14 2019-10-15 Apple Inc. Identification of voice inputs providing credentials
BR112018072539A2 (pt) 2016-05-05 2019-03-26 Aquestive Therapeutics, Inc. composições de epinefrina de administração aumentada
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US9934775B2 (en) 2016-05-26 2018-04-03 Apple Inc. Unit-selection text-to-speech synthesis based on predicted concatenation parameters
US9972304B2 (en) 2016-06-03 2018-05-15 Apple Inc. Privacy preserving distributed evaluation framework for embedded personalized systems
US10249300B2 (en) 2016-06-06 2019-04-02 Apple Inc. Intelligent list reading
US10049663B2 (en) 2016-06-08 2018-08-14 Apple, Inc. Intelligent automated assistant for media exploration
DK179309B1 (en) 2016-06-09 2018-04-23 Apple Inc Intelligent automated assistant in a home environment
US10192552B2 (en) 2016-06-10 2019-01-29 Apple Inc. Digital assistant providing whispered speech
US10490187B2 (en) 2016-06-10 2019-11-26 Apple Inc. Digital assistant providing automated status report
US10586535B2 (en) 2016-06-10 2020-03-10 Apple Inc. Intelligent digital assistant in a multi-tasking environment
US10067938B2 (en) 2016-06-10 2018-09-04 Apple Inc. Multilingual word prediction
US10509862B2 (en) 2016-06-10 2019-12-17 Apple Inc. Dynamic phrase expansion of language input
DK179343B1 (en) 2016-06-11 2018-05-14 Apple Inc Intelligent task discovery
DK201670540A1 (en) 2016-06-11 2018-01-08 Apple Inc Application integration with a digital assistant
DK179049B1 (en) 2016-06-11 2017-09-18 Apple Inc Data driven natural language event detection and classification
DK179415B1 (en) 2016-06-11 2018-06-14 Apple Inc Intelligent device arbitration and control
US11124827B2 (en) 2016-06-23 2021-09-21 Roche Sequencing Solutions, Inc. Period-to-period analysis of AC signals from nanopore sequencing
EP3482196B1 (de) 2016-07-05 2022-02-23 Quantapore, Inc. Optisch basierte nanoporensequenzierung
US9768104B1 (en) 2016-08-19 2017-09-19 International Business Machines Corporation Method and structure to fabricate a nanoporous membrane
US10043516B2 (en) 2016-09-23 2018-08-07 Apple Inc. Intelligent automated assistant
KR102446129B1 (ko) * 2016-10-03 2022-09-22 젠비다 테크놀로지 컴퍼니 리미티드 분자의 식별 및 분석을 위한 장치 및 방법.
JP2020502478A (ja) 2016-10-05 2020-01-23 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 試料分析のためのデバイスおよび方法
US10593346B2 (en) 2016-12-22 2020-03-17 Apple Inc. Rank-reduced token representation for automatic speech recognition
US10724065B2 (en) * 2017-02-21 2020-07-28 Qualcomm Incorporated Noise improvement in DNA sequencing circuit by FinFET-like nanopore formation
DK201770439A1 (en) 2017-05-11 2018-12-13 Apple Inc. Offline personal assistant
DK179496B1 (en) 2017-05-12 2019-01-15 Apple Inc. USER-SPECIFIC Acoustic Models
DK179745B1 (en) 2017-05-12 2019-05-01 Apple Inc. SYNCHRONIZATION AND TASK DELEGATION OF A DIGITAL ASSISTANT
DK201770431A1 (en) 2017-05-15 2018-12-20 Apple Inc. Optimizing dialogue policy decisions for digital assistants using implicit feedback
DK201770432A1 (en) 2017-05-15 2018-12-21 Apple Inc. Hierarchical belief states for digital assistants
DK179549B1 (en) 2017-05-16 2019-02-12 Apple Inc. FAR-FIELD EXTENSION FOR DIGITAL ASSISTANT SERVICES
EP3732484B1 (de) 2017-12-28 2023-06-07 F. Hoffmann-La Roche AG Messung und entfernung von rauschen in stochastischen signalen von einem durch ein wechselsignal angetriebenen nanoporen-dna-sequenziersystem
WO2019160925A1 (en) * 2018-02-16 2019-08-22 Illumina, Inc. Device for sequencing
IL299272A (en) 2020-07-02 2023-02-01 Illumina Inc Devices with field effect transistors
CN113333042B (zh) * 2021-06-21 2022-04-22 太原理工大学 一种用于核酸检测的微流控芯片及其制作方法
EP4160199A1 (de) * 2021-10-04 2023-04-05 Depixus Vorrichtung zur biomolekülanalyse mit einer vertiefung und einem darunter befindlichen hohlraum

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US476797A (en) 1892-06-14 hunter
NL294124A (de) 1962-06-18
US4238757A (en) * 1976-03-19 1980-12-09 General Electric Company Field effect transistor for detection of biological reactions
US4180771A (en) 1977-12-02 1979-12-25 Airco, Inc. Chemical-sensitive field-effect transistor
US4209349A (en) 1978-11-03 1980-06-24 International Business Machines Corporation Method for forming a narrow dimensioned mask opening on a silicon body utilizing reactive ion etching
US4256514A (en) 1978-11-03 1981-03-17 International Business Machines Corporation Method for forming a narrow dimensioned region on a body
US4870004A (en) 1984-06-08 1989-09-26 Autoseq, Inc. Apparatus and method of analyzing nucleic acid molecules
US4656732A (en) 1984-09-26 1987-04-14 Texas Instruments Incorporated Integrated circuit fabrication process
US4660063A (en) * 1985-03-18 1987-04-21 General Electric Company Immersion type ISFET
US4609932A (en) * 1985-03-18 1986-09-02 General Electric Company Nonplanar ion-sensitive field-effect transistor devices
US4597002A (en) * 1985-03-18 1986-06-24 General Electric Company Flow through ISFET and method of forming
DE3513168A1 (de) * 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
GB8522785D0 (en) * 1985-09-14 1985-10-16 Emi Plc Thorn Chemical-sensitive semiconductor device
US5110760A (en) 1990-09-28 1992-05-05 The United States Of America As Represented By The Secretary Of The Navy Method of nanometer lithography
WO1993008464A1 (en) 1991-10-21 1993-04-29 Holm Kennedy James W Method and device for biochemical sensing
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5429734A (en) * 1993-10-12 1995-07-04 Massachusetts Institute Of Technology Monolithic capillary electrophoretic device
DK0725682T3 (da) 1993-10-28 2002-07-15 Houston Advanced Res Ct Mikrofremstillet, porøst gennemløbsapparat til diskret påvisning af bindingsreaktioner
US5871918A (en) 1996-06-20 1999-02-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
FR2722294B1 (fr) 1994-07-07 1996-10-04 Lyon Ecole Centrale Procede d'analyse qualitative et/ou quantitative de substances biologiques presentes dans un milieu liquide conducteur et capteurs biochimiques d'affinite utilises pour la mise en oeuvre de ce procede
US6045995A (en) 1994-08-24 2000-04-04 Isis Pharmaceuticals, Inc. Capillary electrophoretic detection of nucleic acids
US5556790A (en) 1994-12-05 1996-09-17 Pettit; John W. Method for Automated DNA sequencing
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
JPH08278281A (ja) * 1995-04-07 1996-10-22 Hitachi Ltd 電界効果型化学物質検出装置およびそれを用いたｄｎａ配列決定装置
EP0830595A1 (de) * 1995-06-08 1998-03-25 Visible Genetics Inc. Elektroforetischer mikrochip zur bewegung und trennung von nukleinsäuren und von anderen geladenen molekülen
JPH0936385A (ja) 1995-07-25 1997-02-07 Nissan Motor Co Ltd 半導体装置の製造方法
US5654238A (en) 1995-08-03 1997-08-05 International Business Machines Corporation Method for etching vertical contact holes without substrate damage caused by directional etching
EP0792513A1 (de) 1995-09-14 1997-09-03 Advanced Micro Devices, Inc. Damaszenes verfahren für verminderte merkmalgrösse
US5641634A (en) 1995-11-30 1997-06-24 Mandecki; Wlodek Electronically-indexed solid-phase assay for biomolecules
US5736332A (en) 1995-11-30 1998-04-07 Mandecki; Wlodek Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders
AU719454B2 (en) * 1995-12-01 2000-05-11 Innogenetics N.V. Impedimetric detection system and method of production thereof
US5847460A (en) 1995-12-19 1998-12-08 Stmicroelectronics, Inc. Submicron contacts and vias in an integrated circuit
US6054277A (en) 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
US6057167A (en) 1996-05-31 2000-05-02 Motorola, Inc. Magnetoresistance-based method and apparatus for molecular detection
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5827482A (en) 1996-08-20 1998-10-27 Motorola Corporation Transistor-based apparatus and method for molecular detection and field enhancement
US5789316A (en) 1997-03-10 1998-08-04 Vanguard International Semiconductor Corporation Self-aligned method for forming a narrow via
JPH10270657A (ja) * 1997-03-24 1998-10-09 Mitsubishi Electric Corp 半導体記憶装置及びその製造方法
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
US5945286A (en) 1997-10-23 1999-08-31 Motorola, Inc. Electrochemical-based molecular detection apparatus and method
WO1999036573A1 (en) 1998-01-20 1999-07-22 Schichman Steven A Detection of genetic information
US6040214A (en) 1998-02-19 2000-03-21 International Business Machines Corporation Method for making field effect transistors having sub-lithographic gates with vertical side walls
JP3245124B2 (ja) * 1998-02-19 2002-01-07 インターナショナル・ビジネス・マシーンズ・コーポレーション 垂直ゲート側壁を有する電界効果トランジスタおよびその製造方法
JP3233207B2 (ja) * 1998-03-20 2001-11-26 日本電気株式会社 電界効果トランジスタの製造方法
US6002131A (en) 1998-03-25 1999-12-14 The Board Of Trustees Of The Leland Stanford Junior University Scanning probe potentiometer
US6060023A (en) 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus
JP2000124461A (ja) * 1998-10-20 2000-04-28 Matsushita Electric Ind Co Ltd 薄膜トランジスタおよびその製造方法
US6100014A (en) 1998-11-24 2000-08-08 United Microelectronics Corp. Method of forming an opening in a dielectric layer through a photoresist layer with silylated sidewall spacers
JP2000275680A (ja) * 1999-03-19 2000-10-06 Fujitsu Ltd 反射型液晶表示装置及びそれを用いた表示パネル
EP1192453B1 (de) * 1999-06-22 2012-02-15 President and Fellows of Harvard College Bestimmung von biopolymeren entsprechend der molekularen oder atomaren skala
US6413792B1 (en) * 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
EP1285252A1 (de) * 2000-04-24 2003-02-26 Eagle Research & Development, LLC Ultraschnelle nukleinsäuresequenzierungseinrichtung und verfahren zu ihrer herstellung und verwendung

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