DE602004005033D1 - Benzamidinhibitoren des p2x7-rezeptors - Google Patents
Benzamidinhibitoren des p2x7-rezeptorsInfo
- Publication number
- DE602004005033D1 DE602004005033D1 DE602004005033T DE602004005033T DE602004005033D1 DE 602004005033 D1 DE602004005033 D1 DE 602004005033D1 DE 602004005033 T DE602004005033 T DE 602004005033T DE 602004005033 T DE602004005033 T DE 602004005033T DE 602004005033 D1 DE602004005033 D1 DE 602004005033D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor
- benzamidinhibitors
- disorders
- copd
- reperfusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47000103P | 2003-05-12 | 2003-05-12 | |
| US470001P | 2003-05-12 | ||
| PCT/IB2004/001525 WO2004099146A1 (en) | 2003-05-12 | 2004-05-10 | Benzamide inhibitors of the p2x7 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004005033D1 true DE602004005033D1 (de) | 2007-04-12 |
| DE602004005033T2 DE602004005033T2 (de) | 2007-08-09 |
Family
ID=33435257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004005033T Active DE602004005033T2 (de) | 2003-05-12 | 2004-05-10 | Benzamidinhibitoren des p2x7-rezeptors |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7186742B2 (de) |
| EP (1) | EP1626962B1 (de) |
| JP (1) | JP4731468B2 (de) |
| AT (1) | ATE355273T1 (de) |
| BR (1) | BRPI0410349A (de) |
| CA (1) | CA2525437C (de) |
| DE (1) | DE602004005033T2 (de) |
| ES (2) | ES2281801T3 (de) |
| MX (1) | MXPA05012086A (de) |
| WO (1) | WO2004099146A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8557501A1 (es) * | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| EP1626962B1 (de) | 2003-05-12 | 2007-02-28 | Pfizer Products Inc. | Benzamidinhibitoren des p2x7-rezeptors |
| MXPA06014022A (es) * | 2004-06-29 | 2007-02-08 | Pfizer Prod Inc | Prcedimientos para preparar inhibidores de p2x7. |
| WO2006003517A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
| JP2008514691A (ja) * | 2004-09-29 | 2008-05-08 | ケマジス リミティド | 薬学的に純粋な非晶質塩酸ドネペジルを製造するための精製されたマレイン酸ドネペジルの使用 |
| EP1844003A4 (de) * | 2005-01-27 | 2010-09-22 | Astrazeneca Ab | Neue biaromatische verbindungen als inhibitoren des p2x7-rezeptors |
| JP2009514952A (ja) * | 2005-11-09 | 2009-04-09 | アボット・ラボラトリーズ | Ｐ２ｘ７受容体拮抗薬としての２−フェニル−２ｈ−ピラゾール誘導体およびそれの使用 |
| US8501933B2 (en) | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
| MX2009004900A (es) | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Arilamidas sustituidas por tiazol u oxazol. |
| WO2008112205A1 (en) * | 2007-03-09 | 2008-09-18 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| CA2680761A1 (en) * | 2007-03-22 | 2008-09-25 | Astrazeneca Ab | Quinoline derivatives for the treatment of inflammatory diseases |
| EA017250B1 (ru) | 2007-07-19 | 2012-11-30 | Х. Лундбекк А/С | 5-членные гетероциклические амиды и их применение для модуляции рецептора p2x |
| EP2203429A1 (de) * | 2007-10-31 | 2010-07-07 | Nissan Chemical Industries, Ltd. | Pyridazinonderivate und ihre verwendung als p2x7-rezeptorhemmer |
| ES2517602T3 (es) * | 2007-12-17 | 2014-11-03 | F. Hoffmann-La Roche Ag | Derivados arilamida sustituidos con tetrazol y su utilización como antagonistas de receptores purinérgicos P2X3 y/o P2X2/3 |
| WO2009077365A1 (en) * | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Novel imidazole-substituted arylamides |
| EP2234976B1 (de) | 2007-12-17 | 2013-04-10 | F. Hoffmann-La Roche AG | Neue pyrazolsubstituierte arylamide |
| WO2009077366A1 (en) | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Triazole-substituted arylamide derivatives and their use as p2x3 and /or p2x2/3 purinergic receptor antagonists |
| EA022505B1 (ru) | 2008-03-25 | 2016-01-29 | Эффектис Фармасьютиклз Аг | Новые p2x7r антагонисты и их применение |
| KR101347958B1 (ko) * | 2008-12-16 | 2014-02-14 | 에프. 호프만-라 로슈 아게 | 티아디아졸-치환된 아릴아미드 |
| PL2243772T3 (pl) | 2009-04-14 | 2012-05-31 | Affectis Pharmaceuticals Ag | Nowi antagoniści p2x7r i ich zastosowanie |
| JP5540087B2 (ja) | 2009-06-22 | 2014-07-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ３および／またはｐ２ｘ２／３アンタゴニストとしての、新規なインドール、インダゾールおよびベンゾイミダゾールアリールアミド |
| ES2593405T3 (es) | 2009-06-22 | 2016-12-09 | F. Hoffmann-La Roche Ag | Nuevas arilamidas sustituidas por benzoxazolona |
| JP5476467B2 (ja) * | 2009-06-22 | 2014-04-23 | エフ．ホフマン−ラ ロシュ アーゲー | 新規なビフェニルピリジンアミドおよびフェニルピリジンアミド |
| EA201290876A1 (ru) | 2010-03-05 | 2013-03-29 | Президент Энд Феллоуз Оф Гарвард Колледж | Композиции индуцированных дендритных клеток и их использование |
| WO2011141194A1 (en) | 2010-05-14 | 2011-11-17 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of p2x7r antagonists |
| WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| CN103391923A (zh) * | 2011-02-22 | 2013-11-13 | 埃科特莱茵药品有限公司 | 作为p2x7受体拮抗剂的苯甲酰胺衍生物 |
| US9464065B2 (en) | 2011-03-24 | 2016-10-11 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| JP5955957B2 (ja) | 2011-07-22 | 2016-07-20 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体 |
| CN102993096A (zh) * | 2011-09-13 | 2013-03-27 | 宁波大学 | 一种n-吡唑酰胺衍生物及其制备方法 |
| MX336247B (es) | 2012-01-20 | 2016-01-13 | Actelion Pharmaceuticals Ltd | Derivados de amida heterociclicos como antagonistas del receptor p2x7. |
| CA2884848C (en) | 2012-09-28 | 2017-08-22 | Pfizer Inc. | Benzamide and heterobenzamide compounds |
| TWI598325B (zh) * | 2012-10-12 | 2017-09-11 | Ｈ 朗德貝克公司 | 苯甲醯胺類 |
| TW201427947A (zh) | 2012-10-12 | 2014-07-16 | Lundbeck & Co As H | 環狀胺 |
| SG11201504369SA (en) | 2012-12-12 | 2015-07-30 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
| EP2935211B1 (de) | 2012-12-18 | 2016-11-09 | Actelion Pharmaceuticals Ltd. | Indolcarboxamidderivate als p2x7-rezeptorantagonisten |
| JP6282016B2 (ja) | 2013-01-22 | 2018-02-21 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体 |
| ES2616883T3 (es) | 2013-01-22 | 2017-06-14 | Actelion Pharmaceuticals Ltd. | Derivados amida heterocíclicos como antagonistas del receptor P2X7 |
| EP2968330B1 (de) | 2013-03-15 | 2021-09-29 | The Scripps Research Institute | Verbindungen und verfahren zur induktion von chondrogenese |
| JP6422164B2 (ja) | 2013-12-26 | 2018-11-14 | 塩野義製薬株式会社 | 含窒素６員環誘導体およびそれらを含有する医薬組成物 |
| EP2905282A1 (de) * | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituierte Thiazole oder Oxazole als P2X7-Rezeptorantagonisten |
| DK3287443T3 (da) | 2015-04-24 | 2022-02-07 | Shionogi & Co | 6-leddet heterocyklisk derivat og farmaceutisk sammensætning, som omfatter dette |
| US10750742B2 (en) | 2015-12-22 | 2020-08-25 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
| EP3290417A1 (de) | 2016-08-31 | 2018-03-07 | AXXAM S.p.A. | 2-chloro-n-[2-(1,3-thiazol-5-yl)ethyl]-5-(5-fluoropyrimidin-2-yl)-benzamide und ihre verwendung als p2x7 rezeptor antagonisten |
| EP3290416A1 (de) | 2016-08-31 | 2018-03-07 | AXXAM S.p.A. | Substituierte n-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamid- und n-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamid- derivate und ihre verwendung als p2x7 rezeptor antagonist |
| AU2017345923B2 (en) | 2016-10-17 | 2021-11-11 | Shionogi & Co., Ltd. | Bicyclic nitrogenated heterocyclic derivative and pharmaceutical composition containing same |
| EP3398941A1 (de) | 2017-05-03 | 2018-11-07 | AXXAM S.p.A. | Heterozyklische p2x7-antagonisten |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| IL294705A (en) * | 2020-01-24 | 2022-09-01 | Univ Princeton | Heterocyclic compounds and their uses |
| EP4015039A1 (de) | 2020-12-18 | 2022-06-22 | AXXAM S.p.A. | Heterocyclische derivate als p2x7-rezeptor-antagonisten |
| CA3230596A1 (en) | 2021-09-03 | 2023-03-09 | Maria Pia Catalani | 2,4-dihydro-3h-1,2,4-triazol-3-one p2x7 antagonists |
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| JP3906935B2 (ja) * | 1995-12-18 | 2007-04-18 | 杏林製薬株式会社 | Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| US5939418A (en) * | 1995-12-21 | 1999-08-17 | The Dupont Merck Pharmaceutical Company | Isoxazoline, isothiazoline and pyrazoline factor Xa inhibitors |
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-
2004
- 2004-05-10 EP EP04731975A patent/EP1626962B1/de not_active Not-in-force
- 2004-05-10 ES ES04731975T patent/ES2281801T3/es active Active
- 2004-05-10 CA CA002525437A patent/CA2525437C/en not_active Expired - Fee Related
- 2004-05-10 ES ES07103182T patent/ES2396565T3/es active Active
- 2004-05-10 BR BRPI0410349-1A patent/BRPI0410349A/pt not_active IP Right Cessation
- 2004-05-10 JP JP2006506618A patent/JP4731468B2/ja not_active Expired - Fee Related
- 2004-05-10 AT AT04731975T patent/ATE355273T1/de not_active IP Right Cessation
- 2004-05-10 DE DE602004005033T patent/DE602004005033T2/de active Active
- 2004-05-10 MX MXPA05012086A patent/MXPA05012086A/es unknown
- 2004-05-10 WO PCT/IB2004/001525 patent/WO2004099146A1/en active IP Right Grant
- 2004-05-12 US US10/844,251 patent/US7186742B2/en not_active Expired - Fee Related
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2007
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Also Published As
| Publication number | Publication date |
|---|---|
| DE602004005033T2 (de) | 2007-08-09 |
| US20050009900A1 (en) | 2005-01-13 |
| ES2396565T3 (es) | 2013-02-22 |
| MXPA05012086A (es) | 2006-02-22 |
| JP2006525991A (ja) | 2006-11-16 |
| US7186742B2 (en) | 2007-03-06 |
| ATE355273T1 (de) | 2006-03-15 |
| US20070142329A1 (en) | 2007-06-21 |
| CA2525437C (en) | 2009-04-28 |
| ES2281801T3 (es) | 2007-10-01 |
| WO2004099146A1 (en) | 2004-11-18 |
| JP4731468B2 (ja) | 2011-07-27 |
| BRPI0410349A (pt) | 2006-05-30 |
| CA2525437A1 (en) | 2004-11-18 |
| US7553972B2 (en) | 2009-06-30 |
| EP1626962B1 (de) | 2007-02-28 |
| EP1626962A1 (de) | 2006-02-22 |
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