DE602004007662D1 - Rapamycin-carbohydrate derivate - Google Patents
Rapamycin-carbohydrate derivateInfo
- Publication number
- DE602004007662D1 DE602004007662D1 DE602004007662T DE602004007662T DE602004007662D1 DE 602004007662 D1 DE602004007662 D1 DE 602004007662D1 DE 602004007662 T DE602004007662 T DE 602004007662T DE 602004007662 T DE602004007662 T DE 602004007662T DE 602004007662 D1 DE602004007662 D1 DE 602004007662D1
- Authority
- DE
- Germany
- Prior art keywords
- rapamycin
- derivatives
- carbohydrate derivatives
- profiles
- pharmacokinetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47136703P | 2003-05-16 | 2003-05-16 | |
US471367P | 2003-05-16 | ||
US54624004P | 2004-02-20 | 2004-02-20 | |
US546240P | 2004-02-20 | ||
US56284004P | 2004-04-16 | 2004-04-16 | |
US562840P | 2004-04-16 | ||
PCT/CA2004/000724 WO2004101583A1 (en) | 2003-05-16 | 2004-05-14 | Rapamycin carbohydrate derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602004007662D1 true DE602004007662D1 (de) | 2007-08-30 |
DE602004007662T2 DE602004007662T2 (de) | 2007-11-22 |
Family
ID=33458770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004007662T Expired - Fee Related DE602004007662T2 (de) | 2003-05-16 | 2004-05-14 | Rapamycin-carbohydrate derivate |
Country Status (19)
Country | Link |
---|---|
US (3) | US7160867B2 (de) |
EP (2) | EP1644392B1 (de) |
JP (1) | JP2007503452A (de) |
KR (1) | KR20060031603A (de) |
AT (1) | ATE367396T1 (de) |
AU (1) | AU2004238408A1 (de) |
BR (1) | BRPI0411171A (de) |
CA (1) | CA2525907A1 (de) |
DE (1) | DE602004007662T2 (de) |
DK (1) | DK1644392T3 (de) |
ES (1) | ES2286637T3 (de) |
HR (1) | HRP20070383T3 (de) |
MX (1) | MXPA05012376A (de) |
NO (1) | NO20055283L (de) |
NZ (1) | NZ543479A (de) |
PL (1) | PL1644392T3 (de) |
PT (1) | PT1644392E (de) |
TW (1) | TW200511991A (de) |
WO (1) | WO2004101583A1 (de) |
Families Citing this family (38)
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US6955661B1 (en) | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
US8021331B2 (en) * | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
CN102144961A (zh) * | 2003-09-18 | 2011-08-10 | 参天制药株式会社 | 经巩膜递送 |
US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
WO2006086750A1 (en) * | 2005-02-09 | 2006-08-17 | Macusight, Inc. | Liquid formulations for treatment of diseases or conditions |
GB0504994D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
WO2006119018A2 (en) * | 2005-04-29 | 2006-11-09 | Atrium Medical Corporation | Drug delivery coating for use with a medical device and methods of treating vascular injury |
AU2006314444C1 (en) | 2005-11-21 | 2018-01-04 | Novartis Ag | Neuroendocrine tumor treatment using mTOR inhibitors |
JP5528708B2 (ja) | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
US8222271B2 (en) | 2006-03-23 | 2012-07-17 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
GB0609963D0 (en) * | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
US20090253733A1 (en) * | 2008-04-02 | 2009-10-08 | Biointeractions, Ltd. | Rapamycin carbonate esters |
CN101676291B (zh) * | 2008-09-18 | 2012-05-09 | 上海海和药物研究开发有限公司 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
CN104042612A (zh) | 2008-11-11 | 2014-09-17 | 得克萨斯大学体系董事会 | 哺乳动物雷帕霉素靶蛋白的抑制 |
US8653043B2 (en) | 2009-01-07 | 2014-02-18 | Wisconsin Alumni Research Foundation | Enhanced neoglycosides through neoglycosylation and methods of use thereof |
EP2470179B1 (de) | 2009-08-26 | 2017-11-29 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Retard-freisetzungssysteme für die prävention und behandlung von kopf- und halstumoren |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
US10391059B2 (en) | 2009-11-11 | 2019-08-27 | Rapamycin Holdings, Inc. | Oral rapamycin nanoparticle preparations and use |
KR20140013000A (ko) * | 2011-04-01 | 2014-02-04 | 산도즈 아게 | C-42 위치에서 라파마이신의 위치선택적 아실화 |
EP2589383A1 (de) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen |
JP2015512371A (ja) | 2012-03-23 | 2015-04-27 | ザ・ユニバーシティ・オブ・クイーンズランド | 免疫調節性作用物質およびその使用 |
US10751450B2 (en) | 2012-06-08 | 2020-08-25 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
PL2859001T3 (pl) | 2012-06-08 | 2016-08-31 | Biotronik Ag | 40-o-podstawiona pochodna estrowa rapamycyny i węglowodoru cyklicznego, kompozycje i metody |
EP2968281B1 (de) | 2013-03-13 | 2020-08-05 | The Board of Regents of The University of Texas System | Mtor-hemmer zur vorbeugung von darmpolypenwachstum |
WO2014184734A1 (en) | 2013-05-14 | 2014-11-20 | Novartis Ag | Markers associated with mtor inhibition |
CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
WO2015044854A1 (en) | 2013-09-24 | 2015-04-02 | Novartis Ag | Markers associated with mtor inhibition |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
EP3299381B1 (de) | 2016-05-10 | 2020-12-23 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Wasserlösliches rapamycinderivat |
US20210154372A1 (en) | 2017-05-15 | 2021-05-27 | C.R. Bard, Inc. | Medical device with drug-eluting coating and intermediate layer |
CA3098698A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
US20190336609A1 (en) * | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors |
JP7262581B2 (ja) | 2018-11-14 | 2023-04-21 | ルトニックス,インコーポレーテッド | 改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス |
CN113939324A (zh) | 2019-04-08 | 2022-01-14 | 巴德外周血管股份有限公司 | 在经改性装置表面上具有药物洗脱涂层的医疗装置 |
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US3226179A (en) * | 1962-10-01 | 1965-12-28 | Huyck Corp | Papermaker's felt, woven fabrics and fibers of wool modified with an aldehyde - 4,4 - bis(4 - hydroxy phenyl) pentanoic acid reaction product and the production thereof |
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
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US5434260A (en) | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
DE4236237A1 (de) | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
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JP3942641B2 (ja) | 1996-07-30 | 2007-07-11 | ノバルティス アクチエンゲゼルシャフト | サイクロスポリンaおよび40―o―(2―ヒドロキシエチル)―ラパマイシンを含む移植拒絶、自己免疫疾患または炎症性状態の処置用医薬組成物 |
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US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
-
2004
- 2004-05-13 US US10/845,747 patent/US7160867B2/en not_active Expired - Fee Related
- 2004-05-14 PL PL04732898T patent/PL1644392T3/pl unknown
- 2004-05-14 TW TW093113648A patent/TW200511991A/zh unknown
- 2004-05-14 ES ES04732898T patent/ES2286637T3/es active Active
- 2004-05-14 AT AT04732898T patent/ATE367396T1/de not_active IP Right Cessation
- 2004-05-14 BR BRPI0411171-0A patent/BRPI0411171A/pt not_active IP Right Cessation
- 2004-05-14 CA CA002525907A patent/CA2525907A1/en not_active Abandoned
- 2004-05-14 AU AU2004238408A patent/AU2004238408A1/en not_active Abandoned
- 2004-05-14 EP EP04732898A patent/EP1644392B1/de active Active
- 2004-05-14 JP JP2006529489A patent/JP2007503452A/ja not_active Withdrawn
- 2004-05-14 MX MXPA05012376A patent/MXPA05012376A/es active IP Right Grant
- 2004-05-14 NZ NZ543479A patent/NZ543479A/en unknown
- 2004-05-14 PT PT04732898T patent/PT1644392E/pt unknown
- 2004-05-14 DE DE602004007662T patent/DE602004007662T2/de not_active Expired - Fee Related
- 2004-05-14 KR KR1020057021769A patent/KR20060031603A/ko not_active Application Discontinuation
- 2004-05-14 WO PCT/CA2004/000724 patent/WO2004101583A1/en active IP Right Grant
- 2004-05-14 DK DK04732898T patent/DK1644392T3/da active
- 2004-05-14 EP EP07003243A patent/EP1785430A1/de not_active Withdrawn
-
2005
- 2005-09-15 US US11/229,007 patent/US20060079466A1/en not_active Abandoned
- 2005-11-10 NO NO20055283A patent/NO20055283L/no not_active Application Discontinuation
-
2006
- 2006-11-09 US US11/595,397 patent/US20070099848A1/en not_active Abandoned
-
2007
- 2007-09-05 HR HR20070383T patent/HRP20070383T3/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20040235762A1 (en) | 2004-11-25 |
NO20055283D0 (no) | 2005-11-10 |
ATE367396T1 (de) | 2007-08-15 |
PL1644392T3 (pl) | 2007-12-31 |
US20070099848A1 (en) | 2007-05-03 |
MXPA05012376A (es) | 2006-05-25 |
EP1785430A1 (de) | 2007-05-16 |
EP1644392A1 (de) | 2006-04-12 |
NO20055283L (no) | 2005-12-16 |
JP2007503452A (ja) | 2007-02-22 |
NZ543479A (en) | 2008-03-28 |
TW200511991A (en) | 2005-04-01 |
DK1644392T3 (da) | 2007-11-12 |
BRPI0411171A (pt) | 2006-07-18 |
AU2004238408A1 (en) | 2004-11-25 |
US7160867B2 (en) | 2007-01-09 |
EP1644392B1 (de) | 2007-07-18 |
HRP20070383T3 (en) | 2007-10-31 |
KR20060031603A (ko) | 2006-04-12 |
ES2286637T3 (es) | 2007-12-01 |
DE602004007662T2 (de) | 2007-11-22 |
PT1644392E (pt) | 2007-08-03 |
WO2004101583A1 (en) | 2004-11-25 |
US20060079466A1 (en) | 2006-04-13 |
CA2525907A1 (en) | 2004-11-25 |
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