DE602004012241D1 - Polymere modifizierungsmittel und pharmazeutische zusammensetzungen - Google Patents

Polymere modifizierungsmittel und pharmazeutische zusammensetzungen

Info

Publication number
DE602004012241D1
DE602004012241D1 DE602004012241T DE602004012241T DE602004012241D1 DE 602004012241 D1 DE602004012241 D1 DE 602004012241D1 DE 602004012241 T DE602004012241 T DE 602004012241T DE 602004012241 T DE602004012241 T DE 602004012241T DE 602004012241 D1 DE602004012241 D1 DE 602004012241D1
Authority
DE
Germany
Prior art keywords
modificating
polymeric
agents
pharmaceutical compositions
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004012241T
Other languages
English (en)
Other versions
DE602004012241T2 (de
Inventor
Yuji Kasuya
Masashi Honma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of DE602004012241D1 publication Critical patent/DE602004012241D1/de
Application granted granted Critical
Publication of DE602004012241T2 publication Critical patent/DE602004012241T2/de
Anticipated expiration legal-status Critical
Active legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/12Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an ether radical
    • C08F216/14Monomers containing only one unsaturated aliphatic radical
    • C08F216/16Monomers containing no hetero atoms other than the ether oxygen
    • C08F216/18Acyclic compounds
    • C08F216/20Monomers containing three or more carbon atoms in the unsaturated aliphatic radical
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/04Anhydrides, e.g. cyclic anhydrides
    • C08F222/06Maleic anhydride
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/30Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/12Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an ether radical
    • C08F216/14Monomers containing only one unsaturated aliphatic radical
    • C08F216/1416Monomers containing oxygen in addition to the ether oxygen, e.g. allyl glycidyl ether
    • C08F216/1425Monomers containing side chains of polyether groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use
DE602004012241T 2003-03-24 2004-03-24 Polymere modifizierungsmittel und pharmazeutische zusammensetzungen Active DE602004012241T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2003080389 2003-03-24
JP2003080389 2003-03-24
JP2003355853 2003-10-16
JP2003355853 2003-10-16
JP2003426598 2003-12-24
JP2003426598 2003-12-24
PCT/JP2004/004134 WO2004085500A1 (en) 2003-03-24 2004-03-24 Polymeric modifiers and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
DE602004012241D1 true DE602004012241D1 (de) 2008-04-17
DE602004012241T2 DE602004012241T2 (de) 2009-03-12

Family

ID=33101948

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004012241T Active DE602004012241T2 (de) 2003-03-24 2004-03-24 Polymere modifizierungsmittel und pharmazeutische zusammensetzungen

Country Status (23)

Country Link
US (1) US7811556B2 (de)
EP (1) EP1611173B1 (de)
KR (1) KR20050118201A (de)
AR (1) AR043917A1 (de)
AT (1) ATE388173T1 (de)
AU (1) AU2004223964B2 (de)
BR (1) BRPI0408526A (de)
CA (1) CA2520450C (de)
CL (1) CL2004000633A1 (de)
DE (1) DE602004012241T2 (de)
DK (1) DK1611173T3 (de)
ES (1) ES2301978T3 (de)
HK (1) HK1078598A1 (de)
IL (1) IL170489A (de)
MX (1) MXPA05010289A (de)
NZ (1) NZ542352A (de)
PA (1) PA8598701A1 (de)
PE (1) PE20041067A1 (de)
PL (1) PL1611173T3 (de)
PT (1) PT1611173E (de)
SI (1) SI1611173T1 (de)
TW (1) TWI293882B (de)
WO (1) WO2004085500A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2090599A1 (de) * 2008-02-13 2009-08-19 Construction Research and Technology GmbH Copolymer mit Polyetherseitenketten und Dicarbonsäurederivatbausteinen

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1217005A (en) * 1916-05-08 1917-02-20 Judson D Mccarthy Photographic-printing frame.
EP0056627B1 (de) * 1981-01-16 1984-10-03 Nippon Shokubai Kagaku Kogyo Co., Ltd Copolymer und Verfahren zu seiner Herstellung
JP2621308B2 (ja) 1987-03-13 1997-06-18 日本油脂株式会社 アリルエーテル−無水マレイン酸共重合体
JP2701295B2 (ja) 1987-03-13 1998-01-21 日本油脂株式会社 アリルエーテル−無水マレイン酸共重合体
JP2803265B2 (ja) 1989-12-26 1998-09-24 日本油脂株式会社 変性ポリペプチドおよびその用途
US5158622A (en) * 1991-02-12 1992-10-27 Betz Laboratories, Inc. Method and composition for treatment of aluminum
JP3271265B2 (ja) * 1991-03-07 2002-04-02 日本油脂株式会社 修飾プロテアーゼ
JP3035675B2 (ja) * 1991-08-21 2000-04-24 株式会社コーセー 修飾スーパーオキシドディスムターゼ
CA2080174A1 (en) * 1991-10-11 1993-04-12 John E. Hayes Polymer polyol dispersants from polymers containing anhydride groups
JP3106265B2 (ja) 1992-05-26 2000-11-06 株式会社コーセー 修飾リゾチーム
US6004583A (en) * 1995-03-22 1999-12-21 Orex Pharmaceutical Development Corp. Protein-containing polymer composition for oral administration
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
IT1293087B1 (it) 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital Microparticelle a base di materiali polimerici ibridi per il rilascio controllato di molecole biologicamente attive, procedimento per la
DE19834173A1 (de) * 1997-08-01 1999-02-04 Sueddeutsche Kalkstickstoff Copolymere auf Basis von ungesättigten Dicarbonsäure-Derivaten und Oxyalkylenglykol-Alkenylethern
JPH11302199A (ja) 1998-04-16 1999-11-02 Sankyo Co Ltd 薬物運搬体を構成するグラフト共重合体
DE19847868C2 (de) * 1998-10-16 2003-09-25 Clariant Gmbh Sprengstoffe, enthaltend modifizierte Copolymere aus Polyisobutylen und Maleinsäureanhydrid als Emulgatoren
NZ512581A (en) * 1999-01-08 2002-12-20 Univ Virginia Commonwealth Polymeric delivery agents comprising a polymer conjugated to a modified amino acid and derivatives thereof
ITTO20000942A1 (it) 2000-10-10 2001-01-10 Sergio Guzzoni Pricedimento per la gestione di interscambi di messaggi tra fornitorie clienti di servizi di telefonia.
JP2003105040A (ja) 2001-09-28 2003-04-09 Nof Corp 共重合体の製造方法およびその用途
JP5109218B2 (ja) 2001-09-28 2012-12-26 日油株式会社 共重合体の製造方法

Also Published As

Publication number Publication date
HK1078598A1 (en) 2006-03-17
BRPI0408526A (pt) 2006-03-07
PT1611173E (pt) 2008-05-23
TWI293882B (en) 2008-03-01
AR043917A1 (es) 2005-08-17
EP1611173A1 (de) 2006-01-04
CL2004000633A1 (es) 2005-01-21
AU2004223964B2 (en) 2007-02-22
NZ542352A (en) 2007-02-23
IL170489A (en) 2009-06-15
TW200501986A (en) 2005-01-16
US20060062754A1 (en) 2006-03-23
CA2520450A1 (en) 2004-10-07
ATE388173T1 (de) 2008-03-15
SI1611173T1 (sl) 2008-08-31
PL1611173T3 (pl) 2008-08-29
AU2004223964A1 (en) 2004-10-07
PE20041067A1 (es) 2005-01-22
CA2520450C (en) 2009-11-03
MXPA05010289A (es) 2005-11-17
KR20050118201A (ko) 2005-12-15
DE602004012241T2 (de) 2009-03-12
ES2301978T3 (es) 2008-07-01
EP1611173B1 (de) 2008-03-05
PA8598701A1 (es) 2005-02-04
US7811556B2 (en) 2010-10-12
DK1611173T3 (da) 2008-06-23
WO2004085500A1 (en) 2004-10-07

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