DE602004019337D1 - Dezellularisierte extrazelluläre matrix von knochenmark - Google Patents

Dezellularisierte extrazelluläre matrix von knochenmark

Info

Publication number
DE602004019337D1
DE602004019337D1 DE602004019337T DE602004019337T DE602004019337D1 DE 602004019337 D1 DE602004019337 D1 DE 602004019337D1 DE 602004019337 T DE602004019337 T DE 602004019337T DE 602004019337 T DE602004019337 T DE 602004019337T DE 602004019337 D1 DE602004019337 D1 DE 602004019337D1
Authority
DE
Germany
Prior art keywords
bone marrow
extracellular matrix
decellularized extracellular
decellularized
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004019337T
Other languages
English (en)
Inventor
Toby Freyman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Publication of DE602004019337D1 publication Critical patent/DE602004019337D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633Extracellular matrix [ECM]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
DE602004019337T 2003-07-17 2004-07-16 Dezellularisierte extrazelluläre matrix von knochenmark Active DE602004019337D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/622,674 US7326571B2 (en) 2003-07-17 2003-07-17 Decellularized bone marrow extracellular matrix
PCT/US2004/023188 WO2005009498A2 (en) 2003-07-17 2004-07-16 Decellularized bone marrow extracellular matrix

Publications (1)

Publication Number Publication Date
DE602004019337D1 true DE602004019337D1 (de) 2009-03-19

Family

ID=34063242

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004019337T Active DE602004019337D1 (de) 2003-07-17 2004-07-16 Dezellularisierte extrazelluläre matrix von knochenmark

Country Status (4)

Country Link
US (2) US7326571B2 (de)
EP (1) EP1654015B1 (de)
DE (1) DE602004019337D1 (de)
WO (1) WO2005009498A2 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US20070244568A1 (en) * 2003-12-26 2007-10-18 Cardio Incorporated Decellularized Tissue and Method of Preparing the Same
US7764995B2 (en) * 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
WO2009111390A1 (en) * 2008-03-03 2009-09-11 William Marsh Rice University Methods of fabricating enhanced tissue-engineered cartilage
US20110212894A1 (en) * 2004-07-09 2011-09-01 Athanasiou Kyriacos A Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
WO2010022074A1 (en) * 2008-08-18 2010-02-25 William Marsh Rice University A decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
WO2006050459A2 (en) * 2004-10-28 2006-05-11 Cook Incorporated Methods and systems for modifying vascular valves
US8060219B2 (en) * 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US8874204B2 (en) * 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US20060134071A1 (en) * 2004-12-20 2006-06-22 Jeffrey Ross Use of extracellular matrix and electrical therapy
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US20100112543A1 (en) * 2005-03-16 2010-05-06 Manh-Dan Ngo Processing soft tissue, methods and compositions related thereto
WO2006101885A2 (en) * 2005-03-16 2006-09-28 Musculoskeletal Transplant Foundation Soft tissue processing
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
WO2007056547A2 (en) * 2005-11-08 2007-05-18 Georgia Tech Research Corporation Acellularized biomaterial from embryonic stem cells
US7521221B2 (en) * 2005-11-21 2009-04-21 Board Of Trustees Of The University Of Arknasas Staphylococcus aureus strain CYL1892
EP1790350A1 (de) * 2005-11-24 2007-05-30 Interstitial Therapeutics Verwendung einer Keratinozytzusammensetzung für die Behandlung von Restenosis
US8834912B2 (en) * 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US20080046070A1 (en) * 2006-03-31 2008-02-21 Obermiller F J Chemically treated extracellular matrices for affecting the cellular response
WO2007127363A2 (en) 2006-04-26 2007-11-08 Micell Technologies, Inc. Coatings containing multiple drugs
WO2008027783A2 (en) * 2006-08-29 2008-03-06 Vance Products Incorporated, D/B/A Cook Urological Incorporated Prosthetic testicle
GB2443938B (en) 2006-11-16 2009-11-11 Univ Leeds Preparation of tissue for meniscal implantation
US8084023B2 (en) 2007-01-22 2011-12-27 The Board Of Trustees Of The University Of Arkansas Maintenance and propagation of mesenchymal stem cells
DE102007005946A1 (de) * 2007-02-01 2008-08-14 Stiftung Caesar Therapeutische Zusammensetzung und Verwendung einer zellfreien Substanz
WO2008109407A2 (en) 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods
US20100179639A1 (en) * 2007-04-16 2010-07-15 Stephen Bloor Vascular implant
WO2008125850A2 (en) * 2007-04-16 2008-10-23 Tissue Science Laboratories Plc Methods and compositions for tissue regeneration
CA2684014A1 (en) * 2007-04-16 2008-10-23 Tissue Science Laboratories Plc Bone implant
US20080294270A1 (en) * 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
US20090142400A1 (en) * 2007-05-31 2009-06-04 Hiles Michael C Analgesic coated medical product
US20080306610A1 (en) * 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
WO2009009620A2 (en) * 2007-07-10 2009-01-15 Lifecell Corporation Acellular tissue matrix compositions for tissue repair
US20090054906A1 (en) * 2007-08-24 2009-02-26 Zimmer Orthobiologics, Inc. Medical device and method for delivering an implant to an anatomical site
WO2009089110A2 (en) * 2008-01-04 2009-07-16 Boston Scientific Scimed, Inc. Methods for repair and regeneration of bone marrow
US8801725B2 (en) * 2008-03-10 2014-08-12 Zimmer Orthobiologics, Inc. Instruments and methods used when repairing a defect on a tissue surface
EP2303350A2 (de) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprothesen-beschichtung
CA2741770C (en) * 2008-09-30 2018-01-23 The Regents Of The University Of California Compositions and methods for tissue repair with extracellular matrices
KR101056069B1 (ko) 2008-10-13 2011-08-10 아주대학교산학협력단 동물조직 분말을 이용한 다공성 3차원 지지체의 제조방법
US9511093B2 (en) * 2009-03-23 2016-12-06 The Texas A & M University System Compositions of mesenchymal stem cells to regenerate bone
US8906362B2 (en) 2009-03-23 2014-12-09 Wake Forest University Health Sciences Tissue engineered meniscus scaffolds and methods of use
EP2413847A4 (de) 2009-04-01 2013-11-27 Micell Technologies Inc Beschichtete stents
CN102802686A (zh) * 2009-06-18 2012-11-28 Mc2细胞有限责任公司 骨髓胞外基质提取物及其治疗用途
US20110021869A1 (en) * 2009-07-24 2011-01-27 Hilary John Cholhan Single-incision minimally-invasive surgical repair of pelvic organ/vaginal prolapse conditions
CA2797110C (en) 2010-04-22 2020-07-21 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
EP3610861A1 (de) 2010-08-24 2020-02-19 The Regents of the University of California Zusammensetzungen und verfahren für eine herztherapie
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9113916B2 (en) 2010-08-31 2015-08-25 Zimmer, Inc. Drill bit for osteochondral drilling with guiding element and uses thereof
EP2614145B1 (de) 2010-09-07 2020-12-02 The Board of Regents of The University of Texas System Matrizen für gewebespezifische differenzierung und ihre verwendung
TWI399209B (zh) * 2010-11-01 2013-06-21 Taiwan Sugar Corp 豬肺萃取物作為基質金屬蛋白酶抑制劑之用途
US20140030192A1 (en) * 2011-01-28 2014-01-30 Karl A. Deisseroth Functional Targeted Brain Endoskeletonization
WO2012142569A2 (en) 2011-04-15 2012-10-18 The Regents Of The University Of California Decellularized extracellular matrix
US20140154220A1 (en) * 2011-04-25 2014-06-05 University of Southern Califonia Methods and Compositions for Improved Tissue Regeneration by Suppression of Interferon-Gamma and Tumor Necrosis Factor-Alpha
WO2013009595A2 (en) * 2011-07-08 2013-01-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
WO2013036708A2 (en) 2011-09-07 2013-03-14 The Regents Of The University Of California Compositions and methods for tissue repair with extracellular matrices
PT2798057T (pt) * 2011-12-30 2018-11-29 Vivex Biologics Inc Matriz de tecido regenerativa
JP6466323B2 (ja) * 2012-06-14 2019-02-06 グライナー バイオ‐ワン ノース アメリカ,インコーポレイテッド 磁性細胞外マトリックス
EP2883030B1 (de) 2012-08-09 2022-08-31 The Board of Trustees of the Leland Stanford Junior University Verfahren und zusammensetzungen zur herstellung biologischer proben zur mikroskopischen untersuchung
JP6606429B2 (ja) 2013-01-09 2019-11-13 アイエスイー プロフェッショナル テスティング アンド コンサルティング サービシズ,インコーポレーテッド 非哺乳動物組織からの脱細胞化生体材料
EP2968563A4 (de) * 2013-03-15 2016-11-30 Leonard B Miller Kombinationstherapie zur verbesserung der weichgewebeheilung, fetttransplantatheilung, endochondralen knochenheilung und osteointegration
US9861662B2 (en) * 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
AU2014287249A1 (en) * 2013-07-09 2016-02-11 Ams Research Corporation Biodegradable articles and methods for treatment of pelvic floor disorders including extracellular matrix material
WO2015048136A1 (en) * 2013-09-24 2015-04-02 The Johns Hopkins University Tissue extracellular matrix particles and applications
US9539286B2 (en) * 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) * 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9427335B2 (en) 2014-03-18 2016-08-30 Biomet Biologics, LLC. Method for rinsing and delivering bone graft
CA2943182A1 (en) 2014-03-21 2015-09-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
EP3149534A4 (de) 2014-05-30 2018-01-31 The Board of Trustees of The Leland Stanford Junior University Verfahren und vorrichtungen zur bildgebung von intakten grossen gewebeproben
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2016100846A1 (en) * 2014-12-19 2016-06-23 Northwestern University Thromboresistant-anticoagulant extracellular matrix
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN104740684A (zh) * 2015-03-03 2015-07-01 上海市闸北区中心医院 一种犬子宫全器官脱细胞基质及其制备方法和应用
US11160904B2 (en) 2017-05-09 2021-11-02 Vivex Biologies Group, Inc. Biological composition in a protectant shroud and methods
US9687511B2 (en) * 2015-03-06 2017-06-27 Vivex Biomedical, Inc. Acellular biologic composition and method of manufacture
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
WO2017008035A1 (en) * 2015-07-08 2017-01-12 The Trustees Of The University Of Pennesylvania Decellularized organ-derived tissue engineering scaffolds
US11077147B2 (en) * 2015-07-20 2021-08-03 Vivex Biologics Group, Inc. Acellular biologic composition and method of manufacture
CN105311681B (zh) * 2015-12-07 2018-12-25 杭州华迈医疗器械有限公司 一种可注射的骨修复用复合材料及其制备方法
WO2017100600A2 (en) 2015-12-11 2017-06-15 Lifecell Corporation Methods and systems for stiffening of tissue for improved processing
WO2017139501A1 (en) 2016-02-10 2017-08-17 The Board Of Trustees Of The Leland Stanford Junior University Rna fixation and detection in clarity-based hydrogel tissue
CN107456603A (zh) * 2016-06-03 2017-12-12 香港大学深圳医院 一种富集镁离子的骨支架材料及制备方法
US11634448B2 (en) 2016-06-15 2023-04-25 The General Hospital Corporation Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
CN107913436A (zh) 2016-10-09 2018-04-17 刘英芹 作用于伤残组织原位的骨与软组织同步再生诱导剂
US11213545B2 (en) 2017-03-02 2022-01-04 University of Pittsburgh—of the Commonwealth System of Higher Education ECM hydrogel for treating esophageal inflammation
EP3589294B1 (de) 2017-03-02 2022-10-26 University of Pittsburgh - Of the Commonwealth System of Higher Education Hydrogel aus extrazellulärer matrix (ecm) und lösliche fraktion davon zur verwendung in der behandlung von krebs
KR102196026B1 (ko) 2020-04-06 2020-12-29 주식회사 티앤알바이오팹 동물 조직 유래 생체 소재의 제조방법, 이에 따라 제조된 동물 조직 유래 생체 소재 및 이를 이용한 3차원 프린팅 방법
CN111476775B (zh) * 2020-04-07 2021-11-16 广州柏视医疗科技有限公司 Dr征象识别装置和方法
CN112029727A (zh) * 2020-09-14 2020-12-04 首都医科大学附属北京天坛医院 脑脱细胞基质颗粒支架及其制备方法和应用
EP4019035A1 (de) * 2020-12-23 2022-06-29 Institut National De La Sante Et De La Recherche Medicale - Inserm Neue rekombinante fragmente von fibrillin-1 und verwendungsverfahren dafür
CN114984320B (zh) * 2022-05-31 2022-11-22 南开大学 一种脱细胞基质组织纸的制备方法及应用
CN115227868B (zh) * 2022-07-20 2023-07-07 中南大学湘雅医院 骨缺损修复材料及镁预处理脱细胞组织工程骨支架

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314565A (en) 1978-03-03 1982-02-09 Lee Peter F Biopsy and aspiration needle unit
US4513754A (en) 1978-03-03 1985-04-30 Southland Instruments, Inc. Biopsy and aspiration unit with a replaceable cannula
US4486188A (en) 1980-08-14 1984-12-04 Applied Medical Devices, Inc. Bone marrow transplant method and apparatus
US4481946A (en) 1980-08-14 1984-11-13 Altshuler John H Bone marrow transplant method and apparatus
DE3378250D1 (en) 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
SE445884B (sv) 1982-04-30 1986-07-28 Medinvent Sa Anordning for implantation av en rorformig protes
US4664128A (en) 1983-12-16 1987-05-12 Peter F. Lee, Inc Single-hand controlled aspiration device
US4630616A (en) 1984-06-15 1986-12-23 Berkley And Company, Inc. Bone marrow needle
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
SE453258B (sv) 1986-04-21 1988-01-25 Medinvent Sa Elastisk, sjelvexpanderande protes samt forfarande for dess framstellning
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5650148A (en) 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US5012818A (en) 1989-05-04 1991-05-07 Joishy Suresh K Two in one bone marrow surgical needle
WO1990013332A1 (en) 1989-05-11 1990-11-15 Cedars-Sinai Medical Center Stent with sustained drug delivery
WO1991005548A1 (en) 1989-10-10 1991-05-02 Pitman-Moore, Inc. Sustained release composition for macromolecular proteins
AU642932B2 (en) 1989-11-06 1993-11-04 Alkermes Controlled Therapeutics, Inc. Protein microspheres and methods of using them
AU7954191A (en) 1990-05-30 1991-12-31 Cellco, Inc. Culturing bone marrow cells for adoptive immunotherapy
US5192312A (en) 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5257632A (en) 1992-09-09 1993-11-02 Symbiosis Corporation Coaxial bone marrow biopsy coring and aspirating needle assembly and method of use thereof
US5331972A (en) 1992-12-03 1994-07-26 Baxter International Inc. Bone marrow biopsy, aspiration and transplant needles
ES2166370T3 (es) 1993-01-19 2002-04-16 Schneider Usa Inc Filamento implantable en material compuesto.
EP1452153A1 (de) 1994-03-14 2004-09-01 Cryolife, Inc Vorbehandeltes Gewebe für die Implantation und ein Verfahren
US5449373A (en) 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
AU4755696A (en) 1995-01-05 1996-07-24 Board Of Regents Acting For And On Behalf Of The University Of Michigan, The Surface-modified nanoparticles and method of making and using same
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
JP2000507912A (ja) 1995-08-31 2000-06-27 アルカームズ コントロールド セラピューティックス,インコーポレイテッド 作用剤の徐放性組成物
NZ318272A (en) * 1995-09-08 2000-10-27 Res Dev Foundation Glucocorticoid enhancement of gene expression
IT1282207B1 (it) 1995-11-20 1998-03-16 Fidia Advanced Biopolymers Srl Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
US20010009904A1 (en) 1997-12-30 2001-07-26 Jon A. Wolff Process of delivering a polynucleotide to a cell via the vascular system
US5630616A (en) * 1996-02-14 1997-05-20 Lear Seating Corporation Seat frame integrated air bag inflator
ES2213835T3 (es) * 1996-09-16 2004-09-01 Purdue Research Foundation Injerto de tejidos intestinales submucosales para la reparacion de tejidos neurologicos.
WO1998039035A1 (en) 1997-03-07 1998-09-11 The Wistar Institute Of Anatomy & Biology Method and compositions for healing tissue defects and inducing hypervascularity in mammalian tissue
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
SE512663C2 (sv) 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
US6082364A (en) 1997-12-15 2000-07-04 Musculoskeletal Development Enterprises, Llc Pluripotential bone marrow cell line and methods of using the same
WO1999043270A1 (en) 1998-02-24 1999-09-02 Gerigene Medical Corporation Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
US6872819B1 (en) 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
EP1196206A1 (de) 1999-07-09 2002-04-17 Advanced Tissue Sciences, Inc. Mit menschlicher natürlich sekretierter extrazellulärer matrix beschichteter gegenstand
JP2003517858A (ja) 1999-11-05 2003-06-03 ジェリジーン メディカル コーポレーション 老齢関連の軟組織の欠陥の増強と修復
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020077693A1 (en) * 2000-12-19 2002-06-20 Barclay Bruce J. Covered, coiled drug delivery stent and method
CA2419817C (en) * 2000-08-16 2014-11-18 Duke University Decellularized tissue engineered constructs and tissues
US20020082679A1 (en) * 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
JP4426285B2 (ja) * 2001-06-28 2010-03-03 クック・バイオテック・インコーポレーテッド 腎被膜コラーゲンを含有する移植片プロテーゼ用具
WO2003032735A1 (en) * 2001-10-18 2003-04-24 Lifecell Corporation Remodeling of tissues and organs
US7674250B2 (en) * 2002-08-05 2010-03-09 Boston Scientific Scimed, Inc. Methods of delivering therapeutic agents
US20040142014A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US7892205B2 (en) * 2003-06-06 2011-02-22 Boston Scientific Scimed, Inc. Device and method for delivering micronized therapeutic agents in the body
WO2005010172A2 (en) * 2003-07-16 2005-02-03 Boston Scientific Limited Aligned scaffolds for improved myocardial regeneration
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US8740844B2 (en) * 2003-08-20 2014-06-03 Boston Scientific Scimed, Inc. Medical device with drug delivery member
US6984411B2 (en) * 2003-10-14 2006-01-10 Boston Scientific Scimed, Inc. Method for roll coating multiple stents
WO2005097147A1 (en) * 2004-03-30 2005-10-20 Boston Scientific Limited (Incorporated In Ireland) Restenosis therapy using mesenchymal stem cells
US20060029720A1 (en) * 2004-08-03 2006-02-09 Anastasia Panos Methods and apparatus for injection coating a medical device
US20070005011A1 (en) * 2005-06-20 2007-01-04 Boston Scientific Scimed, Inc. Method, system, apparatus, and kit for remote therapeutic delivery
US20070055352A1 (en) * 2005-09-07 2007-03-08 Wendy Naimark Stent with pockets for containing a therapeutic agent
US20070065414A1 (en) * 2005-09-16 2007-03-22 Boston Scientific Scimed, Inc. Enhanced delivery of cells
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US20080085294A1 (en) * 2006-10-04 2008-04-10 Toby Freyman Apparatuses and methods to treat atherosclerotic plaques
WO2008094548A2 (en) * 2007-01-30 2008-08-07 Boston Scientific Limited . Local delivery of therapeutic agent to heart valves

Also Published As

Publication number Publication date
US20080124374A1 (en) 2008-05-29
US8790920B2 (en) 2014-07-29
US20050013872A1 (en) 2005-01-20
WO2005009498A3 (en) 2005-03-24
EP1654015B1 (de) 2009-02-04
EP1654015A2 (de) 2006-05-10
US7326571B2 (en) 2008-02-05
WO2005009498A2 (en) 2005-02-03

Similar Documents

Publication Publication Date Title
DE602004019337D1 (de) Dezellularisierte extrazelluläre matrix von knochenmark
ATE473702T1 (de) Knochenplatte
ATE428362T1 (de) Knochenplatte
FR2859376B1 (fr) Implant rachidien
DE602004022024D1 (de) Neue knochenersatzzusammensetzung
DE50307231D1 (de) Implantat für Osteosynthese
DE602004023302D1 (de) Chirurgisches implantat
DE602004007050D1 (de) Modulares Knochenimplantat
FR2852392B1 (fr) Composition de fixation tissulaire
DE50311261D1 (de) Wirbelsäulenimplantat
FI20020772A0 (fi) Kirurginen implantti
FI20010873A0 (fi) Luuta korvaavat materiaalit
DE502004011714D1 (de) Knochenverankerungselement
DE50206709D1 (de) Knochenplatte
DE50309438D1 (de) Zwischenwirbelimplantat
ATE477757T1 (de) Intramedullärer marknagel
ATE375125T1 (de) Chirurgischer nagel
DE50313143D1 (de) Interspinales Implantat
DK1523342T3 (da) Struktureret komposit som matrix (Schaffold) for vævs- konstruktion af knogler
ATE481991T1 (de) Zusammengesetzte biomaterialien für knochenimplantate
ITVI20050007U1 (it) Pinza chirurgica di fissaggio
DE50307465D1 (de) Wirbelsäulenimplantat aus knochenmaterial
DE112004001799D2 (de) Tensidhaltiger Knochenzement
DE60308412D1 (de) Knochenersatzmaterial
DE602004020115D1 (de) Knochenergänzungsmaterial

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: FISH & RICHARDSON P.C., 80807 MUENCHEN

8364 No opposition during term of opposition