DE602004032107D1 - Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids - Google Patents
Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptidsInfo
- Publication number
- DE602004032107D1 DE602004032107D1 DE602004032107T DE602004032107T DE602004032107D1 DE 602004032107 D1 DE602004032107 D1 DE 602004032107D1 DE 602004032107 T DE602004032107 T DE 602004032107T DE 602004032107 T DE602004032107 T DE 602004032107T DE 602004032107 D1 DE602004032107 D1 DE 602004032107D1
- Authority
- DE
- Germany
- Prior art keywords
- nell peptide
- bone
- making
- expression systems
- nell1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 101000979284 Homo sapiens Protein kinase C-binding protein NELL1 Proteins 0.000 abstract 4
- 102100023068 Protein kinase C-binding protein NELL1 Human genes 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 101000995264 Homo sapiens Protein kinase C-binding protein NELL2 Proteins 0.000 abstract 1
- 102100034433 Protein kinase C-binding protein NELL2 Human genes 0.000 abstract 1
- 230000008468 bone growth Effects 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44567203P | 2003-02-07 | 2003-02-07 | |
PCT/US2003/029281 WO2004024893A2 (en) | 2002-09-13 | 2003-09-15 | Nell-1 enhanced bone mineralization |
PCT/US2004/003808 WO2004072100A2 (en) | 2003-02-07 | 2004-02-09 | Nell peptide expression systems and bone formation activity of nell peptide |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004032107D1 true DE602004032107D1 (de) | 2011-05-19 |
Family
ID=32869406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004032107T Expired - Lifetime DE602004032107D1 (de) | 2003-02-07 | 2004-02-09 | Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids |
Country Status (9)
Country | Link |
---|---|
US (3) | US7544486B2 (de) |
EP (1) | EP1594889B1 (de) |
JP (1) | JP2007524360A (de) |
CN (1) | CN101018562A (de) |
AT (1) | ATE504649T1 (de) |
CA (1) | CA2515208A1 (de) |
DE (1) | DE602004032107D1 (de) |
ES (1) | ES2366950T3 (de) |
WO (1) | WO2004072100A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6005088A (en) | 1996-03-19 | 1999-12-21 | Otsuka Pharmaceutical Co., Ltd. | Human NPIK gene |
JP3646191B2 (ja) | 1996-03-19 | 2005-05-11 | 大塚製薬株式会社 | ヒト遺伝子 |
US7884066B2 (en) | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
US7687462B2 (en) * | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
US7544486B2 (en) * | 2003-02-07 | 2009-06-09 | The Regents Of The University Of California | Nell peptide expression systems and bone formation activity of nell peptide |
EP1694352A2 (de) * | 2003-11-19 | 2006-08-30 | DeveloGen Aktiengesellschaft | Verwendung von sezernierten proteinprodukten zur prävention und behandlung von pankreaserkrankungen und/oder fettsucht und/oder des metabolischen syndroms |
US7691607B2 (en) | 2004-02-09 | 2010-04-06 | The Regents Of The University Of California | Expression system of NELL peptide |
CN101115839B (zh) * | 2004-08-30 | 2011-05-04 | 杨梦甦 | 通过rh核心蛋白聚糖-Fc融合蛋白抑制纤维发生的方法 |
CA2597605A1 (en) | 2005-02-16 | 2006-08-24 | The Regents Of The University Of California | Pharmaceutical compositions for treating or preventing bone conditions |
KR20140109509A (ko) * | 2006-07-11 | 2014-09-15 | 큐피에스 엘엘씨 | 펩타이드의 지속 방출 전달을 위한 의약 조성물 |
JP2008212265A (ja) * | 2007-03-01 | 2008-09-18 | Niigata Univ | 培養人工骨及びその作製方法 |
AU2008304280B2 (en) | 2007-09-28 | 2013-10-31 | Ut-Battelle, Llc | Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell 1 |
CA2699597C (en) * | 2007-09-28 | 2016-10-11 | Ut-Battelle, Llc | Treatment of cardiovascular disorders using the cell differentiation signaling protein nell1 |
EP2214697A4 (de) * | 2007-10-30 | 2011-05-18 | Univ California | Nell-1-zusammensetzungen |
JP2011016723A (ja) * | 2007-11-02 | 2011-01-27 | Katayama Kagaku Kogyo Kk | 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具 |
JP5641477B2 (ja) * | 2008-08-04 | 2014-12-17 | 学校法人昭和大学 | Nell−1による組織・臓器異所再生制御技術 |
GB2463474B (en) * | 2008-09-11 | 2012-05-02 | Agency Science Tech & Res | Therapeutic bone growth and regeneration |
CA2739608A1 (en) * | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
US20110002893A1 (en) * | 2008-11-03 | 2011-01-06 | Ut-Battelle, Llc | Diagnosis and treatment of congenital heart defects using nell1 |
WO2010111421A2 (en) * | 2009-03-25 | 2010-09-30 | The Regents Of The University Of California | Isoform nell-1 peptide |
WO2011022071A2 (en) * | 2009-08-20 | 2011-02-24 | The Regents Of The University Of California | Cardiac compositions |
WO2011090971A2 (en) | 2010-01-19 | 2011-07-28 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for male reproductive disorders |
WO2011091244A1 (en) * | 2010-01-21 | 2011-07-28 | NellOne Therapeutics, Inc. | Methods to treat or prevent a skin condition using a nell1 peptide |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
WO2014152497A2 (en) | 2013-03-15 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for cognitive disorders |
EP3027235A1 (de) | 2013-07-30 | 2016-06-08 | Musculoskeletal Transplant Foundation | Aus einem azellulären weichgewebe gewonnene matrizen und verfahren zur herstellung davon |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
EP3226889A4 (de) | 2014-11-19 | 2018-11-21 | The Trustees of Columbia University in the City of New York | Osteocalcin zur behandlung von gebrechlichkeit im zusammenhang mit alterung |
US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
US10973953B1 (en) | 2016-08-18 | 2021-04-13 | Musculoskeletal Transplant Foundation | Methods and compositions for preparing transplant tissue |
US10752663B2 (en) | 2016-08-29 | 2020-08-25 | NellOne Therapeutics, Inc. | Methods and compositions for regenerating tissues |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP3852823A4 (de) | 2018-09-17 | 2022-05-04 | Rejuvablast LLC | Kombinationstransplantate für gewebereparatur- oder regenerationsanwendungen |
EP3744356A1 (de) | 2019-05-31 | 2020-12-02 | Musculoskeletal Transplant Foundation | Aus einem azellulären weichgewebe gewonnene matrizen und verfahren zur herstellung davon |
CN110420350B (zh) * | 2019-08-28 | 2021-10-22 | 深圳先进技术研究院 | 复合生物玻璃的粘附温敏水凝胶及其制备方法和应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
US4409332A (en) * | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
US5468359A (en) * | 1988-11-14 | 1995-11-21 | Anthony R. Torres | Method of determining presence of an analyte by isoelectric focusing |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
US5674725A (en) * | 1991-07-11 | 1997-10-07 | British Technology Group Limited | Implant materials having a phosphatase and an organophosphorus compound for in vivo mineralization of bone |
US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US5763416A (en) * | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
US5942496A (en) * | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
US6083690A (en) * | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
US6352972B1 (en) * | 1995-06-06 | 2002-03-05 | Marcel E. Nimni | Bone morphogenetic proteins and their use in bone growth |
US6008208A (en) * | 1995-10-23 | 1999-12-28 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
JP3646191B2 (ja) * | 1996-03-19 | 2005-05-11 | 大塚製薬株式会社 | ヒト遺伝子 |
US6005088A (en) * | 1996-03-19 | 1999-12-21 | Otsuka Pharmaceutical Co., Ltd. | Human NPIK gene |
US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
US6462019B1 (en) * | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
WO2000009691A2 (en) * | 1998-08-10 | 2000-02-24 | Urogenesys, Inc. | Bpc-1: a secreted brain specific protein expressed and secreted by prostate and bladder cancer cells |
US7052856B2 (en) * | 1999-10-05 | 2006-05-30 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
US7544486B2 (en) * | 2003-02-07 | 2009-06-09 | The Regents Of The University Of California | Nell peptide expression systems and bone formation activity of nell peptide |
US20030039968A1 (en) | 2001-07-10 | 2003-02-27 | Applera Corporation | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
JP2006512292A (ja) | 2002-09-13 | 2006-04-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Nell−1による骨石灰化の増進 |
TWI296483B (en) * | 2005-12-07 | 2008-05-01 | Marketech Int Corp | Apparatus and method for adjusting input image based on characteristics of display system |
-
2004
- 2004-02-09 US US10/544,553 patent/US7544486B2/en active Active
- 2004-02-09 EP EP04709500A patent/EP1594889B1/de not_active Expired - Lifetime
- 2004-02-09 CA CA002515208A patent/CA2515208A1/en not_active Abandoned
- 2004-02-09 JP JP2006503442A patent/JP2007524360A/ja active Pending
- 2004-02-09 ES ES04709500T patent/ES2366950T3/es not_active Expired - Lifetime
- 2004-02-09 CN CNA2004800094501A patent/CN101018562A/zh active Pending
- 2004-02-09 DE DE602004032107T patent/DE602004032107D1/de not_active Expired - Lifetime
- 2004-02-09 WO PCT/US2004/003808 patent/WO2004072100A2/en active Application Filing
- 2004-02-09 AT AT04709500T patent/ATE504649T1/de not_active IP Right Cessation
-
2009
- 2009-03-09 US US12/400,715 patent/US8048646B2/en not_active Expired - Fee Related
- 2009-03-09 US US12/400,714 patent/US7807787B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1594889B1 (de) | 2011-04-06 |
US20090226505A1 (en) | 2009-09-10 |
WO2004072100A3 (en) | 2007-03-15 |
EP1594889A4 (de) | 2008-03-19 |
JP2007524360A (ja) | 2007-08-30 |
US8048646B2 (en) | 2011-11-01 |
ES2366950T3 (es) | 2011-10-26 |
US7807787B2 (en) | 2010-10-05 |
US20060292670A1 (en) | 2006-12-28 |
EP1594889A2 (de) | 2005-11-16 |
US20100249376A1 (en) | 2010-09-30 |
CA2515208A1 (en) | 2004-08-26 |
WO2004072100A2 (en) | 2004-08-26 |
US7544486B2 (en) | 2009-06-09 |
ATE504649T1 (de) | 2011-04-15 |
CN101018562A (zh) | 2007-08-15 |
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