DE602005016828D1 - Methoden und zusammensetzungen zur analyse von ribonukleinsäuren - Google Patents
Methoden und zusammensetzungen zur analyse von ribonukleinsäurenInfo
- Publication number
- DE602005016828D1 DE602005016828D1 DE602005016828T DE602005016828T DE602005016828D1 DE 602005016828 D1 DE602005016828 D1 DE 602005016828D1 DE 602005016828 T DE602005016828 T DE 602005016828T DE 602005016828 T DE602005016828 T DE 602005016828T DE 602005016828 D1 DE602005016828 D1 DE 602005016828D1
- Authority
- DE
- Germany
- Prior art keywords
- probe
- compositions
- methods
- nucleic acid
- targeted nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/963,415 US20060078894A1 (en) | 2004-10-12 | 2004-10-12 | Methods and compositions for analyzing nucleic acids |
| PCT/US2005/036799 WO2006042303A2 (en) | 2004-10-12 | 2005-10-12 | Methods and compositions for analyzing ribonucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005016828D1 true DE602005016828D1 (de) | 2009-11-05 |
Family
ID=36145799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005016828T Active DE602005016828D1 (de) | 2004-10-12 | 2005-10-12 | Methoden und zusammensetzungen zur analyse von ribonukleinsäuren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060078894A1 (de) |
| EP (1) | EP1812599B1 (de) |
| AT (1) | ATE443777T1 (de) |
| DE (1) | DE602005016828D1 (de) |
| WO (1) | WO2006042303A2 (de) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2471922A1 (de) * | 2004-05-28 | 2012-07-04 | Asuragen, Inc. | Verfahren und Zusammensetzungen mit microRNA |
| EP2322616A1 (de) * | 2004-11-12 | 2011-05-18 | Asuragen, Inc. | Verfahren und Zusammensetzungen, die miRNAs und miRNA-inhibitorischen Molekülen verbunden sind |
| WO2008073922A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| US20080003142A1 (en) | 2006-05-11 | 2008-01-03 | Link Darren R | Microfluidic devices |
| US20090023221A1 (en) * | 2006-05-19 | 2009-01-22 | Exigon A/S | Oligonucleotide probes useful for detection and analysis of microrna precursors |
| WO2008036776A2 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
| EP2061901A2 (de) * | 2006-10-31 | 2009-05-27 | Noxxon Pharma AG | Verfahren zum nachweis eines einzel- oder doppelsträngigen nukleinsäuremoleküls |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| WO2008073919A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| CN101627121A (zh) * | 2006-12-08 | 2010-01-13 | 奥斯瑞根公司 | 作为治疗干预的靶标的miRNA调控基因和路径 |
| WO2008073920A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US20080274458A1 (en) * | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| JP2010529966A (ja) * | 2007-06-08 | 2010-09-02 | アシュラジェン インコーポレイテッド | 治療的介入の標的としてｍｉＲ−３４によって調節される遺伝子および経路 |
| US8008010B1 (en) | 2007-06-27 | 2011-08-30 | Applied Biosystems, Llc | Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor |
| US8389215B2 (en) * | 2007-07-26 | 2013-03-05 | University Of Utah Research Foundation | Non-invasive recovery of RNA and analysis of gene expression in skin |
| US8361714B2 (en) * | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| US7993831B2 (en) * | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
| US20090186015A1 (en) * | 2007-10-18 | 2009-07-23 | Latham Gary J | Micrornas differentially expressed in lung diseases and uses thereof |
| CA2706763C (en) * | 2007-11-27 | 2013-07-30 | Laboratory Corporation Of America Holdings | Enhanced method for detecting and/or quantifying an analyte in a sample |
| US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| US20090192114A1 (en) * | 2007-12-21 | 2009-07-30 | Dmitriy Ovcharenko | miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
| US20090263803A1 (en) * | 2008-02-08 | 2009-10-22 | Sylvie Beaudenon | Mirnas differentially expressed in lymph nodes from cancer patients |
| EP2271757A2 (de) * | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Zusammensetzungen und verfahren in zusammenhang mit mir-16 und prostatakrebstherapie |
| WO2009126726A1 (en) * | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
| US8258111B2 (en) * | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| US20100179213A1 (en) * | 2008-11-11 | 2010-07-15 | Mirna Therapeutics, Inc. | Methods and Compositions Involving miRNAs In Cancer Stem Cells |
| WO2010120803A2 (en) | 2009-04-13 | 2010-10-21 | Somagenics Inc. | Methods and compositions for detection of small rnas |
| AU2010242073C1 (en) | 2009-04-30 | 2015-12-24 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
| WO2010135692A2 (en) | 2009-05-22 | 2010-11-25 | Asuragen, Inc. | Mirna biomarkers of prostate disease |
| WO2011025919A1 (en) | 2009-08-28 | 2011-03-03 | Asuragen, Inc. | Mirna biomarkers of lung disease |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
| WO2012167142A2 (en) | 2011-06-02 | 2012-12-06 | Raindance Technolgies, Inc. | Enzyme quantification |
| CN103781919B9 (zh) | 2011-06-27 | 2017-09-15 | 卫材R&D管理有限公司 | 指示阿尔茨海默氏病的微rna生物标志物 |
| EP2744916A4 (de) | 2011-07-13 | 2015-06-17 | Primeradx Inc | Multimodale verfahren zur simultanen erkennung und quantifizierung mehrerer nukleinsäuren in einer probe |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| EP2761030A4 (de) * | 2011-09-28 | 2015-02-25 | Htg Molecular Diagnostics Inc | Verfahren zur gleichzeitigen erkennung von mrna und kleiner nicht-kodierender rna |
| CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
| US9816130B2 (en) | 2011-12-22 | 2017-11-14 | Somagenics, Inc. | Methods of constructing small RNA libraries and their use for expression profiling of target RNAs |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| CN104603290B (zh) | 2012-06-29 | 2019-02-01 | Htg分子诊断有限公司 | 用于检测核苷酸变异的核酸酶保护方法 |
| CA2890441A1 (en) | 2012-11-07 | 2014-05-15 | Good Start Genetics, Inc. | Methods and systems for identifying contamination in samples |
| US8778609B1 (en) | 2013-03-14 | 2014-07-15 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| US8847799B1 (en) | 2013-06-03 | 2014-09-30 | Good Start Genetics, Inc. | Methods and systems for storing sequence read data |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| EP3058096A1 (de) | 2013-10-18 | 2016-08-24 | Good Start Genetics, Inc. | Verfahren zur beurteilung eines genomischen bereichs einer person |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US20150191794A1 (en) | 2014-01-05 | 2015-07-09 | Biomirna Holdings Ltd. | Lung Cancer Determinations Using MIRNA |
| US10619210B2 (en) | 2014-02-07 | 2020-04-14 | The Johns Hopkins University | Predicting response to epigenetic drug therapy |
| WO2015175530A1 (en) | 2014-05-12 | 2015-11-19 | Gore Athurva | Methods for detecting aneuploidy |
| US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
| WO2016048829A1 (en) | 2014-09-24 | 2016-03-31 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
| WO2016094330A2 (en) | 2014-12-08 | 2016-06-16 | 20/20 Genesystems, Inc | Methods and machine learning systems for predicting the liklihood or risk of having cancer |
| EP3271480B8 (de) | 2015-01-06 | 2022-09-28 | Molecular Loop Biosciences, Inc. | Abtastung auf strukturelle varianten |
| EP3292214A1 (de) | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Verfahren zur quantifizierung von mirnas mittels normalisierung |
| WO2017112666A1 (en) | 2015-12-21 | 2017-06-29 | Somagenics, Inc. | Methods of library construction for polynucleotide sequencing |
| DK3568475T3 (da) * | 2017-01-16 | 2023-04-17 | Spectrum Solutions L L C | Nukleinsyrekonserveringsopløsning og fremgangsmåder til anvendelse |
| US20200263233A1 (en) * | 2017-06-23 | 2020-08-20 | Eiken Kagaku Kabushiki Kaisha | Method For Nucleic Acid Detection, Primer For Nucleic Acid Detection, And Kit For Nucleic Acid Detection |
| EP3719144A1 (de) | 2019-04-05 | 2020-10-07 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung |
| EP3999664A1 (de) | 2019-07-19 | 2022-05-25 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Verfahren zur bestimmung des ansprechens auf die behandlung eines patienten mit nicht-kleinzelligem lungenkarzinom (nsclc) |
| CN116507738A (zh) * | 2020-09-02 | 2023-07-28 | 中尺度技术有限责任公司 | 用于检测样品中的一种或多种靶分析物的试剂盒及其制造和使用方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4876187A (en) * | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US5011769A (en) * | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US4999290A (en) * | 1988-03-31 | 1991-03-12 | The Board Of Regents, The University Of Texas System | Detection of genomic abnormalities with unique aberrant gene transcripts |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| AU8102694A (en) * | 1993-11-17 | 1995-06-06 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| US5801155A (en) * | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
| DE69735313T2 (de) * | 1996-06-04 | 2006-11-02 | University Of Utah Research Foundation, Salt Lake City | Fluoreszenz-Donor-Akzeptor Paar |
| US6232066B1 (en) * | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
| US6458533B1 (en) * | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| US6238869B1 (en) * | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
| US5942398A (en) * | 1998-02-26 | 1999-08-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glutx and uses thereof |
| GB9904991D0 (en) * | 1999-03-05 | 1999-04-28 | Univ Nottingham | Genetic screening |
| US7005261B1 (en) * | 1999-07-29 | 2006-02-28 | British Biocell International Limited | Method for detecting nucleic acid target sequences involving in vitro transcription from an RNA polymerase promoter |
| US7205105B2 (en) * | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
| CA2398107C (en) * | 2000-01-28 | 2013-11-19 | Althea Technologies, Inc. | Methods for analysis of gene expression |
| US6573048B1 (en) * | 2000-04-18 | 2003-06-03 | Naxcor | Degradable nucleic acid probes and nucleic acid detection methods |
| US20030170623A1 (en) * | 2001-04-13 | 2003-09-11 | Jingwen Chen | Multiplexed gene analysis on a mobile solid support |
| DK1436404T3 (da) * | 2001-09-19 | 2010-03-08 | Alexion Pharma Inc | Manipulerede templates og deres anvendelse i single-primer amplifikation |
-
2004
- 2004-10-12 US US10/963,415 patent/US20060078894A1/en not_active Abandoned
-
2005
- 2005-10-12 EP EP05815286A patent/EP1812599B1/de not_active Not-in-force
- 2005-10-12 DE DE602005016828T patent/DE602005016828D1/de active Active
- 2005-10-12 WO PCT/US2005/036799 patent/WO2006042303A2/en active Application Filing
- 2005-10-12 AT AT05815286T patent/ATE443777T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1812599A2 (de) | 2007-08-01 |
| WO2006042303A2 (en) | 2006-04-20 |
| EP1812599B1 (de) | 2009-09-23 |
| ATE443777T1 (de) | 2009-10-15 |
| US20060078894A1 (en) | 2006-04-13 |
| WO2006042303A3 (en) | 2006-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |