DE602006019261D1 - Verfahren zur sequenzierung einer polynukleotidmatrize - Google Patents

Verfahren zur sequenzierung einer polynukleotidmatrize

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Publication number
DE602006019261D1
DE602006019261D1 DE602006019261T DE602006019261T DE602006019261D1 DE 602006019261 D1 DE602006019261 D1 DE 602006019261D1 DE 602006019261 T DE602006019261 T DE 602006019261T DE 602006019261 T DE602006019261 T DE 602006019261T DE 602006019261 D1 DE602006019261 D1 DE 602006019261D1
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DE
Germany
Prior art keywords
sequencing
matrize
polynucleotide
double
stranded polynucleotide
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DE602006019261T
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English (en)
Inventor
Geoffrey Paul Smith
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Illumina Cambridge Ltd
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Illumina Cambridge Ltd
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Application filed by Illumina Cambridge Ltd filed Critical Illumina Cambridge Ltd
Publication of DE602006019261D1 publication Critical patent/DE602006019261D1/de
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
DE602006019261T 2005-07-20 2006-07-20 Verfahren zur sequenzierung einer polynukleotidmatrize Active DE602006019261D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0514910.9A GB0514910D0 (en) 2005-07-20 2005-07-20 Method for sequencing a polynucleotide template
PCT/GB2006/002690 WO2007010252A1 (en) 2005-07-20 2006-07-20 Method for sequencing a polynucleotide template

Publications (1)

Publication Number Publication Date
DE602006019261D1 true DE602006019261D1 (de) 2011-02-10

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DE602006019261T Active DE602006019261D1 (de) 2005-07-20 2006-07-20 Verfahren zur sequenzierung einer polynukleotidmatrize

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US (8) US8017335B2 (de)
EP (1) EP1910560B1 (de)
AT (1) ATE493513T1 (de)
DE (1) DE602006019261D1 (de)
GB (1) GB0514910D0 (de)
WO (1) WO2007010252A1 (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
GB0514910D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
EP1987159B2 (de) 2006-02-08 2020-08-12 Illumina Cambridge Limited Verfahren zur sequenzierung einer polynukleotidmatrize
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
EP2201021A4 (de) * 2007-08-29 2012-01-25 Applied Biosystems Llc Alternative nukleinsäuresequenzierverfahren
US8202691B2 (en) 2008-01-25 2012-06-19 Illumina, Inc. Uniform fragmentation of DNA using binding proteins
US8263367B2 (en) 2008-01-25 2012-09-11 Agency For Science, Technology And Research Nucleic acid interaction analysis
US7767400B2 (en) * 2008-02-03 2010-08-03 Helicos Biosciences Corporation Paired-end reads in sequencing by synthesis
US8198028B2 (en) 2008-07-02 2012-06-12 Illumina Cambridge Limited Using populations of beads for the fabrication of arrays on surfaces
US20100184045A1 (en) * 2008-09-23 2010-07-22 Helicos Biosciences Corporation Methods for sequencing degraded or modified nucleic acids
WO2010038042A1 (en) * 2008-10-02 2010-04-08 Illumina Cambridge Ltd. Nucleic acid sample enrichment for sequencing applications
EP2340314B8 (de) 2008-10-22 2015-02-18 Illumina, Inc. Erhaltung von informationen in verbindung mit genomischer dna-methylierung
US8236532B2 (en) 2008-12-23 2012-08-07 Illumina, Inc. Multibase delivery for long reads in sequencing by synthesis protocols
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US10036063B2 (en) 2009-07-24 2018-07-31 Illumina, Inc. Method for sequencing a polynucleotide template
CN102597256B (zh) 2009-08-25 2014-12-03 伊鲁米那股份有限公司 选择和扩增多核苷酸的方法
GB2487341A (en) * 2009-11-02 2012-07-18 Nugen Technologies Inc Compositions and methods for targeted nucleic acid sequence selection and amplification
SG10201407883PA (en) 2009-12-07 2015-01-29 Illumina Inc Multi-sample indexing for multiplex genotyping
US9029103B2 (en) 2010-08-27 2015-05-12 Illumina Cambridge Limited Methods for sequencing polynucleotides
US8483969B2 (en) 2010-09-17 2013-07-09 Illuminia, Inc. Variation analysis for multiple templates on a solid support
US8759038B2 (en) 2010-09-29 2014-06-24 Illumina Cambridge Limited Compositions and methods for sequencing nucleic acids
US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
EP3360963B1 (de) 2010-11-12 2019-11-06 Gen9, Inc. Verfahren und vorrichtungen für nukleinsäuresynthese
CN103370425B (zh) 2010-12-17 2019-03-19 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
AU2012300401B2 (en) 2011-08-26 2018-02-08 Gen9, Inc. Compositions and methods for high fidelity assembly of nucleic acids
WO2013059746A1 (en) 2011-10-19 2013-04-25 Nugen Technologies, Inc. Compositions and methods for directional nucleic acid amplification and sequencing
CN105861487B (zh) 2012-01-26 2020-05-05 纽亘技术公司 用于靶向核酸序列富集和高效文库产生的组合物和方法
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
WO2013163263A2 (en) 2012-04-24 2013-10-31 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
GB2518078B (en) 2012-06-18 2015-04-29 Nugen Technologies Inc Compositions and methods for negative selection of non-desired nucleic acid sequences
CN104685116A (zh) 2012-06-25 2015-06-03 Gen9股份有限公司 用于核酸组装和高通量测序的方法
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
ES2637538T3 (es) 2012-07-17 2017-10-13 Counsyl, Inc. Sistema y métodos para la detección de una variación genética
US9092401B2 (en) 2012-10-31 2015-07-28 Counsyl, Inc. System and methods for detecting genetic variation
WO2014031163A1 (en) * 2012-08-24 2014-02-27 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid paired end sequencing
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
ES2886507T3 (es) 2012-10-29 2021-12-20 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
EP2971130A4 (de) 2013-03-15 2016-10-05 Nugen Technologies Inc Sequentielle sequenzierung
US11859171B2 (en) 2013-04-17 2024-01-02 Agency For Science, Technology And Research Method for generating extended sequence reads
ES2719579T3 (es) 2013-07-03 2019-07-11 Illumina Inc Sistema para secuenciación por síntesis ortogonal
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ, インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
WO2015131107A1 (en) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
EP3194627B1 (de) 2014-09-18 2023-08-16 Illumina, Inc. Verfahren und systeme zur analyse von nukleinsäuresequenzierungsdaten
US10233490B2 (en) 2014-11-21 2019-03-19 Metabiotech Corporation Methods for assembling and reading nucleic acid sequences from mixed populations
WO2016090266A1 (en) 2014-12-05 2016-06-09 Amyris, Inc. High-throughput sequencing of polynucleotides
CA2985545C (en) 2015-05-29 2021-02-09 Illumina Cambridge Limited Enhanced utilization of surface primers in clusters
JP6712606B2 (ja) 2015-07-30 2020-06-24 イラミーナ インコーポレーテッド ヌクレオチドのオルトゴナルな脱ブロッキング
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
AU2016356395B2 (en) 2015-11-19 2020-12-17 Cygnus Biosciences (Beijing) Co. Ltd. Methods for obtaining and correcting biological sequence information
CA3044231A1 (en) 2016-11-16 2018-05-24 Illumina, Inc. Validation methods and systems for sequence variant calls
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
WO2018200386A1 (en) 2017-04-23 2018-11-01 Illumina, Inc. Compositions and methods for improving sample identification in indexed nucleic acid libraries
EP3615692A1 (de) 2017-04-23 2020-03-04 Illumina Cambridge Limited Zusammensetzungen und verfahren zur verbesserung der probenidentifikation in indizierten nukleinsäurebibliotheken
ES2929837T3 (es) 2017-04-23 2022-12-02 Illumina Cambridge Ltd Composiciones y métodos para mejorar la identificación de muestras en bibliotecas de ácidos nucleicos indexados
NZ759818A (en) 2017-10-16 2022-04-29 Illumina Inc Semi-supervised learning for training an ensemble of deep convolutional neural networks
KR102317911B1 (ko) 2017-10-16 2021-10-26 일루미나, 인코포레이티드 심층 학습 기반 스플라이스 부위 분류
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
WO2019108972A1 (en) 2017-11-30 2019-06-06 Illumina, Inc. Validation methods and systems for sequence variant calls
CN110832510A (zh) 2018-01-15 2020-02-21 因美纳有限公司 基于深度学习的变体分类器
US20190318806A1 (en) 2018-04-12 2019-10-17 Illumina, Inc. Variant Classifier Based on Deep Neural Networks
US20200251183A1 (en) 2018-07-11 2020-08-06 Illumina, Inc. Deep Learning-Based Framework for Identifying Sequence Patterns that Cause Sequence-Specific Errors (SSEs)
CN113705585A (zh) 2018-10-15 2021-11-26 因美纳有限公司 基于神经网络实现的方法和系统
BR112021008999A2 (pt) 2018-11-07 2021-08-10 Seer, Inc. composições, métodos e sistemas para a análise de proteína corona e seus usos.
SG11202012762WA (en) 2018-12-05 2021-01-28 Illumina Cambridge Ltd Methods and compositions for cluster generation by bridge amplification
CN112739830A (zh) 2018-12-18 2021-04-30 伊卢米纳剑桥有限公司 使用单一表面引物进行配对末端测序的方法和组合物
NL2023314B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based quality scoring
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
WO2020191389A1 (en) 2019-03-21 2020-09-24 Illumina, Inc. Training data generation for artificial intelligence-based sequencing
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023312B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based base calling
AU2020326698A1 (en) 2019-08-05 2022-02-24 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
US20210265018A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Knowledge Distillation and Gradient Pruning-Based Compression of Artificial Intelligence-Based Base Caller
CA3173798A1 (en) 2020-03-03 2021-09-10 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing double stranded nucleic acids
KR20220151101A (ko) 2020-03-09 2022-11-14 일루미나, 인코포레이티드 폴리뉴클레오티드를 서열분석하는 방법
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
DE112021004478T5 (de) 2020-08-25 2023-09-14 Seer, Inc. Zusammensetzungen und verfahren zur bestimmung von proteinen und nukleinsäuren
US11859241B2 (en) 2021-06-17 2024-01-02 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
US11236388B1 (en) 2021-06-17 2022-02-01 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
KR20240031968A (ko) 2021-07-19 2024-03-08 일루미나, 인코포레이티드 염기 호출에 대한 보간 및 적응을 갖는 강도 추출
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
WO2023049212A2 (en) 2021-09-22 2023-03-30 Illumina, Inc. State-based base calling
WO2023114397A1 (en) 2021-12-16 2023-06-22 Illumina, Inc. Hybrid clustering
AU2022413263A1 (en) 2021-12-17 2024-01-18 Illumina, Inc. Orthogonal hybridization
CN114457146A (zh) * 2022-01-28 2022-05-10 赛纳生物科技(北京)有限公司 一种固相介质表面双端扩增测序的方法
AU2023234670A1 (en) 2022-03-15 2024-01-18 Illumina, Inc. Concurrent sequencing of forward and reverse complement strands on separate polynucleotides for methylation detection
EP4341435A1 (de) 2022-03-15 2024-03-27 Illumina, Inc. Verfahren für basenrufende nukleobasen
US20230343414A1 (en) 2022-03-25 2023-10-26 Illumina, Inc. Sequence-to-sequence base calling
US20230313294A1 (en) * 2022-03-30 2023-10-05 Illumina Cambridge Limited Methods for chemical cleavage of surface-bound polynucleotides
US20230392201A1 (en) 2022-06-06 2023-12-07 Element Biosciences, Inc. Methods for assembling and reading nucleic acid sequences from mixed populations
WO2023239917A1 (en) 2022-06-09 2023-12-14 Illumina, Inc. Dependence of base calling on flow cell tilt
WO2024033174A1 (en) 2022-08-12 2024-02-15 Miltenyi Biotec B.V. & Co. KG Barcoding of nucleic acids from single cells
US20240124916A1 (en) 2022-09-16 2024-04-18 Illumina Cambridge Limited Nanoparticle with polynucleotide binding site and method of making thereof
WO2024061799A1 (en) 2022-09-19 2024-03-28 Illumina, Inc. Deformable polymers comprising immobilised primers
US20240102067A1 (en) 2022-09-26 2024-03-28 Illumina, Inc. Resynthesis Kits and Methods
US20240124929A1 (en) 2022-09-30 2024-04-18 Illumina, Inc. Mesophilic compositions for nucleic acid amplification
US20240124914A1 (en) 2022-09-30 2024-04-18 Illumina, Inc. Thermophilic compositions for nucleic acid amplification
US20240110221A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of modulating clustering kinetics
US20240110234A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Amplification Compositions and Methods

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB205153A (en) 1922-07-04 1923-10-04 Charles Ashton Henry Bullock Improvements in type setting apparatus
GB522310A (en) 1938-12-02 1940-06-14 Corning Glass Works Improvements in wall structures and in glass construction blocks therefor
US4292503A (en) 1979-05-14 1981-09-29 Emerson Electric Co. Split-band electric heater
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0224126A3 (de) 1985-11-25 1989-02-01 The University of Calgary Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren
CA1340843C (en) 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
SE8801070D0 (sv) 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
US6107023A (en) 1988-06-17 2000-08-22 Genelabs Technologies, Inc. DNA amplification and subtraction techniques
GB8818020D0 (en) 1988-07-28 1988-09-01 Ici Plc Method for amplification of nucleotide sequences
CA2004326A1 (en) 1988-12-23 1990-06-23 Nanibushan Dattagupta Assay of sequences using amplified genes
US5629158A (en) 1989-03-22 1997-05-13 Cemu Bitecknik Ab Solid phase diagnosis of medical conditions
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5302509A (en) * 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
JP3096722B2 (ja) 1990-01-17 2000-10-10 日本ケミカルリサーチ株式会社 ポリメラーゼ・チェーン・リアクション用プライマーの作製法およびそれを用いるdnaの増幅法
US5118604A (en) 1990-06-15 1992-06-02 Yale University Restriction-fragment DNA probes and probe clusters
WO1993004199A2 (en) 1991-08-20 1993-03-04 Scientific Generics Limited Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids
EP0969102B1 (de) 1991-09-24 2007-12-26 Keygene N.V. Primer, Sätze und Restriktions Fragmente und dessen Benutzung in selektive Restriktionsfragmentenamplifikation
EP1382386A3 (de) 1992-02-19 2004-12-01 The Public Health Research Institute Of The City Of New York, Inc. Neue Ordnungen für Oligonukleotide und ihr Nutzen zum Sortieren, Isolieren, Sequenzierung und Manipulieren von Nukleinsäuren
WO1994002634A1 (en) 1992-07-24 1994-02-03 University Of South Australia Amplification and detection process
RU2048522C1 (ru) 1992-10-14 1995-11-20 Институт белка РАН Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления
JPH07203998A (ja) 1994-01-26 1995-08-08 Hamamatsu Photonics Kk 核酸塩基配列決定方法
CN1152946A (zh) 1994-05-28 1997-06-25 特普尼尔医学有限公司 生产核酸的拷贝
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US6060288A (en) 1994-08-03 2000-05-09 Mosaic Technologies Method for performing amplification of nucleic acid on supports
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
JPH11503611A (ja) 1995-04-11 1999-03-30 トラスティーズ・オブ・ボストン・ユニバーシティ 生体高分子の固相配列決定法
DE19515552A1 (de) * 1995-04-27 1996-10-31 Europ Lab Molekularbiolog Simultane Sequenzierung von Nukleinsäuren
SE9504099D0 (sv) 1995-11-16 1995-11-16 Pharmacia Biotech Ab A method of sequencing
US5935788A (en) 1996-06-25 1999-08-10 Lifespan Biosciences, Inc. Subtractive hybridization techniques for identifying differentially expressed and commonly expressed nucleic acid
US5837466A (en) 1996-12-16 1998-11-17 Vysis, Inc. Devices and methods for detecting nucleic acid analytes in samples
US20020061532A1 (en) 1997-02-14 2002-05-23 Mosaic Technologies, Inc. Method and apparatus for performing amplification of nucleic acids on supports
AU6846798A (en) 1997-04-01 1998-10-22 Glaxo Group Limited Method of nucleic acid sequencing
EP3034626A1 (de) 1997-04-01 2016-06-22 Illumina Cambridge Limited Verfahren zur vervielfältigung von nukleinsäuren
US6326489B1 (en) 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
US6087099A (en) 1997-09-08 2000-07-11 Myriad Genetics, Inc. Method for sequencing both strands of a double stranded DNA in a single sequencing reaction
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US20030022207A1 (en) 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6361947B1 (en) 1998-10-27 2002-03-26 Affymetrix, Inc. Complexity management and analysis of genomic DNA
US20030108867A1 (en) 1999-04-20 2003-06-12 Chee Mark S Nucleic acid sequencing using microsphere arrays
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
US6339147B1 (en) 1999-07-29 2002-01-15 Epoch Biosciences, Inc. Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
DE10051564A1 (de) 2000-10-18 2002-08-01 Axaron Bioscience Ag Neue Verfahren zur parallelen Sequenzierung eines Nukleinsäuregemisches an einer Oberfläche
AU3246601A (en) 1999-12-29 2001-07-16 Keygene N.V. Method for generating oligonucleotides, in particular for the detection of amplified restriction fragments obtained using AFLP
WO2001079553A1 (en) 2000-04-14 2001-10-25 Lynx Therapeutics, Inc. Method and compositions for ordering restriction fragments
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
EP1256632A3 (de) 2001-05-07 2004-01-02 Smithkline Beecham Corporation Hochdurchsatz-Screening von Polymorphismen
AU2002365157A1 (en) 2001-11-08 2003-07-15 The Johns Hopkins University Methods and systems of nucleic acid sequencing
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
WO2003074734A2 (en) 2002-03-05 2003-09-12 Solexa Ltd. Methods for detecting genome-wide sequence variations associated with a phenotype
GB0205153D0 (en) 2002-03-05 2002-04-17 Manteia S A Methods for detecting genome-wide sequence variations associated with a phenotype
US20040126765A1 (en) 2002-12-27 2004-07-01 Adams Craig W. Method and compositions for sequencing nucleic acid molecules
ES2342665T3 (es) 2003-01-29 2010-07-12 454 Corporation Secuenciacion desde dos extremos.
WO2004072294A2 (en) 2003-02-12 2004-08-26 Genizon Svenska Ab Methods and means for nucleic acid sequencing
GB0324456D0 (en) 2003-10-20 2003-11-19 Isis Innovation Parallel DNA sequencing methods
EP2202322A1 (de) 2003-10-31 2010-06-30 AB Advanced Genetic Analysis Corporation Verfahren zur Herstellung eines gepaarten Markers aus einer Nukleinsäuresequenz und Verwendungsverfahren dafür
GB0400584D0 (en) 2004-01-12 2004-02-11 Solexa Ltd Nucleic acid chacterisation
GB2412170A (en) 2004-03-16 2005-09-21 Plant Bioscience Ltd A method for enriching for target nucleic acids in a sample
GB2413796B (en) 2004-03-25 2006-03-29 Global Genomics Ab Methods and means for nucleic acid sequencing
US20060078899A1 (en) 2004-10-12 2006-04-13 Scheffer Alicia F Methods and compositions for reducing label variation in array-based comparative genome hybridization assays
DE102004061843A1 (de) 2004-12-22 2006-07-20 Car Trim Biermann, Marktfort und Dr. Rau GbR (vertretungsberechtigter Gesellschafter: Herr Dr. Friedrich Rau, 08261 Schöneck) Verfahren und Einrichtung zum Einbringen von Nähten in Textilien, insbesondere in technische Textilien
WO2006110855A2 (en) 2005-04-12 2006-10-19 454 Life Sciences Corporation Methods for determining sequence variants using ultra-deep sequencing
EP1910537A1 (de) 2005-06-06 2008-04-16 454 Life Sciences Corporation Sequenzierung mit gepaarten enden
US8428882B2 (en) 2005-06-14 2013-04-23 Agency For Science, Technology And Research Method of processing and/or genome mapping of diTag sequences
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0514910D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
WO2007076726A1 (en) 2006-01-04 2007-07-12 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
EP1987159B2 (de) 2006-02-08 2020-08-12 Illumina Cambridge Limited Verfahren zur sequenzierung einer polynukleotidmatrize
EP2021503A1 (de) 2006-03-17 2009-02-11 Solexa Ltd. Isothermische methoden zur entstehung von arrays von einzelnen molekülen
US20070231823A1 (en) 2006-03-23 2007-10-04 Mckernan Kevin J Directed enrichment of genomic DNA for high-throughput sequencing
EP2032686B1 (de) 2006-06-23 2022-01-12 Illumina, Inc. Vorrichtung und verfahren zur erzeugung von dna-cluster-anordnungen
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
WO2009032167A1 (en) 2007-08-29 2009-03-12 Illumina Cambridge Method for sequencing a polynucleotide template

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US9637786B2 (en) 2017-05-02
ATE493513T1 (de) 2011-01-15
US11781184B2 (en) 2023-10-10
US20120053074A1 (en) 2012-03-01
US8247177B2 (en) 2012-08-21
US20130171648A1 (en) 2013-07-04
EP1910560B1 (de) 2010-12-29
WO2007010252A1 (en) 2007-01-25
US9017945B2 (en) 2015-04-28
US20150203911A1 (en) 2015-07-23
US20090181370A1 (en) 2009-07-16
US9297043B2 (en) 2016-03-29
US20230193384A1 (en) 2023-06-22
EP1910560A1 (de) 2008-04-16
US20170327885A1 (en) 2017-11-16
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US8017335B2 (en) 2011-09-13

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