DE60202374D1 - Methode und Vorrichtung zur Aufnahme dreidimensionaler Abbildungen von schwebend gehaltenen Mikroobjekten unter Verwendung hochauflösender Mikroskopie - Google Patents

Methode und Vorrichtung zur Aufnahme dreidimensionaler Abbildungen von schwebend gehaltenen Mikroobjekten unter Verwendung hochauflösender Mikroskopie

Info

Publication number
DE60202374D1
DE60202374D1 DE60202374T DE60202374T DE60202374D1 DE 60202374 D1 DE60202374 D1 DE 60202374D1 DE 60202374 T DE60202374 T DE 60202374T DE 60202374 T DE60202374 T DE 60202374T DE 60202374 D1 DE60202374 D1 DE 60202374D1
Authority
DE
Germany
Prior art keywords
receptacle
objects
taking
data sets
dimensional images
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60202374T
Other languages
English (en)
Other versions
DE60202374T2 (de
Inventor
Spencer Shorte
Torsten Mueller
Thomas Schnelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PerkinElmer Cellular Technologies Germany GmbH
Institut Pasteur de Lille
Original Assignee
Evotec Technologies GmbH
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Technologies GmbH, Institut Pasteur de Lille filed Critical Evotec Technologies GmbH
Application granted granted Critical
Publication of DE60202374D1 publication Critical patent/DE60202374D1/de
Publication of DE60202374T2 publication Critical patent/DE60202374T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
    • G02B21/20—Binocular arrangements
    • G02B21/22—Stereoscopic arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1452—Adjustment of focus; Alignment
DE60202374T 2002-10-25 2002-10-25 Methode und Vorrichtung zur Aufnahme dreidimensionaler Abbildungen von schwebend gehaltenen Mikroobjekten unter Verwendung hochauflösender Mikroskopie Expired - Lifetime DE60202374T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02292658A EP1413911B1 (de) 2002-10-25 2002-10-25 Methode und Vorrichtung zur Aufnahme dreidimensionaler Abbildungen von schwebend gehaltenen Mikroobjekten unter Verwendung hochauflösender Mikroskopie

Publications (2)

Publication Number Publication Date
DE60202374D1 true DE60202374D1 (de) 2005-01-27
DE60202374T2 DE60202374T2 (de) 2005-12-08

Family

ID=32050117

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202374T Expired - Lifetime DE60202374T2 (de) 2002-10-25 2002-10-25 Methode und Vorrichtung zur Aufnahme dreidimensionaler Abbildungen von schwebend gehaltenen Mikroobjekten unter Verwendung hochauflösender Mikroskopie

Country Status (6)

Country Link
US (1) US7738695B2 (de)
EP (1) EP1413911B1 (de)
AT (1) ATE285590T1 (de)
AU (1) AU2003298099A1 (de)
DE (1) DE60202374T2 (de)
WO (1) WO2004038484A2 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050036674A1 (en) * 2003-08-13 2005-02-17 Bar Ilan University Method and system for determining shape of an object from a planar top view thereof
DE102004023466B4 (de) 2004-05-12 2008-11-13 Evotec Technologies Gmbh Verfahren und Vorrichtung zur Sammlung von suspendierten Partikeln
US9041938B2 (en) 2006-05-02 2015-05-26 California Institute Of Technology Surface wave assisted structures and systems
US7768654B2 (en) 2006-05-02 2010-08-03 California Institute Of Technology On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference
US8822894B2 (en) 2011-01-07 2014-09-02 California Institute Of Technology Light-field pixel for detecting a wavefront based on a first intensity normalized by a second intensity
US8055034B2 (en) * 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
US8050516B2 (en) * 2006-09-13 2011-11-01 Fluidigm Corporation Methods and systems for determining a baseline during image processing
DE102006052925A1 (de) * 2006-11-09 2008-05-15 Evotec Technologies Gmbh Feldkäfig und zugehöriges Betriebsverfahren
US8224066B2 (en) * 2007-05-29 2012-07-17 Gerd Haeusler Method and microscopy device for the deflectometric detection of local gradients and the three-dimensional shape of an object
JP5536650B2 (ja) * 2007-08-31 2014-07-02 ザ ジェネラル ホスピタル コーポレイション 自己干渉蛍光顕微鏡検査のためのシステムと方法、及び、それに関連するコンピュータがアクセス可能な媒体
DE102007045897A1 (de) * 2007-09-26 2009-04-09 Carl Zeiss Microimaging Gmbh Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe
FR2923054B1 (fr) * 2007-10-24 2009-12-11 Centre Nat Rech Scient Procede et dispositif de reconstruction du volume d'un objet a partir d'une sequence d'images de coupes dudit objet
JP2009115891A (ja) * 2007-11-02 2009-05-28 Univ Of Tokyo 走査型顕微鏡および標本画像取得方法
US8325349B2 (en) 2008-03-04 2012-12-04 California Institute Of Technology Focal plane adjustment by back propagation in optofluidic microscope devices
WO2009111577A1 (en) * 2008-03-04 2009-09-11 California Institute Of Technology Methods of using optofluidic microscope devices
WO2009111573A2 (en) 2008-03-04 2009-09-11 California Institute Of Technology Optofluidic microscope device with photosensor array
FR2929416B1 (fr) 2008-03-27 2010-11-05 Univ Paris 13 Procede de determination d'une representation tridimensionnelle d'un objet a partir d'une sequence d'images en coupe, produit programme d'ordinateur, procede d 'analyse d'un objet et systeme d'imagerie correspondants
FR2929417B1 (fr) * 2008-03-27 2010-05-21 Univ Paris 13 Procede de determination d'une representation tridimensionnelle d'un objet a partir de points, programme d'ordinateur et systeme d'imagerie correspondant
US8155409B2 (en) * 2008-04-17 2012-04-10 Ruprecht-Karls-Universitat Wave field microscope with sub-wavelength resolution and methods for processing microscopic images to detect objects with sub-wavelength dimensions
US8039776B2 (en) 2008-05-05 2011-10-18 California Institute Of Technology Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors
US8693742B2 (en) * 2008-12-17 2014-04-08 The Regents Of The University Of Colorado Three-dimensional single-molecule fluorescence imaging beyond the diffraction limit using a double-helix point spread function
EP2380055A4 (de) * 2009-01-21 2012-07-11 California Inst Of Techn Quantitative differentialinterferenzkontrastvorrichtung für computergestützte tiefensektionierung
US8416400B2 (en) 2009-06-03 2013-04-09 California Institute Of Technology Wavefront imaging sensor
WO2011035299A2 (en) * 2009-09-21 2011-03-24 California Institute Of Technology Reflective focusing and transmissive projection device
US8767216B2 (en) * 2009-10-13 2014-07-01 California Institute Of Technology Holographically illuminated imaging devices
WO2011106324A2 (en) 2010-02-23 2011-09-01 California Institute Of Technology Nondiffracting beam detection devices for three-dimensional imaging
CN102792151B (zh) 2010-03-23 2015-11-25 加州理工学院 用于2d和3d成像的超分辨率光流体显微镜
US8620065B2 (en) 2010-04-09 2013-12-31 The Regents Of The University Of Colorado Methods and systems for three dimensional optical imaging, sensing, particle localization and manipulation
US8536545B2 (en) 2010-09-09 2013-09-17 California Institute Of Technology Delayed emission detection devices and methods
US9693034B2 (en) 2011-12-13 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for localizing objects for distance and/or in three dimensions using a spiral point spread function
GB2518548B (en) 2012-06-22 2015-12-23 Univ Colorado Regents Imaging or measurement methods and systems
US9091628B2 (en) 2012-12-21 2015-07-28 L-3 Communications Security And Detection Systems, Inc. 3D mapping with two orthogonal imaging views
EP2973403B1 (de) 2013-03-15 2019-01-30 The Regents of the University of Colorado 3d-lokalisierung und -abbildung von dichten partikelarrays
WO2015031395A1 (en) 2013-08-26 2015-03-05 The Regents Of The University Of Colorado Imaging through scattering media with high signal to noise ratio and resolution
US9810893B2 (en) 2014-03-27 2017-11-07 The Board Of Trustees Of The Leland Stanford Junior University Phase mask imaging with characterization of rotational mobility
WO2016073785A1 (en) 2014-11-05 2016-05-12 The Regents Of The University Of Colorado 3d imaging, ranging, and/or tracking using active illumination and point spread function engineering
CN107110761B (zh) * 2014-12-16 2020-06-23 细胞动力学责任有限公司 实时分析流体中悬浮的颗粒的装置和分析所述颗粒的方法
EP3276335B1 (de) * 2015-03-27 2021-06-09 Nikon Corporation Mikroskopvorrichtung, betrachtungsverfahren und steuerungsprogramm
US10341640B2 (en) 2015-04-10 2019-07-02 The Board Of Trustees Of The Leland Stanford Junior University Multi-wavelength phase mask
US11327004B2 (en) 2016-03-02 2022-05-10 Arizona Board Of Regents On Behalf Of Arizona State University Live-cell computed tomography
JP6681068B2 (ja) * 2016-06-14 2020-04-15 国立研究開発法人理化学研究所 データ復元装置、顕微鏡システム、およびデータ復元方法
US11315292B2 (en) 2017-03-02 2022-04-26 Arizona Board Of Regents On Behalf Of Arizona State University Live-cell computed tomography
CN112005277A (zh) 2018-04-27 2020-11-27 惠普发展公司，有限责任合伙企业 三维体积成像
WO2019209347A1 (en) * 2018-04-27 2019-10-31 Hewlett-Packard Development Company, L.P. Nonrotating nonuniform electric field object rotation
US11543356B2 (en) * 2018-10-29 2023-01-03 Hewlett-Packard Development Company, L.P. Rotation and flat-form imaging for microscopic objects
CN114166699A (zh) * 2021-11-12 2022-03-11 清华大学深圳国际研究生院 一种悬浮颗粒体积的光学测量装置和方法
DE102022117214A1 (de) 2022-07-11 2024-01-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Ptychographisches Bildgebungsverfahren und -system
CN115091107B (zh) * 2022-08-24 2023-04-25 中国工程物理研究院激光聚变研究中心 一种用于激光加工的高精度装夹装置及装夹方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3129471B2 (ja) * 1991-06-01 2001-01-29 科学技術振興事業団 マルチビーム微粒子操作方法
EP0746408B1 (de) * 1994-02-24 1998-09-23 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Formen von mikropartikeln in elektrischen feldkaefigen
WO1996024875A1 (de) * 1995-02-08 1996-08-15 Dietmar Schwertner Verfahren und anordnung zur hochauflösenden stereomikroskopie mit erweiterter raumtiefe
US5620857A (en) * 1995-06-07 1997-04-15 United States Of America, As Represented By The Secretary Of Commerce Optical trap for detection and quantitation of subzeptomolar quantities of analytes
DE19653661C1 (de) * 1996-12-20 1998-05-20 Guenter Prof Dr Fuhr Verfahren und Vorrichtung zur Mikropartikelpositionierung in Feldkäfigen
DE19757785B4 (de) * 1997-12-28 2005-09-01 Günter Prof. Dr. Fuhr Verfahren zur Bestimmung optisch induzierter Kräfte
DE19859460C2 (de) * 1998-12-22 2001-02-22 Guenter Fuhr Verfahren und Vorrichtung zur elektro-optischen Einzelpartikelspektroskopie
DE19859461A1 (de) * 1998-12-22 2000-06-29 Evotec Biosystems Ag Verfahren und Vorrichtung zur konvektiven Bewegung von Flüssigkeiten in Mikrosystemen
DE19903001A1 (de) * 1999-01-26 2000-08-24 Evotec Biosystems Ag Verfahren und Vorrichtung zur Detektion mikroskopisch kleiner Objekte
CN1181337C (zh) * 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6806899B1 (en) * 1999-07-17 2004-10-19 David F. Schaack Focusing systems for perspective dimensional measurements and optical metrology
JP2001108619A (ja) * 1999-10-12 2001-04-20 Minolta Co Ltd 分析装置、試料操作針および試料取り出し方法
US6891671B1 (en) * 2000-04-18 2005-05-10 Gary Greenberg Apparatus and methods for creating real-time 3-D images and constructing 3-D models of an object imaged in an optical system
US7065242B2 (en) * 2000-03-28 2006-06-20 Viewpoint Corporation System and method of three-dimensional image capture and modeling
EP1205540A1 (de) * 2000-11-10 2002-05-15 Evotec OAI AG Verfahren zur Vitalitätsmessung an Zellen
US6678413B1 (en) * 2000-11-24 2004-01-13 Yiqing Liang System and method for object identification and behavior characterization using video analysis
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
DE10352416B4 (de) * 2003-11-10 2005-10-20 Evotec Technologies Gmbh Verfahren und Vorrichtungen zur Untersuchung eines deformierbaren Objekts
JP4276929B2 (ja) * 2003-11-18 2009-06-10 株式会社日立ハイテクノロジーズ 荷電粒子線色収差補正装置および該収差補正装置を搭載した荷電粒子線装置

Also Published As

Publication number Publication date
AU2003298099A8 (en) 2004-05-13
AU2003298099A1 (en) 2004-05-13
US7738695B2 (en) 2010-06-15
EP1413911A1 (de) 2004-04-28
WO2004038484A3 (en) 2004-05-27
ATE285590T1 (de) 2005-01-15
US20060126921A1 (en) 2006-06-15
DE60202374T2 (de) 2005-12-08
EP1413911B1 (de) 2004-12-22
WO2004038484A2 (en) 2004-05-06

Similar Documents

Publication Publication Date Title
DE60202374D1 (de) Methode und Vorrichtung zur Aufnahme dreidimensionaler Abbildungen von schwebend gehaltenen Mikroobjekten unter Verwendung hochauflösender Mikroskopie
US6078681A (en) Analytical imaging system and process
DE60309884D1 (de) Verfahren, vorrichtung und gerät zur ablesung von informationen von, zum beispiel, gestapelten jetons
CN102216827A (zh) 显微镜装置以及使用该显微镜装置的荧光观察方法
JP4953092B2 (ja) 細胞観察における生細胞の判別手法、細胞観察の画像処理プログラム及び画像処理装置
WO2009081832A1 (ja) タイムラプス画像の画像処理方法、画像処理プログラム及び画像処理装置
ATE348371T1 (de) Verfahren, vorrichtung, programm und datenträger zur bearbeitung von bilddaten
ATE234043T1 (de) Ultraschall-bildaufnahmegerät und verfahren zur brustuntersuchung
ATE521006T1 (de) Verfahren, software und gerät zur fokussierung eines optischen systems mittels computerbildanalyse
DE60307953D1 (de) Verfahren und Vorrichtung zur Auswahl und Ausgabe von Bildern
AU2002321118A1 (en) Method and device for representing an operative field during laser operations
EP1271496A3 (de) Objektivlinse, optisches Abtastgerät und Aufzeichnungs- und/oder Wiedergabegerät
ATE358438T1 (de) Verfahren und vorrichtung zur aufzeichnung und verarbeitung von bildern eines objekts, wie z.b. eines zahns
DE60005007D1 (de) Robustes autofokussystem für mikroskop
ATE372256T1 (de) Verfahren und vorrichtung zur besichtigung unter wasser
WO2002038034A2 (en) Method and apparatus for diagnosing pathogenic or allergenic microorganisms or microparticles at a remote location
JP2003195174A (ja) 走査型レーザ顕微鏡システム
DE50102209D1 (de) Verfahren und vorrichtung zur abbildung eines hinteren augenabschnittes
EP3223054A1 (de) Mikroskopsystem und probenbeobachtungsverfahren
RU2011146936A (ru) Способ и устройство для планирования сканирования с использованием ультрафиолетового излучения
US20170280051A1 (en) Observation apparatus, measurement system, culture vessel and control method for observation apparatus
CN113916853A (zh) 一种双通道荧光自动化检测装置
Liu et al. Underwater Raman microscopy—a novel in situ tool for deep-sea microscale target studies
ATE319156T1 (de) Verfahren und system zur visualisierung von bildern
Navarro et al. 3D data mapping and real-time experiment control and visualization in brain slices

Legal Events

Date Code Title Description
8364 No opposition during term of opposition